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34th Европейский конгресс патологии - резюме.

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SOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway.

PurposeTo evaluate the expression of sry-box transcription factor 9 (SOX9) in orbital fibroblasts (OFs) of thyroid eye disease (TED) and to find its potential role and underlying mechanism in orbital fibrosis.MethodsOFs were cultured from orbital connective tissues obtained from patients with TED (n = 10) and healthy controls (n = 6). SOX9 was depleted by small interfering RNA or overexpressed through lentivirus transduction in OFs. Fibroblast contractile activity was measured by collagen gel contraction assay and proliferation was examined by EdU assay. Transcriptomic changes were assessed by

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… In addition, the cells stained negatively for desmin (DES), keratin (KRT17), myoglobin, and S100B, excluding the smooth muscle cells and cardiomyocytes, skin cells, muscle and striated muscle, nerve cells and skin melanocytes ( Fig. 1 ). …

Beyond the rare: a case of pseudomyogenic hemangioendothelioma treated sequentially with everolimus, denosumab, and pazopanib.

Pseudomyogenic hemangioendothelioma is an ultra-rare vascular sarcoma that most commonly affects young adults, with a male predominance. It is diagnosed using a combination of imaging studies, histopathological examinations, and immunohistochemical staining. Surgical excision is the mainstay of treatment for pseudomyogenic hemangioendothelioma, with the goal of achieving a wide local excision and reducing the risk of recurrence. The role of systemic therapies is not well established because of the rarity of pseudomyogenic hemangioendothelioma, uncertainty regarding its response to currently ap

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… hemangioendothelioma Table 1 Immunohistochemistry analysis Marker | Antibody/Clone | Result CAMTA-1 | Polyclonal | Negative INI-1 | MRQ-27 | Preserved expression Pan-cytokeratin | AE1/AE3 | Positive CD31 | JC70A | Positive ERG | EP111 | Positive CD34 | QBEnd10mB | Negative S100 | Policlonal | Negative Desmin …

Vertebral giant cell tumour of bone in a domestic shorthair cat.

Case summaryA 10-year-old male neutered domestic shorthair cat was presented with a 5-month history of progressive non-ambulatory paraparesis. Initial vertebral column radiographs revealed an L2-L3 expansile osteolytic lesion. Spinal MRI showed a well-demarcated, compressive expansile extradural mass lesion affecting the caudal lamina, caudal articular processes and right pedicle of the second lumbar vertebra. The mass was hypointense/isointense on T2-weighted images, isointense on T1-weighted images and had mild homogeneous contrast enhancement after gadolinium administration. MRI of the rema

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… Immunohistochemical distribution of vimentin, desmin, glial fibrillary acidic protein and neurofilament proteins in feline tissues. Zentralbl Veterinarmed A 1994 ; 41 . DOI: 10.1111/j.1439-0442.1994.tb00059.x. 10.1111/j.1439-0442.1994.tb00059.x 8085393 3 Pierezan F Mansell J Ambrus A , et al . …

When tissue is not the only issue: Poorly differentiated lung squamous-cell carcinoma with adrenal, costochondral, and cardiac metastases - case report.

Nonmelanoma skin cancer is the most common cancer in the world, and lung cancer is the leading cause of death from cancer. Histologically, squamous cell carcinoma (SCC) is the second most prevalent type of both skin and lung cancers. We report the case of a 38-year-old female with metastatic, poorly differentiated lung SCC detected on chest X-ray after she presented to the hospital with cough and dyspnea. She had had a 7.5 cm moderately differentiated well-circumscribed posterior scalp SCC completely excised eight years earlier. CT scan showed a large right lung mass, nodular filling defect in

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… The adrenal mass biopsy was negative for keratin, TTF-1, S100 protein, SOX10, smooth muscle actin (SMA), desmin, MDM2 and CDK4, and only vimentin was expressed. Occasionally SCCs can dedifferentiate and appear as spindle cell neoplasm. …

Case Report: Lenalidomide as a novel maintenance therapy for metastatic follicular dendritic cell sarcoma.

Follicular dendritic cell sarcoma (FDCS) is a rare, low- to intermediate-grade malignancy arising from mesenchymal-derived follicular dendritic cells, which can also present with high-grade pathological features and may rapidly become fatal. Conventional therapeutic strategies, primarily consisting of surgical resection with adjunctive systemic chemotherapy, such as gemcitabine-docetaxel, ifosfamide, doxorubicin, or other regimens, remain inconsistently effective, with median survival notably reduced in advanced or recurrent disease. Given the limited therapeutic options and frequent relapse,

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… The presence of FDCS was verified by diffuse positive staining for follicular dendritic markers (CD21, CD23, CD35), focal positivity for TTF-1 and D2-40, and absence of staining for epithelial (pancytokeratin) and lineage-specific markers (CD3, CD20, CD45, Desmin, S100, Napsin A, PAX-8, among others) …

Hypercalcemia in poorly differentiated endometrial cancer: a report of two cases.

BACKGROUND: Hypercalcemia as a paraneoplastic syndrome is associated with poor prognosis. It is most commonly caused by parathyroid hormone-related protein (PTHrP) production, less commonly by bony metastases, and very rarely by ectopic parathyroid hormone (PTH) secretion. Hypercalcemia in endometrial cancer is relatively rare. CASE PRESENTATION: We present two cases of hypercalcemia in patients with poorly differentiated endometrial cancer, both of whom had elevated PTH levels and no evidence of parathyroid disease or bone metastases at baseline. In the first case, hypercalcemia rapidly prog

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… IHC showed patchy CK7 positivity, CDX2 positivity, and negativity for CK20, PAX8, and Desmin. It also showed wild-type p53, heterogeneous p16, and loss of MSH6. …

Дисфункция мозгового барьера (BBB) в заболеваниях CNS: уделение внимания перицитам.

Дизфункция мозгового барьера (BBB) является важным патологическим механизмом в заболеваниях центральной нервной системы (CNS) и может вызвать ряд патологических реакций, таких, как нейроинфламмационная реакция, окислительный стресс, иммунная инфильтрация и т.д., что усугубляет повреждение мозга. Вместе с тем исследователи часто игнорируют перициты, и ни одно обзорное исследование пока еще не подытожило механизм, с помощью которого перициты способствуют дисфункции ББД в заболеваниях КНС.Поэтому в настоящем обзоре изучается патофизиология дисфункции ББД в связи с заболеваниями КНС и содержится п

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… (PDGFRβ) Generally expressing in pericytes Pericyte proliferation and recruitment involved in the process of angiogenesis [ 47 ] Aminopeptidase N (CD13) Expressing in the cranial neural crest‐derived pericyte‐like cells (hPSC‐CNC PCs) Participate in the regulation of vascular function [ 48 , 49 ] Desmin …

Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases.

There have been magnificent advancements in the understanding of molecular mechanisms of chronic diseases over the past several years, but these diseases continue to be a considerable cause of death worldwide. Most of the approved medications available for the prevention and treatment of these diseases target only a single gene/protein/pathway and are known to cause severe side effects and are less effective than they are anticipated. Consequently, the development of finer therapeutics that outshine the existing ones is far-reaching. Natural compounds have enormous applications in curbing seve

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… PPARα, PPARγ, ↓lipid droplet accumulation, HIF-1α, apoptosis, SREBP1, FAS, SCD1 | [ 59 ] | In vivo | 30 mg/kg | ICR mice | ↓ Apoptosis, ALT, AST, ALP, IL-6, IL-8, TNF-α | [ 59 ] Hepatic fibrosis | In vitro | 20, 30, 40 μM | HSCs | ↑LC3-B, Atg3, Atg4, Atg5, Atg7, Atg9, beclin, Atg12, Atg14, ↓α-SMA, desmin … contraction | [ 163 ] | In vivo | 40 mg/kg | ICR mice | ↓Liver injury, glycolysis, α-SMA, α1collagen, fibronectin, ALT, AST, TBIL, IBIL, p-MLC2 | [ 163 ] | In vitro | 20, 30, 40 μM | HSC | ↑SLC7A11, GSH, lipid droplet content, retinol, cholesterol, triglyceride ↓ATGL, α-SMA, α1collagen, fibronectin, desmin …

Inflammation in Cardiomyopathies: Cellular Mechanisms Across Cardiac Phenotype.

Cardiomyopathies are traditionally classified by structural and genetic phenotypes, but emerging evidence highlights chronic myocardial inflammation as a pivotal driver of disease progression across different etiologies. This review synthesizes the current literature on the cellular and molecular inflammatory mechanisms underlying hypertrophic cardiomyopathy, Anderson-Fabry disease, cardiac amyloidosis, arrhythmogenic cardiomyopathy, and dilated cardiomyopathy. Across these distinct conditions, endogenous triggers such as metabolic substrates, misfolded amyloid fibrils, mechanical stress, or v

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… variants associated with ACM, pathogenic variants in non-desmosomal genes have also been identified in genes encoding proteins involved in cytoskeletal organization, calcium handling, sodium ion transport, and cytokine signaling; notable non-desmosomal genes implicated in ACM include DES (encoding desmin …

Cellular and molecular mechanisms of muscle atrophy.

Skeletal muscle is a plastic organ that is maintained by multiple pathways regulating cell and protein turnover. During muscle atrophy, proteolytic systems are activated, and contractile proteins and organelles are removed, resulting in the shrinkage of muscle fibers. Excessive loss of muscle mass is associated with poor prognosis in several diseases, including myopathies and muscular dystrophies, as well as in systemic disorders such as cancer, diabetes, sepsis and heart failure. Muscle loss also occurs during aging. In this paper, we review the key mechanisms that regulate the turnover of co

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… A recent paper reported Trim32 as a crucial E3 ligase for the degradation of thin filaments (actin, tropomyosin and troponins), α-actinin and desmin ( Cohen et al., 2012 ). … Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy . J. Cell Biol. 198 , 575 – 589 22908310 10.1083/jcb.201110067 PMC3514026 Combaret L. Adegoke O. A. Bedard N. Baracos V. Attaix D. Wing S. S. ( 2005 ). …

Case Report: Abblation как новая х терапия в режиме слабого гематологического расстройства с внематологическими повреждениями.

Гематологические заболевания как категория злокачественных опухолей, происходящих из гематопоиетической системы, давно полагаются на такие виды лечения, как химиотерапия, радиотерапия и трансплантация стволовых клеток. Вместе с тем по-прежнему сохраняются проблемы, связанные с устранением местных прогрессивных повреждений, рецидивов/обезболивающих повреждений и участием специальных анатомических объектов, особенно в недееспособности. Технология абляции, которая представляет собой минимально инвазивный метод лечения на местном уровне, непосредственно уничтожает поврежденные ткани с помощью физи

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… IHC results for the synovial sarcoma were: Vimentin (+), EMA (+), CK (+), CD68 (+), CD10 (+), bcl-2 (focal cytoplasmic +), CD117 (-), Dog-1 (-), CD34 (vascular +), S100 (-), SMA (-), desmin (-), WT-1 (-), CK5/6 (-), D2-40 (-), and a Ki-67 proliferation index of 70% ( Figure 4C ). …

Histone deacetylase in inflammatory bowel disease: novel insights.

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is characterized by chronic nonspecific intestinal inflammation. Despite considerable efforts, IBD remains a heavy burden on society and human health, with increasing morbidity. Posttranslational modification, especially histone acetylation, is a key process in controlling DNA transcriptional activity. Histone deacetylases (HDACs) play a vital role in the mechanism of IBD pathogenesis through histone and nonhistone protein deacetylation. Herein, we present a summary of different categories of HDACs as well as H

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… Monoclonal antibodies to desmin: evidence for stage-dependent intermediate filament immunoreactivity during cardiac and skeletal muscle development. Ann N Y Acad Sci 1985; 455: 167–184. 83. Shi J, Zhou J, Liu B, et al. …

Nuances in the treatment of malignant tumors of the clival and petroclival region.

Introduction Malignancies of the clivus and petroclival region are mainly chordomas and chondrosarcomas. Although a spectrum of malignancies may present in this area, a finite group of commonly encountered malignant pathologies will be the focus of this review, as they are recognized to be formidable pathologies due to adjacent critical neurovascular structures and challenging surgical approaches. Objectives The objective is to review the literature regarding medical and surgical management of malignant tumors of the clival and petroclival region with a focus on clinical presentation, diagnost

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… patterns can be further analyzed to help distinguish malignant lesions from benign ones: an MNST usually shows reverse expression because it is positive for S-100α and negative for S-100β subunits. 39 MNST can be differentiated from spindle cell sarcomas because of its reaction to neuron-specific enolase, desmin …

Резюме: 31 Европейский конгресс патологии.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Effusion cytology of EBV-associated lymphoma: a concise review.

Epstein-Barr virus (EBV)-associated lymphomas can, on rare occasions, involve body cavities, making effusion cytology an important diagnostic tool. This mini-review explores the spectrum of EBV-related lymphomas that may be detected in serous fluids, including EBV-positive nodal T/NK-cell lymphoma (EBV + nT/NKCL), extranodal NK/T-cell lymphoma, primary effusion lymphoma, EBV-positive diffuse large B-cell lymphoma, and classic Hodgkin lymphoma. We present an index case of EBV + nT/NKCL with lymphomatous pleural effusion and discuss the cytologic features, differential diagnoses, and role of anc

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… Rhabdomyosarcoma may contain strap-like or tadpole-shaped cells with eccentric nuclei and eosinophilic cytoplasm; immunostaining for myogenin and desmin supports its identification [ 33 ]. Small cell carcinoma and Merkel cell carcinoma often form cohesive clusters in effusion cytology. …

Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review.

Despite improvements in cancer survival, cancer therapy-related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symposium proceedings, we present a focused review on the mechanisms that contribute to common cardiovascular toxicities discussed at this meeting, the ongoing international collaborative efforts to impro

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… Gain-of-function mutation in ubiquitin ligase KLHL24 causes desmin degradation and dilatation in hiPSC-derived engineered heart tissues. J Clin Invest. 2021;131 doi: 10.1172/JCI140615. 47. Park H., Kim C.H., Jeong J.H., Park M., Kim K.S. …

Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment.

Pyoderma gangrenosum (PG) is a rare inflammatory skin disease belonging to the group of neutrophilic dermatoses. The pathogenesis of PG involves a predisposing genetic background that facilitates a dysregulated innate and adaptive immune response, with an imbalance between pro-inflammatory and anti-inflammatory mediators, leading to neutrophil-driven inflammatory damage. Several immunosuppressants and immunomodulatory drugs are currently available for the treatment of PG, in combination with topical therapies, wound management and pain control strategies. Systemic corticosteroids and cyclospor

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… Indeed, an interesting study demonstrated a significant decrease of CD4 + and CD34 + fibroblasts as well as IL-15 and desmin in PG wound healing compared with active ulcerative stage and unaffected skin. … These findings, in addition to suggesting a potential pathogenic role of fibroblasts, revealed the destruction of pilosebaceous unit during PG resolution consistent with the almost complete absence of desmin [ 41 ]. …

Pericytes as targets in hereditary hemorrhagic telangiectasia.

Defective paracrine Transforming Growth Factor-β (TGF-β) signaling between endothelial cells and the neighboring mural cells have been thought to lead to the development of vascular lesions that are characteristic of Hereditary Hemorrhagic Telangiectasia (HHT). This review highlights recent progress in our understanding of TGF-β signaling in mural cell recruitment and vessel stabilization and how perturbed TGF-β signaling might contribute to defective endothelial-mural cell interaction affecting vessel functionalities. Our recent findings have provided exciting insights into the role of thalid

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… Several markers have been used to identify pericytes and include Neural/glial antigen 2 (NG2), PDGFR-β, α-Smooth Muscle Actin (α-SMA), desmin, vimentin, aminopeptidase A or N and Regulator of G protein 5 (RGS5) (Armulik et al., 2005 , 2011 ; Díaz-Flores et al., 2009 ; Krueger and Bechmann, 2010 ). …

Malignant Neoplasms Arising in the Cardiac Pacemaker Cavity: A Systematic Review.

Cancer is the abnormal proliferation of physiologically inadequate cells. Studies have identified the cardiac pacemaker pocket as a site of rare neoplasms. To evaluate the clinical outcomes, treatment, prognosis, and individualized management of tumors originating in the cardiac pacemaker pocket, a systematic review was conducted using case reports and case series available in the PubMed/Medline, Science Direct, Cochrane Central, LILACS, and Scientific Electronic Library Online (Scielo) databases. Pacemaker pocket tumors affected patients with a mean age of 72.9 years, with a higher incidence

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… Expression of CD10, CD99, CD68 (focal) and smooth muscle actin (focal), S100 protein, melan-A, desmin, CD34, p63, CD31, and human herpesvirus latent nuclear antigen 8 were markers also identified in atypical fibroxanthoma [ 31 ], together with the presence of hyperchromatic cells described both in atypical …