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Natural language processing for abstraction of cancer treatment toxicities: accuracy versus human experts.

ObjectivesExpert abstraction of acute toxicities is critical in oncology research but is labor-intensive and variable. We assessed the accuracy of a natural language processing (NLP) pipeline to extract symptoms from clinical notes compared to physicians.Materials and methodsTwo independent reviewers identified present and negated National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) v5.0 symptoms from 100 randomly selected notes for on-treatment visits during radiation therapy with adjudication by a third reviewer. A NLP pipeline based on Apache clinical Text Analys

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… Marrakech, Morocco: European Language Resources Association (ELRA); May 28–30, 2008, 3143–50. http://www.lrec-conf.org/proceedings/lrec2008/pdf/796_paper.pdf (accessed August 12, 2020). 25. Miller T, Geva A, Dligach D. Extracting adverse drug event information with minimal engineering. …

Concerns of stem cell transplant patients during routine ambulatory assessment.

BackgroundStem cell transplant (SCT) is a treatment choice for many hematological malignancies. There is currently a lack of evidence regarding the self-reported concerns of SCT patients before and after SCT.Aim and designThis exploratory study performed a secondary analysis of self-reported, written concerns of SCT patients before and after transplant to determine patients' concerns.MethodsContent analysis of text box entries of SCT patients collected between 2005 and 2007 at the Seattle Cancer Care Alliance. Text box entries were collected as part of symptom assessment using the Electronic S

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… F Hussein AA Rihani R Bone marrow and stem cell transplantation at King Hussein cancer center Bone Marrow Transplant 2008 42 Suppl 1 S89 S91 18724314 10.1038/bmt.2008.126 16 Benchekroun S Harif M Madani A Quessar A Zafad S Rachid R Present and future of hematology and stem cell transplantation in Morocco …

Development and implementation of the International AIDA Network Castleman's disease registry.

Castleman's disease (CD) consists of a wide spectrum of rare disorders classified into unicentric CD and multicentric CD (MCD), based on the diffusion of disease distribution and the severity of clinical manifestations. While unicentric CD is characterized by a single lymph node involvement, MCD is defined by multiple lymph node station involvement with more prominent systemic symptoms. MCD is further subdivided into HHV-8 associated MCD, polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes (POEMS)-associated MCD, and idiopathic MCD (iMCD), which is also

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… Results To date, 45 nations in 4 continents (Algeria, Argentina, Australia, Belgium, Brazil, Canada, Chile, China, Colombia, Cyprus, Czechia, Denmark, Dominican Republic, Egypt, France, Germany, Ghana, Greece, India, Iran, Ireland, Israel, Italy, Japan, Jordan, Kazakhstan, Lebanon, Libya, Morocco, Mexico …

Scoping Review and Meta-Analysis Suggests that Cannabis Use May Reduce Cancer Risk in the United States.

Introduction:Cannabis smoke contains carcinogens similar to tobacco, in addition to compounds with antitumor activity. Cannabis use reduces the risk of obesity and cannabinoids inhibit chronic inflammation, known causes of cancer. The net effect of Cannabis use on cancer risk is not known. Objective: To examine the association between Cannabis use and cancer risk in the United States. Methods: Identify and analyze published data on cancer risk in Cannabis users. Results: A total of 55 data points, consisting of risk ratios of cancer in Cannabis users and nonusers, were identified from 34 studi

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… Non-Hodgkin's lymphoma | No adjustments | No use vs. any use Rosenblatt et al. 82 | United States, Washington State | Case–control | Oral | Age, study, race, sex, education level, pack-year, alcohol duration, pipe smoking duration, cigar smoking duration | Ever vs. never user Sasco et al. 83 | North Africa; Morocco … A case-control study of lung cancer in Casablanca, Morocco . Cancer Causes Control . 2002 ; 13 : 609 – 616 . 12296508 10.1023/a:1019504210176 84. Sidney S , Quesenberry CP , Friedman GD . Marijuana use and cancer incidence (California, United States) . …

Anticancer natural products from the Middle East and North Africa: biodiversity, mechanisms, and translational challenges.

Cancer remains one of the leading causes of morbidity and mortality worldwide, imposing substantial clinical, societal, and economic burdens. Despite major advances in surgical oncology, systemic chemotherapy, radiation therapy, molecularly targeted therapeutics, and immune checkpoint inhibition, contemporary cancer treatment remains constrained by dose-limiting toxicities, intratumoral and intertumoral heterogeneity, and the inexorable emergence of multifaceted drug resistance mechanisms. These persistent therapeutic challenges have reinstated interest in natural products (NPs) as evolutionar

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… 204 ) Sesamum indicum | Egypt | Sesamin; sesaminol; methyl linoleate | Lignans; lipid derivatives | Hepatocellular carcinoma | Caspase-dependent apoptosis | ( 205 ) Aberia caffra | Egypt | Aberiamine (alkaloid) | Alkaloids | Hepatocellular carcinoma | Caspase-mediated apoptosis | ( 205 ) Ajuga iva | Morocco … Ajuga iva from Morocco exerts anti-angiogenic effects through modulation of EGFR and VEGFR2 signaling ( 206 ). Sesamum indicum and Aberia caffra from Egypt demonstrate hepatocellular cytotoxicity, driven by their phenolic and lipid-based compounds ( 205 ). …

Adefovir dipivoxil-induced hypophosphatemic osteomalacia and osteoporosis: a case report and literature review.

The nephrotoxicity of adefovir dipivoxil (ADV) can induce Fanconi syndrome, which causes hypophosphatemic osteomalacia. We report a case of a 67-year-old postmenopausal woman who had been receiving long-term adefovir dipivoxil therapy for chronic hepatitis B. She presented with severe bone pain and multiple pseudofractures, and was diagnosed with drug-induced hypophosphatemic osteomalacia. Following discontinuation of adefovir and supplementation with vitamin D and phosphate, her biochemical parameters normalized and bone pain significantly improved, indicating that osteomalacia had been essen

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… Edited by: Abdellah El Maghraoui , Mohammed V University, Morocco Reviewed by: Ignacio Portales , Washington University in St. Louis, United States Neil J. …

Ageing, exposure to pollution, and interactions between climate change and local seasons as oxidant conditions predicting incident hematologic malignancy at KINSHASA University clinics, Democratic Republic of CONGO (DRC).

BACKGROUND: The global burden of hematologic malignancy (HM) is rapidly rising with aging, exposure to polluted environments, and global and local climate variability all being well-established conditions of oxidative stress. However, there is currently no information on the extent and predictors of HM at Kinshasa University Clinics (KUC), DR Congo (DRC). This study evaluated the impact of bio-clinical factors, exposure to polluted environments, and interactions between global climate changes (EL Nino and La Nina) and local climate (dry and rainy seasons) on the incidence of HM. METHODS: This

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… Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years. BMC cancer. 2016;16(1):159. 7. OMS, La fréquence des cancers pourrait augmenter de 50% dans le monde, avec 15 millions de nouveaux cas en 2020. Centre des médias; 2003. 8. …

Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates.

BackgroundTuberculosis is associated with increased risk of cancer. However, the impact of tuberculosis on global cancer burden is unknown.MethodsWe performed random-effects meta-analyses and meta-regressions of studies reporting the association between tuberculosis and cancer risks by searching PubMed, Web of Science, Embase, Cochrane library, and CINAHL from inception to 1 June 2019. Population attributable fractions (PAFs) of cancer incidence attributable to tuberculosis were calculated using relative risks from our meta-analyses and tuberculosis prevalence data from Global Health Data Exch

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… In men, the PAFs were more than 7.2% in Morocco, Sudan, and Vietnam; but less than 1.0% in Australia, Chile, and the United States. In women, the PAFs were more than 4.5% in North Korea, Sudan, and Vietnam; but less than 0.6% in Jordan, Malta, and Spain. …

Mobilising stakeholders to improve access to state-of-the-art radiotherapy in low- and middle-income countries.

In an ongoing effort to improve access to state-of-the-art radiotherapy in low- and middle-income countries (LMICs), a joint symposium was organised by the non-governmental, non-profit organisation Medical physicists in diaspora for Africa e.V. (MephidA e.V.) in collaboration with the Germany-based Cameroon-German medical doctor's association (Camfomedics e.V.) and the Harvard-based Global Health Catalyst summit. The goal of the symposium was to discuss the technical and structural challenges faced in African LMIC settings, re-evaluate strategies to overcome the shortfall of radiotherapy servi

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… Two medical physicists are currently being trained in Morocco under the IAEA programme and are planned to join the physics team in 2021. Although the radiotherapy health insurance covers 90% of treatment costs, most patients still cannot afford the remaining 10%. …

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview.

The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs. The costs associated with gene therapy and stem cell transplants can be prohibitive, especially in low- and middle-income countries. Strategies to address affordability, including local manufacturing, government funding, and partnerships with global health agencies, are essen

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… Geographic Limitations AlloHCT is available in only six of the 54 African countries: Algeria, Egypt, Morocco, Nigeria, South Africa, and Tunisia [ 146 ]. du Toit et al. demonstrated the feasibility of haploidentical HCT, where a younger parent or offspring donor can be a viable option for adults in …

Глобальные, региональные и национальные тенденции и бремя множественного склероза среди подростков и молодежи: анализ данных 1990 в адрес 2021 и прогнозы в отношении 2040.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Множественный склероз (МС) оказывает значительное воздействие на подростков и молодежь (возраст) 15-39 годы), вызывая серьезные неврологические расстройства. Несмотря на прогресс в области лечения, глобальное бремя сохраняется из-за различий в доступе к медицинскому обслуживанию и факторах образа жизни. В настоящем исследовании анализируются глобальные, региональные и национальные тенденции и бремя НР с использованием глобального бремени болезней (ГБЗ) 2021 данные с уделением особого внимания влиянию социально-демографического индекса (ИПД). МЕТОДЫ: Использование

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… Specific countries and territories, including Afghanistan, Albania, Denmark, Palestine, Morocco, and Serbia, demonstrated significantly higher burdens than expected, while Singapore, Japan, Guam, Monaco, and San Marino exhibited considerably lower burdens than anticipated ( Supplementary Figure S10 ) …

Multimodal imaging diagnosis of multiple myeloma with renal involvement: a case report.

BackgroundExtramedullary renal involvement secondary to multiple myeloma (MM) is extremely rare and prone to preoperative misdiagnosis. Its clinical and imaging manifestations have not been systematically summarized, leading to frequent preoperative misdiagnosis. To summarize the multimodal imaging characteristics and clinical diagnostic value of MM with renal involvement through a typical case report, so as to improve the understanding and early recognition rate of this disease.Case presentationA 67-year-old male patient with left lumbodorsal pain was examined by multimodal imaging. Ultrasoun

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… Footnotes Edited by: Francesca Cottini , The Ohio State University, United States Reviewed by: Tan-Huy Chu , Tam Anh Research Institute, Vietnam Malek Bouhani , Salah Azaiez Institute, Tunisia Mouad El Ouazzani , Université Ibn Zohr, Morocco Data availability statement The original contributions …

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Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid

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… Iran and Morocco recorded much higher disability due to drug use disorders than expected based on SDI. In comparison with the rest of the world, ranks of cause-specific disability, and their ratios of observed to expected values, were vastly different in sub-Saharan Africa. … In our assessment, the ten countries with the highest prevalence of opioid dependence in decreasing order in 2015 were Iran, United Arab Emirates, Russia, Morocco, the USA, Australia, Ukraine, Tunisia, Belarus, Canada, and Iraq. …

Global ethylene oxide uses in foods and considerations for food safety.

Ethylene oxide (EtO) is a sterilant widely used for medical devices, but its use is controversial due to its carcinogenicity. In some countries, EtO is also used to fumigate food to eliminate foodborne pathogens, though this practice is banned in others. National regulations on EtO use in food vary widely; exporting countries prioritize trade facilitation and prevention of foodborne illness, while importing countries emphasize maintaining food safety and promoting domestic public health. These divergent public health priorities present challenges to establishing universal maximum residue limit

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… By February 2025, more than 900 EtO-related notifications had been issued for food originating from several countries, including India, China, Ukraine, Pakistan, Turkey, Lebanon, Indonesia, Morocco, Vietnam, and Hong Kong [ 4 , 61 ]. …

Impact of maintenance therapy on survival after autologous stem cell transplant for multiple myeloma regardless of response: a global analysis.

The effect of different maintenance therapies on outcome after autologous hematopoietic cell transplantation (AHCT) was analyzed in newly diagnosed multiple myeloma (NDMM) patients using global real-world data. NDMM patients transplanted between 2013 and 2017 were selected from the Worldwide Network for Blood and Marrow Transplantation (WBMT) registry. Overall survival (OS) was evaluated as primary and progression-free survival (PFS), non-relapse mortality and relapse/progression incidence as secondary endpoints. Multivariable 6- month landmark analyses were performed using Cox proportional ha

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… Morocco 26 Clinical Hospital Dr. …

The Disruptive Impact of COVID-19 on the Utilization of Cancer Chemotherapy-Related Healthcare Assistance at the Principal Nationwide Referral Hospital in Kenya.

Background Lockdown measures to reduce the outbreak of COVID-19 negatively impacted the administration of cancer chemotherapy globally; however, data from Kenya are limited. Researchers strove to address this information gap and assess chemotherapy trends before and during the pandemic at Kenyatta National Hospital (KNH), the most wide-ranging referral infirmary in Kenya, along with associated factors to provide future guidance. Methods Time series analyses and patient interviews were undertaken at the KNH Cancer Treatment Centre. Patient data were analyzed descriptively and inferentially. The

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… Similar findings were seen in Morocco, where there was a 24% reduction in cancer case admissions from March to April 2020 when lockdown and other measures were implemented compared to 2019 [ 30 ]. …

COVID-19: The Impact in Oncology Care.

The COVID-19 pandemic has imposed a critical challenge to the current oncology care and practices including late diagnoses, delayed anti-cancer treatment, and static clinical trials. With the increasing risk of cancer patients acquiring infection during receiving the essential care, the debate ensues on how to balance the risk factors and benefits out of the oncologic emergencies in cancer patients. In this review article, we have focused on the current global re-organization of the integrity and effectiveness of the treatment modalities depending on the patient and cancer-specific urgencies w

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… Beyond this, a recent article in Morocco that report on the possible ways to minimize the risk of spreading infection in cancer patients in the post-COVID-19 period explains the need to strategize and implement a national screening awareness for the infection to all the patients in order to protect them …

Парадокс ХЛА среди различных групп населения в процессе склероза: систематический обзор.

Множественный склероз (МС) свидетельствует о неоднородности курсов по болезням. Несмотря на то, что ХЛА ДРБ1*15::01 представляет собой самый сильный фактор генетического риска для MS-чувствительности, принося примерно в три раза больший риск, не влияет ли эта аллея на прогрессию заболеваний по-прежнему спорным образом. МЕТОДЫ: Этот систематический обзор был проведен с целью уточнения взаимосвязи между полиморфизмом ВЛА и ходом многочисленных склерозов с момента их создания до ноября 2025. A three- для учета ненезависимости статистических данных использовался метаанализ случайного воздействия н

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… Studies | 56 | Qualitative synthesis Studies in Meta-analysis | 35 | 276 effect sizes Total Participants | 22,145 | Range: 30–8,060 Geographic Region | N(%) | European | 32 (57.1%) | UK, France, Sweden, Spain, etc North American | 10 (17.9%) | USA, Canada Middle Eastern | 7 (12.5%) | Iran, Saudi Arabia, Morocco …

Symptomatic cluster headache: a review of 63 cases.

Isotechnika is developing the immunosuppressive drug ISA 247, a calcineurin inhibitor that is undergoing clinical development for the treatm … countries. Three patents relating to this claim were previously issued in the following countries; Morocco (No. 26337 issued 1 October 2004); Pakistan (No. 138338 issued 30 September 2004) and South Africa (No. 2004/2270 issued 25 May 2005). A US patent (No 6 686 454) was issued in February 2004 entitled 'Antibodies to Specific Regions of Cyclosporine Re …