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Anaesthesia for fixation of repeated pathological fractures in a patient with multiple myeloma.

The introduction of new chemotherapeutic agents for the treatment of multiple myeloma (MM) has improved the life expectancy and quality of life for these patients in the last decade. Therefore, more patients with MM are being treated for repeated pathological fractures. The anaesthesiologist should continue the optimum supportive care received by these patients in the perioperative period also, by understanding the pathophysiology of the disease, the adverse effects of the chemotherapeutic agents and the guidelines for their supportive care. We report the perioperative management of a patient

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… Anaesthesia was maintained with FiO 2 0.5 (air oxygen mixture) and sevoflurane. The procedure was uneventful with no haemodynamic disturbances and minimal blood loss. After surgery, inhalational anaesthetics were stopped, and the LMA removed. Patient had an uneventful recovery. …

The Nimodipine-Sparing Effect of Perioperative Dexmedetomidine Infusion During Aneurysmal Subarachnoid Hemorrhage: A Prospective, Randomized, Controlled Trial.

Background: Nimodipine can block the influx of calcium into the vascular smooth muscle cell and prevent secondary ischemia in patients with … d a significantly decreased MAP from T5 to T9 compared with group D1 (P < 0.05). The consumption of sevoflurane, remifentanil, dexmedetomidine, and nimodipine were all significantly reduced in groups D1 and D2 during surgery (P < 0.05). Compared with group C, MAP was significantly decreased in groups D1 and D2 during the first 48 h after surgery (P < 0.05). C …

Интерферонские регулятивные факторы как потенциальная терапевтическая цель для нейроинфламмации: фокус на болезни Альцгеймера.

Регулирующие факторы интерферона (ИРФ) являются важнейшими модуляторами иммунной и подстрекательской реакции, однако их роль в болезни Альцгеймера (AD) и других нейродегенеративных расстройствах остается неполной. В то время как IRF признаются за их регулирующие функции в нейроинфламмации, микроглиальной активации и выживании нейронов, их двойная роль как факторов патологического воспаления и посредников нейрозащитных путей подчеркивает сложный нормативный парадокс в нейродегенеративных расстройствах. Цель этого обзора заключается в обобщении текущих данных о нейрофламмации в области АД и связ

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… The inhaled anesthetic sevoflurane activates IRF3 via the autophagy pathway, which includes the degradation of dehydrocholesterol-reductase-7 (DHCR7) and subsequent activation of AKT3. … The autophagy inhibitor 3-MA can mitigate sevoflurane-induced IRF3 activation and cytokine expression, thereby alleviating cognitive impairment [ 44 ]. NLRP3 inflammasome-mediated pyroptosis may contribute to the progression of AD-related memory loss [ 63 ]. …

Cancer related cognitive impairment: a downside of cancer treatment.

Cancer treatment is associated with long lasting cognitive impairment in cancer survivors. This cognitive impairment is often termed cancer related cognitive impairment (CRCI). Cancer survivors treated for tumors outside the central nervous system are increasingly diagnosed with CRCI. The development of strategies to mitigate the negative effects of cancer treatment on the brain are crucial. Although neuroimaging research has proposed several candidate mechanisms, the pathogenic underpinnings of CRCI remain uncertain. As such, preventative and treatment strategies have not been identified. To

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… A study reported that rats anesthetized with sevoflurane inhalant demonstrate diminished working and recognition memory as compared to untreated control rats ( 93 ). … Chrysin attenuates oxidative stress to alleviate sevoflurane-induced cognitive impairments in aged rats. Psychiatry Invest. (2023) 20:430–8. doi: 10.30773/pi.2022.0287 94. Fleming B, Edison P, Kenny L. …

Efficacy of repetitive transcranial magnetic stimulation on postoperative pain in patients undergoing video-assisted thoracoscopic surgery: study protocol for a prospective, single-center, randomized controlled trial.

BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is a key treatment for many cardiothoracic issues, but intraoperative factors can lead to acute postoperative pain (APSP), impacting recovery and quality of life. While multimodal analgesic methods are used, they have notable side effects. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive pain relief option by stimulating the primary motor cortex (M1), effective in chronic pain management. However, its role in preventing and treating APSP after VATS needs confirmation through high-quality clinical trials. METHODS/

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… Maintenance anesthesia employed a combined intravenous-inhalation technique: continuous propofol infusion at 4–6 mg/(kg⋅h), continuous remifentanil infusion at 8–10 μg/(kg⋅h), supplemented with 1% sevoflurane inhalation (targeting a brain-stem evoked potential BIS of 40–60). … Discontinue sevoflurane inhalation 30 min prior to the end of surgery. All anesthetic agents will be discontinued upon completion of the procedure. The patient will be moved to the post-anesthesia care unit (PACU). …

Postoperative cognitive dysfunction: spotlight on light, circadian rhythms, and sleep.

Postoperative cognitive dysfunction (POCD) is a neurological disorder characterized by the emergence of cognitive impairment after surgery. A growing body of literature suggests that the onset of POCD is closely tied to circadian rhythm disruption (CRD). Circadian rhythms are patterns of behavioral and physiological change that repeat themselves at approximately, but not exactly, every 24 h. They are entrained to the 24 h day by the daily light-dark cycle. Postoperative CRD affects cognitive function likely by disrupting sleep architecture, which in turn provokes a host of pathological process

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… Mori et al. describe how sevoflurane anesthesia suppressed PER2 expression in the mouse SCN, possibly by reducing histone acetylation in the promoter region ( Mori et al., 2014 ). … Epigenetic suppression of mouse Per2 expression in the suprachiasmatic nucleus by the inhalational anesthetic, sevoflurane. PLoS ONE 9:e87319. doi: 10.1371/journal.pone.0087319, PMID: Motomura Y., Katsunuma R., Yoshimura M., Mishima K. (2017). …

Prevalence, Attributes, and Risk Factors of QT-Interval-Prolonging Drugs and Potential Drug-Drug Interactions in Cancer Patients: A Prospective Study in a Tertiary Care Hospital.

Introduction Cancer chemotherapy regimens include multiple classes of adjuvant drugs as supportive therapy. Because of the concurrent intake of other drugs (like antiemetics, antidepressants, analgesics, and antimicrobials), there is a heightened risk for possible QT interval prolongation. There is a dearth of evidence in the literature regarding the usage of QT-prolonging anticancer drugs and associated risk factors that have the propensity to prolong QT interval. The purpose was to explore the extent of the use of QT-interval-prolonging drugs and potential QT-prolonging drug-drug interaction

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… Palonosetron may evoke QTc protraction [ 86 ] (especially during the early general anesthesia period when administered with sevoflurane) [ 87 ]. … Intravenous palonosetron increases the incidence of QTc prolongation during sevoflurane general anesthesia for laparotomy. Min JJ, Yoo Y, Kim TK, Lee JM. Korean J Anesthesiol. 2013;65:397–402. doi: 10.4097/kjae.2013.65.5.397. 88. …

Резюме МКАРЕ 2023 77th Национальный конгресс &quot; СИААРТИ &quot;

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… These decreases might have been due to the effect of sevoflurane on cardiorespiratory reflexes, which seemed to be clinically unimportant. … Patients were randomly assigned to mask induction with Air/O2/Sevoflurane without the presence of parents (control group) or in the presence of parents (experimental group). …

The Potential of Chronotherapy and Nanotherapy-Based Strategies for Glioblastoma Treatment.

Glioblastoma is the most common and aggressive brain tumour in adults, and despite ongoing efforts, effective treatment remains limited. Standard therapies often face challenges because of the tumour's specific biology, its aggressive nature, and the presence of certain physiological barriers in the brain that impede chemotherapeutics from reaching their target. Emerging research in circadian biology highlights the role of the internal circadian clock in tumour progression and treatment response. Evidence suggests that aligning therapy to patients' chronotypes could potentially improve treatme

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… By indirectly regulating the miR-1290/RORA network, Sevoflurane (Sev) has been shown to block glioblastoma progression [ 40 ]. ROR-α overexpression is associated with proliferation and tumorigenesis blockage, achieved by means of the inhibition of the TNF-α-mediated NF-κB signalling pathway [ 43 ]. … Sevoflurane blocks glioma malignant development by upregulating circRELN through circRELN-mediated miR-1290/RORA axis. BMC Anesthesiol. 2021;21:213. doi: 10.1186/s12871-021-01427-1. 41. Zhang Y., Hu X., Li H., Yao J., Yang P., Lan Y., Xia H. …

MicroRNA-150-5p inhibits the proliferation and invasion of human larynx epidermiod cancer cells though regulating peptidyl-prolyl cis/trans isomerase.

ObjectiveThis study aimed to investigate the molecular mechanism of miR-150-5p regulating the malignant biological behavior of Human Epidermoid cancer cell (HEp-2) by targeting peptidyl-prolyl cis/trans isomerase NIMA-Interacting-1 (PIN1).MethodsFirstly, qRT-PCR and Western blot were adopted to detect the expression levels of miR-150-5p and PIN1 in cancer tissue and paracancerous tissues of patients with LSCC, and those in human bronchial epithelial cells (16 HBE) and HEp-2. Next, the targeted relationship between miR-150-5p and PIN1 was assessed by bioinformatics website and dual-luciferase r

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… End-tidal sevoflurane concentration for ProSeal(TM) versus Classic (TM) laryngeal mask airway insertion in unpremedicated anaesthetised adult females. Anaesth Intensive Care. 2016;44:221–226. doi: 10.1177/0310057X1604400208. 4. Yang Q., Zhang C., Huang B., Li H., Zhang R., Huang Y., et al. …

Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy.

Exosomal circular RNA (circRNAs) are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). Their presence in bodily fluids positions them as potential non-invasive biomarkers, revealing the molecular dynamics of cancers. Research in exosomal circRNAs is reshaping our understanding of neoplastic intercellular communication. Exploiting the natural properties of exosomes for targeted drug delivery and disrupting circRNA-mediate

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… For instance, He et al. [ 80 ] demonstrated that sevoflurane, a general anesthetic, suppresses CRC cell viability and invasion while promoting apoptosis by modulating the exosome-mediated circ-HMGCS1/miR-34a-5p/SGPP1 axis. … This study suggests a potential therapeutic role for sevoflurane in CRC treatment . Beyond diagnostics, exosomal circRNAs also play a pivotal role in the dynamic processes of tumor progression as demonstrated by various studies. …

Therapeutic potential of alpha-tocopherol in reducing oxidative stress and inflammatory damage after experimental traumatic brain injury and pentylenetetrazol-induced seizures.

The effects of alpha-tocopherol on seizure parameters, locomotor-cognitive functions, inflammatory response, oxidative stress response, histopathological changes, immunohistochemical parameters, and miRNA fold changes were investigated in rats with traumatic brain injury (TBI) and pentylenetetrazol (PTZ)-induced seizures. Sprague-Dawley male rats were randomly divided into three groups: Control (n = 8), TBI + PTZ (n = 10), and TBI + PTZ + tocopherol (n = 10). After inducing TBI in animals using the weight-drop method, increased post-injury seizure susceptibility was achieved by administering s

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… Bonferroni correction was not applied because only two groups were compared On the first day of the study (day 1), the experimental animals were anesthetized with 3% sevoflurane and then subjected to head trauma using weight drop. … Animals were anesthetized with 3% sevoflurane and then subjected to head trauma using weight drop. The trauma apparatus consisted of a hollow glass tube attached to a foot stand and extending vertically to the floor. …

The protective and chemotherapeutical role of amygdalin in induced mammary cancer in experimental mice and upregulation of related genes.

Breast cancer is a prominent health issue among oncological diseases in emerging nations. The study sought to assess the significant function of amygdalin as a protective and chemotherapeutical substance in combating this lethal condition, either independently or in conjunction with tamoxifen therapy. Breast cancer in mice was induced by 7,12-Dimethylbenz(a)anthracene (DMBA). Mice were divided into six groups, 15 mice in each group. (i) control group, (ii) carcinogenic group, (iii) tamoxifen-treated group, (iv) Amygdalin-treated group, (v) (Amygdalin + tamoxifen) group, (vi) Amygdalin protecti

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… Marquardt N Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide? PloS one 2018 13 e0203793 10.1371/journal.pone.0203793 30199551 PMC6130864 Marquardt, N. et al. … Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide?. PloS one 13 , e0203793 (2018). 30199551 10.1371/journal.pone.0203793 PMC6130864 31. Young, D. Effects of drugs on clinical laboratory tests. Third . Vol. 3 (1990). 32. Belfield A Goldenberg D M. …

MicroRNA-7: a versatile player and core target in brain disorders.

OBJECTIVE: This article provides a systematic review of the biological characteristics, regulatory mechanisms, and roles of MicroRNA-7 (miR-7) in the nervous system, as well as explores its clinical translation potential and challenges. METHODS: A review analysis integrating the progress of basic and clinical research related to miR-7. RESULTS: Characteristics and Regulation: miR-7 is highly expressed in mammalian brain tissues, with its function finely regulated by ceRNA networks (such as ciRS-7 and lncRNA SNHG1) and epigenetic modifications, forming a multi-layer dynamic regulatory system.

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… The anesthetic sevoflurane can inhibit HMMR-AS1 expression, relieving its sponging effect on miR-7, subsequently suppressing CDK4 expression and exerting anti-glioma effects [ 36 ]. … In contrast, the anesthetic sevoflurane can inhibit HMMR-AS1, restore miR-7‘s regulation of CDK4, and exert anti-tumor effects [ 36 ]. …

Воздействие интерферона-β и диметилфумарата на нелинейные динамические характеристики сигнатур электроэнцефалограммы у пациентов с множественным склерозом.

ВВЕДЕНИЕ: Множественный склероз (МС) представляет собой сложное неврологическое состояние, которое затрагивает многих людей во всем мире, и в настоящее время проводится значительный объем исследований, направленных на понимание патологии и развития лечения. Нелинейный анализ все чаще используется для анализа сигналов электроэнцефалографии (ЭЭГ) от пациентов с различными неврологическими расстройствами, включая MS, и он доказал свою эффективность как инструмент понимания сложной природы мозга.МЕТОДЫ: Настоящее исследование направлено на изучение воздействия Интерферона-β (IFN-β) и диметилфумара

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… Shalbaf et al. (2012) used SampEn to measure the effects of sevoflurane on electroencephalogram, and they concluded it outperformed response entropy (RE) ( Shalbaf et al., 2012 ). …

Молекулярные модели, связанные с ущербом от митохондриала: нейроиммуномодуляторы в патофизиологии центральной нервной системы.

Нейроинфламмация способствует широкому спектру нейродегенеративных заболеваний, включая болезнь Альцгеймера, болезнь Паркинсона, болезнь Хантингтона и множественный склероз. Его движут неевропейские глиальные клетки, главным образом микроглии и астроциты. Микроглии являются постоянными иммунными клетками центральной нервной системы, в то время как астроциты являются основными элементами поддержки нейронных функций, но могут также участвовать в нейроиммунной реакции. Оба этих типа глиальных клеток могут стать реактивными при обнаружении определенных внутриклеточных молекул, которые появляются в

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… For example, BV-2 murine microglia treated with sevoflurane, a common inhalation anesthetic, release mtDNA into the cytosol, increasing cGAS/STING signaling and subsequently activating NLRP3. … This is confirmed by the pre-treatment of BV-2 cells with inhibitors of mtDNA release and cGAS/STING activation, which reduces sevoflurane-induced NLRP3 assembly (Yang et al., 2024). Astrocytes also express components of the NLRP3 inflammasome, which is activated by select DAMPs such as ATP. …

Minocycline ameliorates CNS autoimmunity through restraint of CD4+CD11bc+ cells.

Minocycline is a tetracycline antibiotic with profound anti-inflammatory activity directed primarily against microglial cells and macrophages. Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as an important target of minocycline. This drug has been considered a promising therapeutic for multiple sclerosis, an autoimmune disorder of the central nervous system (CNS). Still, its effect on CNS autoimmunity is not entirely understood. The aim of this study was to investigate the potency of short-term minocycline administration in fully developed CNS inflammation. To t

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… Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2 . Int J Mol Med . ( 2017 ) 39 : 869–78 . doi: 10.3892/ijmm.2017.2908 28260081 PMC5360434 15 Almolda B Costa M Montoya M González B Castellano B . …

Risk Factors for Serious Hypotension Induced by Intravenous Acetaminophen in Patients With Hematologic Malignancy.

PURPOSE: Owing to their rapid antipyretic effects and predictable pharmacokinetic properties, acetaminophen (AAP) are commonly administered intravenously to severely ill patients. However, the potential development of hypotension as a consequence of intravenous AAP administration has not been thoroughly addressed. In this study, we aimed to identify the risk factors associated with the occurrence of serious hypotension following intravenous AAP administration during fever in patients with hematologic malignancies. METHODS: This retrospective study included hospitalized patients in the hemato-

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… Tsikas D., Jordan J., and Engeli S., “Blood Pressure‐Lowering Effects of Propofol or Sevoflurane Anaesthesia Are Not due to Enhanced Nitric Oxide Formation or Bioavailability,” British Journal of Clinical Pharmacology 79 (2015): 1030–1033, 10.1111/bcp.12568. 27. …

Dual targeting with 224Ra/212Pb-conjugates for targeted alpha therapy of disseminated cancers: A conceptual approach.

Metastases are the primary cause of death among cancer patients and efficacious new treatments are sorely needed. Targeted alpha-emitting radiopharmaceuticals that are highly cytotoxic may fulfill this critical need. The focus of this paper is to describe and explore a novel technology that may improve the therapeutic effect of targeted alpha therapy by combining two radionuclides from the same decay chain in the same solution. We hypothesize that the dual targeting solution containing bone-seeking 224Ra and cell-directed complexes of progeny 212Pb is a promising approach to treat metastatic c

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… During imaging, mice were under gas anesthesia (∼3.5% Sevoflurane in oxygen at 0.5 L/min; Baxter, IL, USA). All bioluminescence data are displayed in radiance (photons/s/cm 2 /str) under identical acquisition conditions. …

42nd International Symposium on Intensive Care & Emergency Medicine

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