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Midwifery-led continuity-of-care education affects health literacy, empowerment and childbirth fear: a quasi-experimental study.

BACKGROUND: According to the World Health Organisation, antenatal care should ensure continuity, respect and evidence-based education. Fear of childbirth (FOC), affecting 20-40% of women globally, contributes to prolonged labour, higher caesarean rates and negative birth experiences. In Türkiye, where midwifery-led support remains limited, this study examined how pregnant women's health literacy influences empowerment and FOC within antenatal care and evaluated the effectiveness of the midwifery-led continuity-of-care (MLCC) model. METHODS: A quasi-experimental study with a comparative group …

Fear of cancer recurrence among cancer survivors in South Korea: high prevalence and predictors of clinical FCR.

PURPOSE: This study examined the prevalence of fear of cancer recurrence (FCR) and its related factors among cancer survivors in South Korea. METHODS: Between August 2021 and November 2022, 345 cancer survivors were recruited from the National Cancer Center, regional cancer centers, university hospitals, and local communities in South Korea. Participants completed self-report questionnaires, including the Korean version of Fear of Cancer Recurrence Inventory-Short Form (K-FCRI-SF) via mobile platforms, and underwent structured diagnostic interviews using the Korean version of the Mini-Interna…

Serum Neurofilament Light Chain in Diabetic Polyneuropathy: Associations with Neuropathy Burden, Balance Impairment, and Fear of Falling.

Objective: To compare serum neurofilament light chain (NfL) concentrations between individuals with type 2 diabetes mellitus (T2DM) with and without diabetic polyneuropathy (DPN), and to examine associations with neuropathy burden, balance impairment, fear of falling, and fall history. Methods: This analytical cross-sectional study included 88 participants with T2DM (44 with DPN and 44 without DPN). Serum NfL was measured by enzyme-linked immunosorbent assay (ELISA); neuropathy burden was assessed with the Michigan Neuropathy Screening Instrument (MNSI), balance with the Berg Balance Scale (BB…

The Effects of Cancer Fear and Ruminative Thinking Styles on Attitudes Toward Cancer Screening Among Cancer Caregivers.

Despite being exposed to a high risk of cancer and a substantial psychological burden, cancer caregivers often neglect their own health check-ups and cancer screening behaviors. This study aimed to examine the effects of ruminative thinking styles and cancer fear on attitudes toward cancer screening among cancer caregivers. This cross-sectional descriptive study was conducted between August 2025 and January 2026 with 446 primary caregivers of patients receiving outpatient treatment in the medical and radiation oncology departments of a training and research hospital located in eastern Turkey. …

Facial emotion recognition accuracy in women with symptoms of polycystic ovary syndrome: Reduced fear and disgust perception.

BACKGROUND: Research suggests that women with polycystic ovary syndrome (PCOS) are more likely to suffer from mental health disorders, emoti … ut PCOS, and men; N = 178) completed a FER task that involved identifying emotions (anger, disgust, fear, happiness, sadness, surprise, or neutral) in images of emotional faces. Overall emotion recognition and emotion-specific accuracy were examined. PCOS symptom severity and provisional diagnoses were also assessed in women via self-report measures, i …

Social buffering during fear extinction rescues long-term trauma-induced memory and emotional behavioral alterations in rats.

Post-Traumatic Stress Disorder (PTSD) is a psychiatric disease that may develop after experiencing a traumatic event and it is characterized by resistance to extinction of the traumatic memory. Psychotherapy, which mainly focuses on favoring fear memory extinction, represents the first-line treatment for PTSD. However, this approach is not always successful. Emerging evidence suggests the importance of a social support in alleviating PTSD symptomatology; however, the efficacy of group therapy for PTSD remains controversial. Here, we evaluated the impact of social support on the efficacy of fea…

Low-intensity transcranial ultrasound stimulation promotes the extinction of fear memory through the BDNF-TrkB signaling pathway.

Synaptic plasticity plays a crucial role in the extinction of fearful memories. Low-intensity transcranial ultrasound stimulation (TUS) can modulate synaptic plasticity and promote the extinction of fear memories. However, the mechanism by which TUS promotes the extinction of fear memory remains unclear. This study aimed to explore whether and how synaptic plasticity under TUS is involved in modulating fear memory and the role of the brain-derived neurotrophic factor (BDNF)-the tropomyosin-related kinase B (TrkB) signaling pathway in this process. We used behavioral tests and two-photon fluore…

Sex differences in G protein-coupled estrogen receptor-mediated mechanisms in preclinical models of anxiety and fear.

Sex differences are well-documented in the prevalence of psychiatric disorders, with anxiety and stress-related conditions more common in women. Growing evidence highlights the role of sex hormones, particularly estradiol (E2), and its receptor mechanisms as contributing factors to this disparity. Estrogen exerts its effects through three main receptors: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and the G protein-coupled estrogen receptor (GPER). While the classical receptors ERα and ERβ have been widely studied in the context of fear and anxiety, the role of GPER remains le…

Pavlovian fear reversal learning predicts outcome of exposure-based cognitive behavioral therapy for adult obsessive-compulsive disorder.

Extinction of conditioned fear responses is assumed to relate to beneficial effects of exposure-based treatment, but few studies investigated the role of fear conditioning for exposure techniques in clinical settings. Specifically, no study addressed the relationship between psychophysiological indicators of extinction and outcome of exposure and response prevention (ERP) in adult obsessive-compulsive disorder (OCD). This study investigated whether skin conductance responses (SCRs) to threat and safety signals in a pre-treatment Pavlovian reversal learning experiment predicted the outcome of i…

Evaluation of a brief, online imagery rescripting intervention targeting fear-of-self in high obsessive-compulsive participants.

Emerging evidence suggests that rescripting aversive memories related to obsessive-compulsive disorder (OCD) may improve symptoms and OCD-relevant cognitive and affective outcomes. We aimed to validate an online, audio-guided imagery rescripting protocol by comparing it with a focused, thought-listing control. A sample of Prolific online workers (n = 112) with high OCD symptoms identified a memory associated with OCD-related experiences, then were randomly assigned to complete either the rescripting or control task. Select outcomes were re-assessed one-week post-experiment. Feared self-percept…

Fear of Food in Eating Disorders: Its Role in Eating Disorder Symptomatology, Psychopathology, and Early Outpatient Treatment.

Anxiety is known to be correlated with eating disorder (ED) symptoms, but less is known about anxiety in terms of fear of food in EDs. The study aims to compare different ED groups, investigate early changes in fear of food following cognitive-behavioral-based treatment (CBT) with integrated nutritional rehabilitation and counseling and test whether changes in fear of food are associated with changes in eating symptomatology and general psychopatology. ED outpatients (n = 282) and controls (n = 68) were assessed with the Fear of Food Measure (FOFM), Eating Attitude Test-40 (EAT-40), and Eating…

Страх рецидива рака у онкогематологических пациентов: инструменты оценки и основанные на фактических данных психологические меры - систематический обзор.

ВВЕДЕНИЕ: онкогематологические пациенты проходят сложный процесс эмоциональной адаптации, в рамках которого страх перед раком периодически возникает (ОКП). one из наиболее распространенных проблем. Этот страх не только негативно сказывается на их психологическом благополучии, но и связан со значительным снижением качества жизни. ЦЕЛЬ: Цель настоящего исследования заключается в проведении систематического обзора имеющихся доказательств в отношении: (1) факторы, связанные с FCR у онкогематологических пациентов.2) действительность и надежность инструментов, используемых для его оценки (см.3) тера

Совпадение в аннотации оригинала
INTRODUCTION: Oncohematological patients undergo a complex emotional adaptation process, in which Fear of Cancer Recurrence (FCR) is one of the most prevalent concerns. This fear not only negatively impacts their psychological well-being but is also associated with a significant reduction in quality of life. OBJECTIVE: This study aims to conduct a systemati…

Sex-dependent role of Neuropeptide-S on anxiety, fear conditioning, and alcohol seeking in alcohol preferring rats.

Alcohol Use Disorder (AUD) is a global health concern, with stress playing a crucial role in its development and persistence. Currently, no … archigian Sardinian alcohol-preferring (msP) rats. To assess its impact on locomotion, anxiety, and fear memory, we conducted an open-field, an elevated plus maze (EPM), and a fear conditioning (FC) paradigm following intracerebroventricular administration of NPS. Furthermore, we examined the effects of NPS on ASA and yohimbine-induced reinstatement of …

Identifying cognitive-affective mechanisms underlying disability in episodic migraine: Using the fear avoidance model to examine interactions.

OBJECTIVE: Using the fear-avoidance model (FAM) as a theoretical framework, this study examined the interactions between empirical factors contributing to disability in episodic migraine. It was tested whether pain catastrophizing, fear of attacks, and depressiveness mediate the relationship between pain experience and disability. BACKGROUND: Migraine is a prevalent primary headache disorder associated with significant impairment in daily life. Biological and psychosocial factors contribute to its impact; however, a comprehensive model explaining the mechanisms underlying migraine-related dis…

Association between lumbopelvic pain in pregnancy and fear of childbirth: a multicenter cross-sectional case-control study.

BACKGROUND: Fear of childbirth is a common occurrence during pregnancy, causing unnecessary caesarean sections due to anxiety and pain catastrophizing. Lumbopelvic pain is also very prevalent during pregnancy and similarly linked to anxiety and pain catastrophizing. Although these two issues appear to have commonalities, their relationship has not been explored yet. This study aims to investigate the potential correlation between fear of childbirth and lumbopelvic pain during pregnancy, addressing a gap in the current literature. METHODS: Online surveys were emailed to pregnant women with lum…

How Do Fear-Avoidance and Catastrophizing Pain Beliefs Affect Functional Status and Disease Activity in Axial Spondyloarthritis?

Background and Objectives: The objective of our study was to describe the biopsychosocial profile of individuals diagnosed with axial spondyloarthritis (AxSpA) and to analyze how their clinical characteristics interact with disease activity. Materials and Methods: An observational study was conducted, involving 28 participants diagnosed with AxSpA. We evaluated clinical outcomes (perceived pain, range of motion [RoM], pressure pain threshold [PPT], and proprioceptive acuity), psychosocial outcomes (the Pain Catastrophizing Scale [PCS], Tampa Scale of Kinesiophobia [TSK-11], and the Fear-Avoida…

Cumulative genetic effects of HPA axis on social phobia scrutiny fear: psychoticism and social face as mediators.

BACKGROUND: Social phobia scrutiny fear is a stress response triggered by perceptions of social evaluation. However, the role of genetic polymorphisms in the Hypothalamic Pituitary Adrenal (HPA) axis in shaping this fear is not well understood. This study investigates how the cumulative genetic score of the HPA axis influences social phobia scrutiny fear. METHOD: Two independent samples were used. The first examined the relationship between the cumulative genetic effects of the HPA axis and social phobia scrutiny fear. The second sample replicated these findings and explored the mediating rol…

Teaching Cancer Survivors Coping Skills for Managing Fear of Recurrence: Insights From a Pilot Randomized Controlled Trial.

PURPOSE: Fear of cancer recurrence (FCR) is highly common and, if poorly managed, can be distressing and impairing. We developed a virtual, mind-body resiliency intervention for fear of cancer recurrence in survivorship (IN FOCUS), which was shown to be feasible and improved FCR post-intervention. This report aimed to describe coping processes associated with FCR and effects of IN FOCUS on coping over time. METHOD: A single-blinded, 2-arm, randomized controlled trial was conducted from July 2021 to March 2022 comparing IN FOCUS (8 weekly, 90-minute, synchronous virtual group classes teaching …

Sex-specific effects of predator scent stress on fear, anxiety-like behavior and methamphetamine seeking in rats.

UNLABELLED: Recombinant hepatitis B vaccine Engerix B((R)) [Hep-B(Eng)] is a noninfectious subunit hepatitis B viral vaccine indicated for the active immunisation of adults, children and infants against hepatitis B virus infection. It contains hepatitis B surface antigen (HBsAg) which is produced by the yeast Saccharomyces cerevisiae by use of recombinant DNA technology. In adults and children seroprotection rates [anti-HBsAg antibody (anti-HBs) titres >or=10 IU/L] were 93 to 100% 1 month after completion of the immunisation schedule with Hep-B(Eng) [0, 1, 6-month schedule]. A more rapid immun