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34th Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2019): part 2 : National Harbor, MD, USA. 10 November 2019.

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Совпадение в полном тексте источника
… Nature. 2017 Aug 24;548(7668):466-470 4.Diamond JM, Vanpouille-Box C, Spada S, Rudqvist NP, Chapman JR, Ueberheide BM, Pilones KA, Sarfraz Y, Formenti SC, Demaria S. Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs. … Vanpouille-Box C, Alard A, Aryankalayil M, Sarfraz Y, Diamond J, Schneider R et al. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. Nat Commun. 2017;8:15618. 6. Vanpouille-Box C, Formenti, SC, Demaria S. …

γδ T cells: origin and fate, subsets, diseases and immunotherapy.

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering the use of allogeneic Vδ2+ γδ T cells for treating late-stage solid tumors and tuberculosis patients. However, we recognize untapped potential and optimization opportunities to fully harness γδ T cell effector functions in immunotherapy. This review aims to thoroughly examine γδ T cell im

Esid 2014 oral presentations.

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DNA Damaging Drugs

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Cyclic nucleotide phosphodiesterases as drug targets.

Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellular levels by mediating their quick return to the basal steady state levels. This often takes place in subcellular nanodomains. Thus, PDEs govern short-term protein phosphorylation, long-term protein expression, and even epigenetic mechanisms by modulating cyclic nucleotide levels

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease.

The dysregulated accumulation of reactive oxygen species (ROS) and reactive nitrogen species disrupts redox homeostasis, triggering oxidative stress (OS) and driving pathophysiological changes across multiple organ systems. OS modulates critical signaling pathways, induces inflammation, impairs mitochondrial function, alters metabolic homeostasis, and dysregulates autophagy, contributing to disease progression. While prior research has largely focused on OS within single-organ diseases (e.g., neurodegenerative, cardiovascular, and oncological disorders), the systemic role of OS in pan-organ di

45th International Symposium on Intensive Care & Emergency Medicine.

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Резюме: 31 Европейский конгресс патологии.

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:: 45th Ежегодное совещание Европейского общества по трансплантации крови и костного мозга: Врачи - сессия плаката.

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The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session (O010-O173).

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… Reduced Intensity Conditioning is Effective for Hematopoietic stem Cell Transplantation in Patients with Diamond-Blackfan ANEMIA Shun Koyamaishi 1 , Takuya Kamio 1 , Akie Kobayashi 1 , Tomohiko Sato 1 , Ko Kudo 1 , Shinya Sasaki 1 , Rika Kanezaki 1 , Daiichiro Hasegawa 2 , Hideki Muramatsu 3 , Yoshiyuki … University, Fukuoka, Japan , 9 Saga University, Saga, Japan , 10 National Center for Child Health and Development, Tokyo, Japan , 11 Tokai University, Isehara, Japan , 12 Tokyo Women’s Medical University, Tokyo, Japan , 13 Toho University, Tokyo, Japan , 14 University of Tokyo, Tokyo, Japan Background: Diamond-Blackfan …

Evidence for the use of intravenous immunoglobulins--a review of the literature.

Intravenous immunoglobulins (IVIg) were first introduced in the middle of the twentieth century for the treatment of primary immunodeficiencies. In 1981, Paul Imbach noticed an improvement of immune-mediated thrombocytopenia, in patients receiving IVIg for immunodeficiencies. This opened a new era for the treatment of autoimmune conditions with IVIg. Since then, IVIg has become an important treatment option in a wide spectrum of diseases, including autoimmune and acute inflammatory conditions, most of them off-label (not included in the US Food and Drug Administration recommendation). A panel

The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Session (P001-P706).

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Integumentary System

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Артериальный тромбоэмболизм

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… Diamond University of Pennsylvania, Philadelphia, United States Background : Thrombosis is the main complication associated with cardiovascular disease, resulting in myocardial infarction and stroke, the leading causes of death globally. …

Экстраклектные везикли для клинической диагностики: от массовых измерений до одновидового анализа.

Экстраклектные везикулы (ЭМ) играют ключевую роль в межклеточном общении, сигнальных путях и патогенезе заболеваний, перевозя биомолекулы, такие, как ДНК, РНК, белки и липиды, полученные из клеток их происхождения, и они продемонстрировали значительный потенциал в области клинического применения. Их клиническое значение подчеркивает необходимость применения чувствительных методов для полной реализации их диагностического потенциала. В рамках этого всеобъемлющего обзора мы изучаем гетерогенность ЭМ, связанную с биогенезом, структурой, содержанием, происхождением, типом выборки и функциональными

Small molecule inhibitors targeting the cancers.

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer. Due to their advantages in a wide range of targets, convenient medication, and the ability to penetrate into the central nervous system, many efforts have been devoted to developing more small molecule inhibitors. To date, 88 small molecule inhibitors have been approved by the United States Food and Drug Administration to treat cancers. Despite remarkable progress, small molecule inhibitors in cancer treatme

Position Statement on Multimodal Cardiac Imaging in Patients with Systemic Diseases - 2026.

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Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters.

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… E-P03.07 Differential molecular diagnosis of Cystic fibrosis and Shwachman-Diamond syndrom M. Kazaryan 1,2 , T. Adyan 2,1 , A. … Polyakov 2 1 RNRMU, Moscow, Russian Federation, 2 Research Centre for Medical Genetics, Moscow, Russian Federation Cystic fibrosis (CF) and Shwachman-Diamond syndrome (SDS) are autosomal recessive disorders, associated with mutations in CFTR and SBDS genes respectively. …

The Fifth International Meeting of ISEV, ISEV2016, Rotterdam, The Netherlands, 4 - 7 May, 2016.

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… . | Diamond Sponsor Session Caris Life Sciences Room: Willem Burger 4:15 – 5:00 p.m. | Symposium Session 25 EVs Viruses and Viral Infections Room: Jurriaanse | Symposium Session 26 EVs in Cellular Differentiation and Development Room: van Weelde | Symposium Session 27 Cell Biology of EVs II Room: Willem …

ePoster.

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Совпадение в полном тексте источника
… Diamond. FIGURE 2 Hazard ratios (95% CI) for dementia and mortality outcomes in the Down syndrome cohort comparing mechanism groups vs SV2A inhibitors. Panels show: (A) All‐cause dementia, (B) Alzheimer's disease, (C) Mortality, (D) All‐cause dementia + death. Diamond mark. … Diamond. FIGURE 2 Hazard ratios (95% CI) for dementia and mortality outcomes in the Down syndrome cohort comparing mechanism groups vs SV2A inhibitors. Panels show: (A) All‐cause dementia, (B) Alzheimer's disease, (C) Mortality, (D) All‐cause dementia + death. Diamond mark. …