Результаты поиска

Trial watch: Oncolytic viruses for cancer therapy.

Oncolytic virotherapy is emerging as a promising approach for the treatment of several neoplasms. The term "oncolytic viruses" is generally employed to indicate naturally occurring or genetically engineered attenuated viral particles that cause the demise of malignant cells while sparing their non-transformed counterparts. From a conceptual standpoint, oncolytic viruses differ from so-called "oncotropic viruses" in that only the former are able to kill cancer cells, even though both display a preferential tropism for malignant tissues. Of note, such a specificity can originate at several diffe

Совпадение в полном тексте источника
… their oncotropic counterparts in that while the latter only exhibit a specific tropism for malignant cells, the former (be they replication-competent or not) kill their hosts upon infection (via several mechanisms, see below). 9 Thus, oncotropic viruses (e.g., baculovirus, canarypox virus and canine parvovirus … 813 25 10.1007/s00705-002-0944-x 12664303 200 Yaacov B Eliahoo E Lazar I Ben-Shlomo M Greenbaum I Panet A Selective oncolytic effect of an attenuated Newcastle disease virus (NDV-HUJ) in lung tumors Cancer Gene Ther 2008 15 795 807 10.1038/cgt.2008.31 18535620 201 Grekova SP Rommelaere J Raykov Z Parvoviruses-tools …

Intestinal/Multivisceral Transplantation

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Detection of parvovirus B19 DNA in serum or bone marrow by PCR is the diagnostic gold standard, as serology is confounded by the impaired humoral response to infections. … Brown KE Anderson SM Young NS Erythrocyte P antigen: cellular receptor for B19 parvovirus Science 1993 262 114 7 8211117 10.1126/science.8211117 109. …

Use of Immunoglobulin Replacement Therapy in Clinical Practice: A Review.

Immunoglobulins (Igs) are produced by B lymphocytes and play a key role in humoral immunity. Igs are classified into five isotypes (IgG, IgA, IgM, IgE, and IgD). Their primary function is to recognize and bind to foreign antigens. When Igs bind to antigens, they facilitate phagocytosis and promote clearance mediated by other immune cells. It is an essential component in protecting the host from outside pathogens. Hypogammaglobulinemia predisposes an individual to severe and recurrent infections. Therefore, replacement therapy is recommended to maintain optimal Ig level. In addition, Igs can mo

Совпадение в полном тексте источника
… Immunoglobulins are also effective against pure red cell aplasia related to parvovirus B19 infection, likely due to the presence of neutralizing anti-parvovirus B19 antibodies.[ 84 ] The initial report demonstrating the efficacy of immunoglobulins against parvo B19 dates back to 1989,[ 85 ] after which … Intravenous immunoglobulins in autoimmune- or parvovirus B19-mediated pure red-cell aplasia. Autoimmun Rev . 2005;4:264–269. 85. Kurtzman G, Frickhofen N, Kimball J, et al. …

Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women.

Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivatio … ruption (6) and b. Disorders included in the differential diagnosis (syphilis and infections due to parvovirus, herpes virus, cytomegalovirus, and Epstein-Barr virus). 2. The clinical diagnosis of pityriasis rosea should be made according to the morphological criteria (peripheral collarette scaling with central clearance on at least two lesions) put forth by …

Clinical applications of immunoglobulin: update.

Human immunoglobulin is the most used blood product in the clinical practice. Immunoglobulin applications have increased quickly since the elucidation of its immunomodulatory and antiinflammatory properties which turned this blood product into a precious tool in the treatment of numerous diseases that present with humoral immune deficiency or that cause immune system dysfunction. Currently, the approved indications for Ig are: primary immunodeficiencies, secondary immunodeficiencies (multiple myeloma or chronic lymphoid leukemia), Kawasaki syndrome, immune thrombocytopenic purpura, Guillain Ba

Совпадение в полном тексте источника
… Semin Perinatol . 2009 ; 33 ( 1 ): 35 - 42 19167580 10.1053/j.semperi.2008.10.003 28 Chuhjo T Nakao S Matsuda T Successful treatment of persistent erythroid aplasia caused by parvovirus B19 infection in a patient with common variable immunodeficiency with low-dose immunoglobulin . … Am J Hematol . 1999 ; 60 ( 3 ): 222 - 4 10072114 10.1002/(sici)1096-8652(199903)60:3<222::aid-ajh9>3.0.co;2-k 29 Mareschal-Desandes R Andre JL Lesesve JF Krier MJ Bordigoni P Humbert JC Successful treatment of chronic parvovirus B19 infection by high-dose immunoglobulin . …

Биология и болезни крыс

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Biology and Diseases of Dogs

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… They are usually vaccinated against canine distemper virus, parvovirus, adenovirus type 2, parainfluenza virus, Leptospira serovars canicola and icterohemorrhagiae, and Bordetella bronchiseptica. Rabies virus vaccination may also be included. … Viral and Chlamydial Diseases Canine Parvovirus Clinical signs. Clinical signs of canine parvovirus usually appear 5 days after inoculation by the fecal-oral route and are characterized by anorexia, fever, depression, and vomiting. …

Infections in Recipients of Hematopoietic Stem Cell Transplants

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Responses to antiviral therapy are not universal, and benefits of antiviral therapy have not been rigorously determined. 221 Parvovirus Parvovirus B19 (HPV B19) is a rare cause of refractory anemia with erythroid hypoplasia after HSCT. 222 , 223 , 224 , 225 Antibody or PCR tests detect parvovirus, …

A Comprehensive Review of Modern Cancer Therapies Utilizing Oncolytic Viruses.

Oncolytic viruses (OVs) are gaining traction as advanced tools in cancer therapy. They are distinguished by their ability to destroy malignant cells while sparing normal tissue specifically. In addition to their direct tumor-lysing properties, an essential benefit of oncolytic virus therapy is its capacity to activate both the innate and adaptive immune systems. To enhance these therapeutic actions, many OVs have been genetically engineered to encode immune-modulating factors that reestablish or strengthen antitumor immune responses. Recent studies show that combining OVs with other forms of i

Совпадение в полном тексте источника
… The most common types of viruses in OV products are ssRNA and dsDNA viruses, with exceptions such as reovirus (dsRNA) and parvovirus (ssDNA). Double-stranded DNA viruses mainly include adenovirus, vaccinia virus, and herpesvirus. … For instance, parvovirus H-1PV (ParvOryx) has undergone phase II clinical testing for metastatic, inoperable pancreatic ductal adenocarcinoma ( NCT02653313 ), as well as for progressive primary or recurrent glioblastoma multiforme (phase II, NCT01301430 ). …

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management.

Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, a

Совпадение в полном тексте источника
… Reports of AGEP after Chlamydia pneumoniae , Mycoplasma pneumoniae , coccidiomycosis, COVID-19, cytomegalovirus (CMV), Epstein–Barr virus (EBV), and parvovirus B19 have been identified [ 23 , 151 – 160 ]. … Acute generalized exanthematous pustulosis associated with human parvovirus B19 infection in an adolescent. J Dermatol. 2021;48(5):e236–e237. doi: 10.1111/1346-8138.15851. 161. Agaronov A, Makdesi C, Hall CS. …

Liver Disease Associated with Non-Hepatitis Viruses

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… A clinical study of adult human parvovirus B 19 infection Internal Medicine 41 2007 295 299 10.2169/internalmedicine.41.295 11993790 Huggins J.W. Hsiang C.M. Cosgriff T.M. … Human parvovirus B19 infection associated with acute hepatitis Lancet 347 1996 868 869 8622394 10.1016/s0140-6736(96)91348-3 Yotsuyanagi H. Koike K. Meng G. …

Glioblastoma Treatment: State-of-the-Art and Future Perspectives.

(1) Background: Glioblastoma is the most frequent and lethal primary tumor of the central nervous system. Through many years, research has brought various advances in glioblastoma treatment. At this time, glioblastoma management is based on maximal safe surgical resection, radiotherapy, and chemotherapy with temozolomide. Recently, bevacizumab has been added to the treatment arsenal for the recurrent scenario. Nevertheless, patients with glioblastoma still have a poor prognosis. Therefore, many efforts are being made in different clinical research areas to find a new alternative to improve ove

Совпадение в полном тексте источника
… Parvovirus Parvovirus is a single-stranded DNA virus with an icosahedral capsule that belongs to the Parvoviridae family. The virus replicates in the nucleus and cytoplasm, binding to laminin γ1 on the glioma cell surface through silic acid residues. … Oncolytic Virus: Clinical Trials Different vectors have been studied in OV therapy, including adenovirus (DNX-2401/Ad5-delta24-RGD), parvovirus (ParvOryx), measles (MV-CEA), HSV, polio (PVSRIPO), and replicating retroviral vectors (Toca 511), all of which have shown efficacy and safety in phase I and …

Декодирование связи между микроорганизмами и автоиммунизацией: многоаспектный обзор данных по конкретным патогенам, которые вызывают аутоиммунные заболевания.

Происхождение и прогрессирование аутоиммунных заболеваний (АИД) являются результатом совокупного воздействия генетической восприимчивости, дефектов иммунной реакции и экологических факторов. Среди них микроорганизмы, являющиеся ключевыми экологическими факторами, широко гипотезуют для того, чтобы сыграть свою роль в инициировании АИД, однако точная причинно-следственная связь еще не доказана. Цель этого обзора заключается в глубоком изучении ключевой роли конкретных микробных инфекций в инициировании АИД путем интеграции данных, полученных с помощью three - измерения: эпидемиологические исслед

Совпадение в полном тексте источника
… Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus B19 (B19V), and human endogenous retroviruses (HERVs) may be involved in SLE pathogenesis [ 16 ]. Among these, EBV has the most abundant evidence as an etiological candidate virus [ 17 ]. … Other microorganisms associated with RA include parvovirus, human immunodeficiency virus (HIV), hepatitis B virus, and hepatitis C virus [ 30 ]. EBV and RA Epidemiological correlation The association between EBV and RA has a broad epidemiological basis. …

Profile of tocilizumab and its potential in the treatment of giant cell arteritis.

Giant cell arteritis (GCA) remains a medical emergency due to the threat of permanent sight loss. High-dose glucocorticoids (GCs) are effective in inducing remission in the majority of patients, however, relapses are common which lengthen GC therapy. GC toxicity remains a major morbidity in this group of patients, and conventional steroid-sparing therapies have not yet shown enough of a clinical benefit to change the standard of care. As the understanding of the underlying immunopathophysiology of GCA has increased, positive clinical observations have been made with the use of IL-6 receptor in

Совпадение в полном тексте источника
… Some authors have reported a seasonal variation in the disease, 38 whereas others have not found such an association. 39 , 40 Various infectious agents have been linked to the condition; previously, Chlamydia pneumoniae , Mycoplasma pneumoniae and parvovirus B19 have been associated. 41 , 42 More recently … 2007 86 2 61 68 17435586 10.1097/md.0b013e31803d1764 40 Kisza K Murchison AP Dai Y Giant cell arteritis incidence: analysis by season and year in mid-Atlantic United States Clin Exp Ophthalmol 2013 41 6 577 581 23332080 10.1111/ceo.12069 41 Alvarez-Lafuente R Fernandez-Gutierrez B Jover JA Human parvovirus …

Regulation of immunogenic cell death and potential applications in cancer therapy.

Immunogenic cell death (ICD), a type of regulatory cell death, plays an important role in activating the adaptive immune response. Activation of the tumor-specific immune response is accompanied by the cell surface exposure of calreticulin and heat-shock proteins, the secretion of adenosine triphosphate, and the release of high mobility group box-1. In this review, we summarize and classify the latest types of ICD inducers and their molecular mechanisms, and discuss the effects and potential applications of inducing ICD by chemotherapy drugs, targeted drugs, and oncolytic viruses in clinical r

Совпадение в полном тексте источника
… It has been reported that a variety of oncolytic viruses can induce ICD of tumor cells, and these include Newcastle disease virus (NDV), measles virus (MV), herpes simplex virus type 1 (HSV-1), and parvovirus H1 (H-1PV), which has laid a theoretical foundation for the combination of oncolytic viruses … Complementary induction of immunogenic cell death by oncolytic parvovirus H-1PV and gemcitabine in pancreatic cancer. J Virol. (2014) 88:5263–76. doi: 10.1128/JVI.03688-13 55. Zhu Z, Gorman MJ, McKenzie LD, Chai JN, Hubert CG, Prager BC, et al. …

Haematological Diseases in the Tropics

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Myelodysplastic syndrome • Acute leukaemia • Myelofibrosis • Lymphoproliferative disorders • Bone marrow infiltration by solid cancers • Large granular lymphocytic leukaemia Sepsis • Severe bacterial infections (e.g. typhoid) • Viral: mononucleosis, HIV varicella, measles, rubella, hepatitis A&B, parvovirus … Red cell aplasia can develop due to secondary parvovirus infection which has a predilection for erythroid progenitors. Alloimmunization is common in SCD patients who have had frequent transfusions so, if possible, extended red cell phenotyping should be undertaken. …

Hematology

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… All of these may be triggered by viral infections such as parvovirus B19 B ones —bone infarction (pancytopenia), avascular necrosis, fat embolism, orbital compression syndrome C ardiac —myocardial infarction (due to increased oxygen demand from cardiac output) D ermatologic —leg ulcers E yes —proliferative … Parvovirus , drugs) → T-cell subsets produce local concentrations of INFγ → ↑ Fas on CD34+ cells (maturing stem cells) → apoptosis → severe pancytopenia and hypocellular marrow. …

Recommendations on the follow-up of patients with Gaucher disease in Spain: Results from a Delphi survey.

Management of Gaucher disease (GD) is challenging due to its wide genotypic and phenotypic variability and changing clinical manifestations due to effective treatment. Sixteen face-to-face meetings with experts were held in order to discuss daily clinical practice and identify controversies regarding the management of GD. With this information, a questionnaire with 93 recommendations for different clinical scenarios was designed, and a Delphi survey among 86 physicians with experience in GD was conducted. Consensus was reached on 73 out of the 93 items. Recommendations on follow-up of adult an

Совпадение в полном тексте источника
… . | 8 | 73.9 | Agreement Monitoring of blood parameters in patients with persistent thrombocytopenia should include serology for CMV, EBV, parvovirus B19, herpes simplex 6, HIV, hepatitis B, and hepatitis C. | 8 | 69.0 | Agreement a Monitoring of blood parameters in patients with persistent thrombocytopenia … Panelists agreed that monitoring of blood parameters should include assessment of hemostasis, quantification of immunoglobulins and autoantibodies and a serology for cytomegalovirus, Epstein Barr virus, parvovirus B19, herpes simplex 6, human immunodeficiency virus, and hepatitis B and C (Table 2 ). …

2018 ACVIM Forum Research Report Program. Seattle, Washington, June 14 - 16, 2018.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… equi 9:00 AM Barbara Byrne Characterization of hypermuco viscous/hypervirulent Klebsiella pneumoniae isolated from horses with severe pneumonia 9:25 AM Nathan Slovis Identification of Enterococcu s durans as a Cause of Neonatal Diarrhea on a Thoroughbred Breeding Farm 10:20 AM Joy Tomlinson Equine Parvovirus‐He … Equine Parvovirus‐Hepatitis in Horses with Theiler's Disease, a Prospective Case Series (2014‐2017) Joy E. Tomlinson 1 , Alyssa Struzyna 2 , Nimet Browne 3 , Dawn Mrad 4 , Rodney L. Belgrave 5 , Laurie A. Beard 6 , Katherine M. Delph 6 , Elizabeth G. Davis 6 , Harold C. …

Доклад о деле: Синдром Свободного селезённого повреждения перед началом множественных склерозов.

Синдром обратимого селенического поражения часто ассоциируется с инфекциями системной и центральной нервной системы. Неизвестно, может ли инфекция, связанная с возникновением обратимого синдрома селениального поражения, сыграть какую-либо роль в последующем развитии множественного склероза. Отчет по делу. Результаты: 27-летняя женщина разработала связанный с инфекцией обратимый синдром селезенки. Диагностические результаты не выявили конкретного вида инфекции, а выявили признаки потенциального воздействия на автоиммунитет. Через 32 месяца после первоначального представления появились новые кли

Совпадение в полном тексте источника
… Pathogens reported as the cause of infections associated with MERS cases have included, amongst others, influenza virus, rota virus, adenovirus, parainfluenza virus, measles virus, parvovirus B19, rubella virus, cytomegalovirus, mycoplasma pneumoniae, legionella pneumophila, streptococcus pneumoniae …