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Efficacy and Safety of Probiotics, Prebiotics and Synbiotics for the Treatment of Functional Constipation in Children: Systematic Review and Network Meta-analysis.

Several studies have demonstrated that beneficial gut microorganisms, such as probiotics, can treat functional constipation in children. We aim to evaluate the effectiveness of probiotics, prebiotics, and synbiotics in treating childhood functional constipation. We conducted a comprehensive search of eight electronic databases, dating from their inception up to July 11, 2024. The eligibility criteria were randomized controlled trials (RCTs) that reported on the use of probiotics, prebiotics, or synbiotics for treating childhood functional constipation. The RCTs were evaluated using the Cochran…

State-of-the-Art Review on Probiotics, Synbiotics, and Microbial Metabolites: Molecular Mechanisms Shaping Host Immunity, Metabolic Health, and Chronic Disease Prevention.

The human digestive system is first colonized at birth with many microorganisms that impact on the overall health of the individual via various metabolic, immune, and neuroendocrine pathways. Such microorganisms are referred to as probiotics, according to the FAO and WHO, and they exert effects on host and microbiota interaction primarily through strain-specific bioactive metabolites that act both locally and systemically. The current review will detail the various types of bioactive metabolites and their roles in regulating redox homeostasis via the reduction of reactive oxygen species (ROS) …

Characterisation of bacteria-induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease.

Enteropathogenic bacteria are a major cause of morbidity and mortality globally. While mouse models have been indispensable in advancing our understanding of infectious enteric diseases, key differences in intestinal microbiota and immunobiology between mice and humans underscore the need for alternative mammalian models that better recapitulate human disease states. The naked mole rat (NMR), the longest-lived rodent and a model of healthy ageing, presents a unique opportunity. It possesses an exceptionally robust intestinal barrier, an abundance of goblet cells, a thicker mucin layer, and red

Fine particle exposure-induced renal injury and the protective effect of multi-strain probiotics: Involvement of bitter taste transduction and inflammatory response.

Bitter taste receptors are distributed in various non-taste tissues and cells, where they exert crucial roles in neuroimmune regulation and … transient receptor potential melastatin 5 [Trpm5]). However, gavage administration of multi-strain probiotics significantly alleviated the toxic effects of OVA on the mouse kidneys, as evidenced by the reversal of the aforementioned abnormal changes in renal structure, biochemical indicators, oxidative stress markers, inflammatory factors, and bitter taste …

Effect of intravaginal probiotics and enrofloxacin on vaginal microbiota, pH, vaginitis, and fertility in black Iraqi goats synchronized with progesterone impregnated sponges.

BACKGROUND: The prolonged retention of progesterone-infused intravaginal sponges in estrous synchronization protocols, results in alteration of vaginal microflora, disturbance of vaginal pH, and increased vaginitis in goats. These changes lead to the growth of opportunistic pathogenic bacteria, such as Escherichia coli and Staphylococcus aureus, which need antibiotics to treat this condition. Probiotics have recently been suggested as an alternative method for the maintenance of vaginal health and improving animal fertility. AIM: To investigate the effects of probiotics (Lactobacillus plantar…

Modulation of TLR4, hBD-2, and hBD-3 expression and hepatic tissue response by systemic probiotics in experimental apical periodontitis in rats.

OBJECTIVE: To evaluate whether systemic supplementation with L. rhamnosus LR-04 and L. acidophilus LA-14 modulates the expression of TLR4, hBD-2, and hBD-3 in a rat model of experimental apical periodontitis (AP), and to assess potential histopathological alterations in the liver. METHODOLOGY: Twenty-four male Wistar rats were randomly allocated into three groups (n=8): control (AP + water), AP + L. rhamnosus LR-04, and AP + L. acidophilus LA-14. AP was induced by exposing the pulp chambers of the first mandibular molars for 30 days. From the day of induction, probiotics (109 CFU/day via oral…

Protective effects of multi-strain probiotics against polystyrene nanoplastic-induced parotid gland toxicity: role of NRF2/HO-1 and NF-κB pathways.

BACKGROUND: Polystyrene nanoplastics (NPs) represent emerging environmental contaminants with potential adverse effects on salivary glands. This study investigated the protective effects of multi-strain probiotics against NPs-induced toxicity in rat parotid glands. METHODS: Forty male Sprague-Dawley rats were allocated into five groups (n = 8): control, NPs (10 mg/kg), probiotics (1010 CFU), NPs + probiotics low dose (109 CFU), and NPs + Pro high dose (1010 CFU). Treatments were administered orally for 35 days. Oxidative stress markers, histopathological changes, and protein expression were e…

Модуляция микробиотики Гут по пребиотикам, пробиотикам и психобиотикам и ее воздействие на ось гута микробиота - мозг: систематический обзор.

Ось кишечника - это высокоинтегрированная двунаправленная коммуникационная сеть, функционирующая через нейронные, нейроэндокринные, иммунные и метаболические пути, которые поддерживают гомеостаз центральной нервной системы и стали перспективной дополнительной терапевтической целью для неврологических и нейропсихиатрических расстройств. ЦЕЛЬ: Цель настоящего исследования заключается в систематической оценке воздействия предбиотики, пробиотики и психобиотики на коммуникацию кишечника и неврологические и поведенческие результаты, включая нейроинфламматические маркеры, параметры осей ГПА и микробн

Совпадение в аннотации оригинала
BACKGROUND: The gut microbiota-brain axis is a highly integrated bidirectional communication network operating through neural, neuroendocrin … s. OBJECTIVE: The objective of this study is to systematically evaluate the effects of prebiotics, probiotics, and psychobiotics on gut-brain communication and neurological and behavioral outcomes, including neuroinflammatory markers, HPA-axis parameters, and microbial metabolites. METHODS: A systematic review was conducted in accordance with the PRISMA 20 …

Research progress of probiotics intervention on reconstruction of intestinal flora and improvement of quality of life in patients after endometrial cancer surgery.

OBJECTIVE: This study aims to comprehensively assess the impact of probiotic supplementation on gut microbiota composition and quality of li … ended treatment durations (≥8 weeks). CONCLUSION: Current evidence supports the beneficial role of probiotics in restoring gut microbiota balance, enhancing patient well-being, mitigating digestive complications, and reducing systemic inflammation following EC surgery. Further high-quality research is warranted to refine optimal probiotic strains, dosing st …

The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies.

BACKGROUND AND AIMS: Probiotics usually have beneficial effects on the absorption of trace elements and detoxification of toxic metals in human. Hence, the aim of the systematic review was to evaluate various aspects of the effect of the combination of probiotics and heavy metals in human clinical trial studies. METHODS: Nine databases were searched for clinical trials up to June 2024 investigating probiotics for heavy metal exposure in humans. Two reviewers independently screened records and extracted data on study characteristics, interventions, outcomes, and results. Risk of bias was asses…

Потенциальная эффективность пробиотики в деле сокращения множественных склерозовых прогрессий в доклинических и клинических исследованиях: всемирный систематический обзор и метаанализ.

Множественный склероз (MS) — иммунопосредованное заболевание, характеризующееся воспалением нервных клеток и обезвоживанием. Эффективность пробиотики в деле уменьшения подстрекательства к ущербу в НР. Таким образом, цель этого систематического обзора и метаанализа заключалась в потенциальной эффективности пробиотиков в деле сокращения прогрессии множественных склерозов в предклинических и клинических исследованиях. МЕТОДЫ: базы данных PubMed, Scopus, Cochrane и Google Scientific были найдены с использованием нескольких соответствующих ключевых слов, и в период с января 2004 года по 16 августа

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVE: Multiple Sclerosis (MS) is an immune-mediated disease characterized by nerve cell inflammation and demyelination. The effectiveness of probiotics in reducing inflammatory damage in MS. Therefore, the aim of this systematic review and meta-analysis was the potential effectiveness of probiotics in reducing Multiple Sclerosis progressi…

The supplementation of the multi-strain probiotics WHHPRO™ alleviates high-fat diet-induced metabolic symptoms in rats via gut-liver axis.

Metabolic syndrome (MS) has emerged as one of the major global health concerns, accompanied by a series of related complications, such as obesity and type-2 diabetes. The gut-liver axis (GLA) is a bidirectional communication between the gut and the liver. The GLA alterations have been revealed to be closely associated with the development of MS. Probiotics within Lactobacillus and Bifidobacterium confer beneficial effects on improving MS symptoms. WHHPRO™ is a mixture of four probiotic strains, with potential MS-improving abilities. This study aimed to investigate the effects of WHHPRO™ on MS …

A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria.

Aim: Functional gastrointestinal (GI) disorders are recognized as a major public health concern worldwide. These disorders involve persistent digestive symptoms indicative of digestive tract dysfunction.Materials and Methods: A survey examining the utilisation of probiotics and medicinal plants as supplementary treatments was conducted on 160 patients with GI disorders at healthcare institutions in Saïda from March to April 2023 using questionnaires that had been previously adapted and tested for reliability with Cronbach's alpha test. Raw data collected through the questionnaires were transfe…

Mechanism analysis of the differences in relieving constipation in a Balb/c constipation model mouse fed human milk probiotics or fermented milk.

BACKGROUND: Consumers require fermented milk that possesses constipation-relieving functions. To cater to the 'natural and additive-free' consumption habit, this study is dedicated to developing probiotic fermented milk with constipation-relief effects. Previously, we isolated two Lactobacillus strains, Lactobacillus MWLp-12 and Lactobacillus MWLf-4, from breast milk. This study evaluated the efficacy of these strains and their fermented milk in alleviating constipation in a Balb/c mouse model of constipation. The evaluation criteria included fecal water content, time for first black feces exp

Single and Mixed Strains of Probiotics Reduced Hepatic Fat Accumulation and Inflammation and Altered Gut Microbiome in a Nonalcoholic Steatohepatitis Rat Model.

As gut dysbiosis has been implicated in the pathogenesis of nonalcoholic steatohepatitis (NASH), probiotic supplementation might be a potential treatment for this condition. The aim of this study was to evaluate the effects of single- and mixed-strain probiotics on the severity of NASH induced by a high-fat, high-fructose (HFHF) diet and their mechanisms of action. Male Sprague-Dawley rats were divided into four groups (n = 7 per group): control group, NASH group, NASH + single-strain group, and NASH + mixed-strain group. In the single-strain and mixed-strain groups, rats received Lactobacillu…

Co-administration of probiotics and vitamin D reduced disease severity and complications in patients with Parkinson's disease: a randomized controlled clinical trial.

RATIONALE: Probiotics have beneficial effects on the nervous system by modulating the gut-brain axis. Additionally, vitamin D supplementation presents a potential way for ameliorating neuropsychological disorders, particularly in regions with a high prevalence of vitamin D deficiency. OBJECTIVES: The current clinical trial aimed to investigate the role of co-administered supplementation of probiotics and Vitamin D on the different inflammatory aspects of patients with Parkinson's disease. METHODS: Forty-six patients with PD were recruited From the Functional Neurosurgery Research Center, Teh…

Aging-induced dysbiosis worsens sepsis severity but is attenuated by probiotics in D-galactose-administered mice with cecal ligation and puncture model.

INTRODUCTION: Despite the well-established effects of aging on brain function and gut dysbiosis (an imbalance in gut microbiota), the influence of aging on sepsis-associated encephalopathy (SAE) and the role of probiotics in this context remain less understood. METHODS: C57BL/6J mice (8-week-old) were subcutaneously administered with 8 weeks of D-galactose (D-gal) or phosphate buffer solution (PBS) for aging and non-aging models, respectively, with or without 8 weeks of oral Lacticaseibacillus rhamnosus GG (LGG). Additionally, the impact of the condition media from LGG (LCM) was tested in mac…

Knowledge, Attitude, and Practice of Probiotics Among Saudi Health Care Students-A Cross-Sectional Study From Saudi University in Riyadh Saudi Arabia.

Probiotics offer a variety of health benefits for the digestive system, atopic eczema, and immune system. Future healthcare providers should know more about probiotics to advise their patients and the general public appropriately. The purpose of the study was to evaluate health science students' knowledge, attitudes, and practices (KAP) on the use of probiotics in various health conditions. A cross-sectional study was conducted among health college students using a self-administered online questionnaire. The study participants were selected using the convenience sample approach. statistical pa…

The potential Impact of bacterial probiotics on ruminal greenhouse gases production in vitro of dietary Delonix regia seeds in rams and steers.

This study aimed to evaluate the influence of probiotic bacteria (Pediococcus acidilactici BX-B122 and Bacillus coagulans BX-B118) on methan … 05) on the pH of the ruminal contents was found in Delonix regia seeds alone or in combination with probiotics. However, higher (P < 0.05) methane conversion efficiency (i.e., ratios of methane: short-chain fatty acids, methane: metabolizable energy, and methane: organic matter) was observed in experimental diets with Delonix regia seeds compared to diets co …

Daily oral administration of probiotics engineered to constantly secrete short-chain fatty acids effectively prevents myocardial injury from subsequent ischaemic heart disease.

AIMS: Given the extremely limited regeneration potential of the heart, one of the most effective strategies to reduce the prevalence and mortality of coronary artery disease is prevention. Short-chain fatty acids (SCFAs), which are by-products of beneficial probiotics, have been reported to possess cardioprotective effects. Despite their beneficial roles, delivering SCFAs and maintaining their effective concentration in plasma present major challenges. Therefore, in the present study, we aimed to devise a strategy to prevent coronary heart disease effectively by using engineered probiotics to …