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2023 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Montréal, Canada, 19 March–April 1 2023: Posters

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Ось MLKLOPTN регулирует вызванные герпесвирусом неврологические сиквелы.

КОЛИЧЕСТВО: герпес просторексовый вирус-1 (HSV-1) носит пожизненный характер и связан с неврологическими заболеваниями, такими, как множественный склероз (MS), однако основные механизмы в хосте остаются недостаточно понятными. МЕТОДЫ И РЕЗУЛЬТАТЫ: В настоящем исследовании изучается новая молекулярная динамика после заражения HSV-1, выявляется ключевая роль смешанного киназа-домена (MLKL). Помимо известной функции в некроптозе, было установлено, что MLKL контролирует перенос HSV-1 в ядро, жестко регулируемый Оптинёрином (Optineurin). Мы продемонстрировали существенное нормативное взаимодействие

Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination.

Herpes zoster, induced by the reactivation of the varicella-zoster virus (VZV), is a unilaterally distributed vesicular rash that can cause multiple complications. VZV not only causes neurological problems, including postherpetic neuralgia and ocular zoster, but also causes inflammatory vasculopathy and increases the incidence of hemorrhagic or ischemic complications. Therefore, understanding the association between the development of herpes zoster and the subsequent occurrence of acute stroke or cardiovascular diseases, including myocardial infarction and heart failure, is of great interest.

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma.

Mucosal-associated invariant T (MAIT) cells are T cells that recognise vitamin-B derivative Ag presented by the MHC-related-protein 1 (MR1) antigen-presenting molecule. While MAIT cells are highly abundant in humans, their role in tumour immunity remains unknown. Here we have analysed the frequency and function of MAIT cells in multiple myeloma (MM) patients. We show that MAIT cell frequency in blood is reduced compared to healthy adult donors, but comparable to elderly healthy control donors. Furthermore, there was no evidence that MAIT cells accumulated at the disease site (bone marrow) of t

Nuances in the treatment of malignant tumors of the clival and petroclival region.

Introduction Malignancies of the clivus and petroclival region are mainly chordomas and chondrosarcomas. Although a spectrum of malignancies may present in this area, a finite group of commonly encountered malignant pathologies will be the focus of this review, as they are recognized to be formidable pathologies due to adjacent critical neurovascular structures and challenging surgical approaches. Objectives The objective is to review the literature regarding medical and surgical management of malignant tumors of the clival and petroclival region with a focus on clinical presentation, diagnost

Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome.

Skeletal muscle adapts its mass as consequence of physical activity, metabolism and hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the process of muscle loss. Muscle atrophy in adult tissue occurs when protein degradation rates exceed protein synthesis. Two major protein degradation pathways, the ubiquitin-proteasome and the autophagy-lysosome systems, are activated during muscle atrophy and variably contribute to the loss of muscle mass. These degradation systems are controlled by a transcription dependent program that modulates the expression of rate-lim

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… The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms Journal of Physiology 590 2012 5211 5230 22848045 10.1113/jphysiol.2012.240267 PMC3497573 Brunet A. Park J. Tran H. Hu L.S. Hemmings B.A. Greenberg M.E. …

Infectious Diseases

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… Patients do not require bed rest after the procedure” LR+ CSF analysis CSF blood glucose ratio ≤ 0.4 18 CSF glucose >2.2 mmol/L [>40 mg/dL] 23 CSF WBC ≥ 500/μL 15 CSF lactate ≥ 3.5 mmol/L [≥32 mg/dL] 21 | LR+ CSF analysis CSF blood glucose ratio ≤ 0.4 | 18 CSF glucose >2.2 mmol/L [>40 mg/dL] | 23 …

Health-related quality of life domains relevant to people in Europe undergoing cancer treatment: a systematic review of qualitative research.

PurposeTo identify and synthesize evidence from European qualitative studies on cancer-related quality of life outcomes, needs, experiences, preferences, and concerns of people undergoing cancer treatment in the last decade.MethodsSystematic review ( https://www.crd.york.ac.uk/PROSPERO , CRD42024575065) of European studies using qualitative methodology, assessing constructs related to HRQoL, and involving adults receiving cancer treatment. The search was performed in PubMed and Scopus from January 2013 to July 2024. Titles, abstracts, and full texts screening, data extraction and risk of bias

The role of CD8+ T cells in the immunoregulation of osteoporosis.

INTRODUCTION: Osteoporosis weakens the skeleton by lowering bone mass and damaging bone microarchitecture. A growing body of evidence points to disruptions in osteoimmune homeostasis as a key driver of this disease. In particular, apoptosis of bone cells and immune cells appears to be a critical contributing mechanism. Within the bone marrow, CD8+ T cells display a surprising functional duality: whether they protect bone or promote its loss depends heavily on local signals. Under healthy conditions or after mechanical loading, activated CD8+ T cells help maintain bone mass. They do so mainly b

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… When bones are unloaded (bed rest, spinal cord injury, spaceflight), they lose mass quickly. In hindlimb-unloaded mice, CD8 + T cells accumulate in the bone marrow and turn pro-inflammatory: more RANKL, less IFN-γ ( 76 ). This shift partly reflects reduced muscle-derived IL-33, much like in PMOP. …

Rapid Fire

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… However, prolonged bed rest, inadequate pain management, and worsening infection have led to various complications in many cases, prompting the need for surgical interventions when conservative treatments fail. … Recent research has highlighted percutaneous pedicle screw fixation as a promising technique to alleviate immediate pain, reduce the morbidity associated with extended bed rest, and improve pain control. …

Review of imaging techniques for evaluating morphological and functional responses to the treatment of bone metastases in prostate and breast cancer.

Bone metastases are very common complications associated with certain types of cancers that frequently negatively impact the quality of life and functional status of patients; thus, early detection is necessary for the implementation of immediate therapeutic measures to reduce the risk of skeletal complications and improve survival and quality of life. There is no consensus or universal standard approach for the detection of bone metastases in cancer patients based on imaging. Endorsed by the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Medical Radiology (SERAM), and the

42nd International Symposium on Intensive Care & Emergency Medicine

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Физическая активность, упражнения и реабилитация в Миастении Гравис: систематический обзор и сводный анализ.

Миастения гравис вызывает колебания, оживляемую слабость, создавая неопределенность в отношении физической активности и физических упражнений. В ходе этого систематического обзора были изучены обычная физическая активность и оседлое поведение, препятствия и факторы, препятствующие занятиям спортом, структурированные упражнения, мышечная подготовка дыхательных путей и физическая реабилитация в аутоиммунной миастении. С самого начала был проведен поиск в PubMed, Scopus и Web of Science Core Collection. 30 июль 2026, без даты базы данных или лингвистических фильтров; поиск в обратном направлении

Health and economic impact of caregiving on informal caregivers of people with chronic diseases in sub-Saharan Africa: A systematic review.

With a disproportionate burden of chronic diseases and severe shortage of health workers in sub-Saharan Africa, the region implicitly relies on informal caregivers (ICGs) to support the patients both within and outside the health facilities. The aim of this review is to systematically summarise evidence on the health and economic impact of caregiving on informal caregivers of patients with chronic diseases in sub-Saharan Africa. Medline (Ovid), CINAHL (EBSCOhost), PsycINFO (Ovid), Embase (Ovid), Global Health, and Web of Science databases were systematically searched to identify original artic

ECC-4 Abstracts

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Oral Presentations

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… However, most patients reported mild transient headaches and chills which resolved within one day with bed rest and acetaminophen. Neurologic improvement was observed in six out of the eight patients. All patients were classified as ASIA A prior BMSC application. …

Precision-Engineered CD3 T-Cell Engagers for Solid Tumours: Conditional Activation, Microenvironment Modulation, and Clinical Translation.

BackgroundT-cell-engaging bispecific antibodies (TCEs) have transformed haematological malignancy treatment (blinatumomab > 40% complete remission), yet solid tumour efficacy remains limited (MethodsReview of 55 phase I-III trials of CD3-based TCEs in solid tumours, including tarlatamab (DLL3-targeted, small-cell lung cancer) and xaluritamig (STEAP1-targeted, prostate cancer). Analysis of next-generation engineering strategies and resistance mechanisms via genomic and immunohistochemical data.ResultResponse rates now approach ~40% in selected settings, marking an inflection point. In extensive

Navigating isolation- barriers and multidimensional support needs in symptom self-management for HSCT patients within laminar airflow rooms: a descriptive qualitative study.

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a crucial therapy for hematological malignancies and other conditions. However, the intensive therapy and required isolation place significant physical and psychological burdens on patients. Although effective symptom self-management during isolation is pivotal, the current efforts are often challenged, leading to distress and feelings of loss of control. Nevertheless, research specifically addressing the self-management needs and barriers faced by patients with HSCT confined to laminar airflow rooms is limited. This study aimed to

Diagnostic and management dilemmas in pulmonary hypertension.

INTRODUCTION: Although current international guidelines provide comprehensive evidence-based guidance for the management of pulmonary hypertension, clinicians are still regularly faced with uncertainty regarding correct diagnosis and optimal treatment. METHODS: Ten diagnostic and management dilemmas were formulated by a panel of experts in the field of pulmonary hypertension. Current evidence was reviewed and a practical approach suggested for each dilemma. RESULTS: Diagnostic and management dilemmas discussed include pulmonary hypertension with high cardiac output, idiopathic pulmonary arte

Заболеваемость ломками и ее связь со смертностью у нескольких пациентов, страдающих миеломой: общенациональное когортное исследование ( " Microma " )CAREMM-2105 - обучение).

Множественная миелома (ММ), как известно, подрывает целостность костей, что ведет к повышению риска переломов, что подрывает качество жизни и увеличивает смертность. В ходе этого исследования были исследованы случаи переломов у пациентов, страдающих ММ, и была изучена связь между переломами после диагностирования ММ и смертностью с использованием базы данных Корейской национальной службы медицинского страхования. Повреждения были сопоставлены между пациентами MM (n = 9365) и 1::1 Сопоставимая контрольная группа с общим населением. Пациенты MM продемонстрировали значительно более высокую кумуля

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… Hip fractures can lead to functional limitations and often necessitate prolonged bed rest. During this period, patients are susceptible to pressure ulcers, infections, and pneumonia, which may increase the risk of mortality 36 – 38 . …