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Microbiome alterations and host-pathogen interactions in paratuberculosis: A one health perspective.

Paratuberculosis is a chronic ruminal-enteric infection caused by Mycobacterium avium subsp. paratuberculosis (MAP). It has significant econ … in microbes can be the initial signs of diagnosis and pre-treatment components, such as probiotics, prebiotics, dietary modifications, and microbiome-based vaccinations. This summary bridges the research on the veterinary and human microbiome, revealing that MAP-Microbiome interactions reflect immunological evasion and microbial persistence schemes observed …

Кислоты и FFAR2 с короткокалиберным толстым покрытием: модуляторы аксиса Гут-Брэйна в неевро-воспалительных расстройствах.

Короткоцепные жирные кислоты (СКФА), главным образом ацетат, пропионат и ноутрат, являются ключевыми микробными метаболитами, образующимися в результате ферментации неподдельных углеводов кишечными бактериями. Помимо своих местных действий в кишечной среде, эти метаболиты оказывают далеко идущие системные последствия, особенно в формировании нейроиммунной связи по оси кишечника. Их взаимодействие со свободным толстым кислотным рецептором 2 (FFAR2), выражающееся в кишечных эпителиальных клетках, периферийных иммунных популяциях и микроглии, стало центральным механизмом, связывающим кишечную мик

Совпадение в аннотации оригинала
Short-chain fatty acids (SCFAs), primarily acetate, propionate, and butyrate, are key microbial metabolites generated through the fermentati … val. Available strategies to increase endogenous SCFA production include dietary fiber consumption, prebiotics, and customized SCFA formulations, and novel synthetic FFAR2 agonists offer a pharmacological approach to targeted therapy. Nonetheless, there remains a significant degree of variability in dosing, route of delivery, bioavailability, and interindivi …

Comparative analysis of dominant gut microbiota in Inflammatory Bowel Disease patients and healthy individuals: A case-control study.

BACKGROUND: Chronic inflammation in the gut might be linked to microbiota dysbiosis. OBJECTIVE: This study aimed to investigate alterations … ial imbalances provides a foundation for developing microbiota-based therapies, such as probiotics, prebiotics, and fecal microbiota transplantation, as potential interventions for restoring microbial balance and mitigating disease progression. Further research is needed to translate these insights into targeted therapeutic strategies and to explore their ef …

A synbiotic combination of mixed probiotics and oligofructose restores intestinal microbiota disturbance in DSS-induced colitis in mice.

Both probiotics and prebiotics can regulate gut microbiota and produce metabolites that are beneficial to the host, showing potential therapeutic prospects for ulcerative colitis (UC). This study aimed to investigate the therapeutic effects and mechanisms of low-, medium-, and high-dose probiotic mixtures (Bifidobacterium animalis subsp. lactis XLTG11: Lactobacillus paracasei Glory LP16: Lactiplantibacillus plantarum CCFM8661) combined with oligofructose (FOS) on DSS-induced colitis mice. Male BALB/c mice were induced with 2.5% DSS for colitis and then treated with low-, medium-, and high-dose…

Efficacy of a Preparation based on Symbiotic Association Between Inulin, FOS, L. rhamnosus GG, Bromelin, Boswellia, Vitamin D3, Quercetin and L-tryptophan in Mild-to-Moderate Ulcerative Colitis: A Pilot Retrospective Multicenter Study.

BACKGROUND AND OBJECTIVES: Several compounds based on short-chain fatty acids and/or probiotics/prebiotics have shown promising results in the therapy of mild-to-moderate ulcerative colitis (UC). The aim of the present study is to investigate the effectiveness of a preparation based on symbiotic association between inulin, fructooligosaccharides (FOS), Lactobacillus rhamnosus GG, bromelin, Boswellia, vitamin D3, quercetin and L-tryptophanon in patients with active mild-to-moderate UC. MATERIALS: andMethods: This was a multicentre, retrospective, observational cohort study between January 2023…

A comparative evaluation of antibiotic and synbiotic supplementation on production performance and necrotic enteritis severity in broilers during an experimental necrotic enteritis challenge.

The ban on antibiotics in the poultry diet resulted in re-emergence of several infectious diseases including necrotic enteritis (NE). These … oultry industry, but their efficacy needs to be improved through blending additional probiotics and prebiotics, and further exploration is required.

Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure.

The effect of the gut microbiota extends beyond their habitant place from the gastrointestinal tract to distant organs, including the cardio … earch opens new avenues for HF therapies by restoring gut microbiota through dietary interventions, prebiotics, probiotics, or fecal microbiota transplantation and as such normalizing circulating levels of TMAO, SCFA, BAs, IPA, H2S, and PAGln.

Increasing Antimicrobial Resistance to First-Line Therapies in Chronic Endometritis: A 2020-2024 Cross-Sectional Study.

Objectives: In the context of the global rise in antimicrobial resistance (AMR), this study aimed to investigate temporal trends in AMR among pathogens isolated from endometrial cultures of patients diagnosed with chronic endometritis (CE). Methods: This cross-sectional study included 244 women consecutively diagnosed with CE at the Gynecology Unit of the University of Bari, Italy, between January 2020 and June 2024. Exclusion criteria were (i) previous CE diagnosis or treatment; (ii) antimicrobial use in the month prior to hysteroscopy and biopsy; (iii) use of oral or vaginal prebiotics/probi…

The mitigating effect of dietary β-glucan against fipronil-induced intoxication in Nile Tilapia (Oreochromis niloticus): Histopathological, immunological, hematological, and biochemical analysis.

BACKGROUND: Due to its remarkable effectiveness against a wide range of pests and insects at very low concentrations, the broad-spectrum fipronil pesticide is currently gaining popularity in the agricultural, public health, and international industries. However, the stressor effects of fipronil insecticides cause ecological disruption, growth retardation, immunosuppression, and higher fish mortality rates. Both animals and humans have demonstrated the effectiveness of prebiotics such as β-1,3-glucan in their diets. Aquaculture has recently increased in use because of its potential to control d…

Impact of Dietary Probiotics on the Immune and Reproductive Physiology of Pubertal Male Japanese Quail (Coturnix coturnix japonica) Administered at the Onset of Pre-Puberty.

Fertility in males is dependent on the proper production of sperms involving the synchronization of numerous factors like oxidative stress, inflammatory processes, and hormonal regulation. Inflammation associated with oxidative stress is also known to impair sperm function. Nutritional factors like probiotics and prebiotics have the potential benefits to modulate these factors which may enhance male fertility. In the present study, immature male Japanese quail at the beginning of 3rd week were administered with Lactobacillus rhamnosus (L), Bifidobacterium longum (B), and mannan-oligosaccharide…

Effect of different synbiotic administration methods on growth, carcass characteristics, ileum histomorphometry, and blood biochemistry of Cobb-500 broilers.

BACKGROUND AND AIM: To combat enteric infections and antibiotic resistance in the poultry industry, researchers seek alternatives such as probiotics, prebiotics, and synbiotics as growth promoters. Synbiotics support probiotic growth through the supply of essential nutrients. The study's objectives were to assess the most effective delivery methods for synbiotics and evaluate their growth, histomorphometric, and hematological impacts on Cobb-500 broilers. MATERIALS AND METHODS: Two studies, independently conducted, employed a completely randomized design. One hundred and eighty viable eggs in…

Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies.

Aim: This systematic review was aimed at addressing the focused question: What is the protective potential of biological agents against alve … uded if they (i) used non-EP animal models; (ii) focused on antimicrobial agents; (iii) centered on prebiotics or probiotics; (iv) evaluated compounds not classified as biologicals; or (v) included randomized clinical trials, clinical studies, or reviews. Eligibility was determined based on the PI/ECOs framework, and study quality was assessed using the SYRC …

The effects of inulin-type fructans on cardiovascular disease risk factors: systematic review and meta-analysis of randomized controlled trials.

BACKGROUND: Inulin-type fructans (ITF) are the leading prebiotics in the market. Available evidence provides conflicting results regarding the beneficial effects of ITF on cardiovascular disease risk factors. OBJECTIVES: This study aimed to evaluate the effects of ITF supplementation on cardiovascular disease risk factors in adults. METHODS: We searched MEDLINE, EMBASE, Emcare, AMED, CINAHL, and the Cochrane Library databases from inception through May 15, 2022. Eligible randomized controlled trials (RCTs) administered ITF or placebo (for example, control, foods, diets) to adults for ≥2 week…

Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis.

A growing body of evidence from multiple areas proposes that periodontal disease, accompanied by oral inflammation and pathological changes … conventional periodontal treatment and novel microbiome-targeted therapies that include probiotics, prebiotics and bacteriocins would hold great promise for preventing the onset and progression of NAFLD and subsequent complications in patients with periodontal disease.

The effects of synbiotics supplementation on reducing chemotherapy-induced side effects in women with breast cancer: a randomized placebo-controlled double-blind clinical trial.

BACKGROUND: The prevalence of breast cancer and its mortality rate are increasing rapidly among women worldwide. On other hand, the courses of chemotherapy as the main treatment for these patients are too much exhaustive and annoying. This study was designed to evaluate the use of synbiotics (probiotics + prebiotics) supplementation as a safe and inexpensive adjuvant treatment in reducing common chemotherapy side effects in women with breast cancer. METHODS: The current study was conducted on 67 women with definitive diagnosis of breast cancer who were hospitalized to receive one-day chemothe…

Gut permeability may be associated with periprosthetic joint infection after total hip and knee arthroplasty.

A growing number of recent investigations on the human genome, gut microbiome, and proteomics suggests that the loss of mucosal barrier func … thopaedic infections may benefit from administration of gastrointestinal modulators such as pro and prebiotics.

The Microbiome in COPD: Emerging Potential for Microbiome-Targeted Interventions.

The aim of interventions over the respiratory microbiome in COPD is to preserve the original microbial flora, focusing in taxa with a demons … life, and the gut microbiome may be also modified through the oral administration of probiotics or prebiotics, that potentially may determine decreases in lung inflammation and bronchial hyperreactivity. High fiber diets also favor the production of anti-inflammatory molecules by the digestive flora, which would reach the respiratory system through the bloo …

Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata.

Involvement of the microbiome in many different scalp conditions has been investigated over the years. Studies on the role of the scalp micr … opening up novel therapeutic interventions in such kind of hair growth disorders mainly by means of prebiotics, probiotics, and postbiotics.

Hepatoprotective effects of synbiotic soy yogurt on mice fed a high-cholesterol diet.

OBJECTIVES: The role of probiotic yogurt in the prevention and treatment of hypercholesterolemia has attracted global attention. Mounting evidence has indicated that probiotics and prebiotics improve lipid metabolism by lowering low-density lipoprotein cholesterol concentration in plasma of hypercholesterolemic patients. The present study aimed to develop synbiotic soy yogurt that had a greater cholesterol-lowering effect in hypercholesterolemic mice compared with control soy yogurt. METHODS: Synbiotic soy yogurt was prepared using soy milk and synbiotic capsule containing LactoBacil Plus (SC…

Fermented dairy products consumption is associated with attenuated cortical bone loss independently of total calcium, protein, and energy intakes in healthy postmenopausal women.

UNLABELLED: A longitudinal analysis of bone microstructure in postmenopausal women of the Geneva Retirees Cohort indicates that age-related cortical bone loss is attenuated at non-bearing bone sites in fermented dairy products consumers, not in milk or ripened cheese consumers, independently of total energy, calcium, or protein intakes. INTRODUCTION: Fermented dairy products (FDP), including yogurts, provide calcium, phosphorus, and proteins together with prebiotics and probiotics, all being potentially beneficial for bone. In this prospective cohort study, we investigated whether FDP, milk, …