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Interposition of the omentum and/or the peritoneum in the emergency repair of large ventral hernias with polypropylene mesh.

BACKGROUND: Ventral and incisional hernias are common surgical problems and their repairs are among the common surgeries done by a general surgeon. Repair of a large ventral hernia is still associated with high postoperative morbidity and recurrence rates. No single approach to ventral hernia repair will be the best choice for all patients. Large ventral hernias are often better approached with open surgery but may still be problematic when the defect is too wide for primary fascial closure to be achieved, as this leaves mesh exposed, bridging the gap. Techniques for incisional hernia repair h

Твердая неэптическая гипераммония, связанная с уреаплазмой парвума и инфекциями гомини Микопласмы в двойном иммунозапугивании женщины, представляющей как предполагаемый перитональный карциноматоз.

Острая гипераммония, не связанная с гепатической гипераммонией, является редким, но потенциально опасным для жизни заболеванием у пациентов, страдающих иммунокомпромиссной болезнью. Виды Ureaplasma и Mycoplasma являются быстродействующими врожденными организмами, которые генерируют аммиак и могут вызывать распространенную культурно-отрицательную инфекцию. Мы сообщаем о случае 63-year-old Женщина, получающая двойную биологическую терапию, оклелизумаб от множественных склерозов и секукинуумаб от псориаза, которая имела историю стерильности пюрии и симптомов мочи ниже. В течение двух месяцев ее с

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Severe nonhepatic hyperammonemia is a rare but potentially life-threatening condition in immunocompromised patients. Ureaplasma and Mycoplas … sterile pyuria and lower urinary tract symptoms. Within two months, her condition progressed to polyserositis, paralytic ileus, multiorgan dysfunction, and metabolic encephalopathy requiring admission to intensive care. Imaging suggested a left ovarian neoplasm with peritoneal carcinomatosis, prompting exploratory laparotomy, which ultimately revealed diffu …

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent

Diagnostic challenges of systemic juvenile idiopathic arthritis with aberrant M-protein expression: a case report.

BACKGROUND: Systemic juvenile idiopathic arthritis (sJIA), a severe autoinflammatory subtype of JIA, presents diagnostic challenges due to non-specific clinical features and the absence of definitive biomarkers. Current ILAR classification criteria emphasize exclusion of mimicking conditions, yet misdiagnosis rates persist (20%-35%), particularly in early disease stages. CASE PRESENTATION: A 15-year-old female presented with persistent high-grade fever, anemia (Hb: 84→64→73→91 g/L), thrombocytosis (PLT 592→1,044 × 10⁹/L), and iron overload. Initial evaluations excluded infections (CMV-positive

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… Background Systemic juvenile idiopathic arthritis (sJIA), classified under the International League of Associations for Rheumatology (ILAR) criteria [ 1 ], is an autoinflammatory disorder characterized by spiking fever, evanescent rash, polyarticular synovitis, and serositis, frequently accompanied … for sJIA [ 1 ], which require: (1) arthritis (arthritis/arthralgia in ≥ 1 joint, with onset before 16 years of age, lasting ≥ 6 weeks); (2) daily spiking fever (≥ 39 °C) for ≥ 2 weeks; and (3) at least one of the following: evanescent rash, generalized lymphadenopathy, hepatomegaly/splenomegaly, or serositis …

Uterine-sparing Laparoscopic Resection of Accessory Cavitated Uterine Masses.

STUDY OBJECTIVE: To demonstrate surgical techniques utilized during uterine-sparing laparoscopic resections of accessory cavitated uterine masses (ACUMs). ACUMs represent a rare uterine entity observed in premenopausal women suffering from dysmenorrhea and recurrent pelvic pain. The diagnosis is made when an isolated extra-cavitated uterine mass is resected from an otherwise normal appearing uterus with unremarkable endometrial lumen and adnexal structures. Pathologic confirmation requires an accessory cavity lined with endometrial epithelium (and corresponding glands and stroma) filled with c

Gallbladder крупногабаритная нейроэндокринная карцинома у пациента с множественной миеломой: отчет о деле и обзор литературы.

Большой нейроэндокринный карцинома (GB-LCNEC), крайне редкий патологический подтип желчного пузырька, характеризуется высокой агрессивностью и коварным наступлением, часто приводящим к плохому прогнозу и возникновению серьезных проблем в области клинического управления. В настоящем докладе представлен полный курс лечения пациента с диагнозом GB-LCNEC, осложненным активными Multieloma (MM), сопровождаемый систематическим обзором соответствующей литературы, опубликованной за последнее десятилетие. Предварительная съемка выявила желчный пузырь, который был патологически подтвержден в качестве GB-

Kidney Biopsy Findings Among Allogenic Hematopoietic Stem Cell Transplant Recipients With Kidney Injury: A Case Series.

RATIONALE AND OBJECTIVE: The incidence of kidney disease is high in patients after allogeneic hematopoietic cell transplantation (aHCT). Although rarely performed, kidney biopsy may be useful to make a precise diagnosis because several mechanisms and risk factors can be involved, and to adjust the treatment accordingly. This case series aimed to report the spectrum of biopsy findings from patients with kidney injury after aHCT. STUDY DESIGN: Single-center retrospective case series. SETTING AND PARTICIPANTS: All individuals who underwent a native kidney biopsy, among all adult patients who re

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… cyclophosphamide Methotrexate, tacrolimus Yes (gastro-intestinal) Yes (gastro-intestinal, 10 m) Corticosteroids, MMF, pentostatin, sirolimus, tacrolimus Corticosteroids, MMF 3 57 M NHL PBHCT, related Cyclophosphamide, TBI Cyclosporine, methotrexate Yes (liver, skin) Yes (eyes, mouth and skin, 63 m; serositis … F CLL PBHCT, related Fludarabine, melphalan Cyclosporine (120 d), methotrexate No Yes (skin gastro-intestinal and liver, 7 m) Corticosteroids, cyclosporine, MMF, sirolimus tacrolimus Corticosteroids, MMF 16 51 F CML PBHCT, related Busulfan, cyclophosphamide ATG, cyclosporine, methotrexate, No Yes (serositis …

Azathioprine for remission maintenance in anti-interferon-γ autoantibody-associated immunodeficiency syndrome- a retrospective single-center cohort study.

BACKGROUND: Anti-interferon-γ autoantibody (Anti-IFN-γ Aab) disease is associated with frequent recurrent infections. Adjunctive immunosuppressive treatment, including rituximab, can achieve disease remission. However, disease relapses and recurrent infections occur after immunosuppressive drugs are discontinued. Azathioprine (AZA) is used for maintenance therapy in many autoimmune diseases with few adverse effects. This study aimed to assess the effectiveness of AZA in maintaining clinical remission in patients with Anti-IFN-γ Aab disease. METHODS: This retrospective observational study was

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… Lymphadenopathy | 8 (57.1) | 8 (53.3) | 0.837 Lungs | 6 (42.9) | 5 (33.3) | 0.597 Sepsis | 4 (28.6) | 2 (13.3) | 0.390 Osteomyelitis | 3 (21.4) | 2 (13.3) | 0.651 Arthritis | 1 (7.1) | 2 (13.3) | 1.000 Autoimmune hemolytic anemia | 0 (0.0) | 2 (12.5) | 0.483 Neurologic involvement | 0 (0.0) | 1 (6.7) | 1.000 Serositis … 4 (100.0) | 9 (81.8) | Sweet’s syndrome, n (%) | | | Yes | 0 (0.0) | 2 (18.2) | 0.360 No | 4 (100.0) | 9 (81.8) | AIHA, n (%) | | | Yes | 0 (0.0) | 2 (18.2) | 0.360 No | 4 (100.0) | 9 (81.8) | Pulmonary infection, n (%) | | | Yes | 1 (25.0) | 4 (36.4) | 0.680 No | 3 (75.0) | 7 (63.6) | Serositis …

Systemic amyloidosis causing intestinal hemorrhage and pseudo-obstruction.

There are two major forms of amyloidosis, primary amyloidosis (AL) and secondary amyloidosis. AL amyloidosis results from deposition of immunoglobulin light chains or their fragments. One such example is AL amyloidosis associated with multiple myeloma, in which overproduced immunoglobulin light chains get deposited onto tissues, leading to tissue dysfunction. Amyloidosis in the intestines can present as a wide spectrum of non-specific gastrointestinal (GI) complaints including abdominal pain, changes in bowel habits, overt gastrointestinal bleeding and complaints related to altered motility in

CAR T cell therapy for refractory pediatric systemic lupus erythematosus: a new era of hope?

Systemic lupus erythematosus (SLE) is a chronic autoimmune condition that can affect multiple organ systems and is heterogenous in its presentation and response to therapy. When diagnosed in childhood, SLE is associated with increased morbidity and mortality compared to adult SLE, often requiring substantial immunosuppression with the risk of significant side effects. There remains a significant unmet need for new therapies that can improve disease control and reduce glucocorticoid and other toxic medication exposure for patients with severe or refractory disease. The pathogenesis of SLE invol

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… Clinical manifestations included serositis, nephritis, cytopenias, immunologic findings (ANA, dsDNA, hypocomplementemia), and concern for central nervous system involvement. She remained refractory to treatment with multiple agents including tacrolimus, belimumab, CYC, and rituximab. … No CNS disease. | Class III, IV, or III/V in all 5 patients | Pulsed glucocorticoids (5/5), hydroxychloroquine (5/5),MMF (5/5), belimumab (5/5), azathioprine (2/5), and CYC (3/5) | 5–17 months, mean 9.8 months | CRS grade 1 (fever) in 3 patients Taubmann | 1 | Less than one year | Lupus nephritis, serositis …

Systemic Lupus Erythematosus in Primary Care: An Update and Practical Messages for the General Practitioner.

Systemic Lupus Erythematosus (SLE) is a complex chronic autoimmune disease that manifests a wide range of organ involvement. Traditionally, the diagnosis and management of SLE is provided at secondary and tertiary centers to ensure prompt initiation of treatment, adequate control of flares and prevention of irreversible organ damage. Notwithstanding, the role of primary care in SLE is also emerging as there are still significant unmet needs such as the diagnostic delay at the community level and the high burden of therapy- and disease-related comorbidities. In the present review, we summarize

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… Conversely, only few patients reported signs of active involvement of the kidneys (proteinuria or cellular casts) or other major organs (serositis, seizures, or psychosis) prior to SLE diagnosis ( 42 ). … Most cases appear after medium-to-long term exposure to the offending agent and tend to manifest arthralgias or arthritis, myalgia, fatigue, and serositis. …

Feline Coronavirus Infection

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… Testicular enlargement may occur in cats with serositis that involves the tunica vaginalis. … Necropsy Findings Necropsy showed moderate to severe, multifocal to coalescing pyogranulomatous capsulitis and serositis that involved the spleen, liver, kidney, intestines, diaphragm, thoracic and abdominal walls, and pericardium. …

Juvenile-onset Systemic Lupus Erythematosus: Recent Advances in Pathogenesis and Treatment.

PURPOSE OF REVIEW: This review summarizes recent advances in understanding the pathogenesis and therapeutic landscape of juvenile-onset systemic lupus erythematosus (jSLE), with a focus on how emerging genetic and immunologic insights inform patient stratification, targeted treatments, and Treat-to-Target (T2T) approaches in pediatric care. RECENT FINDINGS: Studies of (ultra-)rare gene variants (e.g., affecting TLR7, UNC93B1, PLD4, PTPN2, BACH2) aided in understanding key pathogenic pathways, and allowed linking these to associated clinical phenotypes. Multi-ancestral genomic studies and cumu

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… None [ 21 ] The DDX58 gene encodes for RIG-I (retinoic acid–inducible gene I), a cytosolic sensor for viral double-stranded RNA that triggers IFN production and initiates innate antiviral immune responses. rs138425677/p.Pro885Ser Swedish Patient 6: 17-year-old patient with rash, arthritis, serositis, … | rs138425677/p.Pro885Ser | Swedish | Patient 6: 17-year-old patient with rash, arthritis, serositis, mildly reduced glomerular filtration rate, tested positive for ANA and dsDNA antibodies. | None | [ 21 ] | DNASE1L3 | c.290_291delCA/p.Thr97Ilefs*2 (Homozygous) | Turkish | 15-month-old patients with …

Abstracts from the ISSAID 2021 Periodic Congress : Virtual. May - Dec 2021

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… Sönmez Introduction: Familial Mediterranean fever (FMF) is a systemic autoinflammatory disease manifesting with recurrent attacks of serositis accompanied by fever, usually lasting 12-72 hours. … It is characterized by recurrent inflammatory episodes of fever and serositis. Its lifelong and inflammatory nature can cause detrimental effects on all aspects of patients' quality of life. …

Noninfectious pulmonary complications of haematopoietic stem cell transplantation.

Haematopoietic stem cell transplantation (HSCT) is an established treatment for a variety of malignant and nonmalignant conditions. Pulmonary complications, both infectious and noninfectious, are a major cause of morbidity and mortality in patients who undergo HSCT. Recent advances in prophylaxis and treatment of infectious complications has increased the significance of noninfectious pulmonary conditions. Acute lung injury associated with idiopathic pneumonia syndrome remains a major acute complication with high morbidity and mortality. On the other hand, bronchiolitis obliterans syndrome is

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… Late-onset (>100 days) pleural effusions are also commonly due to volume overload or infections, but serositis-type GVHD involving the pleura may also be considered in differential diagnosis. Incidence of serositis-type GVHD is 0.8 to 1.23%. … Most patients develop extensive GVHD of other organs before development of serositis-type GVHD and may require repeated thoracentesis. Treatment involves increasing GVHD therapy after exclusion of other causes. …

Иммуноглобулин А лямбда, связанный с миеломой, легкий сердечный амилоидоз с постепенной сердечной недостаточностью с консервируемой фракцией выброса: отчет о мультимодальной съемке.

Участие в кардиологической деятельности является основным фактором, определяющим прогноз иммуноглобулиновой световой цепи (AL) амилоидоз, но может быть недооценено у пациентов с множественной миеломой (MM), особенно в тех случаях, когда отсутствуют классические электрокардиографические или сердечные магнитные резонансные характеристики. Таким образом, раннее признание зависит от интеграции сердечных биомаркеров и мультимодальных изображений в тех случаях, когда биопсия тканей или синтиграфическая подстилка непрактична.Резюме дела: A 74-year-old - у человека с иммуноглобулином Алямбда ММ и имму

Molecular imaging in oncology: Common PET/CT radiopharmaceuticals and applications.

PET/CT is a commonly used modality in cancer imaging, as it can help in diagnosis, staging and assessment of treatment response in many cancer types. A better understanding of the tumor microenvironment and identification of multiple selective targets are promoting further investigation into different radiotracers for diagnosis and therapy. In the past few decades many radiopharmaceuticals have emerged for specific oncologic indications providing superior detection rate than some morphologic modalities. The purpose of this review is to provide an update on the most current radiopharmaceuticals

Эндоскопический диагностический и клинический курс по изолированному верхнему кишечному амилоидозу: ретроспективное исследование.

ЦЕЛИ: Ранняя диагностика амилоидоза верхней части желудочно-кишечного кишечника (УГИ) и разработка соответствующих стратегий лечения и последующей деятельности по-прежнему сопряжены с трудностями. Цель этого исследования заключалась в выяснении эндоскопических характеристик и клинических курсов пациентов с изолированным амилоидозом УГИ. МЕТОДЫ: Мы провели ретроспективный обзор 11 У пациентов был диагностирован изолированный амилоидоз УГИ в больнице Национального университета им. Чоннама и в больнице Национального университета им. Чоннама Хвасуна. Ни у одного из пациентов не было системного уча

Disorders of the Gastrointestinal System

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Imaging of abdominal and pelvic infections in the cancer patient.

Infections are the most commonly encountered complications in patients with cancer. The classical signs and symptoms of infections are often not present in this patient population, which makes the diagnosis more challenging. Host factors play a major role in the development and prognosis of infections in cancer patients; these can be related to the underlying type of malignancy (solid organ versus hematological), tumor burden, anatomic obstruction, altered integrity of barriers (skin or mucosa), treatment-related factors (from chemotherapy, radiation treatment, surgery, interventional procedur