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Rare Coexistence of Hemoglobin D-Iran and Hemoglobin S in a Case from Central India.

The hemoglobin variant, Hb D-Iran (HBB:c.67G > C), is a rare structural hemoglobinopathy mainly reported from Iran and Pakistan, with only limited documentation in India. Although usually clinically silent in the heterozygous state, it may coexist with other variants and complicate chromatographic interpretation. A 40-year-old woman from Central India was found to have two abnormal peaks in the HbA2 (43.5%) and HbS (43.4%) windows on CE-HPLC, prompting further investigation. ARMS-PCR verified the presence of heterozygous HbS (HBB:c.20A > T), and additional tests excluded HbE and Lepore disorde…

Lessons from the Past: Examining the Historical Context of Trachoma Management in Iran (1925-1941).

Trachoma was one of the most prevalent infectious illnesses in Iran during the first Pahlavi era, causing widespread suffering and blindness. This research aims to investigate the background of dealing with trachoma in Iran from 1925 to 1941. It seeks to answer questions about trachoma by using descriptive and analytical methods, drawing on documents and evaluating historical data. The results of the research show that during the first Pahlavi era, due to the serious health situation, there was a pressing need to address trachoma and take necessary steps. The government worked in a number of s…

Prevalence and contributing factors of drug-resistant tuberculosis (DR-TB) in iran: a systematic review.

INTRODUCTION: Drug-resistant tuberculosis (DR-TB) is an increasing public health concern in Iran, with multidrug-resistant tuberculosis (MDR-TB) posing significant challenges to disease control efforts. This study examines the prevalence of DR-TB in Iran from January 2000 to October 2023. METHODS: A comprehensive systematic search was conducted across multiple databases, including PubMed, Scopus, Google Scholar, EMBASE, BioMed Central, and Web of Science. The search utilized specific keywords such as "drug-resistant tuberculosis," "DR-TB," "MDR-TB," "XDR-TB," "Iran," "prevalence," and "risk f…

Нарушения сна и связанные с ними факторы у пациентов с множественным склерозом: перекрестное исследование в Иране.

У людей с множественным склерозом (PwMS) часто отмечаются нарушения сна. Эти расстройства часто недооцениваются из-за того, что люди склонны сосредоточивать внимание на своих более заметных физических симптомах. Цель этого исследования заключалась в изучении факторов, влияющих на нарушения сна в Иране. МЕТОДЫ: В рамках этого межсекторального исследования была привлечена компания " PwMS " из провинции Исфахан Ирана. Для оценки серьезности нарушений сна использовались вопросники Международной исследовательской группы по синдрому беспощадных ног, STOP-Bang, Berlin, и индекс бессонницы.Р

Совпадение в аннотации оригинала
BACKGROUND: Sleep disorders are commonly noted in people with multiple sclerosis (PwMS). These disorders are often underestimated due to the tendency of individuals to focus on their more noticeable physical symptoms. This study aimed to survey factors affecting the sleep disorders of PwMS in Iran. METHODS: This cross-sectional study recruited PwMS from the…

The Black Cloud of Endometriosis on different aspects of the Life of Women with Endometriosis: a qualitative study in Iran.

AIM: To explore the perception of the impact of endometriosis on various aspects in affected women with endometriosis. METHOD: Data was gathered through in-depth and semi-structured individual interviews using open questions to comprehend women's experiences with endometriosis and their health-promoting lifestyle. The Conventional Qualitative Content Analysis approach was utilized, and sampling continued until data saturation. Ultimately, 14 women with endometriosis were interviewed. RESULTS: The theme was following the dominance of the Black Cloud of Endometriosis on Different Aspects of th

Cost-effectiveness of pretreatment HIV drug resistance testing in people living with HIV in Iran.

INTRODUCTION: HIV drug resistance (HIVDR) is an important challenge in the fight against HIV/AIDS and can threaten progress toward achieving the target of HIV elimination by 2030. Genotyping pretreatment HIVDR testing (DRT) has been proposed as a potential solution. However, the cost-effectiveness of this intervention needs to be evaluated to determine its feasibility and potential impact on healthcare systems. This study aimed to assess the cost-effectiveness of DRT among people living with HIV (PLHIV) in Iran. METHODS: 1000 hypothetical PLHIV were simulated in terms of cost and effectivenes…

Cardiovascular disease development in COVID-19 patients admitted to a tertiary medical centre in Iran.

Cardiovascular diseases (CVDs) have been reported to occur in a significant number of patients diagnosed with coronavirus disease 2019 (COVID-19). We report our experience regarding the occurrence of symptomatic and asymptomatic CVDs in COVID-19 patients. In this cross-sectional study, 690 COVID-19 patients were included. Cardiovascular consultation had been requested for all of the patients based on their primary clinical examination, vital signs, and electrocardiogram (ECG). Additionally, 2D transthoracic echocardiography (TTE), and myocardial injury serum biomarkers assays (creatine phospho

Prevalence of tobacco use among cancer patients in Iran: a systematic review and meta-analysis.

BACKGROUND: The prevalence of tobacco use among various cancer types in Iran remains a significant concern, necessitating a comprehensive analysis to understand the extent and patterns of consumption. This study aimed to systematically review and analyze existing literature to delineate the prevalence of tobacco use across different cancer types in Iran, thereby providing a robust basis for future interventions and policy formulations. METHODS: Adhering to the PRISMA guidelines, we conducted a systematic review and meta-analysis of literature available in PubMed and Scopus databases. The init…

Applying a Computer-based Warfarin Management System at a Large Tertiary Cardiovascular Center in Iran.

BACKGROUND: Regarding adjustments to warfarin dosage, numerous studies have shown that computerized methods are superior to those based on personal experience. OBJECTIVES: To report the efficacy of a computer-based warfarin management system (WMS) in the Iranian population. METHODS: By utilizing the existing dosing algorithms and obtaining expert opinions, we developed a computer-based WMS at a large tertiary cardiovascular center. The time in therapeutic range and the number of international normalized ratio (INR) tests of clinic patients were compared before and after the implementation of…

Contribution of chromosomal aberrations to the pathogenesis of primary and secondary amenorrhea: A study from Western Iran.

OBJECTIVE: Amenorrhea is an abnormal condition characterized by the absence of menstruation in women of reproductive age. According to the W … e frequency and types of chromosomal abnormalities in women with amenorrhea in Kermanshah Province, Iran. METHODS: This retrospective study included patients with PA and SA who underwent standard cytogenetic analysis. We also conducted a review of the literature on chromosomal abnormalities and their prevalence in SA. RESULTS: Among the 137 cases of …

Motivation in caregiving among mothers of children with intellectual and developmental disabilities in Iran: A qualitative study.

BACKGROUND: The motivation of caregivers plays a crucial role in the treatment, follow-up, and care of children with intellectual and developmental disabilities. Previous studies have focused on the older people and end-stage diseases, while giving less attention to the motivation of mothers caring for children with special needs. This study aimed to explore the motivations of mothers caring for children with intellectual and developmental disabilities in Iran. METHODS: This study employed a qualitative approach, guided by the Self-Determination Theory. Purposeful sampling was initially used,…

Exposure to occupational air pollution and vascular endothelial dysfunction in workers of the steel industry in Iran.

Air pollution is recognized as a risk factor for cardiovascular diseases; however, the precise underlying mechanisms remain unclear. This study investigated the impact of occupational air pollution exposure on endothelial function in workers within the steel industry. Specifically, we examined male employees in the coke-making division of the Isfahan Steel Company in Iran, as well as those in administrative roles with no known history of cardiovascular risk. Data on age, body mass index, duration of employment, blood pressure, fasting blood sugar, and lipid profile were collected. To assess en…

Temporal characteristics and health effects related to NO2, O3, and SO2 in an urban area of Iran.

This study reports on temporal variations of NO2, O3, and SO2 pollutants and their related health effects in urban air of Khorramabad, Iran using AirQ 2.2.3 software. Based on data between 2015 and 2021, hourly NO2, O3, and SO2 concentrations increase starting at 6:00 a.m. local time until 9:00 p.m., 3:00 p.m., and 7:00 p.m. local time, respectively, before gradually decreasing. The highest monthly NO2, O3, and SO2 concentrations are observed in October, August, and September, respectively. Annual median NO2, O3, and SO2 concentrations range between 17 ppb and 38.8 ppb, 17.5 ppb-36.6 ppb, and …

Assessing the carcinogenic and non-carcinogenic health risks of metals in the drinking water of Isfahan, Iran.

Metals are significant contributors to water pollution, posing serious threats to human health. This study aims to assess the carcinogenic and non-carcinogenic health risks associated with metals in Isfahan drinking water. Eighty water samples were randomly collected from the city's distribution network between January and March 2020-2021. Inductively coupled plasma Optical Emission Spectrometry was used to measure toxic metals, namely Pb, Cr, Cd, Ni, and As concentrations. Results revealed that the mean concentration of Ni (70.03 µg/L) exceeded the WHO reference value (70 µg/L), while the oth

Seasonal Trends and Emergency Admissions for Obstetric Hemorrhage and Trauma among Pregnant Women in Iran.

OBJECTIVE: Globally, obstetric hemorrhage and trauma are the leading causes of maternal and fetal morbidity and mortality during pregnancy. Delivering high-quality medical care to these patients is therefore imperative.This study aims to examine the relationship between month of referral and the severity of emergency admissions among pregnant women referred for obstetric hemorrhage and trauma. MATERIALS AND METHODS: A retrospective cross-sectional analysis was conducted on hospital records of 1,684 pregnant women admitted to the case emergency center at Imam Reza Hospital in Mashhad, Iran for…

Assessment of trace element and mineral levels in students from Turkmenistan in comparison to Iran and Russia.

THE OBJECTIVE: Of the present study was to assess essential trace element and mineral levels in serum, hair, and urine of healthy first-year students from Turkmenistan (n = 73) in comparison to students from Iran (n = 78) or Russia (n = 95). MATERIALS AND METHODS: Examination of foreign students was performed within two days after arrival to Russia during medical examination prior admission to RUDN University. Serum, hair, and urine trace element and mineral levels were assessed with inductively coupled plasma-mass spectrometry (ICP-MS). RESULTS: The data demonstrate that the levels of trace…

Phylogeography and genetic structure of Papaver bracteatum populations in Iran based on genotyping-by-sequencing (GBS).

Papaver bracteatum, known for its high thebaine content and absence of morphine, has emerged as a promising alternative to opium poppy for codeine production. In this study, our objective was to create a diverse panel representing the natural variation of this species in Iran. To achieve this, we employed genotyping-by-sequencing to obtain genome-wide distributed single-nucleotide polymorphisms (SNPs) for phylogeographic analysis, population structure assessment, and evaluation of genetic diversity within P. bracteatum populations. A total of 244 P. bracteatum individuals from 13 distinct popu…

Clinical cause of neonatal mortality in Iran: analysis of the national Iranian Maternal And Neonatal network.

BACKGROUND: The neonatal mortality rate is a main indicator of the health and development of a country. Having insight into the cause of neonatal deaths may be the first step to reducing it. This paper depicts the cause of newborn deaths in Iran. METHODS: This cross-sectional study was performed on data from the national Iranian Maternal And Neonatal network to investigate all neonatal deaths in the country during the year 2019. The cause of death data were reported according to categories of birth weight, gestational age (GA), death time and place. RESULTS: The main causes of the 9959 neona…

The Prevalence of Epstein-Barr Virus in Normal, Premalignant, and Malignant Uterine Cervical Samples in Iran.

INTRODUCTION: It is suggested that Epstein-Barr virus (EBV) may play an important role in cervical cancer development. Most studies found a higher rate of EBV in cervical cancer samples in comparison to premalignant and normal groups. In this regard, this study aimed to investigate the prevalence of EBV in cervical samples. METHODS: In total, 364 samples from 179 healthy subjects, 124 women with premalignant lesions, and 61 patients with cervical cancer were investigated using nested-PCR. RESULTS: The mean age ± SE was 54.1 ± 13.4 in women with cervical cancer, 36.1 ± 9.4 among women with pr

High prevalence of HPV-56 and HPV-39 in Sari, Iran: an analysis of genotype distribution.

BACKGROUND: Human papillomavirus (HPV) is responsible for the most common sexually transmitted infection, particularly among sexually active individuals. Understanding the geographical distribution and epidemiology of the most prevalent HPV genotypes is essential for developing effective prevention strategies. Consequently, this study aimed to examine the distribution of HPV genotypes among HPV-positive women and men in Sari, the capital city of Mazandaran province in northern Iran. MATERIALS AND METHODS: HPV DNA was extracted (PZP Company, Molecular IVD, Iran) from genital and cervical sampl…