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High brain network dynamics mediate audiovisual integration deficits and cognitive impairment in Alzheimer's disease.

BackgroundAudiovisual integration deficits are frequent in patients with Alzheimer's disease (AD). In addition, patients with AD have altere … tion and positively with Mini-Mental State Examination, Montreal Cognitive Assessment, and Auditory Verbal Learning Test delayed scores. Notably, excessive integration between the DMN and VN mediated the relationship between audiovisual integration deficits and cognitive impairment in patients with AD.ConclusionsThese findings suggest that audiovisual integration …

Anterior attentional system efficacy in Parkinson's disease: a cross-sectional study in Poland.

INTRODUCTION: Cognitive impairment is a prevalent nonmotor symptom of Parkinson's disease (PD), significantly affecting patients' quality of … ogical examination. To assess cognitive status, we used: Mini-Mental State Examination, Californian Verbal Learning Test, Digit Span Test, Rey Complex Figure, and Trail Making Test (A and B form). The ROtman Baycrest Battery was employed to evaluate the Anterior Attentional System. RESULTS: Participants with PDD exhibited significant impairments in the Anterior …

Cognitive-Linguistic Profiles of German Adults with Dyslexia.

Past research has extensively explored reading in English-speaking children with dyslexia who acquire a highly irregular and opaque orthography. Far less is known about the manifestation of dyslexia in shallow, highly consistent orthographies like German, especially in adults. To shed further light on the heterogenous manifestation of dyslexia in German-speaking adults, we assessed reading and reading-related abilities, spelling, cognitive abilities, and language learning experience in 33 healthy German-speaking adults (17 females) and 33 adults with dyslexia (20 females). The four main aims w

The gender-sensitive spectrum of neurodevelopmental disorders: a case report on a ZMYM3 variant in a 19-year-old female.

BACKGROUND: Neurodevelopmental disorders (NDDs) such as Intellectual Disability, Autism Spectrum Disorder (ASD), and Attention-Deficit/Hyperactivity Disorder (ADHD) impact cognitive, behavioral, and social functions. The Zinc finger MYM-type protein 3, located on the X-chromosome, has been implicated in neurodevelopment, but its effects in females remain poorly understood due to limited research. CASE PRESENTATION: We report a 19-year-old female with a de novo heterozygous variant in ZMYM3 (NM_201599.3:c.1927C>G, p.(His643Asp)), presenting with ADHD symptoms, poor motor coordination, and mild

Disrupted resting-state interhemispheric functional connectivity in patients with first-episode moyamoya disease.

Moyamoya disease (MMD) has been reported to be associated with a wide range of structural and functional abnormalities of bilateral hemisphe … gnificant positive correlation was found between the recognition section scores of the Rey Auditory-Verbal Learning Test (AVLT) and the VMHC value for the PoCG and AG in MMD patients. This study is limited by its small sample size and cross-sectional design, which preclude the establishment of causal relationships between imaging indicators and clinical symptoms. …

Короткая международная когнитивная оценка множественного склероза (БИКАМС): иранские нормативные ценности и корреляции когнитивных функций.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Краткий международный когнитивный анализ множественного склероза (БИКАМС) является простым инструментом точной когнитивной оценки у пациентов с множественным склерозом (МС). Несмотря на то, что эти испытания были ранее подтверждены на персидском языке, в них отсутствовали установленные нормативные значения. Целью этого исследования является определение регрессивных нормативных ценностей для иранского населения и изучение факторов, связанных с показателями BICAMS.МАТЕРИАЛЫ И МЕТОДЫ: Пациенты MS и здоровые люди (HI), которые в разбивке по возрасту, полу и учебным годам про

Совпадение в аннотации оригинала
BACKGROUND: The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) is an easy instrument for accurate cognitive assess … g of the Symbol Digit Modalities Test (SDMT), Brief Visual Memory Test (BVMT-R), and the California Verbal Learning Test (CVLT-II). Depression was assessed with Beck Depression Inventory-Fast Screen (BDI-FS) questionnaire. RESULTS: We obtained 68 MS patients and 68 HI samples. The mean raw scores for HI were as follows: SDMT: 51.24 ± 9.77; CVLT-II: 52.04 ± 8.06; …

Exploring the Feasibility of Bidirectional Control of Beta Oscillatory Power in Healthy Controls as a Potential Intervention for Parkinson's Disease Movement Impairment.

Neurofeedback (NF) is a promising intervention for improvements in motor performance in Parkinson's disease. This NF pilot study in healthy participants aimed to achieve the following: (1) determine participants' ability to bi-directionally modulate sensorimotor beta power and (2) determine the effect of NF on movement performance. A real-time EEG-NF protocol was used to train participants to increase and decrease their individual motor cortex beta power amplitude, using a within-subject double-blind sham-controlled approach. Movement was assessed using a Go/No-go task. Participants completed

Re-analyzing and confirming a differential use of redintegration in students with mild and borderline intellectual disabilities.

While numerous studies on verbal working memory have investigated the capacity of the phonological loop and the effectiveness of rehearsal as one core process for maintaining the memory trace, the reconstruction of the memory trace from long-term memory, called redintegration, has been studied less thoroughly. This holds particularly for the population of students with special educational learning needs and mild and borderline intellectual disabilities (MBID). In a previous study, we found a differential developmental relation between the effectiveness of redintegration and vocabulary size, co

Изучение дополнительного значения OCT для MRI в когнитивном повреждении в релапсирующей многократном склерозе.

КОЛИЧЕСТВО: Когнитивное сокращение множественных склерозов (МС) связано с нейроаксональными потерями, поддающимися количественной оценке под воздействием оптической последовательности томографии (OCT). Взаимосвязь между мерами в области ОХТ и когнитивированием при повторном производстве эмиссий MS (RRMS) по-прежнему не полностью изучена, в частности, вопрос о дополнительной ценности ОХТ в сочетании с магнитными резонансными изображениями (MRI). Мы изучили вклад OCT и MRI, применив строгие критерии контроля за субклинической оптической нейропатией.МЕТОДЫ: В ходе этого перекрестного исследования

Совпадение в аннотации оригинала
BACKGROUND: Cognitive decline in multiple sclerosis (MS) is associated with neuro-axonal loss, quantifiable by optical coherence tomography … odalities Test (SDMT), 37.23% impaired Brief Visuospatial Memory Test and 5.11% impaired California Verbal Learning and Memory Test; better SDMT performance was associated with thicker ganglion cell-inner plexiform (GCIPL) layers for eyes unaffected by optic neuritis (B = 0.23, 95% CI = (0.01-0.44), p = 0.03), but not when MRI measures were included (B = 0.18, CI …

A Comparison of Neuropsychological Outcomes following Responsive Neurostimulation and Anterior Temporal Lobectomy in Drug-Resistant Epilepsy.

Neuropsychological outcomes following temporal lobe resection for drug-resistant epilepsy (DRE) are well established. For instance, left anterior temporal lobectomy (LATL) is associated with a greater risk for cognitive morbidity compared to right (RATL). However, the impact of neuromodulatory devices, specifically responsive neurostimulation (RNS), remains an area of active interest. There are currently no head-to-head comparisons of neuropsychological outcomes after surgical resection and neuromodulation. This study reports on a cohort of 21 DRE patients with the RNS System who received comp

The association of CSF biomarkers and cognitive decline with choroid plexus volume in early Parkinson's disease.

OBJECTIVE: This study aims to determine the link between choroid plexus (CP) volume and cognitive decline in patients with early-stage Parki … ile group suffered from a more rapid cognitive decline in the Symbol Digit Modalities test, Hopkins Verbal Learning Test (HVLT)-retention, and HVLT delayed recalled score. Furthermore, path analysis showed that the pathological effects of CP volume on the 5-year decline in memory might be partly mediated by the CSF Aβ1-42/αsyn ratio. CONCLUSION: CP enlargement c …

Altered Functional Connectivity Density in Type 2 Diabetes Mellitus with and without Mild Cognitive Impairment.

Although disturbed functional connectivity is known to be a factor influencing cognitive impairment, the neuropathological mechanisms underl … ong-range FCD in the left superior temporal gyrus (STG), which was correlated with the Rey auditory verbal learning test score in all T2DM patients. Thus, DMCI patients show functional architecture abnormalities in more brain regions involved in higher-level cognitive function (executive function and auditory memory function), and the left STG may be involved in …

Harnessing neuroplasticity.

Twenty years ago, cognitive impairments were recognized as an unmet treatment need in schizophrenia. Basic science discoveries in neuroplasticity had led to cognitive training approaches for dyslexia. We wondered whether a similar approach could target working memory deficits in schizophrenia by harnessing plasticity in the auditory cortex. Our per protocol experimental therapeutics studies tested the hypothesis that sharpening auditory cortical representations would result in better verbal learning and memory. We also later studied the effects of intensive training of basic social cognitive o…

Depression and Cognitive Dysfunction in Patients with Chronic Hepatitis C: Correlation with Viral Replication in the Peripheral Blood Mononuclear Cells and Cytokines in Serum.

Chronic hepatitis C virus (HCV) infection is commonly associated with depression and cognitive dysfunction, the cause of which could be rela … sting included the Wisconsin Card Sorting Test (WCST), Ruff Figural Fluency Test (RFFT), California Verbal Learning Test (CVLT), and Grooved Pegboard Test (GPT). The HCV RNA-negative strand was detected in PBMCs from 24 (30%) patients and these patients had significantly higher BDI scores (median 12.5 [IQR] 6.3-20.5 vs. median 8.00 [IQR] 3-12; p = 0.013). Both de …

Evaluating associations of RNFL thickness and multifocal VEP with cognitive assessment and brain MRI volumes in older adults: Optic nerve decline and cognitive change (ONDCC) initiative.

To examine the relationships of retinal structural (optical coherence tomography) and visual functional (multifocal visual evoked potentials … ociated with global and sectoral RNFL. RNFL thickness correlated with delayed recalls of California verbal learning test (CVLT) and Rey complex figure test (RCFT). The mfVEP amplitudes associated with cerebral white matter (WM) and cingulate GM volumes in MRI and CVLT, RCFT and trail making test outcomes. A significant association of mfVEP latency with logical me …

Poor subjective sleep predicts compromised quality of life but not cognitive impairment in abstinent individuals with Alcohol Use Disorder.

How disrupted sleep contributes to cognitive dysfunction over the dynamic course of Alcohol Use Disorder (AUD) is an emerging topic of inves … mance on cognitive composite tests (executive functioning, attention and working memory, visual and verbal learning or memory). Among AUD individuals, a higher PSQI score correlated with a higher BDI-II score and worse QoL, but not with cognitive scales. Also noted in the AUD group were higher global PSQI scores in individuals also diagnosed with major depressive …

Case Series: Neurobehavioral Profile of Adolescents with PTEN Hamartoma Tumor Syndrome.

BACKGROUND: PTEN Hamartoma Tumor Syndrome (PHTS) is a rare genetic condition caused by germline mutations in the phosphatase and tensin homologue (PTEN) gene with a phenotype that includes macrocephaly, cancer predisposition, developmental delay, increased risk for autism spectrum disorder (ASD), and learning difficulties. Studies characterizing neurobehavioral profiles are limited. METHODS: This single-site, retrospective case series was completed in children who have PHTS followed in a cancer predisposition clinic. Demographic and clinical, data were abstracted from the medical record for 1

A comparison of formal and informal methods for assessing language and cognition in children with Rett syndrome.

BACKGROUND: Opinions about the cognitive and receptive language skills of people with Rett syndrome (RTT) range from severe intellectual impairment to near-normal development. Assessment is challenging because most are non-verbal, with no purposeful hand use. Clarkson et al. (2017) adapted the Mullen Scales of Early Learning for use with eye gaze technology (MSEL-A/ET) for people with RTT. AIMS: To investigate and compare the performance of children with RTT on formal and newly-designed informal assessments of language and cognition using eye gaze/tracking technology. METHODS AND PROCEDURES:

Neuropsychological Profile of an Adolescent Female With Ectodermal Dysplasia With Hypohidrosis.

The ectodermal dysplasias are a group of rare genetic disorders that are caused by abnormalities in cell and tissue development of the embryonic ectoderm. A paucity of research has systematically examined the cognitive, academic, and psychological phenotype of individuals with ectodermal dysplasia. We describe the neuropsychological profile of a female adolescent with ectodermal dysplasia with hypohidrosis. Using a battery of standardized tests, we assessed the adolescent's intellectual functioning, language processing, visuospatial and visuomotor functioning, perceptual reasoning, sensory-mot

Split-Second Unlearning: Developing a Theory of Psychophysiological Dis-ease.

Psychophysiological "stress" underpins many conditions including anxiety, depression, phobias, chronic fatigue syndrome and non-specific musculoskeletal pain such as fibromyalgia. In this article we develop an understanding of chronic psychophysiological stress from a psychological educational perspective, by drawing on supporting evidence that significant emotional events in early life (traumatic and benign) can influence health and well-being later in life. We suggest that traumatic events instigate psychophysiological "stress" responses and the formation of emotional memory images (EMIs) wi