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THE ETIOLOGY OF COLORADO TICK FEVER.

1. The infectious agent of Colorado tick fever filtered through 181 mmicro membranes caused infection in hamsters and one volunteer. 2. In five out of seven instances, hamsters were infected initially with serum filtered through 24 mmicro membranes or the tick fever appeared on serial transfer. 3. We could not infect two volunteers with 24 mmicro filtrates, though these filtrates did cause infection in hamsters as shown by development of the fever on serial transfer. In one instance, the serum of the hamsters rendered ill in this way was injected into the volunteer who had remained well after …