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Disposition and clinical outcome after intraperitoneal meperidine and ropivacaine administration during laparoscopic surgery.

BACKGROUND: Limited evidence supports the efficacy of intraperitoneal (IP) meperidine or local anesthetic for postoperative analgesia. Our study aims were to investigate analgesic efficacy and to quantify the plasma concentrations of meperidine and ropivacaine after IP administration. The null hypothesis was that there was no significant difference among groups for dynamic pain in the first 24 h after major abdominal laparoscopic surgery. METHODS: This double-blind, five parallel group, placebo-controlled, two-center trial randomized 250 women having laparoscopic surgery to receive IP meperid

Energy transfer in single hydrogen-bonded water molecules.

We study the structure and dynamics of hydrogen-bonded complexes of H2O/HDO and acetone dissolved in carbon tetrachloride by probing the response of the O-H stretching vibrations with linear mid-infrared spectroscopy and femtosecond mid-infrared pump-probe spectroscopy. We find that the hydrogen bonds in these complexes break and reform with a characteristic time scale of approximately 1 ps. These hydrogen-bond dynamics are observed to play an important role in the equilibration of vibrational energy over the two O-H groups of the H2O molecule. For both H2O and HDO, the O-H stretching vibratio

The effect of foot structure and range of motion on musculoskeletal overuse injuries.

The purpose of this prospective study was to determine whether an association exists between foot structure and the development of musculoskeletal overuse injuries. The study group was a well-defined cohort of 449 trainees at the Naval Special Warfare Training Center in Coronado, California. Before beginning training, measurements were made of ankle motion, subtalar motion, and the static (standing) and dynamic (walking) characteristics of the foot arch. The subjects were tracked prospectively for injuries throughout training. We identified risk factors that predispose people to lower extremit

Mechanical properties of the urethra in healthy and stress incontinent females: dynamic measurements in the resting urethra.

The relationship between pressure and cross-sectional area in the resting urethra during its inflation and deflation was examined in 30 healthy females and in 30 patients with genuine stress incontinence (GSI). Measurements were performed at the bladder neck, in the high-pressure zone and distally in the urethra. The mechanical properties of the urethra were found to vary significantly as a function of time after induction of a cross-sectional area (stress episode) in both groups of women. The pattern of response of the urethra showed significant differences between normals and GSI particularl

[Examination of the vocal range in school children].

The author examined in 50 children (pupils of the 1st 50 5th form of primary school), selected at random, the vocal field. The group comprised 22 boys and 28 girls, always 10 children from the same form. Their mean vocal range was 17 semi-tones from G sharp to C2. The maximal dynamic range varied between 10 and 13 dB and did not exceed the intensity of 75 dB A. These results suggest relatively limited dynamics of the singing voice in children and indicate the optimal vocal position and range. Marked transcendence of these limits is probably one of the reasons which lead in some children singin

Comparison of wrist flexor and extensor muscle recruitment between adults with and without chronic wrist hypermobility.

BACKGROUND: Chronic wrist hypermobility (CWH), a common condition among young adults due to atraumatic carpal region laxity or benign joint hypermobility, is characterized by decreased strength and proprioception, often without pain. Wrist function depends on both dynamic and static stabilizers, which mediate neuromuscular reflex responses. CWH may alter normal wrist neuromuscular recruitment and cause inadequate dynamic stabilization at different functional forearm positions. PURPOSE: This study aimed to determine electromyographic (EMG) wrist muscle recruitment differences between individua

Semiquantitative analysis using whole-body dynamic F-18 fluoro-2-deoxy-glucose-positron emission tomography to differentiate between benign and malignant lesions.

OBJECTIVES: To investigate whether whole-body dynamic positron emission tomography (PET) is useful for differentiating benign and malignant lesions. METHODS: In this retrospective study, data from a cohort of 146 lesions from 187 patients who consecutively underwent whole-body dynamic PET scans at our hospital for suspected lesions in the lung, lymph nodes, liver, bone, esophagus, and colon were analyzed. Patients with malignant lymphomas, accumulations > 5 cm in length along the long axis of the esophagus, or lesions in the colon in which the site of accumulation moved during the imaging per

Design and Implementation of a Psychotherapy Group Program for Individuals and Families Impacted by Li-Fraumeni Syndrome: A Pilot Study.

OBJECTIVES: There is a paucity of evidence-based psychosocial resources for individuals and families impacted by Li-Fraumeni Syndrome (LFS). This mixed-methods study aimed to (1) establish interest in and need for a dedicated LFS psychotherapy group, (2) design and implement a psychotherapy group, and (3) evaluate participant experiences and gather feedback for future group interventions. METHODS: Eligible participants were English-speaking, ≥ 18 years, and an individual with LFS or a caregiver/family member. An anonymous needs assessment survey determined preferences, formatting and content

Mindfulness-Based Group Cognitive Behavior Therapy for Provoked Localized Vulvodynia: A Randomized Controlled Trial.

OBJECTIVE: The aim of the study was to compare the effectiveness of mindfulness-based group cognitive behavior therapy (M-gCBT) versus educa … mpletion of the study period, 3 months, and 6 months. Sample size was based on the ideal number for group dynamics of 6 to 12 participants per group. RESULTS: Participants were enrolled from August 1, 2016, to January 30, 2017. Thirty-two participants were enrolled and 31 were randomized: 14 to M-gCBT and 17 to education support. Baseline characteristics did no …

Impaired myocardial blood flow and coronary flow reserve of the anatomical right systemic ventricle in patients with congenitally corrected transposition of the great arteries.

OBJECTIVES: To investigate myocardial blood flow of the morphological right systemic ventricle in unoperated patients with congenitally corrected transposition of the great arteries (CCTGA) by positron emission tomography (PET). DESIGN: Prospective cross sectional clinical study. SETTING: Tertiary referral centre for paediatric cardiology. PATIENTS: 15 patients with CCTGA were investigated by PET with nitrogen-13 ammonia at rest and during adenosine vasodilatation. A subgroup of seven patients had isolated CCTGA (group A, mean (SD) age 30.3 (11.9) years) and the remaining eight patients had

Поэтапное сокращение сотрудничества между людьми.

Сотрудничество между людьми носит динамичный характер и зачастую сокращается даже при наличии благоприятных условий conditions1-4. Многие из существующих теорий объясняют уменьшение масштабов сотрудничества с точки зрения стратегического поведения или обучения, сформулированного как свидетельство рационального поведения или продвижения в направлении rationality5-9. Здесь мы показываем, что одним из ключевых источников долгосрочного спада являются отклонения от рационального поведения, которые систематически меняются с течением времени. Мы анализируем естественную социальную дилемму на местах,

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… In the ‘Modelling’ section below, we define cooperative outcome measures using a 30-day window to capture meaningful behaviour attributable to internal group dynamics, distinct from institutional debt recovery efforts. … The interview content was instrumental in interpreting the quantitative dataset, providing context, and offering cross-validation of borrowers’ descriptions of the group dynamics from an external perspective. …

Evaluating the play fighting of rats: A sociological perspective.

BACKGROUND: Play fighting is a prominent social behavior in juvenile rats and is widely used to assess social motivation, affect, and neurobiological function. Traditional dyadic paradigms quantify how much play occurs and how it is expressed but provide limited insight into how rats select play partners. NEW METHOD: We synthesize evidence from group-based paradigms that allow animals to choose among multiple partners and highlight analytical approaches-including social network analysis and machine-learning-based tracking-that enable quantification of partner selection and group dynamics. RE…

Efficacy and Safety of Rb-bFGF in Hair Transplantation: A Prospective and Comparative Study.

OBJECTIVE: This prospective randomized controlled trial aimed to evaluate the clinical value of recombinant bovine basic fibroblast growth factor (rb-bFGF)-based combined therapy in hair transplantation, focusing on its optimization effects on follicle survival rate, postoperative hair-loss dynamics, complication control, and patient satisfaction. METHODS: Sixty patients with moderate-to-severe androgenetic alopecia were randomly assigned to either an rb-bFGF group or a control group. In the rb-bFGF group, harvested follicles were intraoperatively immersed in an rb-bFGF-enriched solution and

Love addiction and gender modality: An empirical, comparative study involving Italian transgender and cisgender individuals.

INTRODUCTION: Love addiction is a state of addiction to relationships, from which dysfunctional emotions and behaviors develop, leading individuals to have a constant need for the other person and to failure in attempts of detachment. Given its recent scientific understanding, the study of love addiction has not yet been extended to the transgender community. AIMS: The present study aims to integrate gender modality into the study of love addiction. Specifically, the aims are to analyze the dynamics of love addiction by comparing a group of transgender people to a group of cisgender people, a

Distinct Features of Germinal Center Reactions in Macaques Infected by SIV or Vaccinated with a T-Dependent Model Antigen.

B-cell follicles constitute large reservoirs of infectious HIV/SIV associated to follicular dendritic cells and infecting follicular helper (TFH) and regulatory (TFR) T-cells in germinal centers (GCs). Thus, follicular and GC B-cells are persistently exposed to viral antigens. Despite recent development of potent HIV immunogens, numerous questions are still open regarding GC reaction during early HIV/SIV infection. Here, we dissect the dynamics of B- and T-cells in GCs of macaques acutely infected by SIV (Group SIV+) or vaccinated with Tetanus Toxoid (Group TT), a T-dependent model antigen. Sy

[Does the assay of acute phase protein concentrations in cerebrospinal fluid and/or in serum in patient with viral meningitis have a diagnostic value? Part II. Lymphocytic meningitis caused by echo 30 virus].

The aim of the study was to evaluate dynamics of selected acute phase proteins in serum and cerebrospinal fluid (CSF) in children with viral meningitis and to assess diagnostic power of protein determination for detection and treatment monitoring. 51 children with viral meningitis caused by ECHO 30 virus were included in the study group. Concentration of C-reactive protein (CRP), alpha 1-antitrypsin (AAT), alpha1-acid glycoprotein (AAG), alpha2-haptoglobin (HPT) and C3 complement fragment were determined in serum and CSF at entry and at day 14 after admittance to hospital. Control group for se

Frequency-Domain Dynamic Light Scattering (FEDSA) for in vivo screening of breast tissue abnormalities: A proof-of-concept study.

BACKGROUND AND OBJECTIVE: Dynamic light scattering (DLS) provides valuable information on nanoscale and microscale dynamics, but its systematic application to in vivo tissue evaluation remains limited. This study introduces field effect detection by spectral analysis (FEDSA), a frequency-domain approach designed to analyze backscattered light signals and identify tissue abnormalities associated with the field cancerization effect in breast tissue. The objective was to establish a proof of concept showing that FEDSA can differentiate normal from abnormal tissue. METHODS: A two-stage proof-of-c

Electroencephalogram microstate analysis in temporal lobe epilepsy: A comparative study with and without anxiety.

BACKGROUND: Anxiety is a prevalent psychiatric comorbidity in temporal lobe epilepsy (TLE), however, limited attention has been given to the dynamic characteristics of TLE coexisting with anxiety.The aim of this study was to examine abnormal resting-state Electroencephalography (EEG) microstate dynamics in TLE patients with anxiety disorders compared with TLE patients without anxiety disorders and healthy controls. METHODS: Ninety participants in this study: 30 healthy controls (HC), 30 TLE patients with anxiety (PAS), and 30 TLE patients without anxiety (nPAS). The dynamic changes in the ent

Smartphone Evaluation of Dynamic and Static Naturalness After Double-Eyelid Blepharoplasty.

BACKGROUND: Recent studies on postoperative measurements for upper blepharoplasty utilized static photographs, which fail to accurately reflect the postsurgical dynamic naturalness of the eyelids. OBJECTIVES: In this study we aimed to analyze dynamic naturalness after double-eyelid blepharoplasty with a simple smartphone method involving slow-motion videos. METHODS: In this prospective observational study we enrolled patients who underwent double-eyelid blepharoplasty with the flexible suspension technique (FST) and rigid fixation technique (RFT), and individuals with congenital double eyeli

Effects of core stability exercises on balance ability of children and adolescents with intellectual disabilities: A systematic review and meta-analysis.

BACKGROUND: Children and adolescents with intellectual disabilities (IDs) are at risk of falls due to balance problems. One way to palliate balance deficits among this population is via core stability exercises. However, comprehensive studies that examine the effectiveness of core stability exercises in improving balance in this target population are lacking. OBJECTIVE: This study aims to summarise and quantify the effectiveness of core stability exercises in improving the balance of this target population. METHODS: This study followed PRISMA principles and conducted comprehensive searches i