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The Significant Antioxidant Effect Exerted by Pomegranate (Punica granatum): The Hidden Polyphenols.

Background: Although the definition of dietary fibre is complex and constantly evolving, today we can identify it as "carbohydrate polymers with at least 10 monomeric units, which are not hydrolysed in the small intestine of humans". In addition to the numerous and well-known benefits of dietary fibre for human health, our attention is drawn to its antioxidant properties, achieved through polyphenolic compounds linked to polysaccharide complexes. This study investigated the antioxidant effects of an extract from the fruit of Punica granatum (PUN), particularly rich in polyphenols, fibre, flavo…

NADES-Extracted SunGold Kiwifruit Polyphenols as Functional Ingredients in Antioxidant-Enriched Yoghurt.

Natural deep eutectic solvents (NADES) offer a potentially food-compatible alternative for extracting plant polyphenols, although their direct application in yoghurt remains limited. This study evaluated the antioxidant and physicochemical properties of yoghurt fortified with SunGold kiwifruit extracts obtained using a selected choline chloride and glycerol NADES, with water extraction used for comparison. The phenolic profile of the NADES extract was characterised using LC-MS/MS. Both extracts were incorporated before (PRE) or after (POS) fermentation at concentrations of 10%, 20%, and 30% (v…

Tea polyphenols: Effects on growth, immune function, and reproductive performance of roosters.

Tea polyphenols (TPs), bioactive secondary metabolites from Camellia sinensis, demonstrate significant potential for enhancing poultry reproductive efficiency. This 43-week study systematically evaluated graded TPs supplementation (0-500 mg/kg Food Weight) in Tianfu G02 Blue-shell roosters (n = 540) through growth monitoring, histopathological analysis (Hematoxylin and Eosin staining, H&E), and molecular profiling (ELISA, qPCR). The data were analyzed using a sampling T-test or ANOVA and Tukey's Test. Optimal growth performance was achieved at 100-400 mg/kg TP doses, improved daily feed intake…

Natural polyphenols in ulcerative colitis: preclinical mechanisms of action and therapeutic potential.

Ulcerative colitis is an idiopathic, chronic inflammatory disease affecting the mucosa of the rectum and colon to a variable extent. Current therapeutic strategies demonstrate only moderate efficacy, highlighting the unmet need to develop new therapies that induce and maintain remission. Encouraging results have been obtained from pre-clinical studies and a few clinical trials using natural polyphenols for ulcerative colitis treatment. In this review, we mainly examine the available evidence from both in vivo and limited clinical studies supporting the therapeutic potential of natural polyphen…

Dietary Polyphenols and Inflammatory Markers in Rural Adult Women in Puno, Peru.

BACKGROUND: Dietary polyphenols are bioactive compounds credited with health protection and reducing inflammation. Evidence on their effects is limited in low- and middle-income countries, especially among rural populations. OBJECTIVES: To evaluate the association between dietary polyphenols intake and markers of inflammation and endothelial adhesion over 12 mo of follow-up among rural adult women participating in the Cardiopulmonary Outcomes and Household Air Pollution randomized controlled trial. METHODS: We used data at baseline and 12-mo visit in 100 healthy women aged 25-64 y living in …

Protection of Green Tea Polyphenols against Neurodegenerative Diseases: Evidence and Possible Mechanisms.

Aging is a major risk factor for neurodegenerative diseases. With aging of the global population, the prevalence of neurodegenerative diseas … decline and decreased risk of AD and PD, providing an attractive preventive and therapeutic option. Polyphenols are major bioactive components in green tea, which contribute to the beneficial effects of green tea. Accumulating data suggest that green tea polyphenols (GTPs) have neuroprotective properties that inhibit the pathological development of neurodegen …

The Role of Stem Cell Polyphenols in Wound Healing: A Narrative Review.

Stem cell polyphenols represent a promising avenue for enhancing wound healing through their multifaceted biological activities. Polyphenols, naturally occurring compounds with potent antioxidant properties, can modulate inflammatory responses, reduce oxidative stress, and promote the proliferation and migration of essential cells involved in tissue repair, such as fibroblasts and keratinocytes. Additionally, they play a critical role in angiogenesis, facilitating improved blood supply to healing tissues. Research indicates that the synergistic use of polyphenols with stem cell therapies could…

Extraction, Purification, Component Analysis and Bioactivity of Polyphenols from Artemisia dracunculus L.

A. dracunculus L., is a species of traditional Chinese medicine herbs, widely distributed northwestern China and used as antidiabetic, antib … oxidant and antibacterial properties. The results showed that the highest extraction yield of crude polyphenols of A. dracunculus (CPA) reached 5.02 ± 0.04% at an ethanol concentration of 70% of 70 °C with a solid-to-liquid ratio of 1:20 (g/mL). The D101 macroporous resin is the best one for polyphenolpurification of A. dracunculus (PPA), with a purification …

Invasive Plants as a Source of Polyphenols with High Radical Scavenging Activity.

The wide occurrence and expansive nature of invasive plant species are worldwide problems because these plants by their competitive characte … lysed to assess the feasibility of their use for bioactive compound extraction. The amount of total polyphenols and flavonoids was determined in various parts of the studied invasive plants, and their corresponding radical scavenging activities were determined using DPPH, ABTS, FRAP and CUPRAC. The studied invasive plants are rich sources of polyphenols, and …

Cupressus torulosa, a Source of Antioxidant Polyphenols: An Analytical and Pharmacological Study.

INTRODUCTION: Cupressus torulosa (family Cupressaceae), widely distributed in the northwestern Himalayan region of India, is a coniferous aromatic tree traditionally used for its aerial parts. Its needles are renowned for their anti-inflammatory, anticonvulsant, antimicrobial, and wound-healing properties. Antioxidants from this plant are vital in combating oxidative stress, which are implicated in these diseases. METHODS: This study employed a range of methods, including in vitro, in vivo, and ex vivo assays; biochemical estimations such as Total Phenolics Content and Total Flavonoids Conten

Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols.

Neurodegenerative diseases are a group of diseases that share common features, such as the generation of misfolded protein deposits and incr … new molecular and biochemical targets that could be exploited in the treatment of the disease using polyphenols.

Tea polyphenols and EGCG induce preeclampsia-like symptoms by reducing 2-methoxyestradiol.

Preeclampsia (PE), a severe pregnancy-specific disorder, poses significant health risks to both mothers and fetuses. Certain dietary habits, such as tea consumption, may affect the activity of enzymes involved in hormone metabolism, leading to alterations in the levels of important pregnancy-related hormone metabolites, such as 2-methoxyestradiol (2-MeO-E2), which may contribute to the development of PE. To investigate the effect of tea intake on pregnancy, we conducted both in vivo and in vitro experiments. Pregnant rats were administered tea polyphenols and epigallocatechin gallate (EGCG) by…

Полифенолы в центральной нервной системе: клеточные эффекты и подходы к липосомной добыче.

Нейродегенеративные и нейровоспалительные заболевания центральной нервной системы тесно связаны со старением и устойчивым окислительным и подстрекательским стрессом. Полифенолы, производящиеся растениями вторичные метаболиты, демонстрируют широкую биологическую деятельность, включая антиоксидантные и противовоспалительные эффекты, модуляцию таких путей, как PI3K/Akt, MAPK, Nrf2 и CREB, а также регулирование нейрогенеза и микроглиальной активации. Основное внимание в этом обзоре уделяется конкретным клеточным действиям отдельных полифенолов в нейронах, астроцитах, микроглиях и олигодендроцитах

Совпадение в аннотации оригинала
Neurodegenerative and neuroinflammatory diseases of the central nervous system are closely linked to aging and sustained oxidative and inflammatory stress. Polyphenols, plant-derived secondary metabolites, exhibit broad biological activities, including antioxidant and anti-inflammatory effects, the modulation of pathways such as PI3K/Akt, MAPK, Nrf2, and CRE…

Anti-Staphylococcal Biofilm Effects of a Liposome-Based Formulation Containing Citrus Polyphenols.

Biofilms are surface-associated microbial communities embedded in a matrix that is almost impenetrable to antibiotics, thus constituting a critical health threat. Biofilm formation on the cornea or ocular devices can lead to serious and difficult-to-treat infections. Nowadays, natural molecules with antimicrobial activity and liposome-based delivery systems are proposed as anti-biofilm candidates. In this study, the anti-biofilm activity of a formulation containing citrus polyphenols encapsulated in liposomes was evaluated against Staphylococcus aureus and Staphylococcus epidermidis, the most …

The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats.

Endometriosis is a common gynecological condition with a complex physio-pathological background. This study aimed to assess the role of Rubus idaeus leaf extract (RiDE) as a potential therapeutic agent in reducing the size of the endometriotic lesions and modulate the plasma expression of MMP-2, MMP-9, and TGF-β1. The endometriotic lesions were induced in a rat model by the autologous transplant of endometrium. Thirty-six female rats, Wistar breed, with induced endometriosis, were divided into four groups and underwent treatment for 28 days. The CTRL group received 0.5 mL/day of the vehicle; t

Antiviral flavonoids- and polyphenols-driven novel anti-HBV efficacy of Ilex paraguariensis.

INTRODUCTION: Antiviral natural products have shown great promise as alternatives to conventional therapies to address drug resistance in he … LC revealed known anti-HBV flavonoids (rutin: 18.98, quercetin: 6.52 and kaempferol: 9.10 μg/g) and polyphenols (caffeic acid: 11.43 and chlorogenic acid: 3.22 μg/g) in the extract. Their (10 μg/ml, each) anti-HBV activities were: quercetin (HBsAg: 67.8% and HBeAg: 64.4%), kaempferol (HBsAg: 63.5% and HBeAg: 61.6%), chlorogenic acid (HBsAg: 55.2% and HBeAg: 5 …

Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic Streptococcus mutans.

Dental caries are an oral infectious disease that can affect human health both orally and systemically. It remains an urgent issue to establish a novel antibacterial method to prevent oral infection for a healthy life expectancy. The aim of this study was to evaluate the inhibitory effects of novel iron chelators, super-polyphenols (SPs), on the cariogenic bacterium Streptococcus mutans, in vitro. SPs were developed to reduce the side effects of iron chelation therapy and were either water-soluble or insoluble depending on their isoforms. We found that SP6 and SP10 inhibited bacterial growth e…

Dietary polyphenols drive dose-dependent behavioral and molecular alterations to repeated morphine.

Opioid Use Disorder (OUD) is associated with tremendous morbidity and mortality. Despite this burden, current pharmacotherapies for OUD are … in showed a dose × polyphenol interaction. We also profiled microbiome composition and function, as polyphenols are metabolized by the microbiome and can act as prebiotics. The profile revealed polyphenol treatment markedly altered microbiome composition and function. Finally, we investigated involvement of the SIRT1 deacetylase, and the role of polyphenol me …

Polyphenols in Inner Ear Neurobiology, Health and Disease: From Bench to Clinics.

There is substantial experimental and clinical interest in providing effective ways to both prevent and slow the onset of hearing loss. Audi … may become ineffective and/or potentially harmful. According to hormesis, phytochemicals including polyphenols exhibit biphasic dose-response effects activating low-dose antioxidant signaling pathways, resulting in the upregulation of vitagenes, a group of genes involved in preserving cellular homeostasis during stressful conditions. Modulation of the vitage …

Polyphenols and atherosclerosis: A critical review of clinical effects on LDL oxidation.

Atherosclerosis is a major etiology of cardiovascular disease that causes considerable mortality. Oxidized low-density lipoprotein (oxLDL) is a fundamental attributor to atherosclerosis. Therefore, there seems to be an essential place for antioxidant therapy besides the current treatment protocols for coronary heart disease. Polyphenols are a class of compounds with substantial antioxidant properties that have shown the ability to reduce LDL oxidation in preclinical studies. However, clinical evidence has not been as conclusive although offering many promising signs. This review aims to examin…