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Turner Syndrome and Psychosocial Interventions: Recommendations for Collaborative Communication Between Medical and School Teams.

Individuals with Turner Syndrome (TS) can experience not only physical and medical differences but are also at risk for neurocognitive and associated psychosocial challenges. Specifically, research shows increased likelihood of difficulties with visual-spatial reasoning, executive functioning, attention, and mathematics skills. One emerging area of research focuses on deficits in social skills and increased prevalence of anxiety within this population. This review introduces relevant genetic influences of TS and examines existing research on social skills and anxiety in individuals with TS. Th

Digital communication and social cognition in adults with frontal lobe epilepsy: A scoping review.

BACKGROUND: Patients with Frontal Lobe Epilepsy (FLE) face problems with social cognition (SC) since their difficulties in humor appreciatio … : We aimed at exploring, elaborate and critically examine a) the ways deficits in SC impact digital communication (DC) in FLE; b) the way specific neuropsychological abnormalities that may disrupt DC in FLE; c) how to integrate neuropsychological assessment and rehabilitation to provide FLE patients strategies and enhance social outcomes in DC. We anticipate th …

Cell-cell communication dysregulation in tuberous sclerosis complex cortical tubers and focal cortical dysplasia.

Malformations of cortical development are manifestations of mTORopathies, including tubers in context of Tuberous Sclerosis Complex (TSC) cortical tubers and Focal Cortical Dysplasia (FCD), and are associated with epilepsy, often accompanied by comorbidities such as autism spectrum disorder (ASD). This study aims to investigate the cell-type-specific transcriptional alterations and disrupted intercellular communication networks in mTORopathies, focusing on their implications for cortical network dysfunction. Using single-cell RNA sequencing, we identified 33 transcriptionally distinct cell clu…

Associations between white matter asymmetry and communication skills in children with prenatal alcohol exposure.

BACKGROUND: Prenatal alcohol exposure (PAE) occurs in ~10 % of pregnancies and can cause behavioral and neurological deficits, including alterations to white matter pathways involved in language processing. Language and communication skills are generally left-lateralized in the brain, and this asymmetry is associated with better performance in typically developing individuals, while alterations to this association are found in children with language challenges. However, the degree of asymmetry and its relationship with language skills remain poorly understood in children with PAE. METHODS: 20…

Congenital Pleuro-Pleural Communication Presenting as a Simultaneous Bilateral Spontaneous Pneumothorax: A Case Report.

Bilateral spontaneous pneumothorax is a rare condition that accounts for approximately 1% of all pneumothorax cases. Most cases are attributed to underlying lung disease or prior thoracic surgery, as congenital pleuro-pleural communication is rare. We report the case of a 15-year-old girl with bilateral pneumothorax who underwent video-assisted thoracoscopic surgery. Intraoperative air leak testing unexpectedly revealed congenital pleuro-pleural communication. A retrospective review of preoperative computed tomography suggested a potential bilateral pleural communication between the esophagus …

Disc inflammation and intercellular communication in shaping the immune microenvironment of intervertebral disc degeneration.

BACKGROUND: Intervertebral disc degeneration (IDD) is a major cause of low back pain, significantly affecting the quality of life of elderly individuals worldwide. Its pathogenesis is complex, involving extracellular matrix degradation, inflammatory responses, and immune regulation. METHODS: This study integrated multiple transcriptomic and single-cell RNA-seq datasets, and systematically identified and validated key IDD-related genes and their immune regulatory roles through differential gene analysis, GO/KEGG enrichment, PPI network construction, ANN, LASSO, random forest, SVM-RFE, SHAP, Me

Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication.

OBJECTIVE: To comprehensively summarize the clinical and pathological characteristics of primary orbital neoplastic lesions with communication, thereby providing a solid basis for the diagnosis and treatment of such conditions. METHOD: A retrospective analysis of clinical cases was conducted. The clinical and pathological data of 862 patients diagnosed with primary orbital neoplasms with communication, including orbito-cranial, orbito-nasal, and orbito-crano-nasal communicating tumors, were collected. The data covered gender distribution, age at onset, presenting symptoms and signs, imaging f…

An Atypical Presentation of Aggressive Oral Pyogenic Granuloma With Oroantral Communication and Bone Erosion.

Oral pyogenic granuloma is a benign, reactive vascular lesion that commonly affects the oral mucosa and is often triggered by trauma or irri … hesia with the extraction of an adjacent tooth due to lesion infiltration. Intraoperative oroantral communication was identified and closed using a hemostatic agent and sutures. Histopathology confirmed oral pyogenic granuloma, characterized by vascular proliferation and inflammatory infiltrates. Postoperative care included antibiotics, nasal decongestants, and …

Pleuroperitoneal Communication following Right Hepatectomy: Successful Treatment with a Combined Thoracoscopic and Laparoscopic Approach.

INTRODUCTION: Pleuroperitoneal communication (PPC) is an abnormal connection between the thoracic and abdominal cavities, allowing ascitic fluid to migrate into the pleural space and cause pleural effusion. Although PPC is a recognized complication in peritoneal dialysis patients, it is rarely reported as a postoperative complication. CASE PRESENTATION: A 54-year-old female patient with a history of right hemicolectomy and right hepatectomy for ascending colon cancer and metastatic liver tumor developed persistent right pleural effusion 3 months postoperatively. She also had ovarian metastase…

Expressive language and social communication abilities in children with spinal muscular atrophy type 1.

AIM: To investigate parent-reported expressive language and social communication abilities in children with spinal muscular atrophy type 1 (SMA1) treated with disease-modifying therapies. METHOD: This was a cross-sectional feasibility study performed at the Dubowitz Neuromuscular Centre, London (UK), and the Centro Clinico Nemo Pediatrico, Rome (Italy), testing the use of the MacArthur-Bates Communicative Development Inventories (MB-CDIs, 8 months+) to explore vocabulary production, and the Social Communication Questionnaire (SCQ, 4 years+) to investigate social communication. RESULTS: Fifte…

Brief communication: demographic disparities and modes of transmission of HIV in Mizoram, Northeast India.

This study examines the prevalence of Human immunodeficiency virus (HIV) in Mizoram, Northeast India, with a focus on age-group transmission routes and gender-specific prevalence. According to data from the ART Plus Centre at Civil Hospital Aizawl (January-December 2023), men were more likely to be infected with HIV, with the 26-35 age group being the most affected. Heterosexual transmission and intravenous drug use (IDU) were shown to be the most common modes of transmission. Gender and age variations were identified by statistical analysis using SPSS® (V 27.0), highlighting the need for focu

Молекулярное профилирование мозговой эндотелиальной клетки для астроцитной связи между мышью и человеком.

Наше понимание того, как тело взаимодействует с мозгом для координации их функций, удивительно ограничено. На кровеносном барьере (BBB) эндотелиальные клетки мозга (BEC) находятся в идеальном положении для того, чтобы выступать посредником между кровью и паренхимой мозга посредством прямой связи с астроцитовыми периваскулярными процессами (endfeet). Мы разрабатываем метод определения мыши в протеоме vivo astrocyte endfoot, который в сочетании с RNA-seq, специфической для BEC, открывает BEC для астроцитных пар эндфутового лиганда-рецептора, которые модифицируются, когда мыши подвергаются перифе

Совпадение в аннотации оригинала
Our understanding of how the body communicates with the brain to coordinate their functions is remarkably limited. At the blood-brain barrier (BBB), brain endothelial cells (BECs) are ideally positioned to mediate signaling between blood and brain parenchyma via direct communication with astrocyte perivascular processes (endfeet). We develop a method to defi…

DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication.

Recent studies have shown that the hypothalamus functions as a control center of aging in mammals that counteracts age-associated physiological decline through inter-tissue communications. We have identified a key neuronal subpopulation in the dorsomedial hypothalamus (DMH), marked by Ppp1r17 expression (DMHPpp1r17 neurons), that regulates aging and longevity in mice. DMHPpp1r17 neurons regulate physical activity and WAT function, including the secretion of extracellular nicotinamide phosphoribosyltransferase (eNAMPT), through sympathetic nervous stimulation. Within DMHPpp1r17 neurons, the pho…

Brain-Gut and Microbiota-Gut-Brain Communication in Type-2 Diabetes Linked Alzheimer's Disease.

The gastrointestinal (GI) tract, home to the largest microbial population in the human body, plays a crucial role in overall health through various mechanisms. Recent advancements in research have revealed the potential implications of gut-brain and vice-versa communication mediated by gut-microbiota and their microbial products in various diseases including type-2 diabetes and Alzheimer's disease (AD). AD is the most common type of dementia where most of cases are sporadic with no clearly identified cause. However, multiple factors are implicated in the progression of sporadic AD which can be …

Integrated analysis reveals the dysfunction of intercellular communication and metabolic signals in dilated cardiomyopathy.

AIMS: Dilated cardiomyopathy refers to a heart muscle condition characterized by structural and functional irregularities in the myocardium that are not related to ischemia. Due to diverse etiologies such as genetic mutations, infections, and exposure to toxins, dilated cardiomyopathy can lead to substantial morbidity and mortality despite advances in the management of heart failure in dilated cardiomyopathy patients. We sought to analyze the characteristics of cell-cell communication and the metabolic signaling pathways in dilated cardiomyopathy. METHODS AND RESULTS: The single-nucleus seque…

Surgical management of a cervical oesophageal duplication cyst with tracheal communication in a dog.

Foregut duplication cysts can arise anywhere in the gastrointestinal system, leading to non-specific clinical signs in small animals. There are few reports of foregut duplication cysts in the literature that have been managed surgically. This report describes a case of multilevel foregut duplication cysts in a dog, including a cervical oesophageal duplication cyst with tracheal communication. Surgical treatment by resection resulted in the resolution of clinical signs. No clinical evidence of recurrence was noted at 12 months post-operatively. Surgical resection may be a feasible option for th…

Analysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin.

A comprehensive understanding of the intricate cellular and molecular changes governing the complex interactions between cells within acne lesions is currently lacking. Herein, we analyzed early papules from six subjects with active acne vulgaris, utilizing single-cell and high-resolution spatial RNA sequencing. We observed significant changes in signaling pathways across seven different cell types when comparing lesional skin samples (LSS) to healthy skin samples (HSS). Using CellChat, we constructed an atlas of signaling pathways for the HSS, identifying key signal distributions and cell-spe

Analysis of intracellular communication reveals consistent gene changes associated with early-stage acne skin.

A comprehensive understanding of the intricate cellular and molecular changes governing the complex interactions between cells within acne lesions is currently lacking. Herein, we analyzed early papules from six subjects with active acne vulgaris, utilizing single-cell and high-resolution spatial RNA sequencing. We observed significant changes in signaling pathways across seven different cell types when comparing lesional skin samples (LSS) to healthy skin samples (HSS). Using CellChat, we constructed an atlas of signaling pathways for the HSS, identifying key signal distributions and cell-spe

How Health Care Organizations Are Implementing Disability Accommodations for Effective Communication: A Qualitative Study.

BACKGROUND: Prior studies have documented that, despite federal mandates, clinicians infrequently provide accommodations that enable equitable health care engagement for patients with communication disabilities. To date, there has been a paucity of empirical research describing the organizational approach to implementing these accommodations. The authors asked US health care organizations how they were delivering these accommodations in the context of clinical care, what communication accommodations they provided, and what disability populations they addressed. METHODS: In this study, 19 qual…

Pig conceptuses utilize extracellular vesicles for interferon-gamma-mediated paracrine communication with the endometrium†.

Interferon-gamma (IFNG) is a pro-inflammatory cytokine secreted by the porcine conceptus (embryo and extra-embryonic membranes) during the p … sults suggest that EVs are involved in IFNG transport across the endometrial LE to enable paracrine communication between the conceptus and cells within the endometrial stroma.