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[Cardiovascular risk factors and prevention in women: similarities and differences].

Epidemiological evidence shows that among women, the incidence of all, including less severe, coronary events is still increasing. However, owing both to diminished lethality as well as the reduction in the rate of acute myocardial infarction, mortality has globally decreased. The strong association observed between mortality and major cardiovascular risk factors as well as between their temporal changes and the occurrence of coronary disease makes the undertaking of multifactorial prevention strategies, including the formulation of risk charts for asymptomatic women and men, necessary. The di

Exenatide added to insulin therapy: a retrospective review of clinical practice over two years in an academic endocrinology outpatient setting.

BACKGROUND: Exenatide is an antidiabctic agent currently indicated as adjunctive therapy with oral agents for the treatment of type 2 diabetes mellitus (T2DM). Limited published data exist on the off-label use of exenatide in conjunction with insulin in the treatment of T2DM. OBJECTIVE: The aim of this retrospective study was to examine the effects of exenatide on glycemic control, weight, and insulin dose in patients with T2DM treated with insulin. METHODS: Patients with T2DM receivirg insulin and adjuvant therapy with exenatide at an endocrinology clinic at a university hospital for up to

Цитокиновые профили молекулярных маркеров связаны с физическими упражнениями и инсулиновой терапией у пациентов с типом 2 Диабет Mellitus.

Тип фона 2 Для сахарного диабета характерны хроническое низкосортное воспаление, иммунная диагностика и нарушение метаболизма. В ходе этого исследования были изучены цитокины, связанные с физическими упражнениями и инсулиновой терапией у пациентов с типом 2 Отбор проб метеотипов был произведен из сахарного диабета. 51 Добровольцы для оценки метаболических параметров и концентраций цитокина. Согласно глицемическому статусу и инсулину, участники были отнесены к недиабетическим, не зависящим от инсулина типам 2 Диабет Mellitus и инсулин-зависимый тип 2 Диабет группы Mellitus. Оскорбляет физически

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… Abbreviations ADA American Diabetes Association ANOVA Analysis of Variance BMI Body Mass Index CBA Cytometric Bead Array CRP C-Reactive Protein DM Diabetes Mellitus GI Glycemic Index HIV Human Immunodeficiency Virus I-T2DM Insulin-Dependent Type 2 Diabetes Mellitus IFN-γ Interferon Gamma IL Interleukin …

Report of the committee on the classification and diagnostic criteria of diabetes mellitus.

Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involves both genetic and environmental factors. The long-term persistence of metabolic disorders can cause susceptibility to specific complications and also foster arteriosclerosis. Diabetes mellitus is associated with a broad range of clinical presentations, from being asymptomatic to ketoacidosis or coma, depending on the degree of metabolic disorder. CLASSIFICATION TABLES 1 AND 2 AND FIGURE 1: [Table: s

Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study.

There have been conflicting results regarding the association between diabetes and the risk of hematologic malignancies, and its interaction with obesity is unknown. This study determined the risk of hematologic malignancies according to the glycemic status in a population-based study involving health screening 9,774,625 participants. The baseline glycemic status of the participants was categorized into no diabetes, impaired fasting glucose (IFG), newly detected diabetes, diabetes duration <5 years, and diabetes duration ≥5 year groups. The risks of overall and specific hematologic malignancie

Регулирование глюкозы как движущая сила аутоиммунной мимикрии, воспаления и психиатрических Симптомов: обзор наизусть.

Происхождение глицемии влияет на широкий спектр психических и физиологических симптомов. Многие психические заболевания связаны с плохим регулированием глюкозы. Антиядерные антитела (АНА), широко используемые для выявления аутоиммунных заболеваний, могут иногда отражать переходную метаболическую активацию иммунной системы, а не хроническую патологию. Имеющиеся данные свидетельствуют о том, что регулирование глюкозы, включая глицемическую изменчивость, реактивную гипогликемию и постприндиальные шипы, может вызвать системное воспаление, нейропсихиатрические симптомы и временное производство авто

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… Classic examples of VLCDs and related approaches include the classic ketogenic diet [ 67 , 68 ], modified Atkins diet [ 70 , 71 , 72 ], low glycemic index treatment [ 73 ], paleo [ 74 , 75 , 76 ], carnivore [ 77 ], and broadly, the very low-calorie ketogenic diet, among others. … A network meta-analysis comparing multiple dietary approaches found that ketogenic and low-carbohydrate diets produced significant reductions in HbA1c of approximately −0.73% and −0.69%, respectively, compared to control diets, with Mediterranean and low glycemic index diets demonstrating the strongest …

Endoscopic management of obesity: Impact of endoscopic sleeve gastroplasty on weight loss and co-morbidities at six months and one year.

INTRODUCTION: Endoscopic sleeve gastroplasty (ESG) is one of the new minimally invasive endoscopic treatments aimed at inducing weight loss. Its effectiveness in terms of weight loss is proven. Gastric volume reduction and delayed gastric emptying are the mechanisms that drive weight loss. However, potential benefits for co-morbidities in relation to weight loss after ESG are still being investigated. This study aims to evaluate the effect of ESG procedures on major obesity-associated co-morbidities, and on some biological parameters. PATIENTS AND METHODS: This is a series of consecutive case

Enteral Nutrition Preparations for Blood Glucose Variability and Prognosis for Severe Acute Pancreatitis With Stress Hyperglycemia.

CONTEXT: Severe acute pancreatitis (SAP) is a common critical illness, and stress hyperglycemia is the greatest independent risk factor for poor prognoses in critically ill patients. Enteral nutrition can not only provide an essential energy source for the body and improve a patient's intestinal micro-ecology but also can play a critical role in blood glucose management, especially for blood glucose variability. OBJECTIVE: The study intended to investigate the effects of different enteral nutrition preparations, including a slow-release starch, on blood glucose variability, nutritional status

Alpha-lipoic acid as a trigger of insulin autoimmune syndrome: Current evidence, a case-based approach, diagnostic pitfalls, and practical management.

Insulin autoimmune syndrome (IAS), also known as Hirata disease, is a rare immune-mediated cause of endogenous hyperinsulinemic hypoglycemia characterized by circulating insulin autoantibodies (IAAs). It typically develops in individuals without prior exposure to exogenous insulin. Although IAS has been associated with viral infections and, less commonly, with autoimmune and hematologic disorders, medications and dietary supplements are considered the most frequent precipitating factors. Sulfhydryl-containing compounds are the most commonly implicated triggers. Methimazole represents the class

Применение непрерывного мониторинга глюкозы в когнитивных исследованиях диабета: обзор скопирования.

ЦЕЛЬ ОБЗОРА: Непрерывный мониторинг глюкозы (КГМ) все чаще включается в исследования по изучению когнитивных функций у больных диабетом. В этом аналитическом обзоре систематически картируется, каким образом КГМ применяется в когнитивных исследованиях среди лиц, страдающих диабетом, для характеристики нынешних методологических подходов, выявления ключевых пробелов в знаниях и информирования о будущих исследованиях. ПОСЛЕДНИЕ ВЫВОДЫ: Обзор аналитического исследования был проведен в соответствии с принципами Аркси и О'Мэлли. Систематический поиск five Были созданы электронные базы данных (PubMed,

Воздействие лирагулитида на инсулиновую аллергию у пациента с глюкокортикоидным диабетом и множественным склерозом.

Глюкокортикоидное применение может вызвать вторичный диабет или усугубить гипергликемию у пациентов с сахарным диабетом (DM). Лираглютид - это глюкагон. peptide-1 (В тыс.GLP-1) рецептор агонист, используемый для лечения пациентов с типом 2 диабет. В нескольких сообщениях лирагулитид упоминается в качестве средства лечения ДМ, вызванного стероидами (SIDM). Здесь мы сообщаем о пациенте с SIDM и множественным склерозом, для которого переход на лирагулитид в сочетании с метформиновой терапией повысил уровень глюкозы и улучшил симптомы инсулиновой аллергии. Лираглютид может быть полезен для лечения

Association of Deviation From Glycated Hemoglobin (HbA1c) Target in the Guidelines for the Treatment of Diabetes in Older Patients With Place of Care and Interval Between HbA1c Tests Among Older Patients Receiving Home Medical Care.

AimWe examined the association of deviation from the glycated hemoglobin (HbA1c) target proposed in the Guidelines for the Treatment of Diabetes in Older Patients in Japan 2016 with the place of care and interval between HbA1c tests among older patients with diabetes.MethodsWe included patients aged > 65 years receiving biweekly home medical care by physicians from four clinics in Tokyo and Kanagawa Prefecture for > 2 months with ≥ 2 HbA1c tests between November 14, 2016 and November 13, 2021. Among patients meeting the glycemic target according to the above guidelines at the beginning of the

Risk Factors and Prevention of Cancer and CVDs: A Chicken and Egg Situation.

Cardiovascular diseases and cancer are the two primary causes of mortality worldwide. Although traditionally regarded as distinct pathologies, they share numerous pathophysiological mechanisms and risk factors, including chronic inflammation, insulin resistance, obesity, and metabolic dysregulation. Notably, several cancers have been identified as closely linked to cardiovascular diseases, including lung, breast, prostate, and colorectal cancers, as well as hematological malignancies, such as leukemia and lymphoma. Additionally, renal and pancreatic cancers exhibit a significant association wi

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… Dietary glycemic index, glycemic load, and renal cancer risk: Findings from prostate, lung, colorectal, and ovarian cancer trial Front. Nutr. 2023 10 1073373 10.3389/fnut.2023.1073373 37346909 PMC10279873 18. Ke J. Lin T. Liu X. Wu K. Ruan X. Ding Y. Liu W. Qiu H. Tan X. Wang X. … Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC) Nutr. Metab. Cardiovasc. Dis. 2015 25 795 815 10.1016/j.numecd.2015.05.005 26160327 89. Tang W.W. Kitai T. Hazen S.L. …

Semaglutide: a key medication for managing cardiovascular-kidney-metabolic syndrome.

Recent trials underscore the cardiovascular (CV), renal, and metabolic benefits of semaglutide in individuals with and without type 2 diabetes (T2D). In T2D, semaglutide enhances glycemic control, reduces major adverse CV events (MACE), and slows chronic kidney disease (CKD) progression. The SUSTAIN-6 trial demonstrated a 26% MACE reduction (HR 0.74; 95% CI: 0.58-0.95; p = 0.02) in high CV-risk patients with T2D using semaglutide (0.5 or 1.0 mg weekly). Similarly, the FLOW trial showed a 24% reduction in major kidney disease events (HR 0.76; 95% CI: 0.66-0.88; p = 0.002) with weekly 1.0 mg sem

Уровни гингивальной креветочной жидкости пролактина у пациентов, страдающих периодонтитом, с контролируемым или неконтролируемым типом 2 диабет. Контролируемое клиническое испытание.

В ходе этого исследования были исследованы уровни гингивальной кревикулярной жидкости (ГХФ) гормона пролактина (ПРЛ) на этапе III периодонтит (П) пациентов с типом 2 сахарный диабет (T2DM) до и 3 через несколько месяцев после нехирургической периодической терапии (НППТ). В этом деле под контролем суда, 80 Темы были разделены на 4 группы: группа I: здоровый контроль; группа II: системно здоровый этап III P пациентов; группа III: этап III P пациентов с контролируемым Т2ДМ; группа IV: этап III P пациентов с неконтролируемым Т2ДМ. Все пациенты П получили NSPT. Three Спустя несколько месяцев после

Interactions between kidney disease and diabetes: dangerous liaisons.

BackgroundType 2 diabetes mellitus (DM) globally affects 18-20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-third of the patients with DM2. In addition to the pancreas, adipocytes, liver, and intestines, the kidneys also play an important role in glycemic control, particularly due to renal contribution to gluconeogenesis and tubular reabsorption of glucose.MethodsIn this review article, based on a report of discussions from an interdisciplinary group of experts in the areas of endocrinolo

Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials.

Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. GLP-1 agonists, used to treat type 2 diabetes, have been shown to be effective in promoting weight loss in preclinical and clinical studies. This review summarizes numerous studies conducted on the main drugs in the GLP-1 agonists class, outlini

Management and Clinical Outcomes of Scleredema Diabeticorum: A Scoping Review.

Background/objectivesThe objective of this scoping review was to systematically map the available evidence for the management of scleredema diabeticorum (SD) to summarize the documented clinical outcomes with the aim to inform clinical practice and identify research gaps.MethodsWe conducted a scoping review identifying studies published in English from January 2005 to July 2025 through a comprehensive search of Scopus, MEDLINE, and the Cochrane Library. Eligible studies included randomized controlled trials, observational studies, case series, and case reports on treatment interventions and cl

The Multifaceted Nature of GLP-1: Molecular Mechanisms and Signaling Pathways in Metabolic and Neurodegenerative Diseases.

The aim of this article is to present the current state of knowledge regarding the use of GLP-1 agonists in the treatment of type 2 diabetes, obesity, and other potential clinical indications, including neurodegenerative conditions. The article describes the characteristics of the diseases discussed, with particular emphasis on the pathophysiological mechanisms and the impact of metabolic disorders on the course of the diseases. In addition, the specific role of GLP-1 receptor agonists and their mechanisms of action leading to improved clinical outcomes were discussed, including their impact o

Micro- and Macrovascular Complications in Early-Onset Type 2 Diabetes in Indians: Prevalence and Predictors in a Prospective Cross-Sectional Study.

Introductionand Aims: The prevalence of T2DM is rising among young people, placing them at greater risk for complications. We studied the prevalence and predictors of micro- and macrovascular complications in early-onset diabetes subjects (EOD, MethodsA total of 800 subjects (400 EOD, 400 LOD), matched for gender and diabetes duration, were prospectively recruited and assessed for the prevalence of peripheral neuropathy, retinopathy, nephropathy, and ASCVD. Multivariate logistic regression analyzed predictors of diabetes complications.ResultsThe median age at diagnosis of diabetes was 35 years