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Diseases of the Nervous System

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Социальная когнитивная терапия (T-ScEmo) для различных неврологических групп пациентов: обоснование и протокол случайного испытания (T-ScEmo)T-ScEmo4ALL).

КОЛИЧЕСТВО: Социальные когнитивные расстройства часто происходят у пациентов с различными неврологическими расстройствами, связанными с повреждением мозга, такими, как травма мозга, инсульт, опухоли головного мозга и множественный склероз. Пациенты, страдающие социальными когнитивными расстройствами, сталкиваются с трудностями в восприятии и понимании социальной информации и проявляют неадекватное социальное поведение. Недавно была разработана и проведена оценка первого многопланового лечения, т.е. Т-СЭМО продемонстрировал свою эффективность в улучшении социального когнитивного функционировани

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… Besides, physical restrictions and quarantine rules make it difficult to follow a 20-week during treatment in a hospital. On the other hand, due to the COVID-19 pandemic, it has become more common to create a videocall which creates more possibilities for practicing T-ScEmo online. …

Electronic Patient Symptom Management Program to Support Patients Receiving Cancer Treatment at Home During the COVID-19 Pandemic.

OBJECTIVES: Remote patient monitoring became critical for patients receiving cancer treatment during the COVID-19 pandemic. We sought to test feasibility of an electronic patient symptom management program implemented during a pandemic. We collected and analyzed the real-world data to inform practice quality improvement and understand the patient experience. METHODS: Eligible patients had breast, lung, or ovarian cancers, multiple myeloma, or acute myeloid leukemia and 12 weeks of planned chemotherapy. Patients were notified that a symptom survey with common symptoms derived from the National

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… In addition, staff could also quarantine at home and securely access the patient reports to assure continuity of care. There are several limitations in this study. …

Тенденции заболеваемости астмой, аптечным дерматитом и множественным склерозом до, во время и после COVID-19 Пандемия в базе данных о претензиях США.

Имеются лишь ограниченные данные о том, каким образом сокращение использования ресурсов здравоохранения в период COVID-19 Пандемия повлияла на выявление подстрекательских и иммунологических заболеваний. Мы стремились описать наблюдаемые показатели заболеваемости (ИР) астмой, атомным дерматитом (АД) и множественным склерозом (МС) до, во время и после пандемии. Лица пожилого возраста ≥6 Годы были определены в базе данных Optum, в которой не были указаны данные по клинформатике. 2018 в адрес 2022 для изготовления 20 сезонные когорты. Была проведена оценка ИП астмы, AD и MS с разбивкой по возрасту

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… Mass quarantine measures in the time of COVID-19 pandemic: psychosocial implications for chronic skin conditions and a call for qualitative studies . …

Inactivated vaccine dosage and serum IgG levels correlate with persistent COVID-19 infections in hematologic malignancy patients during the Omicron Surge in China.

PurposeThe essence of this scholarly work was to carefully outline the key factors intensifying the virulence and protracted contagion of COVID-19, particularly among individuals afflicted with hematologic malignancies (HM), in an epoch predominantly governed by the Omicron variant.MethodsAdults with HM diagnosed with COVID-19 from November 2022 to February 2023 were monitored in this retrospective study. Patient blood samples yielded biochemical data, and COVID-19 was confirmed through RNA or antigen testing. The factors affecting severity and infection duration were examined using both univa

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… Following the relaxation of quarantine measures in China in November 2022, a new development arose with the emergence of the Omicron variant. …

COVID-19 in 96 Patients With Hematologic Disease: The First Single-center Experience From the Czech Republic.

BackgroundCoronavirus disease 2019 (COVID-19) represents an important infectious complication associated with high mortality rates in patients with hematologic diseases. There have not been published any epidemiologic studies from Czech Republic so far.Patients and methodsThis study is the first analysis of patients with hematologic malignancies and bone marrow failure syndromes treated at single hematology center in the Czech Republic between March 1 and December 31, 2020, in whom COVID-19 infection was confirmed.ResultsThe sample comprised 96 patients aged 26 to 84 years (median, 66.0 years)

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… Patients requiring acute admission had to stay in quarantine rooms until their RT-PCR test results were obtained. Subsequently, they were moved to either a general medical unit or a COVID care unit at the center, in the university hospital, or in a nearby hospital. …

Quality of life and financial toxicity of hematopoietic stem cell transplant recipients in COVID-19.

Objectiveto evaluate and correlate the quality of life and financial toxicity of adult patients undergoing hematopoietic stem cell transplantation during the COVID-19 pandemic.Methodobservational, analytical study, carried out with 35 patients in a reference hospital for transplantation in Latin America. For data collection, the Functional Assessment Cancer Therapy Bone Marrow Transplantation and COmprehensive Score for Financial Toxicity questionnaires were used. Spearman and Mann-Whitney correlation tests were used for data analysis.Resultsgeneral quality of life during COVID-19 had a low sc

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… Social distancing, prolonged quarantine, isolation at home due to the risk of contamination, long treatment period, indisposition due to side effects, time incompatibility between consultations and work possibly increased the chances of unemployment ( 15 ) and impact on quality of life. …

The cancer patient's perspective of COVID-19-induced distress-A cross-sectional study and a longitudinal comparison of HRQOL assessed before and during the pandemic.

BackgroundTo permit timely mitigation of adverse effects on overall clinical outcome, it is essential to understand how the pandemic influences distress and health-related quality of life (HRQOL) in cancer patients during the coronavirus disease 2019 (COVID-19) pandemic.MethodsIn this cross-sectional study, adult cancer patients, without COVID-19 symptoms, completed a 13-item questionnaire about the pandemic's impacts on distress and everyday-life; associations with age, sex, or impaired HRQOL were then assessed by binary logistic regressions. In a subsample of patients with HRQOL assessment a

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… The local government initiated strict quarantine measures starting mid‐March including a stay‐at‐home order; a ban on travel between counties; homeschooling; a ban on sports, and the closing of all skiing areas. …

Incidence of Arrhythmias and Their Prognostic Value in Patients With Multiple Myeloma.

Background: Arrhythmias are common cardiovascular complications in multiple myeloma (MM) patients and are related to a poor prognosis. Objective: This study aimed to assess the burden of arrhythmias and their prognostic value in patients with MM. Methods: This was a retrospective study of patients with MM between January 2015 and April 2020 at the First Affiliated Hospital of Xi'an Jiaotong University. The incidence of arrhythmia and associated risk factors were evaluated. The relationship between the type of arrhythmia and survival was analyzed. Results: A total of 319 patients with MM were i

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… Follow-up measures included outpatient visits, telephone calls or other electronic communications due to social quarantine measures during the coronavirus 2019 (COVID-19) pandemic. Statistical Analysis All statistical analyses were conducted using SPSS version 24. …

Safety and toxicity of Iopofosine I 131 (CLR 131) with external beam radiation therapy in recurrent or metastatic head and neck cancer: results of a phase 1 single-centre, open-label, single-arm, dose escalation and dose expansion study.

BACKGROUND: Re-irradiation of recurrent head and neck cancer (HNC) is often limited by tumour adherence to critical structures and/or radiation tolerance of critical normal tissues. Iopofosine I 131 (CLR 131) is a targeted small molecular phospholipid ether (PLE) drug conjugate that delivers iodine-131 selectively to tumour cells. We conducted a phase 1, single-centre, open-label study to determine whether CLR 131 given with reduced dose of external beam radiation therapy (EBRT) would be tolerable and feasible. METHODS: All participants received previous curative intent treatment with radioth

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… | 6 | 4 Xerostomia inventory | 10 (83) | 6 | 4 Salivary flow rate | 10 (83) | 6 | 4 DIGEST | 10 (83) | 6 | 4 Of note, the trial was suspended for accrual for the COVID-19 pandemic from April 1, 2020 until July 23, 2020, which delayed accrual, and manufacturing issues of CLR 131 due to local COVID quarantine …

Insights into the Impact of Hesitancy on Cancer Care and COVID-19.

World Health Organization findings indicate that the COVID-19 pandemic adversely affected cancer diagnosis and management. The COVID-19 pandemic disrupted the optimal management of outpatient appointments, scheduled treatments, and hospitalizations for cancer patients because of hesitancy among patients and health-care providers. Travel restrictions and other factors likely affected medical, surgical, and radiation treatments during the COVID-19 pandemic. Cancer patients were more likely to be affected by severe illness and complications if they contracted COVID-19. A compromised immune system

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… Patients with cancer were at a higher risk of severe COVID-19, while quarantines, social distancing measures, and interruptions to routine health-care delivery disrupted cancer therapy delivery. …

Consultation-Based Deprescribing Service to Optimize Palliative Care for Terminal Cancer Patients.

(1) Background: A pharmacist-led deprescribing service previously developed within the Consultation-Based Palliative Care Team (CB-PCT) was implemented for terminal cancer patients. (2) Objective: To evaluate the clinical outcomes of the developed deprescribing service for terminal cancer patients in CB-PCT. (3) Methods: A retrospective analysis compared the active care (AC) group to the historical usual care (UC) group. The clinical outcomes included the deprescribing rate of preventive medications, the proportion of patients with one or more medication-related problems (MRPs) resolved upon d

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… However, in accordance with national quarantine guidelines, the weekly CB-PCT meetings were adjusted to be held every two weeks. 2.2. Study Design A retrospective cohort study was conducted, comparing the AC group with the historically controlled UC group. …

Indian Expert Opinion on Cancer Care during COVID-19 Pandemic.

Coronavirus pandemic has increased human disease burden, as well as economic distress globally. Being in an immunocompromised state, patients with cancer comprise an important at-risk population for novel coronavirus disease 2019 (COVID-19) infection. It is necessary to modify individualized clinical management for every cancer patient in the context of the ongoing COVID-19 pandemic. Simultaneously, additional safety precautions for the cancer care providers are mandatory. This review will provide general recommendations in the Indian context optimizing the same.

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… hospital beds, intensive care unit beds, and ventilators Inability to maximize social distancing among our patients, colleagues, and staff due to humongous patient load in outpatient departments and space constraint Human resource constraints: potential shortage of hospital personnel due to sickness, quarantine …

The EHA Research Roadmap: Infections in Hematology.

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… Few positive changes brought in by this pandemic are the emphasis on the relevance of daily preventive measures, including personal protective equipment and the need for social distancing and quarantine, the importance of immunization, and an increased use of telemedicine that allows to reduce the physical …

SARS-CoV-2 Вакцины и множественный склероз: обновление.

В высшей степени заразная зоонозная болезнь коронавируса 2019 (В тыс.COVID-19), вызванной острым острым респираторным синдромом коронавируса 2 (В тыс.SARS-CoV-2), была объявлена пандемией Всемирной организацией здравоохранения в марте 11, 2020, и это привело к глобальному кризису в области здравоохранения с почти 777 million подтвержденные инфекции и более 7 million к ноябрю 10, 2024.1-3 Со временем появились различные варианты, при этом Омикрон и его подлинии доминировали над миром в прошлом. 3 Годы.4 Кроме того, растет число свидетельств, касающихся иммунной реакции SARS-CoV-2 вакцины, особе

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… were in the age range of 60 years or older, mostly in the first booster-receiving population and during the Omicron wave. e5 Nevertheless, vaccinations, infections, and hybrid immunity do not provide absolute protection, which is why adherence to nonpharmacologic regimens such as social distancing, quarantine …

Biology and Diseases of Dogs

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… A study by Bradfield et al. (1996) reported that 74% of the dogs entering a research institute's quarantine facility from sources in eastern North Carolina were seropositive for E. platys. Hoskins et al. (1988) reported a 54.2% seropositive prevalence in healthy dogs from kennels in Louisiana. …

Использование стационарной гемато-онкологической службы до, во время и после COVID-19 Ограничения в румынском Третичном центре.

Введение Болезнь коронавируса 2019 (В тыс.COVID-19) пандемия помешала диагностике и лечению рака, однако имеющиеся в больницах данные об использовании стационарного гемато-онкологического обслуживания в Восточной Европе остаются ограниченными. В ходе этого исследования была проведена оценка того, как период пандемии повлиял на улавливание, диагностическое подтверждение, повторное стационарное лечение, госпитализацию и больничные дни среди взрослых с лимфомой, лейкемией или множественными миеломой в румынском высшем центре. В больнице скорой помощи округа Сибиу, Сибиу, Румыния, был проведен рет

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… Organization: WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020 5 2026 19 10 2026 2020 https://www.who.int/news-room/speeches/item/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 2 Embassy of Romania in Washington: The quarantine …

CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer.

BACKGROUND: Gamabufotalin (CS-6), a bufadienolide derived from Chansu, has been reported to exhibit anti-tumor effects in various cancers, including glioblastoma, nonsmall cell lung cancer, and breast cancer. However,its role in colorectal cancer (CRC) remains unexplored. OBJECTIVE: Our study aimed to evaluate the inhibition of CS-6 to CRC cells by cell viability assay, colony formation assay, comet assay, and cell cycle analysis firstly. And its molecular mechanism was studied by immunofluorescence (IF) assay, western blot (WB) assay, siRNA transfection, protein-protein interaction (PPI) net

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… Animals were observed in quarantine for 7 days prior to use and raised in specific pathogen-free animal rooms. SW620 cells (5 × 10 7 ) in 0.1 mL PBS were subcutaneously injected into the armpits of mice for tumorigenesis. …

Treatment Approaches for Managing Patients with Hematological Malignancies in the Time of COVID-19 Pandemic.

Background/aimThe COVID-19 pandemic is a unique challenge to the care of patients with hematological malignancies. We aim to provide supportive guidance to clinicians making individual patients decisions during the COVID-19 pandemic, in particular during periods that access to healthcare resources may be limited.ConclusionThis review also provides recommendations, which are convenient in evaluating indications for therapy, reducing therapy-associated immunosuppression, and reducing healthcare utilization in patients with specific hematological malignancies in the COVID-19 era. Specific decisio

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… Asymptomatic patients for COVID-19 should be quarantined at home for at least 14 days, under close surveillance for determining COVID-19-associated signs and symptoms, in such cases antimyeloma therapy should be deferred [ 28 ]. …

Physical interventions to interrupt or reduce the spread of respiratory viruses.

BACKGROUND: Viral epidemics or pandemics of acute respiratory infections (ARIs) pose a global threat. Examples are influenza (H1N1) caused b … (RCTs) and cluster-RCTs investigating physical interventions (screening at entry ports, isolation, quarantine, physical distancing, personal protection, hand hygiene, face masks, glasses, and gargling) to prevent respiratory virus transmission.  DATA COLLECTION AND ANALYSIS: We used standard Cochrane methodological procedures. MAIN RESULTS: We included 11 …