Результаты поиска

Sexuality and quality of life after hematopoietic stem cell transplantation.

BACKGROUND: The quality of sexuality is significantly affected by physical changes following hematopoietic stem cell transplantation (HSCT) and the dissatisfied and/or dysfunctional sexuality may cause deterioration in the quality of life (QOL). METHODS: With two models of questionnaires, we interviewed thirty-eight patients who remained in the disease-free status after HSCT and had sex partners, to assess: 1) the changes in sexuality, 2) QOL in physical, psychological, social and spiritual domains and 3) the correlation between sexuality and QOL. RESULTS: The common physical changes that ma

Совпадение в полном тексте источника
… Impotence and decreased libido can be early symptoms of hyperprolactinemia that is related to the inhibition of gonadotropin-releasing-hormone secretion by the elevated prolactin levels and some degree of antagonism by prolactin to the peripheral action of testosterone 9 ) . …

Romosuzumab used to treat a 29-year-old patient with anorexia nervosa related osteoporosis - A case report.

Osteoporosis and decreased bone density is a frequent complication of anorexia nervosa (AN). As of yet, there have been no studies of accomplished treatment of AN-related osteoporosis with romosuzumab, a monoclonal antibody to sclerostin. We report the first case of a premenopausal, 29-year old patient in Switzerland with decreased bone density and osteoporotic fractures due to anorexia nervosa, who completed the treatment with romosuzumab. There was a significant increase in bone mineral density (BMD) after 12 months of therapy. No serious side effects were reported. To date, only bisphosphon

Совпадение в полном тексте источника
… Endocrine disease | Hematological disease | Gastrointestinal disease | Rheumatological disease | Congenital disease | Medications | others Diabetes mellitus Hyperparathyreoidism Hypogonadism Hyperthyroidism Hyperprolactinemia | Multiple myeloma Thalassemia Heamochromatosis Mastocytosis | Chronic inflammatory …

Множественный склероз, инфекция мочевого тракта и бесплодие: всеобъемлющий обзор аналитического исследования.

Множественный склероз (MS) — аутоиммунное заболевание, связанное с центральной нервной системой. ПМС широко распространены среди взрослых молодых людей и постепенно уничтожают аксоны и миелин. Лица, страдающие НР, часто сталкиваются с такими осложнениями, как дефункция мочевого тракта, инфекция мочевого тракта и сексуальная дисфункция. У молодых людей РС может вызывать сексуальную дисфункцию и бесплодие, которое ухудшается по мере развития болезни. Были рассмотрены имеющиеся данные из различных исследований (микробиологические и клинические исследования, полученные из баз данных PubMed и Scopu

Совпадение в полном тексте источника
… Various different studies have reported an increased prevalence of hyperandrogenism and hyperprolactinemia in women with MS ( 55 ). …

[Polycystic ovary syndrome of extra-ovarian origin. Review].

An established fact in the polycystic ovarian syndrome (POS) is an abnormal ovarian steroidogenesis. Though this suggest an intrinsic ovarian defect, the syndrome could also be influenced by factors outside the ovaries. Although of unknown etiology, the POS is one of the most frequent endocrine disorders in the gynecologic practice. The disorder is characterized by ultrasound findings of enlarged polycystic ovaries, hyperandrogenism, menstrual disorders, obesity and including the appearance of infertility. There are a series of mechanisms involved in the extraovarian androgen increase in patie

Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy.

Secondary adrenal insufficiency (SAI) is an endocrine disorder due to impaired secretion of ACTH resulting from any disease affecting the pituitary gland. Glucocorticoid replacement therapy is mandatory to ensure patient survival, haemodynamic stability, and quality of life. In fact, a correct dose adjustement is mandatory due to the fact that inappropriately low doses expose patients to hypoadrenal crisis, while inappropriately high doses contribute to glucose metabolic and cardiovascular deterioration. This review analyses the current evidence from available publications on the epidemiology

Совпадение в полном тексте источника
… (who underwent a hormonal work-up up to 6 months before surgery, assessing central adrenal insufficiency by basal plasma cortisol levels and a standard 250 µg ACTH stimulation test) found that male patients and patients with hyperprolactinemia at diagnosis were more likely to experience recovery of pituitary … Hyperprolactinemia was also common (affecting 2 out of 3 patients). SAI was diagnosed in one in four patients: the diagnosis was made with ACTH test. Breast cancer and lymphoma were the most common primary causes in the study by Javanbakht et al. …

[Guidelines for the prescription of mood stabilizers for adolescents: A literature review].

INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different … n for adults. As in adults, adverse effects are metabolic, motor and cognitive disorders. Moreover, hyperprolactinemia, sedation and weight gain are more frequent than in adults. DISCUSSION: Epidemiologic data for prescription of mood stabilizers in adolescents only partially concord with recommendations from drug administrations and scientific societies. On the on …

Bridging the Gap: Pregnancy-And Lactation-Associated Osteoporosis.

Early diagnosis of pregnancy- and lactation-associated osteoporosis (PLO) is mandatory for a good outcome. Standard care is not a matter of conventional guidelines, rather it requires an individualized strategy while true overall incidence and pathogeny remain open issues. This is a narrative review based on full-length English articles, published between January 2021 and March 2023 and accessed via PubMed (no traumatic fractures or secondary osteoporosis are included). Our case-sample-based analysis included 836 females with PLO (the largest cohort based on published cases so far) through 12

Совпадение в полном тексте источника
… She had a history of schizophrenia and associated drug-induced hyperprolactinemia and was confirmed with gestational diabetes mellitus. … Siva et al. [ 23 ] reported the use of anti-psychotic medication, hyperprolactinemia, and gestational diabetes mellitus as contributors to bone loss [ 23 ]. …

A scoping review of biopsychosocial risk factors and co-morbidities for common spinal disorders.

OBJECTIVE: The purpose of this review was to identify risk factors, prognostic factors, and comorbidities associated with common spinal disorders. METHODS: A scoping review of the literature of common spinal disorders was performed through September 2016. To identify search terms, we developed 3 terminology groups for case definitions: 1) spinal pain of unknown origin, 2) spinal syndromes, and 3) spinal pathology. We used a comprehensive strategy to search PubMed for meta-analyses and systematic reviews of case-control studies, cohort studies, and randomized controlled trials for risk and pro

Совпадение в полном тексте источника
… One meta-analysis found an increase in fractures in patients with untreated hyperprolactinemia [ 128 ]. With regard to medications, some people take vitamin K antagonists as anticoagulant medications. … Osteoporotic fractures in patients with untreated hyperprolactinemia vs. those taking dopamine agonists: A systematic review and meta-analysis. Neuro Endocrinol Lett. 2015;36(8):745–9. . 129. Jackson C, Gaugris S, Sen SS, Hosking D. …

POEMS SYNDROME: an Update.

POEMS syndrome is a rare, chronic and disabling condition. The causes of this condition remain unknown; however, chronic overproduction of proinflammatory cytokines appears to be a major contributor. Early diagnosis is essential to start treatment before the clinical state of the patient becomes compromised. A complete evaluation of the disease at its onset is critical to the treatment decision. In localized disease, curative doses of radiation (50 Gy) is the recommended therapy. On the other hand, patients with disseminated disease should be given systemic therapy. Treatment-related morbidity

Совпадение в полном тексте источника
… The majority of patients have evidence of multiple endocrinopathies in the four principal axes (gonadal, thyroid, glucose and adrenal), such as hypogonadism, diabetes mellitus, hypothyroidism, hyperprolactinemia, adrenal insufficiency, gynecomastia and hypoparathyroidism. 1 The etiology of endocrinopathy …

Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects.

The prognosis of patients with systemic lupus erythematosus has greatly improved since treatment regimens combining corticosteroids and immunosuppressive medications have been widely adopted in therapeutic strategies given to these patients. Immune suppression is evidently efficient but also leads to higher susceptibility to infectious and malignant diseases. Toxic effects and sometimes unexpectedly dramatic complications of current therapies have been progressively reported. Identifying novel molecular targets therefore remains an important issue in the treatment of lupus. The aim of this rev

Совпадение в полном тексте источника
… Inhibition of prolactin An increased frequency of hyperprolactinemia is observed in patients with SLE, and elevated prolactin levels have been correlated with clinical disease [ 22 ]. …

Polymorphic Variants of Genes Encoding Angiogenesis-Related Factors in Infertile Women with Recurrent Implantation Failure.

Recurrent implantation failure (RIF) is a global health issue affecting a significant number of infertile women who undergo in vitro fertilization (IVF) cycles. Extensive vasculogenesis and angiogenesis occur in both maternal and fetal placental tissues, and vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) family molecules and their receptors are potent angiogenic mediators in the placenta. Five single nucleotide polymorphisms (SNPs) in the genes encoding angiogenesis-related factors were selected and genotyped in 247 women who had undergone the ART procedure and 12

Совпадение в полном тексте источника
… criteria for the study group were as follows: an abnormal karyotype of parents and any identified fetal genetic abnormalities, systemic connective tissue disorder, antiphospholipid antibody syndrome, hereditary thrombophilia, positive antinuclear antibodies, endocrine dysfunction (luteal insufficiency, hyperprolactinemia …

Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals.

PurposeThis study investigated the effect of bone metastasis on the biomechanical environment of human vertebrae in patients with metastatic spine disease through the metric of load-to-strength ratio (LSR). Specifically, we compared the patients' LSRs to age and sex-similar noncancer controls from the Framingham Heart Study.MethodsDerived from clinical CT data of 135 metastatic spine disease patients planned for radiotherapy and 246 normative controls from the Framingham Heart Study, individualized spinal musculoskeletal models and vertebral strength estimates were used to compute level-specif

Совпадение в полном тексте источника
… Patients were excluded if they had: (1) diseases of abnormal bone metabolism (Paget disease and untreated hyperthyroidism, hyperprolactinemia, or Cushing disease); (2) received RT < 6 months before the current study radiation therapy at baseline, surgery, or vertebral augmentation at the site of radiation …

Сексуальная дисфункция при расстройствах движения: распространенность, клинические особенности, связанные с этим факторы и управление.

Сексуальная дисфункция является распространенным, но недостаточно изученным симптомом немоторного расстройства движения. В то время как болезнь Паркинсона (PD) чаще всего исследуется, сексуальная дисфункция также отмечается в болезни Хантингтона, диспропорции и других расстройствах движения. Клинические представления являются разнородными и включают в себя сокращение желания, эректильную дисфункцию, эякуляционные и оргазмические расстройства, трудности с смазкой, диспаревинию и гиперсексуальность. В ДИ оценки распространенности заболеваний в различных исследованиях сильно различаются, главным

Совпадение в полном тексте источника
… Vasculogenic factors include atherosclerotic endothelial dysfunction affecting penile circulation, while endocrinologic factors include testosterone deficiency, hyperprolactinemia and disruption of the hypothalamic-pituitary–gonadal axis, though data on hormonal pathophysiology in PD remain heterogeneous …

Fertility Preservation in Female Patients with Cancer. Part I: Challenges and Future Prospects in Developing Countries; A Narrative Review Study.

While international guidelines on oncofertility practice have been published in developed countries, there is limited information available on oncofertility practice in developing countries, which often face limitations in their cancer health support networks. As survival rates improve in the field of cancer and other diseases, there is a growing need for stronger oncofertility services in developing countries. Given that 50% of cancer patients are under the age of 65, many of these patients are of reproductive age and preserving their fertility health prior to starting treatment is valuable.

Совпадение в полном тексте источника
… Hyperprolactinemia is a consequence of irradiation that can cause secondary infertility ( 25 ). Like chemotherapy, ovarian sensitivity to radiotherapy increases with age. …

Clinical challenges in the management of osteoporosis.

While knowledge regarding the diagnosis and treatment of osteoporosis has expanded dramatically over the last few years, gaps in knowledge still exist with guidance lacking on the appropriate management of several common clinical scenarios. This article uses fictional clinical scenarios to help answer three challenging questions commonly encountered in clinical practice. The first clinical challenge is when to initiate drug therapy in a patient with low bone density. It is estimated that 34 million America have low bone density and are at a higher risk for low trauma fractures. Limitations of

Совпадение в полном тексте источника
… Gonadotropin-releasing hormone (GnRH) agonists such as leuprolide Celiac disease | Aromatase Inhibitors Inflammatory bowel disease | Other malabsorptive states | Growth hormone deficiency | Rheumatoid arthritis | Anorexia nervosa | Organ transplant | Chronic kidney disease | Malignancies | Hyperprolactinemia …

Recent Advances in the Treatment and Supportive Care of POEMS Syndrome.

POEMS is a rare clonal plasma cell disorder characterized by multi-systemic features that include demyelinating peripheral neuropathy, organomegaly, endocrinopathy, presence of monoclonal proteins (M-protein), and skin changes. Even though the pathophysiology is poorly understood, recent studies suggest that both clonal and polyclonal plasmacytosis leading to the production of pro-inflammatory cytokines and angiogenic mediators play the central role. These mediators including vascular endothelial growth factor (VEGF) are the driving forces of the syndrome. The diagnosis of POEMS is not always

Совпадение в полном тексте источника
… Endocrinopathy Endocrinopathy is central in the disease process with hypogonadism being the most common abnormality followed by different endocrinopathies such as thyroid dysfunction, glucose metabolism abnormalities, adrenal insufficiency, and hyperprolactinemia. …

Биомаркеры по исследованиям в области клинической медицины: исследование литературы в базе данных PubMed и критическая оценка.

Биомаркер, короткая форма "биологического маркера", появилась в научной литературе в 1940-х годах. С тех пор было предложено множество различных определений, однако общеприменимое объяснение термина &quot; биомаркер &quot; в науке является чрезвычайно сложным. Слово "биомаркер" встречается в 1.3 million статьи в научной базе данных PubMed , которая в настоящее время включает более 39 million Ссылки на биомедицинскую литературу. Биомаркеры тесно связаны со здоровьем и болезнями человека. В настоящей статье делается попытка подойти к многогранному термину "биомаркет" и оценить его с клинической

Совпадение в полном тексте источника
… Testosterone and prolactin have a low yield, but specific therapy with a dopamine agonist for hyperprolactinemia and with testosterone for hypogonadism was effective. Glucose and lipids have a higher yield but specific therapy was not immediately effective for ED [ 45 ]. …

Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications.

Omega-3 polyunsaturated fatty acids (PUFAs) are considered immunonutrients and are commonly used in the nutritional therapy of cancer patients due to their ample biological effects. Omega-3 PUFAs play essential roles in cell signaling and in the cell structure and fluidity of membranes. They participate in the resolution of inflammation and have anti-inflammatory and antinociceptive effects. Additionally, they can act as agonists of G protein-coupled receptors, namely, GPR40/FFA1 and GPR120/FFA4. Cancer patients undergo complications, such as anorexia-cachexia syndrome, pain, depression, and p

Совпадение в полном тексте источника
… On the other hand, other complications, such as non-islet cell tumor hypoglycemia, gynecomastia, acromegaly, hypertension, ovarian hyperstimulation syndrome, hyperprolactinemia, hyperthyroidism, and secretory diarrhea, are considered rare endocrine paraneoplastic syndromes [ 145 ]. …

Neurotransmitters in cancer: how receptor signaling and posttranslational modifications modulate tumor progression and offer new therapeutic targets.

Recent studies highlight the multifaceted roles of neurotransmitters in tumor immunomodulation, offering novel avenues for increasing therapeutic efficacy. These signaling molecules are classified into cholinergic agents, monoamines, amino acids, and peptides and regulate tumorigenesis, metastasis, and immune evasion via autocrine/paracrine pathways and receptor-mediated interactions. Notably, neurotransmitters influence tumor cell proliferation, apoptosis, and immune cell activity by modulating intracellular signaling cascades through posttranslational modifications (serotonylation and dopami

Совпадение в полном тексте источника
… DA and DRD2 agonists have long been utilized in the clinical management of Parkinson’s disease, hyperprolactinemia, and cardiovascular and renal disorders. These pharmacological agents may represent a novel approach to mitigate the impact of chronic stress on tumor growth [ 65 ]. …

Drug Repurposing for the Management of Depression: Where Do We Stand Currently?

A slow rate of new drug discovery and higher costs of new drug development attracted the attention of scientists and physicians for the repurposing and repositioning of old medications. Experimental studies and off-label use of drugs have helped drive data for further studies of approving these medications. A deeper understanding of the pathogenesis of depression encourages novel discoveries through drug repurposing and drug repositioning to treat depression. In addition to reducing neurotransmitters like epinephrine and serotonin, other mechanisms such as inflammation, insufficient blood supp

Совпадение в полном тексте источника
… . | Activating/sedating effects, angioedema, dyslipidemia, extrapyramidal symptoms, hematologic abnormalities, hyperglycemia, weight gain, hyperprolactinemia, neuroleptic malignant syndrome, orthostatic hypotension, QT prolongation, sexual dysfunction, temperature dysregulation | Hypersensitivity to …