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Exosome-Enriched Hub Gene Networks Identify Diagnostic Biomarkers and Repurposable Therapeutic Targets in Endometriosis.

Endometriosis is a heterogeneous chronic inflammatory disorder associated with substantial diagnostic delay and limited therapeutic options, highlighting the need of robust non-invasive biomarkers and actionable molecular targets to complement existing low-sensitivity tests. To identify conserved pathogenic mechanisms with translational potential, here, we uniformly reprocessed three independent the Gene Expression Omnibus (GEO) microarray cohorts (GSE7305, GSE25628, and GSE11691) and applied a strict, directionally consistent intersection strategy to identify conserved transcriptional signals

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… VI, alpha 2 | 4.3 | 4.4 | 3.1 | cell adhesion CPE | carboxypeptidase E | 5.8 | 4.8 | 19.3 | None CPVL | carboxypeptidase, vitellogenic-like | 8.9 | 2.1 | 4.5 | None CRYAB | crystallin alpha B | 3.1 | 4.2 | 2.0 | None CXCL12 | chemokine (C-X-C motif) ligand 12 | 3.1 | 2.0 | 10.1 | cell adhesion DES | desmin …

BREAST

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… Tumor cells were focally positive for desmin and ALK (diffuse cytoplasmic staining) while negative for CK, SALL4, MUC4, SMA, CD30, CD45, CD3, CD20, SOX10, SMMHC, CD21, CD35, cathepsin K, myogenin, ERG, MPO, DOG1 and ROS1. BRG and INI1 expression was retained. … The mesothelial cells were immunopositive for cytokeratin, calretinin, desmin (diffuse) and EMA (focal) while were immunonegative for TTF-1, and claudin-4. P53 showed wild type immunoexpression. BAP1 was retained. Fluorescence in situ hybridisation assay was negative for CDKN2A homozygous deletion. …

Metastatic Breast Cancer: Review of Emerging Nanotherapeutics.

Metastases of breast cancer (BC) are often referred to as stage IV breast cancer due to their severity and high rate of mortality. The median survival time of patients with metastatic BC is reduced to 3 years. Currently, the treatment regimens for metastatic BC are similar to the primary cancer therapeutics and are limited to conventional chemotherapy, immunotherapy, radiotherapy, and surgery. However, metastatic BC shows organ-specific complex tumor cell heterogeneity, plasticity, and a distinct tumor microenvironment, leading to therapeutic failure. This issue can be successfully addressed b

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… Subsequently, a change in pericyte phenotype involving the altered expression of desmin and CD13 affects the permeability of the barrier, as seen in BC brain metastasis [ 79 ]. These changes allow metastatic BC cells to easily cross the BBB. …

The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?

Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small lung cancer or renal cell carcinoma. These humanized monoclonal antibodies target inhibitory receptors (e.g. CTLA-4, PD-1, LAG-3, TIM-3) and ligands (PD-L1) expressed on T lymphocytes, antigen presenting cells and tumor cells and elicit an anti-tumor response by stimulating immune system. Nevertheless, the improved overall survival is complicated by the manifestation of Immune-related Adverse Effects (irAEs). During treat

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… Within the tumors of these patients, Authors observed high levels of self-muscle-specific antigens (desmin and troponin) indicating that T cells could be targeting an antigen shared by the melanoma, skeletal muscle, and the heart ( 69 ). …

Translational horizons in the tumor microenvironment: harnessing breakthroughs and targeting cures.

Chemotherapy and targeted therapy have opened new avenues in clinical oncology. However, there is a lack of response in a substantial percentage of cancer patients and diseases frequently relapse in those who even initially respond. Resistance is, at present, the major barrier to conquering cancer, the most lethal age-related pathology. Identification of mechanisms underlying resistance and development of effective strategies to circumvent treatment pitfalls thereby improving clinical outcomes remain overarching tasks for scientists and clinicians. Growing bodies of data indicate that stromal

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… and activity occurs in morbid contexts, including desmoplasia that is characterized by a dense collagenous stroma and accumulation of fibroblasts within the primary tumor. 25 Activated fibroblasts express mesenchymal markers, such as fibroblast-specific protein 1, fibroblast-activating protein (FAP), desmin …

Malignant mesothelioma tumours: molecular pathogenesis, diagnosis, and therapies accompanying clinical studies.

The pathetic malignant mesothelioma (MM) is a extremely uncommon and confrontational tumor that evolves in the mesothelium layer of the pleural cavities (inner lining- visceral pleura and outer lining- parietal pleura), peritoneum, pericardium, and tunica vaginalis and is highly resistant to standard treatments. In mesothelioma, the predominant pattern of lesions is a loss of genes that limit tumour growth. Despite the worldwide ban on the manufacture and supply of asbestos, the prevalence of mesothelioma continues to increase. Mesothelioma presents and behaves in a variety of ways, making dia

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… Utility of BerEp4/calretinin and desmin/epithelial membrane antigen (EMA) dual immunocytochemical staining in effusion cytology. Cancer Med (2022) 12:5334–5340. doi: 10.1002/cam4.5353 70. Barrette L-X, Suresh N, Salmon MK, De Ravin E, Harris J, Kamdar R, et al. …

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research.

Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research

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… The mechanism by which changes in circulating testosterone and 17-beta-estradiol drive voiding dysfunction are not clear but may include direct actions on the bladder [ 134 , 135 ], changes in prostatic desmin and smooth muscle actin content or function [ 136 , 137 , 138 , 139 ]. …

Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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… In hDM1-myo, we quantified MSI2 silencing, myogenic fusion (desmin immunostaining) and transcriptomic changes. … The ASPIRO trial assessed the safety and efficacy of resamirigene bilparvovec (rAAV8-desmin-hMTM1), a gene replacement therapy that expresses human MTM1 in muscles, in children with XLMTM. …

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination.

The stromal microenvironment regulates mammary gland development and tumorigenesis. In normal mammary glands, the stromal microenvironment encompasses the ducts and contains fibroblasts, the main regulators of branching morphogenesis. Understanding the way fibroblast signaling pathways regulate mammary gland development may offer insights into the mechanisms of breast cancer (BC) biology. In fact, the unregulated mammary fibroblast signaling pathways, associated with alterations in extracellular matrix (ECM) remodeling and branching morphogenesis, drive breast cancer microenvironment (BCM) rem

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… Other important markers for the identification and characterization of BCAFs are vimentin, fibroblast specific protein (FSP), fibroblast activation protein (FAP), osteonectin, desmin, TNC, PDGFR α/β, and the loss of Cav-1 and/or CD34 [ 12 , 94 , 95 ]. …

Research Communications of the 26th ECVIM‐CA Congress

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Nanoimmunotherapy: the smart trooper for cancer therapy.

Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body's immune system to fight cancer. Despite initial successes, its broader clinical application is hindered by limitations such as heterogeneity in patient response and challenges associated with the tumor immune microenvironment. Recent advancements in nanotechnology have offered innovative solutions to these barriers, providing significant enhancements to cancer immunotherapy. Nanotechnology-based approaches exhibit multifaceted mechanisms, including effective anti-tumor immune response

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… During their quiescent state, pancreatic stellate cells (PSCs) produce degradation enzymes and ECM proteins including desmin and vimentin, which aid in the alteration of ECM. …

The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease.

The well-orchestrated turnover of proteins in cross-striated muscles is one of the fundamental processes required for muscle cell function and survival. Dysfunction of the intricate protein degradation machinery is often associated with development of cardiac and skeletal muscle myopathies. Most muscle proteins are degraded by the ubiquitin-proteasome system (UPS). The UPS involves a number of enzymes, including E3-ligases, which tightly control which protein substrates are marked for degradation by the proteasome. Recent data reveal that E3-ligases of the cullin family play more diverse and c

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… At the molecular level, Fbxl22 overexpression affected protein levels of dystrophin, desmin, vimentin, and sarcomeric Actn2. However, alterations in Actn2 levels were Fbxl22 isoform-dependent, displaying a significant reduction of Actn2 only upon loss of the shorter Fbxl22 transcript. …

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities.

The evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signaling pathways. Cellular behaviors such as proliferation, differentiation, maturation, and proper body-axis specification are carried out by the canonical pathway, which is the best characterized of the known Wnt signaling paths. Wnt signaling has emerged as an important factor in stem cell biology and is

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… with dilated cardiomyopathy and ischemic cardiomyopathy, suggesting similarity with the phenotype observed in sFRP1 knockout mice. 312 Hou et al discovered that β-catenin is stabilized and translocated to the nucleus of cardiomyocytes in human ischemic and dilated cardiomyopathy, as well as in mouse desmin …

Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies.

Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment str

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… RMS differs from other small round blue cell tumors such as neuroblastoma and Ewing sarcoma via immunohistochemical staining revealing muscle cell markers such as alpha-actin, MyoD1, myogenin, and desmin [ 3 ]. …

Program-Abstracts

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UEG Week 2015 Poster Presentations

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Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022

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Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations.

Protein folding is a fundamental process ensuring that polypeptide chains acquire the correct three-dimensional structures required for biological function. This complex journey from nascent polypeptides to mature proteins is tightly regulated by the cellular proteostasis network-an integrated system of molecular chaperones, folding enzymes, and degradation machineries. Disruptions in this network lead to dysproteostasis, a pathological state implicated in a growing list of human diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. In this review, we provide a comp

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… CRYAB variants are also linked to diseases of muscle tissue, such as desmin-related myopathy (DRM; D109G, R120G) and dilated cardiomyopathy (DCM; D109G, R120G, R123W, G154S, R157H). 237 An in vivo study on cardiomyocyte-specific expression of the R120G variant further demonstrated how it may affect the …

ISEV2018 абстрактная книга

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Integumentary System

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