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R-GAT: cancer document classification leveraging graph-based residual network for scenarios with limited data.

Accurate classification of cancer-related biomedical abstracts is critical for advancing cancer informatics and supporting decision-making in healthcare research. Yet progress in this domain is often constrained by limited availability of labeled corpora and the high computational demands of transformer-based approaches. To address these challenges, we propose a Residual Graph Attention Network (R-GAT) that integrates multi-head attention with residual connections to capture semantic and relational dependencies in biomedical texts. Evaluated on a curated dataset of 1,875 PubMed abstracts spann

Institutional data commons: a federated Data Use Certification-aware architecture for secure and scalable data use in biomedical data ecosystems.

BACKGROUND: Modern biomedical data ecosystems increasingly rely on global cloud platforms to coordinate access to large-scale genomic and cl … s. DISCUSSION: Shifting governance from investigators to institutional infrastructure ensures that biomedical research remains both secure and economically sustainable.

NIDCD's 5-Year Strategic Plan Describes Scientific Priorities and Commitment to Basic Science.

The National Institute on Deafness and Other Communication Disorders (NIDCD) recently issued a new strategic plan that describes the institute's scientific priorities over the next five years. Developed in collaboration with informed stakeholders, the 2023-2027 NIDCD Strategic Plan: Advancing the Science of Communication to Improve Lives creates a unified vision to stimulate discoveries in basic research, model systems, innovative technologies, individualized treatment approaches, scientific data sharing, and translation of research findings into clinical practice. To further accelerate scient

Location-enhanced syntactic knowledge for biomedical relation extraction.

Biomedical relation extraction has long been considered a challenging task due to the specialization and complexity of biomedical texts. Syntactic knowledge has been widely employed in existing research to enhance relation extraction, providing guidance for the semantic understanding and text representation of models. However, the utilization of syntactic knowledge in most studies is not exhaustive, and there is often a lack of fine-grained noise reduction, leading to confusion in relation classification. In this paper, we propose an attention generator that comprehensively considers both synt

A Scoping Review of the Evidence for the Medicinal Use of Natural Honey in Animals.

Honey has a history of medicinal use that predates written records. In recent decades, there has been renewed interest in the use of honey i … literature, all animal species except insects and humans were eligible, including animals used for biomedical research. Electronic databases searched were MEDLINE, CAB Abstracts, AGRICOLA, Web of Science Core Collection, and Web of Science SciELO Citation Index. A total of 397 articles reporting 436 primary research studies were included in this review. The majority …

Decoding the cholangiocarcinoma tumor microenvironment: from single-cell and spatial atlases to translational therapeutic targeting.

BACKGROUND: Cholangiocarcinoma is a heterogeneous biliary malignancy characterized by late diagnosis, stromal desmoplasia, immune exclusion, and frequent resistance to chemotherapy, immunotherapy, and molecularly targeted therapy. Although genomic stratification has enabled biomarker-directed treatment for selected patients, cancer cell-intrinsic alterations alone do not fully explain disease progression or therapeutic failure. MAIN BODY: Recent advances in single-cell RNA sequencing, single-cell multi-omics, spatial transcriptomics, spatial proteomics, multiplex imaging, and pathomics have r

Clinical and translational science award hub portfolio analysis and interorganizational collaborations with Los Angeles County to improve population health and health care delivery (ID 1565096).

Demonstrating impact in the Clinical and Translational Science Award (CTSA) Program is crucial to continue governmental, taxpayer, institutional, and donor support and investment. We present an innovative portfolio analysis to summarize the Scientific Achievement Translational Science Impact at the hub level. Additionally, a unique feature of the UCLA CTSA hub includes the many interorganizational collaborations with Los Angeles County (LAC). This is the first study to examine the Translational Science Benefits Model (TSBM) impact on projects with CTSA hub-county interorganizational collaborat

Integrating quality improvement, evidence-based practice, and knowledge translation into a health Sciences masters' programme: a mixed methods study.

BACKGROUND: In recent years, the emphasis on quality improvement (QI), evidence-based practice (EBP), and knowledge translation (KT) in the education of health professionals has increased. Efforts have been made to identify commonalities between quality improvement and implementation science. However, the development of curricula that encompass these approaches remains poorly understood. Consequently, this study examines the implementation of a novel teaching module in quality improvement and evidence-based practice, designed for health sciences master’s students. The objective was to explore

Experimental Cell Models for Investigating Neurodegenerative Diseases.

Experimental models play a pivotal role in biomedical research, facilitating the understanding of disease mechanisms and the development of novel therapeutics. This is particularly true for neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and motor neuron disease, which present complex challenges for research and therapy development. In this work, we review the recent literature about experimental models and motor neuron disease. We identified three main categories of models that are highly studied by scientists.…

Misaligned Expectations: Motivations of Medically Underserved People to Enroll in the All of Us Research Program.

It is important to know what motivates people, especially from groups underrepresented in biomedical research, to accept or decline participation in research studies. With this information, engagement strategies, incentives to participate, and benefits of participation can be aligned with what potential research participants value and expect from participating in research. Our project sought to identify what motivated people recruited at a Federally Qualified Health Center (FQHC) to enroll, or not, in the All of Us Research Program (AoU). Qualitative interviews revealed that the most common mo…

Aerogels as Next-generation Materials for Biomedical and Pharmaceutical Applications: A Comprehensive Review.

Aerogels are ultralight materials characterized by highly porous structures and adaptable physicochemical properties, which have gained increasing attention in pharmaceutical and biomedical research. Their interconnected porous networks, extensive surface areas, and adjustable compositions render them particularly suitable for the incorporation and transport of therapeutic agents, biomolecules, and living cells into the body. This review presents an overview of the major methods of synthesizing the material, classification of aerogel types, and their applications, particularly in the biomedica…

Getting the Word Out: Teaching Middle-School Children about Cardiovascular Disease.

Cardiovascular disease (CVD) has roots in childhood; since CVD begins early, a clear strong case for early education focused on CVD primary prevention exists. Scientists are not traditionally involved in disseminating health knowledge into public education. Similarly, public school teachers typically do not have access to biomedical research that may increase their students' health science literacy. One way to bridge the 'cultural' gap between researchers and school teachers is to form science education partnerships. In order for such partnerships to be successful, teams of scientists and teac…

Systematic comparison of the effects of various fixatives on the stability of the cellular proteome.

Proteomics research represents a critical area within modern biomedical science. Fixatives, as essential components in proteomic analysis, p … atives and mass spectrometry technologies, offering dependable technical support for biological and biomedical research. SIGNIFICANCE: We conducted a systematic comparison of commonly used fixation agents-specifically formaldehyde, paraformaldehyde, methanol, and ethanol-to evaluate how they affect the stability of the cellular proteome. These results provide a scien …

Revisiting cultural theory in the era of biomedical HIV prevention: Risk, sexual practice, and belonging among MSM in Amsterdam.

How is risk experienced, reframed, and redistributed in a sexual culture shifting from HIV prevention toward elimination? Drawing on ethnographic research conducted from March 2016 to August 2019 among men who have sex with men (MSM) in Amsterdam's sex clubs and private party scenes, this article revisits Mary Douglas's cultural theory of risk, particularly her grid (degree of social regulation) and group (strength of group incorporation/norms) typology. In the context of contemporary biomedical HIV prevention strategies, notably PrEP and the U=U (undetectable equals untransmittable) principle

Regenerative Medicine Strategies in Biomedical Implants.

PURPOSE OF REVIEW: Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in orthopedics and dentistry are facing many challenges and posing clinical concerns. The purpose of this chapter is to provide an overview of the clinical applications of current regenerative strategies to the fields of dentistry and orthopedic surgery. The main research question in this review is: What are the major advancement strategies in regenerative medicine that can be used for implant research? RECENT FINDINGS: The implant surfaces ca

Bilharzia and the boys: questioning common assumptions.

There is insufficient and inadequate information to gauge the impact of schistosomal infection on the health of women. Biomedical research has equated women's health with the study of reproductive performance and reproductive organs and this narrow focus has left a number of important questions unanswered. Attempts to explore the economic and social aspects of schistosomal infection have been minimal and most research has focused on men rather than women. It has two characteristics: first, economists have relied on single performance indicators which are rooted in the cultural traditions of th…

агитационные рамки ИИ, связывающие языковые модели с электронными медицинскими записями, и график биомедицинских знаний для реальных доказательств.

Доступ к крупномасштабным клиническим и биомедицинским базам данных по-прежнему является серьезным препятствием для клинических и научных работников, требующим значительных вычислительных знаний. Агентские системы искусственного интеллекта, в которых крупные языковые модели (МПМ) организуют многоэтапное рассмотрение и выполнение запросов под интерактивным контролем человека, открывают возможности для демократизации доступа к данным и ускорения процесса получения доказательств. MethodsWe применяли Типовой контекстный протокол (МКП) для интеграции в рамках одного агентского рабочего процесса ста

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… Importantly, as any other LLM-driven system to date, MedCP is an example of an agentic-AI biomedical research harness that assists human experts to accelerate hypothesis generation and testing. … Conclusions In conclusion, this work demonstrates that applying the Model Context Protocol to a real institutional EHR and a curated biomedical knowledge graph can accelerate hypothesis generation and real-world evidence studies for biomedical researchers. …

The role of trust and relationship building in the ethical recruitment of youth living with HIV in research: perspectives from Kenyan youth living with HIV, their caregivers and subject matter experts.

BACKGROUND: Inclusion of youth (10–24 years) living with HIV (YLWH) in clinical research is critical to addressing their unique vulnerabilities and improving care outcomes. Examining the role of trust and relationship building in research decision-making is critical to designing ethical recruitment and engagement strategies. METHODS: We conducted in-depth, semi-structured interviews with YLWH (10–24 years, enrolled in HIV care at Academic Model Providing Access to Healthcare (AMPATH) in western Kenya), caregivers (parents and guardians) of YLWH, and other subject matter experts (SMEs). Intervi

From COVID-19 research to vaccine application: why might it take 17 months not 17 years and what are the wider lessons?

It is often said that it takes 17 years to move medical research from bench to bedside. In a coronavirus disease (COVID-19) world, such time-lags feel intolerable. In these extraordinary circumstances could years be made into months? If so, could those lessons be used to accelerate medical research when the crisis eases?To measure time-lags in health and biomedical research as well as to identify ways of reducing them, we developed and published (in 2015) a matrix consisting of overlapping tracks (or stages/phases) in the translation from discovery research to developed products, policies and …

Molecular cartooning with knowledge graphs.

Molecular "cartoons," such as pathway diagrams, provide a visual summary of biomedical research results and hypotheses. Their ubiquitous appearance within the literature indicates their universal application in mechanistic communication. A recent survey of pathway diagrams identified 64,643 pathway figures published between 1995 and 2019 with 1,112,551 mentions of 13,464 unique human genes participating in a wide variety of biological processes. Researchers generally create these diagrams using generic diagram editing software that does not itself embody any biomedical knowledge. Biomedical kn…