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The role of healthcare delivery in the outcome of meningococcal disease in children: case-control study of fatal and non-fatal cases.

OBJECTIVE: To determine whether suboptimal management in hospital could contribute to poor outcome in children admitted with meningococcal disease. DESIGN: Case-control study of childhood deaths from meningococcal disease, comparing hospital care in fatal and non-fatal cases. SETTING: National statistics and hospital records. SUBJECTS: All children under 17 years who died from meningococcal disease (cases) matched by age with three survivors (controls) from the same region of the country. MAIN OUTCOME MEASURES: Predefined criteria defined optimal management. A panel of paediatricians blind

Extravasation of vesicant drugs in combined regimens: A case with a fatal outcome.

IntroductionExtravasation of vesicant chemotherapy is an oncological emergency that may result in severe tissue injury, functional impairment, and long-term morbidity. Management becomes particularly challenging in combination regimens containing agents with different vesicant properties and opposing treatment recommendations.Case ReportWe report a fatal case associated with administration of a combination chemotherapy regimen through difficult peripheral venous access. Mild symptoms during infusion of a non-vesicant agent led to suspected extravasation; consequently, antidotes were not admini

Acute Intoxication with Caffeine-Containing Tablets: A Case Report with a Fatal Outcome.

Caffeine is widely consumed and generally considered safe at customary doses. How-ever, high-dose preparations available online pose a risk of severe and potentially fatal intoxication. Although uncommon, lethal caffeine poisoning is associated with profound cardiovascular and neurological toxicity. A rare case of intentional acute caffeine intoxication with fatal outcome is presented. A 25-year-old woman ingested an estimated 60 tablets containing 200 mg of caffeine each, purchased online. She was admitted to hospital shortly after ingestion of the caffeine tablets with palpitations, agitatio…

Constrictive Pericarditis After Minimally Invasive Triple Valve Replacement: Insights From a Fatal Outcome.

Triple valve surgery is performed in only a small minority of valvular procedures and carries substantial perioperative risk and a demanding postoperative course. Pericardial complications after cardiac surgery are well recognized, but progression to constrictive physiology following a minimally invasive triple valve operation is exceptionally uncommon and poorly characterized. We describe an elderly woman with longstanding hypertension, dyslipidemia, and paroxysmal atrial fibrillation who underwent minimally invasive replacement of the aortic, mitral, and tricuspid valves for combined multiva

Cutaneous Extramedullary Hematopoiesis in Primary Myelofibrosis: A Case Report With Rapidly Fatal Outcome.

Extramedullary hematopoiesis (EMH) is the formation of hematopoietic cells outside the bone marrow, typically as a compensatory mechanism in the setting of marrow failure. Cutaneous EMH is an exceptionally rare manifestation, usually associated with chronic myeloproliferative disorders such as primary myelofibrosis. We report the case of a 54-year-old woman with Janus kinase 2 (JAK2)-positive primary myelofibrosis and long-standing transfusion-dependent cytopenias who presented with multiple firm, erythematous-to-violaceous nodular lesions on the trunk. Histological examination of a skin biops

Well-Differentiated, Low-Grade Subcutaneous Liposarcoma With a Fatal Outcome in a Dog.

A 10-year-old intact male Rottweiler was presented with a large, rapidly growing subcutaneous mass on the right thoracic limb. Physical examination revealed a firm, raised, non-ulcerated mass extending from the proximal scapula to the distal humerus. Cytological evaluation identified a highly cellular population of vacuolated cells with marked anisocytosis and anisokaryosis, consistent with a lipid-rich mesenchymal neoplasm. Histopathology of incisional biopsies confirmed a well-differentiated, low-grade subcutaneous liposarcoma. The owner declined therapeutic and surgical treatments. The dog

Malignant triton tumor of the bladder with fatal outcome: a rare case report.

Malignant triton tumors (MTTs) are a rare subtype of malignant peripheral nerve sheath tumors characterized by rhabdomyoblastic differentiation, often associated with neurofibromatosis type 1 (NF-1). Primary MTTs of the bladder are exceptionally uncommon, with few documented cases. We report a case of a 75-year-old male without neurofibromatosis type 1 history presenting with hematuria and urinary obstruction. Imaging revealed a 6.5 × 4 × 2 cm invasive bladder mass, and histopathology confirmed a high-grade spindle cell neoplasm with biphasic neurogenic (S100-positive) and rhabdomyoblastic (de

Awareness of neonatal heat illness: a fatal outcome in a late preterm infant.

Extreme heat impacts on child health and well-being due to immature thermoregulation, less sweating and a high surface-to-body mass ratio that make them more vulnerable to heat-related illness. Severe dehydration, especially if struggling with breastfeeding, renal failure and electrolyte imbalance, and neurological and cardiorespiratory failure may result. This late preterm was born healthy during a heatwave and developed lethargy and minimal responsiveness from day of life (DOL) 5, developed seizures at DOL 12, then demised at DOL 20. All hospitals involved in the diagnostic workup and treatm

[Fatal outcome of complete resection of undifferentiated pleomorphic cardiac sarcoma : About a case].

INTRODUCTION: Undifferentiated pleomorphic sarcoma (UPS) is a very rare malignant primary cardiac tumor with a poor prognosis. OBSERVATION: … cal case of invasive UPS, which was surgically resected and scheduled for radio-chemotherapy with a fatal outcome.

Fatal Outcome Due to Kounis Syndrome Following Fluorescein Retinal Angiography: A Case Report.

Kounis Syndrome (KS) is a clinical entity triggered by allergic or hypersensitivity reactions capable of inducing acute coronary events. Several causes can induce KS, including drugs and insect stings. Here, a rare case of post mortem assessment of fatal KS related to fluorescein retinal angiography has been reported. An 80-year-old man in follow-up for a retinal vein thrombosis underwent a retinal fluoroangiography. Approximately 30 min later, the patient complained of sweating and dizziness, and suddenly lost consciousness due to a cardiac arrest. Despite the immediate cardiopulmonary resusc

Fatal outcome of BK virus encephalitis in an allogeneic stem cell transplantation recipient.

BK virus (BKV) encephalitis is a rare complication after hematopoietic stem cell transplantation (HSCT). A 43-year-old woman with recurrent follicular lymphoma after autologous HSCT received allogeneic bone marrow transplantation from a human leukocyte antigen-matched related donor. Neutrophil engraftment was achieved on post-transplant day 13. Memory loss and noncooperative attitude toward the medical staff were observed on day 16, and her mental status worsened progressively. Magnetic resonance imaging (MRI) showed nonspecific findings on day 19; however, cerebrospinal fluid (CSF) analysis i

Тяжелый мпокс у пациентов с продвинутым СПИДом: долгосрочные заболевания и смертельный исход.

В этой связи мы сообщаем о двух случаях острого мпокса у пациентов с продвинутым синдромом приобретенного иммунодефицита в Бразилии, у которых возникли нетипичные повреждения и продолжительные заболевания, один из которых имел смертельный исход. Оба пациента испытывали серьезные осложнения, связанные с перианальными и гениталиями и продолжительными заболеваниями с постоянной виремией.

Совпадение в аннотации оригинала
Herein, we report two cases of severe mpox in patients with advanced acquired immunodeficiency syndrome from Brazil who developed atypical lesions and prolonged illness, one of whom had a fatal outcome. Both patients experienced serious complications involving the perianal and genital regions and prolonged disease with persistent viremia.

Fatal outcome of catheter-related bloodstream infection caused by Multidrug-Resistant Mycobacterium mucogenicum.

Mycobacteria mucogenicum (M. mucogenicum) is a rarely isolated pathogen. It has emerged as a significant pathogen in immunocompromised patients including those with cancer, organ transplant, or patients on immunosuppressive medication. Chemotherapy may reduce the ability of the bone marrow of these to respond to infection, and patients will be at risk for neutropenic sepsis, which leads to fatal complications. Here, we report a case of an 18-year-old boy was seen at Hospital Raja Perempuan Zainab II, Kelantan with acute lymphoblastic leukaemia (ALL) who presented with catheter-related bloodstr

Stent compression during resuscitation of a neonate with complex heart disease: fatal outcome.

A newborn with hypoplastic left heart underwent a Norwood operation. Obstruction of the Blalock-Thomas-Taussig shunt was treated with a stent. During resuscitation, this was compressed, which contributed to a fatal outcome.

How safe is BDSM? A literature review on fatal outcome in BDSM play.

A noteworthy number of people are interested in BDSM (bondage and discipline, dominance and submission, sadism, and masochism). Fatal outcomes while participating in BDSM activities occur. The aim of this literature review is to give a better insight into potential dangerous BDSM play by summarizing published data on BDSM fatalities. A literature search was conducted. It was searched for non-natural death related to BDSM activity. Seventeen cases were found. The age of the deceased ranged between 23 and 49 years (mean age 34.9 years). Strangulation in the course of erotic asphyxiation was the …