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Sleep aspects on video-polysomnography in LRRK2 mutation carriers.

BACKGROUND: Rapid eye movement sleep behavior disorder and sleepiness precede or accompany idiopathic Parkinson's disease (PD), but their presence in subjects with leucine-rich repeat kinase 2 mutations is unknown. METHODS: Ten patients with leucine-rich repeat kinase 2-associated PD, four healthy leucine-rich repeat kinase 2 mutation carriers, 20 patients with idiopathic PD, and 12 healthy controls underwent clinical assessments and a nighttime video-polysomnography. RESULTS: No sleep changes, no rapid eye movement sleep behavior disorder, or rapid eye movement sleep without atonia was foun

Stereotypic Movements in Case of Sporadic Creutzfeldt-Jakob Disease: Possible Role of Anti-NMDA Receptor Antibodies.

Sporadic Creutzfeldt-Jakob disease (sCJD) and anti-NMDA receptor antibody encephalitis (NMDAE) can both produce a rapidly progressive dementia with resulting state of catatonia or akinetic mutism. Both are associated with movement disorders. In published case series, myoclonus appears to be the most frequent movement disorder in sCJD, while stereotypic, synchronized, one-cycle-per-second movements such as arm or leg elevation, jaw opening, grimacing, head turning, and eye deviation are seen in NMDAE. We report a case of a 59-year-old woman with rapidly worsening cognitive disturbance leading t…

Clinical Utility of Neurophysiologic Classification (and Declassification) of Myoclonus.

BACKGROUND: Movement clinical neurophysiology studies can distinguish myoclonus, tremor, and other jerky movements; however, there has been … tified unsuspected myoclonus, leading to changes in diagnosis and management. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Sympathetic Activation and Sleep-Related Movements: Integrating Autonomic, Dopaminergic, and Iron Deficiency Mechanisms.

OBJECTIVE: Recent research has expanded the understanding of the potential role of sympathetic nervous system activation in the implications of sleep-related movement disorders, particularly in the mechanisms of dopaminergic dysfunction and iron deficiency. This multifactorial perspective aims to provide insights into disease mechanisms and opportunities for targeted interventions that address both neurological and autonomic contributors to sleep-related movements. METHODS: To synthesize the current evidence on the role of sympathetic activation in sleep-related movement disorders, we conduct…

Ballism after stroke responds to standard physical therapeutic interventions.

OBJECTIVE: To report the effects of noninvasive standard physical therapy (PT) interventions on an involuntary movement disorder after strok … inesia after stroke. The benefit may be adjunctive or alternative to current invasive treatments of movement disorders after brain injury and merits confirmation. The improvements are consistent with current research indicating that (1) intact cortical, subcortical, cerebellar, and spinal areas interact to generate bilateral rhythmic limb movements that can overcome …

Tetrabenazine therapy of dystonia, chorea, tics, and other dyskinesias.

Dopamine receptor blocking drugs, commonly used in the treatment of involuntary movements, may cause potentially serious adverse effects, in … s syndrome, and 3.4 in 25 with other focal dystonias. Twenty-two patients with a variety of unusual movement disorders had a mean effect of 2.9. Parkinsonism occurred as a side effect in 53 patients, sedation in 28, depression in 23, anxiety in 16, insomnia in 11, and akathisia in 10. The choreatic movement disorders are most amenable to tetrabenazine therapy, but t …

Pelvic movements as rhythmic motor manifestation associated with restless legs syndrome.

Video-polysomnographic monitoring of a patient with a 4-year history of an unpleasant restless sensation originating in his lower abdomen showed stereotyped, repetitive, rhythmic pelvic body movements resembling coital behaviour at the wake-sleep transition. We discuss the association between restless legs syndrome and rhythmic movement disorder as a particular manifestation of a spectrum of rhythmic sleep-related movement disorders.

Epidemiology of myoclonus.

All studies that attempt to evaluate the general occurrence of myoclonus have various biases. Even so, myoclonus has been demonstrated to be an important cause of abnormal movement control when compared to other movement disorders. Clearly, posthypoxia etiology, neurodegenerative disease, and epilepsy syndromes are important individual causes of myoclonus. The epidemiology of myoclonus is worthy of further study in other defined populations.

Влияние износимой ритмической стимуляции слуха на болезнь Паркинсона, множественный склероз и инсульт: систематический обзор и метаанализ.

Движущаяся терапия с использованием рифмического стимула (RAS) оказалась полезной для болезни Паркинсона (PD). Вместе с тем необходимо провести исследования, касающиеся применения изношенных устройств во всех неврологических расстройствах. Цель этого исследования состоит в том, чтобы изучить эффективность терапии с использованием изношенных устройств при перемещении лиц с неврологическими расстройствами. Систематический обзор и метаанализ. Источники данных 27, 2024. Были проведены обыски PubMed, Web of Science, Medline, PEDro и ScienceDirect. В соответствии с руководящими принципами ПРИСМА 202

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… Bach et al. (2011) 1 , it was predicted that the prevalence of movement disorders would increase considerably between 2010 and 2050 with the greatest increase in Lewy Body Dementia. Interestingly, the authors suggested that the prevalence of Parkinson’s disease could double in some countries. … Consequently, the pressure on society to accommodate the increasing amount of those suffering with movement disorders will continue to rise 3 . Movement disorders can manifest themselves in several ways, of which tremor being the most common symptom worldwide 4 . …

Organophosphate intoxication-related coital-like involuntary movements: report of A case.

The neurologic manifestations of organophosphate intoxication are many, and different pathophysiologic mechanisms are responsible for the different presentations occurring at different stages of the disease process. Movement disorders constitute one of the neurologic manifestations, which may include Parkinsonism or other dyskinetic movements. However, involuntary coital-like movements have not been reported as one of the organophosphate intoxication-related movement disorders. In this case report, we describe a 71-year-old man who developed involuntary coital-like movements about one and a ha…

[Athetosis].

Athetosis is a peculiar involuntary movement resulting from pathologic involvement of the basal ganglia. Although mechanism of this movement is still far from established, athetosis is clinically differentiated from chorea and dystonia. The purpose of this article is to review and summarise the classification of this involuntary movement disorder. This movement disorder is classified into double athetosis, chorea-athetosis, unilateral athetosis and pseudo-athetosis. The double athetosis is featured by increased muscle tonus and irregular small amplitude movement, which appears the most frequen

Phenotypic variability of DYT1-PTD: does the clinical spectrum include psychogenic dystonia?

Primary torsion dystonia (PTD) is a clinically and genetically heterogeneous group of movement disorders, usually inherited in an autosomal dominant manner with reduced (30-40%) penetrance. The DYT1 gene on chromosome 9q34 is responsible for most cases of early limb-onset PTD. DYT1-PTD clinical spectrum is broad, as the disease may present with several degrees of body involvement and severity. We identified an Italian family with 4 members definitely affected by PTD, genetically diagnosed as carriers of the GAG mutation at DYT1 gene. Phenotype was homogeneous when considering the presentation …

Functional neurological disorder treated with psychoeducation: A case report.

RATIONALE: Psychogenic tremor (PT) is the most common subtype of psychogenic movement disorder, characterized by involuntary movement, and is usually related to occupational injuries or accidents. Psychogenic movement disorder falls under the category of functional neurological disorders, which are diagnosed based on the criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders. PATIENT CONCERNS: A 25-year-old Saudi male with a history of recurrent superior ventricular tachycardia presented to the emergency department with tremors affecting all his extremities for 8 days.

Spotlight on Oculogyric Crisis: A Review.

BACKGROUND: Oculogyric crisis (OGC) is a form of acute dystonia characterized by sustained dystonic, conjugate, and upward deviation of the eyes. It was initially reported in patients with postencephalitic parkinsonism. But later, other factors such as medications, movement disorders, metabolic disorders, and focal brain lesions were also found to be associated with OGC. METHODS: The literature regarding OGC was searched via PubMed, Google Scholar, and through citations in relevant articles till December 2019, with keywords including OGC, oculogyric eye movements, tonic eye movement, neurolep…

[Paroxysmal dyskinesias - disorder categories, their causes and treatment].

Paroxysmal dyskinesias refer to category of abnormal involuntary movements, such as chorea, dystonia, athetosis, ballism or their various co … includes synthetic information developed based on specialistic literature cencerned with paroxysmal movement disorders. The authors focused primarily on characteristics of the most important issues in this area, into which types of disorders, their causes and treament as well as psychopathology aspect having crucial influence on patients' life comfort were included. …

[Psychiatric aspects of tics].

BACKGROUND: Tics, the most serious form of which is the Gilles de la Tourette syndrome (GTS), belong to the group of hyperkinetic movement disorders. The most extreme forms of these movement disorders are often characterised by psychiatric comorbidity. AIM: To acquaint the reader with the psychiatric aspects of tics and with the role played by comorbidities in OCD and ADHD patients who also suffer from tics. METHOD: Recent new insights in psychiatric aspects of GTS are described. RESULTS: Tics in GTS have marked psychological characteristics because of their relatively capricious nature, th…

Long-term increase in coherence between the basal ganglia and motor cortex after asphyxial cardiac arrest and resuscitation in developing rats.

BACKGROUND: The basal ganglia are vulnerable to injury during cardiac arrest. Movement disorders are a common morbidity in survivors. Yet, neuronal motor network changes post-arrest remain poorly understood. METHODS: We compared function of the motor network in adult rats that, during postnatal week 3, underwent 9.5 min of asphyxial cardiac arrest (n = 9) or sham intervention (n = 8). Six months after injury, we simultaneously recorded local field potentials (LFP) from the primary motor cortex (MCx) and single neuron firing and LFP from the rat entopeduncular nucleus (EPN), which corresponds …

Past and present in drug treatment of sleep disorders.

Sleep disorders are frequent and disturbing, mostly chronic conditions. Despite the fact practice of sleep medicine is a young field. Sleep disorders were reduced to insomnia and even insomnia was not well studied until 1960ies. This article maps amazing development of sleep disorders treatment from the beginning till current date. The text covers both scientific and clinical perspectives on most frequent sleep related disorders including insomnias, hypersomnias, parasomnias, sleep related movement and breathing disorders, restless legs syndrome and circadian rhythm sleep disorders.

Brainstem vascular syndromes.

The brainstem is a heterogeneous assembly of well-organized nuclei and pathways that play a critical role in motor, sensory, arousal, and au … al neurology, may predominate in midbrain stroke. Pontine stroke is characterized by horizontal eye movement disorders and motor, sensory, and cerebellar manifestations, either isolated or in combination. Sensory and cerebellar deficits and eye movement disorders due to central vestibular pathway involvement are the main clinical features of medullary stroke; autono …

Zebrafish Erc1b mediates motor innervation and organization of craniofacial muscles in control of jaw movement.

BACKGROUND: Movement of the lower jaw, a common behavior observed among vertebrates, is required for eating and processing food. This movement is controlled by signals sent from the trigeminal motor nerve through neuromuscular junctions (NMJs) to the masticatory muscles. Dysfunctional jaw movements contribute to craniomandibular disorders, yet the pathophysiology of these disorders is not well understood, as limited studies have been conducted on the molecular mechanisms of jaw movement. RESULTS: Using erc1b/kimm533 genetic loss of function mutant, we evaluated lower jaw muscle organization a