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Stool microbial composition is associated with recent and future diarrhea and fever events in breastfed Danish infants.

UNLABELLED: Gastroenteritis is an important cause of ailment among infants in high-income countries, including Denmark. There are many cases … the study presented here, infant stool Staphylococcales abundance (comprised of Staphylococcus and Gemella) and Haemophilus abundance during the first few months of life were positively associated with later diarrhea in well-nourished and breastfeeding Danish infants. Meanwhile, the abundance of Granulicatella (a facultative anaerobe with pathogenic pote …

Oral Microbiome Profile of the US Population.

IMPORTANCE: The oral microbiome likely plays key roles in human health. Yet, population-representative characterizations are lacking. OBJEC … and Fusobacteria) and 6 genera (Veillonella, Streptococcus, Prevotella 7, Rothia, Actinomyces, and Gemella) were present in nearly all US adults (weighted prevalence, >99%). These genera were the most abundant, accounting for 65.7% of total abundance. Observed ASVs showed a quadratic pattern with age (peak at 30 years), were similar by sex, significantly …

Evaluation of the association between the concentrations of key vaginal bacteria and the increased risk of HIV acquisition in African women from five cohorts: a nested case-control study.

BACKGROUND: Disruptions of vaginal microbiota might increase women's susceptibility to HIV infection. Advances in molecular microbiology hav … t tertile 3·52, 1·63-7·61; second tertile 0·85, 0·36-2·02; third tertile 2·18, 1·01-4·72; p=0·004), Gemella asaccharolytica (first tertile 2·09, 1·01-4·36; second tertile 2·02, 0·98-4·17; third tertile 3·03, 1·46-6·30; p=0·010), Mycoplasma hominis (first tertile 1·46, 0·69-3·11; second tertile 1·40, 0·66-2·98; third tertile 2·76, 1·36-5·63; p=0·048), Lept …

Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study.

AIM: Comparing oral and gut microbiome profiles between patients with and without ulcerative mucositis during allogeneic stem cell transplantation (aSCT). MATERIALS AND METHODS: Specimens from oral mucosa, saliva, and stool were collected pre-(T0) and post- (T0 +28d ± 14d) aSCT (T1). Microbiome structure differences were analyzed by 16S-rRNA-gene sequencing, and associations to patients' clinical characteristics were investigated. RESULTS: Ten of 25 included patients developed ulcerations. The α-diversity decreased between T0 and T1, independent of ulcerations. PERMANOVA revealed differences

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… Similarly, we observed a decreased relative abundance of TM7X sp., Prevotella sp., Oribacterium sinus, Leptotrichia sp., Haemopilus sp., Gemella sp., Fusobacterium periodonticum, Fusobacterium sp ., and Alloprevotella sp . (Figure 2c ). … As for the saliva, we observed an overall lower abundance in Haemophilus sp . and Gemella sp . in patients without ulcerations at T1 and additionally of Rothia mucilaginosa and Leptotrichia sp . in patients with ulcerations at T1. …

GMrepo v3: кустарная база данных о кишечном микробиоме человека с расширенным охватом заболеваний и усовершенствованным биомаркером с перекрестными данными.

GMrepo (Gut Microbiome Data Repository) представляет собой кустарную и последовательно аннотированную базу данных по метагеномам человеческого кишечника, предназначенную для повышения возможности повторного использования данных и создания возможностей для межпроектных и перекрестных сопоставлений. В этом последнем выпуске GMrepo v3 был расширен до 890 проектов и 118 965 пробегов/выборок, включая 87 048 16S rRNA и 31 917 метагеномических наборов данных. Количество аннотированных заболеваний возросло со 133 до 302, что позволило провести более комплексный микробиомический анализ, связанный с заб

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… For instance, CRC markers identified from ten metagenomic projects consistently show enrichment of Fusobacterium nucleatum and Gemella morbillorum in CRC samples (Fig. 4b ), which is in agreement with previous studies [ 40 – 42 ]. … For instance, CRC markers consistently enriched for Fusobacterium nucleatum and Gemella morbillorum across multiple metagenomic datasets exemplify reproducible disease associations. …

Autologous stem cell transplantation for multiple myeloma patients whose myeloma-defining event was SLiM.

In 2014, the International Myeloma Working Group (IMWG) updated the criteria for diagnosing myeloma and added three additional criteria to the traditional Calcium elevation, Renal impairment, Anemia, Bone disease (CRAB) criteria, called the Sixty % marrow plama cells, Light chain ratio >60, Mri demonstates lytic lesions (SLiM) criteria (clonal bone marrow plasma cells ≥60%, involved to uninvolved free light chain ratio (FLCr) ≥100 and >1 focal lesion on magnetic resonance imaging (MRI)). We report on the outcomes of 30 patients who underwent autologous stem cell transplantation (ASCT) where th

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… Bacteraemia was confirmed in seven patients (2 E. coli , 1 Pseudomonas aeruginosa , 2 Staphylococcus epidermidis , 1 Streptococcus , 1 Gemella haemolysans ). …

Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients: a cohort study.

BackgroundWe aimed to assess whether longer indwelling time of peripherally inserted central catheters (PICC) increases risk of central line associated bloodstream infections (CLABSI) in haematology patients.MethodsMulticentre retrospective cohort study among haematology patients receiving PICCs between 2013 and 2015. Occurrence of CLABSI based on CDC definitions was assessed. We calculated incidence rates, determined risk factors for CLABSI and used Poisson regression models to assess the risk of developing CLABSI as a function of PICC dwell time. We compared diagnoses and treatment character

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… incidence of CLABSI. autoSCT: autologous stem cell transplantation (n = 164), AA: aplastic anaemia (n = 10) Table 2 Cultured pathogens in CLABSI *In 14 episodes, blood cultures showed 2 different pathogens ** Chrysobacterium indologenes, Citrobacter freundii, Enterococcus casselflavius, Fusarium dimerum, Gemella …

Association of HSV-1 and Reduced Oral Bacteriota Diversity with Chemotherapy-Induced Oral Mucositis in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation.

Oral mucositis (OM) is a common complication of chemotherapy and remains a significant unmet need. The aim of this study was to investigate the role of oral bacteriota and HSV-1 in OM. Forty-six patients admitted for autologous hematopoietic stem cell transplantation were longitudinally evaluated for OM, Candida, HSV-1, and leukocyte count, and buccal mucosal bacterial samples were obtained during their admission period. The bacterial communities collected at the baseline and post-chemotherapy, chosen from the time with the highest severity, were analyzed by sequencing the 16S rRNA gene. Twent

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… OM severity was negatively correlated with the relative abundance of 27 species, some from the health-associated genera Streptococcus , Rothia , Actinomyces , Gemella , Veillonella , and Stomatobaculum and others from the genera Leptotrichia and Prevotella . …

Влияние лечения рака на оральные структуры и лицо черепа - последствия для протезирования и онкологического риска.

ЦЕЛЬ ОБЗОРА: Настоящее исследование направлено на выявление осложнений и трудностей при проведении остеоинтеграции имплантатов в онкологических пациентах, учитывая влияние лечения на микроархитектуру краниофасциальной области, микробиомо рта и воспаление полости рта. НОВЫЕ ДАННЫЕ: Хирургическая резекция, радиотерапия, химиотерапия и таргетная терапия значительно влияют на состояние костей, слизистых оболочек и мягких тканей, а также на возможности и ограничения протезирования. Химиотерапия значительно влияет на метаболизм кальция и фосфора. Было замечено, что существует увеличенный риск перел

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… These included bacteria of the genera Streptococcus spp. , Actinomyces spp. , Gemella spp. , Granulicatella spp., and Veillonella spp. On the other hand, there was an increase in the number of Gram-negative bacteria – Fusobacterium nucleatum a nd Prevotella oris. … The dominant bacteria here were Gemella spp. and Streptococcus spp.. Microorganisms that were only observed after chemotherapy are bacteria from the Lachnospiraccae family. …

Микробиота человека в области здравоохранения и отдельные раковые заболевания.

Большинство эпителиальных поверхностей нашего тела, пищеварительный тракт, дыхательные и врожденные системы, колонизируются большим количеством бактерий, археи, грибов, протозоанов и вирусов. Эти микробиота, особенно кишки, играют важную и полезную роль в пищеварении, метаболизме и синтезе витаминов. Их метаболиты стимулируют производство цитокина человеком, которое используется против потенциальных патогенов. На состав микробиоты влияет ряд внутренних и внешних факторов, включая питание, возраст, болезни и образ жизни. Такие изменения, называемые дисбиозом, могут быть связаны с развитием разл

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… Several other studies have also reported higher proportions of Fusobacterium , Parvimonas , Butyrivibrio , Gemella , Fusobacteria , and Akkermansia in patients with CRC, and lower levels of Ruminococcus , Bifidobacterium , Eubacteria , and Lachnospira compared to healthy subjects [ 240 , … For example, young children demonstrate high levels of Streptococcus , Rothia , Gemella , Granulicatela , and Haemophilus , while adults are more associated with Propionibacterium , Lactobacillus , Anaerococcus , Finegoldia , and Corynebacterium . …

Взрывы в кишечном микробиотическом составе у пациентов с аутоиммунными неврологическими заболеваниями: систематический обзор и метаанализ.

UNLABELLED: Исследования показывают, что дисбиоз кишечника происходит в аутоиммунных неврологических заболеваниях, однако всеобъемлющего обобщения данных не имеется. Наша цель заключалась в систематическом анализе и метаанализе взаимосвязи между кишечными микробиотами и аутоиммунными неврологическими расстройствами, с тем чтобы получить информацию о клиническом диагнозе и терапевтическом вмешательстве. Мы обыскали базы данных PubMed, Embase, Web of Science, и Kochrane Bibrary. 1 Март 2024 для исследования связи между кишечными микробиотами и аутоиммунными неврологическими расстройствами. Всего

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… Increases in the genera Acinetobacter , Collinsella , Enterococcus , Escherichia , Fusicatenibacter , Succinivibrio , and Sutterella , along with decreases in the family Rikenellaceae and the genera Gemella and Haemophilus , were exclusively reported in treatment-naive studies. …

Кишечная флора связана с риском возникновения хронических неинфекционных заболеваний.

КИСЛОТА: Кишечная флора (IF) связана с риском неинфекционных заболеваний, особенно различных видов рака, инсульта и болезни Альцгеймера. Однако на различных этапах роста, развития и старения все еще существует много неопределенностей в отношении этих ассоциаций. Поэтому необходимы дальнейшие углубленные исследования. AIM: Изучение связей человека с риском заболевания на различных этапах роста, развития и старения в целях получения более точных и убедительных выводов.МЕТОДЫ: Коорт, кросс-секции, контроль за конкретными случаями и исследования по случайной менделии, опубликованные в базах данных

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… Gastric cancer: One case-control study[ 24 ] reported that that Prevotella (pooled OR = 0.90, 95%CI: 0.85-0.95) was negatively associated with gastric cancer, while Streptococcus (pooled OR = 1.28, 95%CI: 1.00-1.63) and Gemella (pooled OR = 1.10, 95%CI: 0.75-1.62) were not significantly associated …

Изменения в отношениях между Гутом и Микробиоме-хостом после неизлечимых переживаний у пациентов с множественным склерозом.

ИСТОРИЯ ВОПРОСА И ЦЕЛИ: Было продемонстрировано, что микробные симбионты гута оказывают влияние на развитие автономного иммунитета при множественном склерозе (МС). Появляющиеся исследования указывают на важную связь между микробным интерфейсом и патофизиологией MS. Ига-секретные клетки B наблюдаются в мозге MS, и изменения в кишечной бактерии-IgA были описаны в некоторых пациентах с MS. Однако связи между кишечным микробиомом и иммунной реакцией принимающей стороны, особенно в отношении иммуномодуляции, разрушающей клетки В, остаются недостаточно изученными. Цель этого исследования заключалась

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… After 6 months of B-cell depletion therapy, we observed that certain organisms ( Akkermansia muciniphila , Bifidobacterium bifidum , Blautia obeum , and Gemella ) displayed immune coating patterns more similar to those of controls than to patients with untreated MS. …

Metagenomic Profiling of Oral Microbiome Dynamics During Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma Patients.

BACKGROUND: We explored the interaction between the oral microbiome and the development of radiation-induced mucositis in patients with head and neck squamous cell cancer (HNSCC) undergoing chemoradiotherapy (CRT). We prospectively studied the oral microbiome and compared it to healthy controls. Additionally, we compared patients with low-grade (LGM) vs. high-grade mucositis (HGM). METHODS: Ten HNSCC patients scheduled for CRT were included. Saliva samples were characterized prior to, during, and nine months after CRT using metagenomic sequencing. We similarly characterized samples from seven

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… abundance in the control group were found at baseline, such as from the Actinobacteria class, including the Rothia genus and Rothia mucilaginosa species, the Candidatus Saccharibacteria phylum, the Sanguibacteraceae family including the Sanguibacter genus and Sanguibacter keddieii species, as well as Gemella …

Antibiotic lock therapy for the treatment of peripherally inserted central venous catheter-related bloodstream infection in patients with hematological malignancies: a single center retrospective study.

Catheter-related bloodstream infections represent one of the most prevalent complications in patients with peripherally inserted central venous catheters (PICCs). The application of antibiotic lock therapy (ALT), particularly in patients with hematological malignancies, has not been well documented. We aim to share our experience on ALT for these patients and to evaluate its effectiveness and safety. All cases of patients with hematological malignancies who had PICC from January 2018 to October 2024 were retrospectively reviewed. Microbiologic data of PICC-related bloodstream infections (PRBSI

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… Table 3 Microbiology of PRBSIs 1 Other GPC: Streptococcus viridans (1), Gemella haemolysans (1), Micrococcus luteus (1); 2 Other GNB: Alcaligenes xylosoxidans (1), Moraxella osloensis (1), Fusobacterium nucleatum (1); 3 Percentage among their species. …

Role of Actinomyces spp. and related organisms in the development of medication-related osteonecrosis of the jaw (MRONJ): Clinical evidence based on a case series.

Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common consequence of antiresorptive treatment, which often leads to the development of necrotic exposed bone surfaces with inflammatory processes affecting the jawbone. Although the development of MRONJ is often associated with the inflammatory response or infections caused by the colonizing members of the oral microbiota, the exact pathogenesis of MRONJ is still not fully understood. In the present paper, we aimed to provide additional, microbiological culture-supported evidence, supporting the "infection hypothesis" that

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… Fusobacterium nucleatum | 10 7 CFU/mL | Filifactor alocis | 10 7 CFU/mL | Veillonella atypica | 10 5 CFU/mL Fusobacterium mortiferum | 10 7 CFU/mL | Solobacterium moorei | 10 6 CFU/mL | Veillonella dispar | 10 5 CFU/mL Clostridium beijerneckii | 10 6 CFU/mL | Eubacterium cellulosolvens | 10 5 CFU/mL | Gemella …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

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… Gemella spp. Yeasts Candida spp. … . | | Gemella spp. | Yeasts | Candida spp. | C. albicans , C. glabrata , C. krusei , C . lusitania Normally, the alimentary tract flora contains in excess of 10 14 microorganisms, representing between 500 and 1,000 different species [ 24 ] and amounting to several grams, but only very few species …

Bisphosphonate-Related Osteonecrosis of the Jaw and Oral Microbiome: Clinical Risk Factors, Pathophysiology and Treatment Options.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) represents a serious health condition, impacting the lives of many patients worldwide. The condition challenges clinical care due to its complex etiology and limited therapeutic options. A thorough understanding of the pathophysiological and patient-related factors that promote disease development is essential. Recently, the oral microbiome has been implicated as a potential driver and modulating factor of BRONJ by several studies. Modern genomic sequencing methods have provided a wealth of data on the microbial composition of BRONJ lesio

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… The study unveiled a wide range of bacteria in the BRONJ cohort, for instance Gram-positive genera such as Parvimonas , Eubacterium , Gemella , Leptotrichia , and Selenomonas . …

From Pathogenesis to Intervention: The Importance of the Microbiome in Oral Mucositis.

Oral mucositis (OM) is a common and impactful toxicity of standard cancer therapy, affecting up to 80% of patients. Its aetiology centres on the initial destruction of epithelial cells and the increase in inflammatory signals. These changes in the oral mucosa create a hostile environment for resident microbes, with oral infections co-occurring with OM, especially at sites of ulceration. Increasing evidence suggests that oral microbiome changes occur beyond opportunistic infection, with a growing appreciation for the potential role of the microbiome in OM development and severity. This review c

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… Similarly, a reduction in microbial diversity and compositional changes has been observed following radiotherapy, with changes observed in several oral taxa, including Lactobacillus, Streptococcus, Gemella, Leptotrichia, Neisseria, Capnocytophaga, Neisseria, Olsenella, Parviomonas, Tannerella and Capnocytophaga …

Conference Proceedings - 6th International Conference on Molecular Diagnostics and Biomarker Discovery (MDBD 2022): Building Resilience in Biomedical Research : Penang, Malaysia. 11-13 October 2022.

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