Результаты поиска

Design, synthesis, and anti-oomycete, antifungal and nematicidal activities of novel paeonol ether derivatives containing isoxazoline/isoxazole moiety.

BACKGROUND: Paeonol is the main active ingredient in root bark of Paeonia suffruticosa, with broad-spectrum bioactivity. Additionally, isoxa … vely. (2) Compounds 2 and 4 also exhibited excellent antifungal activity against the plant pathogen Fusarium graminearum, with EC50 values of 29.11 and 31.23 mg L-1, respectively. (3) Nine compounds (3f-h,j,o-q and 5f,g) showed significant nematicidal activity against Heterodera glycines, with LC50 values all <30.00 mg L-1. Especially for compound 3g, its …

Bioremediation Potential of Leaf Endophytic Fungi in Allium ampeloprasum and Brassica oleracea var. capitata.

Polycyclic aromatic hydrocarbons (PAHs) are toxic air pollutants mainly released through vehicular emissions and can accumulate on edible pl … with PAHs, producing colonies exceeding 20 mm in diameter. Spectrophotometric analysis showed that Fusarium liriodendri SP2 (PV400499.1) and Trichoderma atroviride SP1 (PV400486.1) achieved approximately 75% degradation of selected PAHs. Furthermore, HPLC analysis confirmed that these isolates effectively degraded all tested PAHs, with degradation rates o …

Bioprocess optimisation for chitosan production by chitinolytic microorganisms.

Chitin-rich organic wastes in aquatic environments provide ecological niches for chitinolytic microorganisms capable of converting chitin in … oxygen and moderate temperatures favoured chitinolytic genera, including Aspergillus, Bacillus, and Fusarium, with Aspergillus niger exhibiting the highest chitosan yield. Incubation time was the most significant factor (p < 0.001), while temperature, pH, and substrate concentration showed strong interaction effects. Initial batch fermentations yielded up …

Advancing the battle against panama disease: a critical appraisal of global biocontrol research and applications.

BACKGROUND: Banana, the fourth most important food crop globally, is severely threatened by Panama disease caused by Fusarium oxysporum f. sp. cubense (Foc). The continued spread of Foc tropical race 4 (TR4), with recent first reports in Peru and Venezuela, demands renewed attention and a critical reevaluation of eco-friendly management strategies. Biocontrol has emerged as a promising approach, but its efficacy varies widely across studies and geographic regions, and a comprehensive synthesis of research trends and outcomes is lacking. AIM OF REVIEW: This review critically synthesizes the pa…

Characteristics of Burkholderia pyrrocinia and the biocontrol mechanism by which it affects lily bulb rot caused by F. oxysporum.

BACKGROUND: Lily bulb rot, which is mainly caused by Fusarium oxysporum (F. oxysporum), is a destructive soil-borne disease that significantly reduces lily yield and quality. Biocontrol strategies are preferable for counteracting the threats associated with pathogens. METHODS: Confrontation assays were used to screen antagonistic rhizosphere bacteria against F. oxysporum and evaluate their antifungal activity. The most effective isolate, Burkholderia pyrrocinia, was further characterized using a multi-omics approach to investigate its modulation of lily defense responses. RESULTS: In this st…

Invasive Fungal Sinusitis in Patients With Hematological Malignancies: A 20-Year Study From a Tertiary Academic US Hospital System.

BACKGROUND: Invasive fungal sinusitis (IFS) profoundly impacts individuals with hematological malignancies, with rapid progression and high … 4%), and antibody-drug conjugates (6.4%). The most common fungal isolates were Aspergillus (22.6%), Fusarium (16.1%), and Rhizopus (9.7%). Amphotericin B (96.8%) and voriconazole (71.0%) were frequently used, and newer antifungals included isavuconazole (38.7%), olorofim (3.3%), and fosmanogepix (3.3%). Necrotic tissue (45.2%) and mucosal thickening (87.1% …

Development and Formulation of Nanofiber-Based Ophthalmic Inserts for the Treatment of Fungal Keratitis.

Background/Objectives: Fungal keratitis remains a vision-threatening infection, and current amphotericin B (AmphB) eye drops suffer from low … ). Drug content, in vitro release (Weibull modeling), antifungal activity against Candida albicans, Fusarium solani, and Aspergillus fumigatus, ocular cytocompatibility using the Hen's Egg Test on Chorioallantoic Membrane (HET-CAM), and accelerated stability (40 ± 2 °C, 75 ± 5% relative humidity, 4 weeks) were evaluated. Results: Bead-free nanofibers with …

Comparison of Tear Fluid Vascular Endothelial Growth Factor and Corneal Neovascularization between Bacterial and Fungal Corneal Ulcers.

PURPOSE: Keratoplasty had a higher risk for rejection with the recipient's corneal neovascularization. Bacterial corneal ulcers have more ne … of 37 years old. The most common bacteria was Pseudomonas aeruginosa and the most common fungi was Fusarium sp. The neovascular area was similar among the groups at the first visit (bacterial 10,3% (2,3-37,5) vs fungal 8,0% (3,7-22,8), p = 0,262), however, the bacterial group showed a larger neovascularization area at the fourth week (bacterial 21,6% (2,3 …

Clinical presentation, etiology, and treatment outcomes of mycetoma: A 25-year retrospective study in Southern Thailand.

BACKGROUND: Mycetoma is a chronic subcutaneous infection caused by fungi (eumycetoma) or filamentous bacteria (actinomycetoma). Although rec … included dematiaceous fungi such as Exophiala jeanselmei and hyaline molds such as Scedosporium and Fusarium. Among the few culture-positive actinomycetoma cases, all isolates were Nocardia spp. Itraconazole was the main antifungal, whereas trimethoprim-sulfamethoxazole was used for actinomycetoma. Surgery was performed in 66% of patients. At a median foll …

Biocontrol of Cheese Spoilage Moulds Using Native Yeasts.

Biocontrol is one of the most promising alternatives to chemical preservatives for food preservation. This study investigated the biocontrol potential of yeasts isolated from raw milk cheese against spoilage moulds. Eighty-four native yeast strains were screened for antagonistic activity against Penicillium commune, Fusarium verticillioides, and Mucor plumbeus/racemosus via confrontation using a milk-based culture medium. Fifteen strains from the species Pichia jadinii, Kluyveromyces lactis, Kluyveromyces marxianus, and Geotrichum candidum exhibited significant antagonistic activity (inhibitio…

Toxic effects of subchronic T-2 toxin exposure on systemic immune deficiency in developing juvenile rats.

T-2 toxin, a potent immunosuppressive mycotoxin produced by Fusarium species, has not yet been fully elucidated regarding its immunotoxic effects under chronic exposure during developmental stages. To address the limitations of previous studies that primarily focused on single-organ assessments or acute toxicity evaluations in adult animals, this study established a 28-day subchronic T-2 toxin exposure model in Wistar juvenile rats (0-0.8 mg/kg body weight). We systematically evaluated its developmental immunotoxicity through three integrated dimensions: 1) immune organs (thymus, spleen), 2) i…

Histopathologic Insights Into Curvularia-Induced Chronic Granulomatous Fungal Sinusitis: A Guide for Surgical Pathologists.

Chronic granulomatous fungal sinusitis is a rare, debilitating infection characterized by an enlarging mass affecting the orbit, nose, palat … tity and variable morphology led to initial misidentification in 3 cases as hyaline septate hyphae (Fusarium), yeasts, and Blastomyces. All cases showed extracellular and intracellular (within multinucleated giant cells) hyphae and round forms with thick refractile cell walls lacking intracellular contents, yielding a characteristic "ghost shell" morpholog …

Unraveling the Role of Contaminants Reshaping the Microflora in Zea mays Seeds from Heavy Metal-Contaminated and Pristine Environment.

Heavy metal (HM) contaminants are the emerging driving force for reshaping the microflora of plants by eradicating the non-tolerance and non … deria were dominant, while in SD Pseudomonas and Streptomyces were dominant. Among the fungal taxa, Fusarium, Saccharomycopsis, and Lecanicillium were prevalent in HM-contaminated sites. Our finding revealed the influential effect of HM contaminants on reshaping the seed microbiome of the Zea mays, showing both the resilience of certain important microbial …

Isolation and identification of endophytic fungi from Alhagi sparsifolia Shap. and their antibacterial activity.

In order to explore the endophytic resources of Alhagi sparsifolia Shap. and identified novel antibacterial substances. Thirty endophytic fungal strains were isolated from the stems and roots of A. sparsifolia Shap. Morphological and molecular biology methods were used to identify ten strains of fungi, including four strains of Aspergillus niger, three strains of Alternaria alternata, two strains of Aspergillus flavus, and one strain of Fusarium incarnatum. All these strains were isolated from A. sparsifolia Shap. for the first time, and of these Aspergillus was the dominant genus. Antibacteri…

Design, synthesis, antifungal activity and molecular docking of novel pyrazole-4-carboxamides containing tertiary alcohol and difluoromethyl moiety as potential succinate dehydrogenase inhibitors.

BACKGROUND: Resistance problems with the long-term and frequent use of existing fungicides, and the lack of structure diversity of tradition … rystal X-ray diffraction. Their in vitro antifungal activities were evaluated against phytopathogen Fusarium graminearum, Botrytis cinerea, Phytophthora capsica, Sclerotinia sclerotiorum, Thanatephorus cucumeris. The results displayed that most of them exhibited significant antifungal activities against S. sclerotiorum at 50 mg/L, the half maximal effectiv …

Impact of ultra-high-pressure treatment on microbial community composition and flavor quality of jujube juice: Insights from high-throughput sequencing technology, intelligent bionic sensory system, and metabolomics approach.

Ultra-high-pressure (UHP1) technology for cold pasteurization is a viable alternative to traditional heat sterilization for preserving food … Pa clusters in terms of bacterial spoilage, whereas Torulaspora, Lodderomyces, Wickerhamomyces, and Fusarium were the primary fungal spoilage genera. UHP treatment exerted no significant impact on the taste of jujube juice but influenced its sourness. Treatment at 330 MPa had the most pronounced effect on the presence of aromatic compounds and other odoran …

The activity of leaf extracts, fractions, and isolated compounds from Ptaeroxylon obliquum against nine phytopathogenic fungi and the nematode Meloidogyne incognita.

Phytopathogenic fungi and nematodes cause great losses in economically important crops and food production especially in developing countrie … ita. Nine phytopathogenic fungi (Aspergillus niger, A. parasiticus, Colletotrichum gloeosporioides, Fusarium oxysporum, Penicillium digitatum, P. expansum, P. italicum, P. janthinellum, and Rhizoctonia solani) were used for testing and nematocidal activity was determined on motility of plant parasitic nematode Meloidogyne incognita race 2 juveniles. Serial …

Distribution of pathogenic bacteria and antimicrobial sensitivity of eye infections in Suzhou.

AIM: To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial … mon strain in the conjunctiva, cornea, aqueous humor or vitreous body and other eye parts. Besides, Fusarium and Pseudomonas aeruginosa were also among the most common strains of conjunctival and corneal infections. CONCLUSION: Gram-positive bacteria are the dominant bacteria in eye infections, followed by gram-negative bacteria and fungi. Considering the …

Микробиота грибкового кишечника в педиатрии с множественным склерозом.

По имеющимся данным, кишечный микробиом может играть определенную роль в множестве склероза (MS). Однако в большинстве исследований основное внимание уделяется кишечным бактериальным сообществам; ни одно из них не изучало грибковую микробиоту (mycobiota) у лиц с педиатрическим множественным склерозом (POMS). Мы изучили кишечник микобиота у людей с ПОМС и без нее посредством перекрестного обследования кишечника микобиота из 46 Образцы стульев участниковthree группы: 18 ПОМЫ, 13 приобретенные монофазные демиелинизирующие синдромы [моноАДС], и 15 Не связанные с этим меры контроля). Использование

Совпадение в аннотации оригинала
Evidence suggests that the gut microbiome may play a role in multiple sclerosis (MS). However, the majority of the studies have focused on g … tive modeling of differential abundance associated with Candida albicans, Cyberlindera jadinii, and Fusarium poae revealed that these fungi were strongly associated with the POMS participants. Our study provides novel insight into the fungal gut mycobiota in POMS. While findings indicate that the gut mycobiome of participants with POMS may largely comprise …

Rumen fermentation and microbial diversity of sheep fed a high-concentrate diet supplemented with hydroethanolic extract of walnut green husks.

OBJECTIVE: This study aimed to assess the impact of a hydroethanolic extract of walnut green husks (WGH) on rumen fermentation and the diver … 05). The relative abundance of the fungus Pseudomonas significantly increased, while Basidiomycota, Fusarium, and Alternaria significantly decreased (p<0.05). However, there was no significant change in the community structure of methanogenic archaea. CONCLUSION: Supplementation of hydroethanolic extract of WGH to a high-concentrate diet improved the rumi …