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Effect of Maturation on the Chemical Composition, Nutritional Value, Biological Activities In Vitro and Volatile Organic Compounds in the Coconut Meat of Wenye No. 3 Variety.

Coconut meat (solid endosperm) is a valuable oilseed product with significant nutritional and functional properties, yet the quality changes … ith maturity, whereas ABTS scavenging activity was significantly higher at CM-12 than at CM-10, and hydroxyl radical scavenging activity was similarly elevated at CM-10 and CM-12. α-Amylase inhibitory activity peaked at CM-10 (20.4%). Phosphorus, magnesium, zinc, and copper peaked at CM-12. Lauric acid predominated at all stages, with unsaturated fatty acids trans …

A self-amplifying responsive nanoplatform for dual inhibition of fibroblast-like synoviocytes in rheumatoid arthritis: coupled regulation of cell cycle arrest and apoptosis.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that features by the overproliferation of fibroblast-like synoviocytes (FLSs). Rap … ates with Abe to induce cell cycle arrest of FLSs. Moreover, Mn2+ catalyzes the generation of toxic hydroxyl radical (·OH) to synergize upregulated p53 to kill abnormal FLSs. In summary, a "dual pronged attack" strategy is proposed by the multifunctional nanoplatform Mn/Si-Abe@BSA with novel enzyme-mimic activities, representing a promising platform for the compre …

Shengmai Yin Attenuates Hypobaric Hypoxia-Induced Erythrocyte Echinocytosis by Restoring Redox Homeostasis and Normalizing Band 3-Syk/SHP2 Interactions.

Acute exposure to high-altitude hypobaric hypoxia (HH) disrupts redox homeostasis and impairs erythrocyte morphology and oxygen transport. Shengmai Yin (SMY) is a botanical formulation with reported antioxidant activity, but its effects on HH-induced erythrocyte injury remain unclear. Male C57BL/6J mice received SMY in drinking water for 3 days before 24 h of simulated HH equivalent to 6000 m. Complementary in vivo and in vitro experiments assessed redox indices, lipid peroxidation, hemoglobin redox status, erythrocyte morphology, arterial oxygenation, and Band 3-associated protein interaction

Deciphering Augmented Dual-ROS-Driven Biofilm Eradication by Facilitating Long-Range Spatial Charge Decoupling in Polymer Carbon Dots.

Developing carbon dots (CDs) with reactive oxygen species (ROS) production capability provides an attractive approach to address the dilemma … polynaphthalenediimide (PNDI) network, which significantly boosts the superoxide anion (·O2 -) and hydroxyl radical (·OH) dual-ROS generation of the constructed polymer CDs. Systematic mechanism exploration reveals that ultrafast intramolecular charge transfer after photoirradiation enables energetic long-life electrons to migrate along the PNDI highway for abund …

The clinical ionizable lipid SM-102 enhances photochemical immunogenic cell death by verteporfin-conjugated liposomes and improves survival in vivo.

Light activation of photosensitizers, including verteporfin-conjugates entrapped in liposomes, can induce photochemical immunogenic cell dea … associated with photochemical ICD. We show that SM-102 incorporation increases the ratio of Type I (hydroxyl radical and peroxynitrite anion)-to-Type II (singlet oxygen) reactive oxygen species by ~ 2.5-fold, increases mitochondrial localization, and improves CT1BA5 mouse pancreatic cancer cell uptake by 7-fold and phototoxicity by 10-fold. These result in more po …

A hesperidin-engineered metal-phenolic nanoplatform for biofilm-targeted and self-amplified photothermal/chemodynamic therapy of skin abscesses.

Biofilm-associated skin abscesses remain challenging to manage because the extracellular polymeric matrix restricts drug access and bacteria … ent, the nanoparticles dissociate, releasing Fe3+, which is reduced to Fe2+ and subsequently drives hydroxyl radical generation. Meanwhile, hesperidin further interferes with quorum sensing and virulence-related responses. Consequently, HF@PBA effectively eliminated planktonic bacteria and mature biofilms in vitro, and transcriptomic/protein analyses revealed mark …

Polysaccharide Accumulation and Antioxidant Activity in Space-Mutated Spirulina platensis H11 Under Seawater Versus Freshwater Cultivation.

As a microalga of significant economic value, the polysaccharide synthesis efficiency and bioactivity of Spirulina platensis are significant … y, compared to FSPS (0.78% sulfate group, 6.57% glucuronide), SSPS exhibited significantly enhanced hydroxyl radical-scavenging activity, demonstrated by a decreased IC50 value of 2.53 mg mL-1 as opposed to 3.07 mg mL-1. The present study confirms that seawater cultivation is an effective strategy for inducing the synthesis of highly active polysaccharides in spac …

Breaking Kasha's rule for photoswitchable reactive oxygen species generation in carbonylated carbon nitride.

Photoswitchable catalysis enables the non-invasive regulation of light-to-chemical energy conversion, in which catalysts with wavelength-dep … tion that is achieved by incorporating carbonyl groups into the matrix: in the range of 300-400 nm, hydroxyl radical and singlet oxygen are identified as the dominant reactive oxygen species under high- and low-energy excitations, respectively. Photoluminescence and ultrafast transient absorption measurements confirm the breakdown of Kasha's rule in carbonylated c …

Effect of Donor and Acceptor on Improving the ROS Generation of Benzothiadiazole-Based Photosensitizers and Effective Photodynamic Therapy to Pancreatic Cancer Cells.

Photodynamic therapy (PDT) has emerged as a promising strategy for pancreatic cancer treatment, yet its efficacy is hindered by the limited … tween the singlet and triplet states, thereby boosting ROS generation, including singlet oxygen and hydroxyl radical, but the fluorescent intensity of the emitter showed an obvious reduction. However, the introduction of the electronic donor anisole not only achieved better fluorescent strength but also maintained satisfactory ROS efficiency. The investigation of …

A Transition Metal-Free Approach for the Conversion of Real-Life Cellulose-Based Biomass into Formate.

Formic acid (FA) and its salt are recognized as valuable molecules for various industries such as textiles and pharmaceuticals. Currently, t … s at room temperature as well as at atmospheric pressure. In this approach, selective generation of hydroxyl radical has been achieved which later converted sugars, cellulose, and hemicellulose into formate. Furthermore, the conversion of cellulose-rich daily-life materials such as discarded paper into the product through a series of flow experiments is demonstrat …

Circumneutral microbial Fenton catalysis: Harnessing iron-redox synergy for sustainable pharmaceutical degradation.

The persistence of pharmaceutical contaminants like ketoprofen (KET) in aquatic environments poses escalating ecological and health risks, y … iogenically generate Fe(II) and H2O2 through alternating anaerobic-aerobic phases, enabling in-situ hydroxyl radical (HO˙) production at pH 7.0. Decoding microbial black-box interactions, we identify Sporanaerobacter, Sedimentibacter, Clostridium, Petrimonas, and Actinomyces as keystone genera orchestrating Fe2+/H2O2 dynamics, while UPLC-ESI-HRMS analyses reveal K …

Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal.

Wild Ganoderma lucidum from Nepal's high-altitude regions was studied to identify key bioactive compounds and assess the influence of solvent type-water, ethanol, methanol, and acetone-on extraction efficiency and biological activity. Extracts were evaluated for antioxidant potential, cytotoxicity against HeLa cells, and phytochemical composition via gas chromatography-mass spectrometry (GC-MS). Solvent type significantly affected both yield and bioactivity. Acetone yielded the highest crude extract (5.01%), while ethanol extract exhibited the highest total phenolic (376.5 ± 9.3 mg PG/g) and f

Antianemic Activity, Inhibition of Oxidative Stress, and Iron Supplementation in Mice with Iron-Deficiency Anemia through HG-Hawthorn Pectin-Iron(III) Complexes.

In this study, we initially assessed the antioxidant activities of various HG-type hawthorn pectin-iron(III) complexes, which were synthesized in our previous research, utilizing methods such as reducing assay, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and scavenging, and hydroxyl radical scavenging. The results showed that the antioxidant capacity of the hawthorn pectin iron(III) complexes exhibited a positive correlation with increasing concentrations, ranging from 0.2 to 1.0 mg/mL. Notably, the pectin complex chelated with iron via ultrasonic extraction and de-esterificati…

Photodegradation of naphthalene-derived particle oxidation products.

While photochemical aging is known to alter secondary organic aerosol (SOA) properties, this process remains poorly constrained for anthropogenic SOA. This study investigates the photodegradation of SOA produced from the hydroxyl radical-initiated oxidation of naphthalene under low- and high-NO x conditions. We used state-of-the-art mass spectrometry (MS) techniques, including extractive electrospray ionization and chemical ionization MS, for the in-depth molecular characterization of gas and particulate phases. SOA were exposed to simulated irradiation at different stages, i.e., during format…

Efficient generation of highly reactive FeIVO2+ via the Fe(II)/Cl2 reaction for water purification.

The coexistence of ferrous iron (Fe(II)) and chlorine species (e.g., molecular chlorine (Cl2), HOCl, and OCl-) in aqueous systems can initia … ine atoms (Cl•) via single electron transfer. The generated FeIVO2+and Cl• can subsequently produce hydroxyl radical (HO•) through hydrolysis. Compared to the Fe(II)/H2O2 system, the Fe(II)/chlorine system demonstrated selective oxidation of structurally diverse micropollutants and exhibited 1.7 to 6.1 times higher rate constants of nucleic acid component eliminat …

Ultrafast ROS Scavenging Activity of Amur Maple Tree Extracts Confers Robust Cardioprotection for Myocardial Ischemia/Reperfusion Injury.

Ginnalin A (GA), a polyphenolic compound derived from amur maple trees, has been identified as a powerful scavenger of reactive oxygen speci … a extracts acted as natural antioxidases, directly scavenging various ROS such as superoxide, H2O2, hydroxyl radical, and Fe2+ within just 20 min. In a MIRI rat model, the in vivo administration of ginnala extracts provided significant cardioprotection by preserving viable myocardia and enhancing cardiac functions. Additionally, treatment with ginnala extracts sig …

Лекарства, основанные на фумаратах, защищают от нейроинфламмации за счет регулирования антиферптотических путей.

Ферроптоз определяется как смерть клеточной клетки в зависимости от железа. Он основан на пероксидации полилюннасыщенных фосфолипидов и последующем разрыве мембраны. Липидное пероксидация вызывается главным образом гидроксиловым радикалом - продуктом фентонской реакции между железом и пероксидом водорода. Ферроптоз связан со многими органами и болезнями, включая нейроинфламму. Наиболее часто встречающейся воспаляющей болезнью центральной нервной системы в западных странах является множественный склероз, ведущий к провокационному обезвоживанию и нейродегенерации. Фумараты, диметилфумарат (ДМФ)

Совпадение в аннотации оригинала
Ferroptosis is defined as iron dependent non-apoptotic cell death. It is based on peroxidation of polyunsaturated phospholipids and subsequent membrane rupture. Lipid peroxidation is induced mainly by the hydroxyl radical, the product of the Fenton reaction between iron and hydrogen peroxide. Ferroptosis is connected to many organs and diseases including neu…

MnO2@CeOx-GAMP radiosensitizer with oxygen vacancies depended mimicking enzyme-like activities for radiosensitization-mediated STING pathway activation.

Activation of the stimulator of interferon genes (STING) pathway by radiotherapy (RT) has a significant effect on eliciting antitumor immune responses. The generation of hydroxyl radical (·OH) storm and the sensitization of STING-relative catalytic reactions could improve radiosensitization-mediated STING activation. Herein, multi-functional radiosensitizer with oxygen vacancies depended mimicking enzyme-like activities was fabricated to produce more dsDNA which benefits intracellular 2', 3'-cyclic GMP-AMP (cGAMP) generation, together with introducing exogenous cGAMP to activate immune respons…

Dissolved Black Carbon Facilitates the Photodegradation of Microplastics via Molecular Weight-Dependent Generation of Reactive Intermediates.

Photodegradation of microplastics (MPs) induced by sunlight plays a crucial role in determining their transport, fate, and impacts in aquati … primarily occurred at the benzene ring rather than the aliphatic segments due to the fast attack of hydroxyl radical (•OH) and singlet oxygen (1O2) on the benzene ring. The photosensitivity of DBC accelerated the degradation of PS MPs, primarily attributed to the increased production of •OH, 1O2, and triplet-excited state DBC (3DBC*). Notably, DBC-mediated photode …

Cascade-catalysed nanocarrier degradation for regulating metabolism homeostasis and enhancing drug penetration on breast cancer.

The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy. Herein, an integrated … ucleotide (NADPH/FAD) during the metabolism homeostasis of tumor. The Cu+ can generate highly toxic hydroxyl radical through the Fenton-like reaction, enhancing the chemodynamic therapeutic effect. In addition, Cu+ also decomposes GSNO to release NO by ionic reduction, leading to vasodilation and increased vascular permeability, significantly promoting the deep pe …