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Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment.

Fibromyalgia syndrome is mainly characterized by pain, fatigue, and sleep disruption. The etiology of fibromyalgia is still unclear: if central sensitization is considered to be the main mechanism involved, then many other factors, genetic, immunological, and hormonal, may play an important role. The diagnosis is typically clinical (there are no laboratory abnormalities) and the physician must concentrate on pain and on its features. Additional symptoms (e.g., Raynaud's phenomenon, irritable bowel disease, and heat and cold intolerance) can be associated with this condition. A careful differen

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… In particular, viruses such as HCV, HIV, Coxsackie B, and Parvovirus [ 121 – 124 ] and bacteria like Borrelia [ 125 , 126 ] could be involved. … Rheumatology 1997 36 9 981 985 2-s2.0-0030798295 9376995 10.1093/rheumatology/36.9.981 122 Nash P Chard M Hazleman B Chronic Coxsackie B infection mimicking primary fibromyalgia Journal of Rheumatology 1989 16 11 1506 1508 2-s2.0-0024845330 2557447 123 Leventhal LJ Naides SJ Freundlich B Fibromyalgia and parvovirus …

COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches.

Extensive research in countries with high sociodemographic indices (SDIs) to date has shown that coronavirus disease 2019 (COVID-19) may be directly associated with more severe outcomes among patients living with haematological disorders and malignancies (HDMs). Because individuals with moderate to severe immunodeficiency are likely to undergo persistent infections, shed virus particles for prolonged periods, and lack an inflammatory or abortive phase, this represents an overall risk of morbidity and mortality from COVID-19. In cases suffering from HDMs, further investigation is needed to achi

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… Accordingly, the most common infectious agents include viral hepatitis, human immunodeficiency virus (HIV) [ 58 ], cytomegalovirus (CMV) [ 59 ], parvovirus B19 (PVB19) [ 60 ], and Epstein-Barr virus (EBV) [ 59 ]. … A review of blood diseases and cytopenias associated with human parvovirus B19 infection. Rev Med Virol. 2015;25:224–240. doi: 10.1002/rmv.1839. 61. Nasiri K, Mohammadzadehsaliani S, Kheradjoo H, Shabestari AM, Eshaghizadeh P, Pakmehr A, Alsaffar MF, Al-Naqeeb BZT, Yasamineh S, Gholizadeh O. …

Changes in C-Reactive Protein Forecast Infection Risk Following Treatment with Chimeric Antigen Receptor T Cells.

BACKGROUND: Immunosuppressive conditioning regimens for chimeric antigen receptor-modified T cell immunotherapy (CARTx) and subsequent T cell dysfunction increase risk for infection. However, it is difficult to discern infection from CRS in the early (up to Day 30) and late (Days 31-180) periods after CARTx due to overlapping signs and symptoms. METHODS: We analyzed infectious complications and predictors of infection during the early and late periods after CARTx in 213 adult patients with malignancies over a 5-year period. RESULTS: Overall, 75 patients (35%) had at least one infection, most

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… (Days 31–180) All infections | 57 | 24 Bacteremia | 15 | 3 Gram-negative | 7 | 2 Gram-positive | 8 | 1 C. difficile infection | 7 | 0 Viral infection | 10 | 14 Adenovirus | 1 | 1 BK virus | - | 1 CMV | 4 | - HHV-6 | - | 1 Parainfluenza | 1 | 2 Parvovirus B19 | - | 1 Rhinovirus/enterovirus | 3 | 2 RSV …

Взгляды на амбулаторное лечение би-специальных T-Cell-Worker терапий для нескольких миелом.

В последние несколько лет была разработана новая перспективная терапия под названием < < Участок Т-клеток > > (TCE), которая в настоящее время доступна во многих странах для пациентов с повторной или рефрактной множественной миеломой. Лица, занимающиеся деятельностью Т-клеток, связаны с устойчивыми показателями эффективности и беспрогрессивными льготами по выживанию у пациентов с хорошо обработанной миеломой. Однако такие осложнения, как синдром высвобождения цитокина (CRS), синдром нейротоксичности, связанный с иммунным эффектом клеток (ICANS), и инфекционные заболевания затрудняю

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… Opportunistic infections have also been reported, including cytomegalovirus (CMV), Epstein–Barr virus (EBV), pneumocystis jirovecii (PJP), adenovirus, parvovirus B19, human herpes virus 6 (HHV6), and progressive multifocal leukoencephalopathy. …

Gene therapy: principles, challenges and use in clinical practice.

INTRODUCTION: Gene therapy is an emerging topic in medicine. The first products have already been licensed in the European Union for the treatment of immune deficiency, spinal muscular atrophy, hemophilia, retinal dystrophy, a rare neurotransmitter disorder and some hematological cancers, while many more are being assessed in preclinical and clinical trials. OBJECTIVE: The purpose of this review is to provide an overview of the core principles of gene therapy along with information on challenges and risks. Benefits, adverse effects and potential risks are illustrated based on the examples of

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… AAV is a very small ( parvovirus) single-stranded DNA virus that is non-pathogenic and naturally replication-defective. Wild-type AAV requires the presence of another virus, such as an adenovirus, to replicate [ 25 ]. …

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes.

Background and aimsAs a curative procedure, hematopoietic stemcell transplantation (HSCT) is an approved treatment for many malignant orbenign hematologic and non-hematologic diseases. There are different outcomes of HSCT, as well as several parameters influencing these outcomes.MethodsWe had searched scientific sources like Web ofScience and PubMed with a combination of keywords such as HSCT, engraftment,survival, outcomes, etc. Totally, 80 articles were included.ResultsHere we have reviewed the effective factors onmain outcomes of HSCT including engraftment, survival, graft versus hostdiseas

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… engraftment has been occurred in 50‐59 years old in comparison with younger patients. 33 It has been reported about the weight, as a criterion of performance, that the chance of platelet engraftment was 1.93 times faster when patients weight more than 60 kg. 4 Viral infections, such as human herpes virus‐6, parvovirus …

Complication from Desensitization

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… It is also used in the treatment of polyomavirus and parvovirus disease. Some common side effects of IVIg infusion include pyrexia, rigors, and headache. … However, in the Swedish study, one patient had prolonged parvovirus B19 viremia and one had persistent myalgias after the IdeS infusion. A total of 38 serious adverse events occurred in 15 patients (five events were adjudicated as being possibly related to IdeS). …

Research Communications of the 26th ECVIM‐CA Congress

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… ISCAID‐O‐9 The Role of Canine Circovirus in Acute Haemorrhagic Diarrhoea Syndrome and Its Impact on Canine Parvovirus Infection A.L. Proksch 1 , A. Anderson 1 , K. Hartmann 1 , C.M. Leutenegger 2 , R.S. Mueller 1 , S. … CPV‐2 and Canine Parvovirus type 2c (CPV‐2c) antibody titres were measured by seroneutralisation tests (SN). SN antibody titre > 10 1.05 after vaccination is considered as positive and is correlated with clinical protection. …

Proceedings of the RAMI Intern Section Meeting.

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Case report and review: Angiosarcoma with thrombocytopenia after total hip arthroplasty.

Total hip arthroplasty (THA) is a common treatment for osteoarthritis and is also performed for other conditions, such as secondary arthritis due to developmental dysplasia of the hip. Various THA types may be complicated by osteolysis and an inflammatory pseudotumor due to an adverse reaction to metal debris. Rarely, THA has been associated with malignant tumors, but their causality remains unclear. In this case report, we describe a female patient with developmental dysplasia of the hip. She had undergone left metal-on-polyethylene THA, acetabular revision of the THA, and left total knee art

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… Further tests were performed, which resulted negative for hepatitis, parvovirus, Epstein–Barr virus, and human immunodeficiency virus. Among the blood coagulation factors, factors VIII and IX, as well as the active von Willebrandt factor (vWF) and vWF antigen, were slightly above the normal ranges. …

Progress in Biological Therapies for Adult-Onset Still's Disease.

Adult-onset Still's disease (AOSD) is a rare multifactorial autoinflammatory disorder of unknown etiology, characterized by an excessive release of cytokines triggered by dysregulated inflammation and articular and systemic manifestations. The clinical spectrum of AOSD ranges from self-limiting forms with mild symptoms to life-threatening cases and presents clinical and biological similarities with the juvenile form (sJIA). Nowadays, the advances in biologic agents no longer limit the treatment to NSAIDs, glucocorticoids, or conventional synthetic DMARDs. The blockade of IL-1 and IL-6 is effec

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… Several infectious triggers, including viruses ( Parvovirus B19 , Epstein Barr virus , Cytomegalovirus ) and bacteria ( Yersinia and Mycoplasma ), as well as genetic factors related to the HLA (HLA-Bw35, -B17, -B18, -B35, -DR2, -DR4, -DR5, -DQ1, DRw6, -DRB1, and -DQB1) are also believed to trigger the …

A case of renal damage induced by cryoglobulinemia associated with Monoclonal Gammopathy of Renal Significance.

BACKGROUND: Cryoglobulins are abnormal immunoglobulins present in circulation, capable of precipitating at lower temperatures and redissolving upon rewarming to body temperature (37 °C). It is widely accepted that mixed cryoglobulinemia is more commonly seen in chronic infections and autoimmune diseases. Here, we present a case of cryoglobulinemic nephritis due to Monoclonal Gammopathy of Renal Significance. CASE PRESENTATION: The patient was a 60-year-old male who presented with “bilateral lower limb edema for one month.” Clinical features included purpura on the lower extremities, proteinuri

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… Types II and III are more commonly associated with chronic infections (e.g., HCV, HBV, EBV, CMV, parvovirus, bacteria) and autoimmune diseases (e.g.,systemic lupus erythematosus, sjogren syndrome, rheumatoid arthritis) [ 9 ]. …

Autoimmune Hemolytic Anemias: Challenges in Diagnosis and Therapy.

BackgroundAutoimmune hemolytic anemia (AIHA) is a rare disease due to increased destruction of erythrocytes by autoantibodies, with or without complement activation.SummaryAIHA is usually classified in warm AIHA (wAIHA) and cold agglutinin disease (CAD), based on isotype and thermal amplitude of the autoantibody. The direct antiglobulin test (DAT) or Coombs test is the cornerstone of AIHA diagnosis, as it is positive with anti-IgG in wAIHA, and with anti-C3d/IgM antisera plus high titer cold agglutinins in CAD. Therapy is quite different, as steroids and rituximab are effective in the former,

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… anti-phospholipid syndrome, autoimmune lymphoproliferative syndrome, autoimmune bowel disease, autoimmune hepatitis), solid organ and hematopoietic stem cell transplants, numerous drugs (including immune checkpoint inhibitors anti-PD-1, PD-L1, and CTLA-4), congenital immunodeficiencies and infections (Parvovirus …

30 years in service, 1996-2026: Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).

The Infectious Diseases Working Party (AGIHO) was established in 1996 as one of the subgroups of the German Society of Hematology and Medical Oncology (DGHO). Marking its 30th anniversary this year, the AGIHO reflects on a period of significant achievement and growth. Beyond its core mission of developing evidence-based clinical practice guidelines for the prevention, diagnosis, and management of infections in patients with cancer, the AGIHO has evolved into a vital platform for clinical trials, collaborative research, and postgraduate medical education. To ensure long-term sustainability and

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… Holzem A Stemler J Böhm S Gruell H Zeuzem A Schalk E Diverse clinical manifestations of Parvovirus B19 infections during the 2024 outbreak in Germany Infection 2024 53 5 2219 26 10.1007/s15010-025-02598-6 PMC12460526 40668297 Holzem A, Stemler J, Böhm S, Gruell H, Zeuzem A, Schalk E et al (2024) Diverse … clinical manifestations of Parvovirus B19 infections during the 2024 outbreak in Germany. …

Delayed gastric emptying in critical illness: is enhanced enterogastric inhibition with cholecystokinin and peptide YY involved?

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… Because the product is derived from pooled plasma, with as many as 2500 donors in each lot, it has the potential to actually increase recipient exposure to pathogens not inactivated by the solvent-detergent method, such as hepatitis A and parvovirus B19, and be more vulnerable to any newly emerging non–lipid-enveloped … Emerging Infections in Transfusion Medicine Parvovirus B19 has now been recognized as a pathogen capable of transmission by transfusion, with typical clinical findings and the potential for severe hematologic complications. …

Oncolytic Viruses for Cancer Therapy in Dogs.

Cancer remains the leading cause of death in domestic dogs. Conventional therapeutic approaches, including surgery, chemotherapy, and radiotherapy, frequently fail to achieve sustained remission or stabilization. Oncolytic virotherapy, a rapidly advancing therapeutic modality in human oncology, is emerging as a novel strategy in veterinary medicine. This systematic review summarizes current knowledge on the application of oncolytic viruses (OVs) in canine cancer treatment, focusing on their mechanisms of action, safety profiles, and clinical efficacy. We evaluate diverse OV platforms, includin

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… Serum antibody response to canine parvovirus, canine adenovirus-1, and canine distemper virus in dogs with known status of immunization: Study of dogs in Sweden Am. J. Vet. Res. 1988 49 1460 1466 10.2460/ajvr.1988.49.09.1460 3223653 88. Laborda E. Puig-Saus C. Rodriguez-García A. Moreno R. …

Tuning epigenetics to enhance cancer virotherapy.

Cancer remains a major global health challenge, driving intensive research into novel therapeutic strategies. Oncolytic viruses (OVs) including herpesviruses, adenoviruses and echoviruses, have emerged as promising agents for cancer treatment, with several achieving regulatory approval. These viruses selectively lyse tumor cells and stimulate antitumor immunity. Nevertheless, their efficacy is constrained by limitations such as neutralization by serum factors and tumor cell resistance. Concurrently, epigenetic inhibitors modulate gene expression to suppress tumor proliferation and reshape immu

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… In addition, HDACis synergistically heighten the oncolytic potency of parvoviruses, driving robust caspase-mediated apoptosis and amplifying tumor cytotoxicity. … Bretscher et al. demonstrated that combined treatment with HDACis (VPA) and H1 parvovirus (H1PV) induced oxidative stress and apoptosis in cancer cells 65 . …

Комплексное исследование двустороннего взаимодействия между микробиомами человека и злокачественными заболеваниями крови и гематологическими условиями: акцент на новых терапевтических стратегиях.

Микробиота человека играет ключевую роль в поддержании хомостаза, регулируя иммунную реакцию, метаболизм и гематопоисис. Микробиальный дисбиоз все чаще ассоциируется с иммунной дисфункцией, воспалением и аномалиями костного мозга, которые могут привести к гематологическим заболеваниям. В настоящем обзоре резюмируются текущие данные о роли микробиота в нормальном гематопоисе и ее потенциальной причастности к доброкачественным и злокачественным гематологическим расстройствам.МЕТОДЫ: Обзор описательной литературы был проведен на основе всестороннего поиска основных научных баз данных без временны

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… hydroxyeicosatetraenoic Acid 6‐trans‐12‐epi‐leukotriene B4 allogeneic hematopoietic stem cell transplantation acute lymphoblastic leukemia alanine aminotransferase acute myelogenous leukemia antimicrobial peptides antigen presenting cells aspartate aminotransferase adolescent/young adult Hodgkin lymphoma Parvovirus … Viral infections such as viral hepatitis (such as A, B, C, E, and G), Cytomegalovirus (CMV), Epstein–Barr virus (EBV), and Parvovirus B19 (B19V) may be associated with the development of aplastic anemia. …

Сбалансирую эффективность и безопасность в нескольких пациентах с миеломой, получающих B-камерную антигенную терапию CAR-Cell.

В качестве новаторского и эффективного метода лечения пациентов с повторной/неизлечимой миеломой (BCMA) вспыхнула антигенная терапия созревания (BCMA), которая была ориентирована на CAR T-клеточную терапию, что свидетельствует о высокой доле респондентов и продолжительной ремиссии. Однако его применение связано с широким спектром токсичных свойств, начиная от хорошо известных общих событий и кончая более редкими и менее хорошо описанными осложнениями. Всеобъемлющее понимание как общих, так и редких токсичных свойств имеет важнейшее значение для своевременного признания и регулирования в целях

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… A full infectious work-up should be performed, because pathogens like adenovirus, parvovirus, cytomegalovirus (CMV), Clostridium difficile , shigella, salmonella and Escherichia coli have been documented in this context [ 48 ]. Furthermore, endoscopic evaluation with targeted biopsies is essential. …

Oncolytic Viruses as Reliable Adjuvants in CAR-T Cell Therapy for Solid Tumors.

Although impactful scientific advancements have recently been made in cancer therapy, there remains an opportunity for future improvements. Immunotherapy is perhaps one of the most cutting-edge categories of therapies demonstrating potential in the clinical setting. Genetically engineered T cells express chimeric antigen receptors (CARs), which can detect signals expressed by the molecules present on the surface of cancer cells, also called tumor-associated antigens (TAAs). Their effectiveness has been extensively demonstrated in hematological cancers; therefore, these results can establish th

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… Clinical Trials for Oncolytic Virus-Related Therapy In the past two decades, >3000 patients enrolled in clinical trials using oncolytic viruses, including adenovirus, herpesvirus, picornavirus, measles virus, vaccinia virus, reovirus, poliovirus, coxsackievirus, vesicular stomatitis virus, parvovirus …