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2018 ACVIM Forum Research Report Program. Seattle, Washington, June 14 - 16, 2018.

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… Sommardahl 4 1 Equine Health Studies Program, Department of Veterinary Clinical Sciences, LSU, Baton Rouge, LA, USA, 2 University of Tennessee, College of Veterinary Medicine, Knoxvile, TN, USA, 3 Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA, USA, 4 University of Tennessee … Gary Magdesian 2 1 Marion duPontScott Equine Medical Center Virginia‐Maryland College of Veterinary Medicine, Leesburg, VA, USA, 2 Department of Medicine and Epidemiology, UC Davis School of Veterinary Medicine, Davis, CA, USA Eosinophilic airway disease (EAD) is a component of inflammatory airway …

Abstracts of the 3rd International Conference on Cancer Cachexia, September 23–25, 2016 in Washington, DC, USA

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… Pistilli 1,3,5 1 Division of Exercise Physiology; 2 Animal Models and Imaging Facility; 3 West Virginia University Cancer Institute; 4 Department of Biostatistics; 5 West Virginia Clinical and Translational Sciences Institute, West Virginia University, Morgantown, WV, USA The aims of this project were …

Incidence and survival of lymphoid neoplasms in Spain, 2002-2013: A population-based study from the Spanish Network of Cancer Registries (REDECAN).

IntroductionThe aim of this study was to describe incidence, incidence trends and survival patterns of lymphoid neoplasms (LNs) and its subtypes in Spain in the period 2002-2013 using data from the Spanish Network of Cancer Registries (REDECAN).Materials and methodsData were extracted from 13 Spanish population-based cancer registries. LNs incident cases were codified using the International Classification of Diseases for Oncology, third edition (ICD-O-3) and grouped according to the WHO 2008 classification. Age-standardized incidence rates to the 2013 European standard population (ASIRe) were

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… RM-G, Montse Puigdemont, Anna Vidal Vila, AS, Andrés Castillo-Bonilla; Tarragona Cancer Registry – Data coordination in REDECAN: MC, AA, CP, and JG; Álava Cancer Registry: AL-d-M, Patricia Sancho, María Luisa Iruretagoyena ; Albacete Cancer Registry: Cristina Ramírez; Asturias Cancer Registry: SM, Virginia … Contributor Information REDECAN working group: RM-G , Montse Puigdemont , Anna Vidal Vila , AS , Andrés Castillo-Bonilla , MC , AA , CP , JG , AL-d-M , Patricia Sancho , María Luisa Iruretagoyena , Cristina Ramírez , SM , Virginia Menéndez García , Marta Rodríguez Camblor , Visitación de Castro , Marta …

2022 NATIONAL CONGRESS OF THE ITALIAN SOCIETY OF HYPERTENSION (SIIA)

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… METABOLIC CONTROL AMELIORATES LEFT VENTRICULAR MECHANO-ENERGETIC EFFICIENCY IN HYPERTENSIVE PATIENTS Maria Lembo, Costantino Mancusi, Maria Virginia Manzi, Maria Assunta Elena Rao, Giovanni De Simone, Carmine Morisco, Giovanni Esposito, Raffaele Izzo, Bruno Trimarco Department of Advanced Biomedical … EPIDEMIOLOGY AND CLINICAL ASPECTS CAROTID PLAQUE OFFSETS THE SEX DIFFERENCE IN CARDIOVASCULAR RISK IN YOUNG TO MIDDLE AGE HYPERTENSIVE PATIENTS: THE CAMPANIA SALUTE NETWORK Costantino Mancusi, Ilaria Fucile, Maria Lembo, Maria Virginia Manzi, Christian Basile, Eva Gerdts, Carmine Morisco, Giovanni …

Geographic and Racial Disparities in Access to Chimeric Antigen Receptor-T Cells and Bispecific Antibodies Trials for Multiple Myeloma.

ImportanceThe use of chimeric antigen receptor-T cell (CAR-T) therapy and bispecific antibodies in multiple myeloma is expanding, with encouraging early results. It is unknown if the current geographic distribution of CAR-T therapy and bispecific antibodies in multiple myeloma allows access for patients in need, especially for Black populations, which have a higher incidence of multiple myeloma.ObjectiveTo investigate if the current geographic distribution of CAR-T cell therapy and bispecific antibodies for multiple myeloma allows equitable access for Black patients with multiple myeloma.Desig

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… Those include 4 in the Northeast (Maine, New Hampshire, Rhode Island, and Vermont), 4 in the South (Delaware, District of Columbia, West Virginia, and Mississippi), 2 in the Midwest (North and South Dakota), and 7 in the West (Idaho, New Mexico, Montana, Nevada, Wyoming, Alaska, and Hawaii) ( Figure …

The Medicare experience with end-stage renal disease: trends in incidence, prevalence, and survival.

This article presents a detailed account of the incidence, prevalence, and survival experience of people with end-stage renal disease (ESRD) covered by Medicare. The number of new entrants into the ESRD program has risen since its inception. This increase is greatest for people whose cause of renal failure is primary hypertensive disease or diabetic nephropathy. The program incidence rates for black people is 2.8 times that of white people. Incidence is highest for persons 65 to 69 years of age. Total patient survival is 44 percent 5 years after renal failure onset. Total Medicare enrollment f

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… The rate reported for the District of Columbia appears strikingly high when, in fact, many of the patients dialyzing there live in Maryland or Virginia. … | 5150 | 481.0 | 93 | 3591 | 193.7 | 54 Washington | 3774 | 217.7 | 58 | 2945 | 149.7 | 51 West Virginia | 1860 | 113.0 | 61 | 1518 | 79.0 | 52 Wisconsin | 4679 | 295.7 | 63 | 3877 | 196.3 | 51 Wyoming | 424 | 15.3 | 36 | 311 | 10.7 | 34 As shown, average yearly Medicare program incidence for all people …

Схемы проявления автоантибиоза в множестве склероза, выявленные благодаря разработке технологии обнаружения автоантигенов.

Множественный склероз (MS) — изнурительное аутоиммунное заболевание CNS, которое характеризуется демиэлированием и аксонной травмой и которому часто предшествует демиелионирующее явление, называемое клинически изолированным синдромом (CIS). Несмотря на важность клеток B и автоантител в патологии MS, их целевые особенности остаются в значительной степени неизвестными. Для агностической и всеобъемлющей оценки автоантител в MS мы разработали и использовали то, что мы считаем новой автоантигенной технологией открытия, Антигеномной платформой. Эта Платформа представляет собой высокопроизводительный

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… JH’s present address is: Department of Biological Sciences, Fralin Life Sciences Institute and Center for Emerging, Zoonotic, and Arthropod-bourne Pathogens, Virginia Tech, Blacksburg, Virginia, USA. …

Роль холинергической системы в психопатологии и лечении шизофрения: протокол для аналитического обзора.

Введение и цель " Шолинергическая система " имеет широкие последствия для аффлективных и когнитивных процессов, что делает ее актуальной для психопатологии и лечения психических расстройств. Вопросы, касающиеся его роли в шизофрении, хроническом расстройстве, характеризующемся психозом, эмоциональным туманом и когнитивным дефицитом, стали особенно актуальными в связи с недавним утверждением Администрацией продовольствия и наркотиков (ДПП) мускаринического агониста в качестве антипсихотического агента. В настоящем документе подробно излагается протокол проведения аналитического обзора

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… Zotero (Corporation for Digital Scholarship, Vienna, Virginia) will be used to store and manage the references and to compile the reference list in the manuscript. …

Biomarker Jeopardy.

In the popular Biomarker Jeopardy session, Sandra E. Kurtin, PhD, ANP-C, AOCN®, Alyssa Henglefelt, PharmD, BCOP, and Haleigh Mistry, MS, PA-C, paired biomarkers with tumor types for which their expression is most commonly used to determine targeted therapy, identified key assays used to measure common biomarkers, and discussed guidelines for biomarker testing.

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… In a session called “Biomarker Jeopardy” during JADPRO Live Virtual 2021, Alyssa Henglefelt, PharmD, BCOP, HonorHealth – Virginia G. …

Assisted reproductive technology surveillance -- United States, 2010.

PROBLEM/CONDITION: Since the first U.S. infant conceived with Assisted Reproductive Technology (ART) was born in 1981, both the use of advan … nois, Maryland, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Virginia), this proxy measure was higher than the national rate, and in four states (Connecticut, Massachusetts, New Jersey, and New York) and the District of Columbia, it exceeded twice the national rate. Nationally, among cycles in which at least one embry …

Receipt of Selected Preventive Health Services for Women and Men of Reproductive Age - United States, 2011-2013.

PROBLEM/CONDITION: Receipt of key preventive health services among women and men of reproductive age (i.e., 15-44 years) can help them achie … aii, Maine, Maryland, Michigan, Minnesota, Nebraska, New Jersey, Tennessee, Utah, Vermont, and West Virginia). The National Health Interview Survey (NHIS) is a nationally representative survey of noninstitutionalized civilians in the United States. NHIS collects data on a broad range of health topics, including the prevalence, distribution, and effects of …

2022 International Cancer Education Conference Late-Breaking Abstracts

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… Late-Breaking Oral Abstracts 2B-5: The West Virginia Cancer Survivorship Needs Assessment Project Nicole L. … The West Virginia Tumor Registrar direct mailed 2,000 hard copy surveys to patients with a cancer diagnosis from 2015 to 2021. …

Dusquetide: Reduction in oral mucositis associated with enduring ancillary benefits in tumor resolution and decreased mortality in head and neck cancer patients.

Innate immunity is a key component in the pathogenesis of oral mucositis, a universal toxicity of chemoradiation therapy (CRT). Dusquetide, a novel Innate Defense Regulator, has demonstrated both nonclinical and clinical efficacy in ameliorating severe oral mucositis (SOM). Long term follow-up studies from the Phase 2 clinical study evaluating dusquetide as a treatment for SOM in head and neck cancer (HNC) patients receiving CRT have now been completed. Extended analysis indicates that dusquetide therapy was well-tolerated and did not contribute to increased infection, tumor growth or mortalit

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… University of Rochester, University of Wisconsin-Carbone Cancer, University of Washington Medical Center, VA Long Beach Health System, VA Puget Sound Health Care System, Wake Forest Health Sciences Medical Center, Washington Cancer Institute, Washington University, Willis-Knighton Cancer Center and Virginia …

Oral cancer therapy: policy implications for the uninsured and underinsured populations.

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… laws: Oregon (2008), Indiana (2009), Iowa (2009), Hawaii (2009), District of Columbia (2009), Vermont (2010), Connecticut (2010), Kansas (2010), Colorado (2010), Minnesota (2010), Illinois (2011), New Mexico (2011), Texas (2011), New York (2011), Washington (2011), New Jersey (2012), Maryland (2012), Virginia …

Viewing the US presidential electoral map through the lens of public health.

Health, disease, and mortality vary greatly at the county level, and there are strong geographical trends of disease in the United States. Healthcare is and has been a top priority for voters in the U.S., and an important political issue. Consequently, it is important to determine what relationship voting patterns have with health, disease, and mortality, as doing so may help guide appropriate policy. We performed a comprehensive analysis of the relationship between voting patterns and over 150 different public health and wellbeing variables at the county level, comparing all states, including

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… "Battleground states” are the tightly contested states of the 2016 Presidential election: Nevada, Colorado, Virginia, Florida, Michigan, Minnesota, Wisconsin, Iowa, New Hampshire, Ohio, and Pennsylvania. … The battleground states are: Nevada, Colorado, Virginia, Florida, Michigan, Minnesota, Wisconsin, Iowa, New Hampshire, Ohio, and Pennsylvania. The flipped states are: Michigan, Pennsylvania, Wisconsin and Maine. …

The Host Cell ViroCheckpoint: Identification and Pharmacologic Targeting of Novel Mechanistic Determinants of Coronavirus-Mediated Hijacked Cell States

Most antiviral agents are designed to target virus-specific proteins and mechanisms rather than the host cell proteins that are critically dysregulated following virus-mediated reprogramming of the host cell transcriptional state. To overcome these limitations, we propose that elucidation and pharmacologic targeting of host cell Master Regulator proteins—whose aberrant activities govern the reprogramed state of infected-coronavirus cells—presents unique opportunities to develop novel mechanism-based therapeutic approaches to antiviral therapy, either as monotherapy or as a complement to establ

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… Gabrielle, Komissarova Elena V, Hagan Elizabeth A, Bodei Lisa, Clemons Paul A, Dela Cruz Filemon S, Dhall Deepti, Diolaiti Daniel, Fraker Douglas A, Ghavami Afshin, Kaemmerer Daniel, Karan Charles, Kidd Mark, Kim Kyoung M, Kim Hee C, Kunju Lakshmi P, Langel Ülo, Li Zhong, Lee Jeeyun, Li Hai, LiVolsi Virginia … Ikiz Burcin, Alvarez Mariano J, Ré Diane B, Le Verche Virginia, Politi Kristin, Lotti Francesco, Phani Sudarshan, Pradhan Radhika, Yu Changhao, Croft Gist F, Jacquier Arnaud, Henderson Christopher E, Califano Andrea, and Przedborski Serge. …

Preclinical development of three novel CARs targeting CD79b for the treatment of non-Hodgkin's lymphoma and characterization of the loss of the target antigen.

BackgroundInfusion of T cells modified with a chimeric antigen receptor (CAR) targeting CD19 has achieved exceptional responses in patients with non-Hodgkin's lymphoma (NHL), which led to the approval of CAR targeting CD19 (CART19) (Axi-cel and Liso-cel) as second line of treatment for adult patients with relapsed/refractory NHL. Unfortunately, 60% of patients still relapse after CART19 due to either a loss of expression of the target antigen (CD19) in the tumor cell, observed in 27% of relapsed patients, a limited CAR-T persistence, and additional mechanisms, including the suppression of the

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… Tumor cell lines WSU, SC1, and K562 cell lines were purchased from the American Tissue Culture Collection (Manassas, Virginia, USA). Ramos cell line was kindly provided by Juan Manuel Zapata (Instituto de Investigaciones Biomedicas “Alberto Sols”, CSIC-UAM, Madrid). … Virginia Peña-Blanque, Email: virginia.pena@quironsalud.es. Javier Fernández-Calles, Email: jfernandezcalles@ub.edu. Narcis Fernandez-Fuentes, Email: narcis.fernandez@gmail.com. Juana Serrano-Lopez, Email: juana.serrano@quironsalud.es. Manel Juan, Email: mjuan@clinic.cat. …

2021 International Cancer Education Conference Program and Abstracts.

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… Aaron Kruse-Diehr (University of Kentucky) 1A-5 Paige Lake (Moffitt Cancer Center) 4C-2 Karen Lawrie (Princess Margaret Cancer Centre) 2A-3 Nicolette Olivia Le (University of California San Diego) P8 Viena Le (University of California San Diego) P95 Vy Le (UCSD) P113 Emily Leventhal (University of Virginia … National Cancer Institute, Center to Reduce Cancer Health Disparities) Invited Workshop 5 Nicole Liscio (Princess Margaret Cancer Centre, University Health Network) 1B-5, P17 Lydia Lo (United States Postal Service) P27 Amy Loeber (UC San Diego Moores Cancer Center) P52 Shina Luu (UC San Diego) P115 Virginia …

Use of real-world evidence in the Medicare Drug Price Negotiation Program: A checklist for the Centers for Medicare and Medicaid Services and manufacturers.

Under the Inflation Reduction Act's (IRA's) - Medicare Drug Price Negotiation Program, the Centers for Medicare & Medicaid Services' (CMS's) "maximum fair price" must be informed by evidence on factors such as therapeutic advance of the selected drug compared with its alternative, comparative effectiveness across clinical and patient-reported outcomes, the impact on specific populations, and the ability to address unmet medical needs. This paper describes how real-world evidence could improve CMS decision-making and creates a best practices checklist to help CMS evaluate the quality of any man

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… Murtuza Bharmal, Oncology Outcomes Research, AstraZeneca, Boston, MA 02210, United States; School of Pharmacy, Department of Pharmaceutical Systems and Policy, West Virginia University, Morgantown, WV 26501, United States. …

Гут Микробиота как ключевой модулятор хронических заболеваний: последствия для диабета, автономного иммунитета и рака.

Кишечная микробиота (ГМ) представляет собой сложную, динамичную и сложную экосистему. Она играет ключевую роль в области здравоохранения и болезней. ГМ взаимодействует с принимающей стороной и модифицирует различные физиологические функции, включая метаболизм, иммунное регулирование и неврологическую функцию. В настоящем описательном обзоре всесторонне анализируется роль ГМ в развитии и развитии three Основные хронические заболевания, а именно диабет, аутоиммунные расстройства и рак. Используя структурированную стратегию поиска литературы в таких базах данных, как Google Scientist, PubMed, Sco

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… Screening and Data Extraction All retrieved studies were imported into Zotero (Corporation for Digital Scholarship, Virginia, USA) reference management software to manage and remove duplicates. …