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Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update.

In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were influenced for each individual solute or group of solutes, with some impacting up to 7 different biolo

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… Prolactin Hyperprolactinemia is common in CKD and has been observed since many years [ 476 , 477 , 478 , 479 ]. …

Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments.

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of bone remodeling. It affects postmenopausal women but also significantly impacts older men. Estrogen can promote the production of osteoprotegerin, a decoy receptor for RANKL, thereby preventing RANKL from activating osteoclasts. Furthermore, estrogen promotes osteoblast survival and function via activation of the Wnt signaling pathway. Likewise, androgens play a critical role in bone metabolism, primarily through their conversion to estrogen in men. Estrogen deficiency accelerates bone resorption throug

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… lymphomas, sickle cell disease, multiple myeloma, monoclonal gammopathies, systemic mastocytosis, thalassemia Endocrine Disorders | Obesity, Cushing’s syndrome, diabetes mellitus (types 1 and 2), hyperparathyroidism Hypogonadal States | Anorexia nervosa, androgen insensitivity, female athlete triad, hyperprolactinemia …

Exosomes: innovative biomarkers leading the charge in non-invasive cancer diagnostics.

Exosomes, nanoscale extracellular vesicles secreted by diverse cell types, have emerged as promising biomarkers for non-invasive tumor diagnostics, offering significant advantages over traditional methods. These vesicles, typically ranging from 30 to 150 nanometers in size, carry a diverse cargo of proteins, lipids, RNA, and microRNAs, which reflect the molecular alterations occurring within their parent cells. Notably, exosomes can be isolated from easily accessible biofluids such as blood, urine, and saliva, making them ideal candidates for liquid biopsy applications. This review explores th

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… Functional adenomas cause hormone-related syndromes, such as prolactinomas (hyperprolactinemia), acromegaly (excess growth hormone), or Cushing's disease (excess cortisol), while non-functional pituitary adenomas (NFPAs) often present with symptoms like headaches or visual disturbances due to compression …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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Proceedings of the RAMI Intern Section Meeting.

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Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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Abstracts - IANCON 2025

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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