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Electrochemical behavior and determination of tumor inhibiting or promoting activities of flavonoids.

This paper deals with determination of the tumor inhibiting or promoting activities of 11 flavonoids performed by DC polarography. Flavonoids were tested in the presence of polyaromatic carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) or in combination with DMBA and 12-O-tetradecanoylphorbol-13-acetate (TPA), which is known as a specific tumor promoter for epidermal carcinogenesis. We found that in this experimental system the promotory or inhibitory activities of studied flavonoids depend on the number and position of hydroxyl groups in their chemical structures and are related to the polarog…

Potential health benefits from the flavonoids in grape products on vascular disease.

In the dog, monkey, a nd human we have shown that 5 ml/kg of red wine or 5-10 ml/kg of purple grape juice but not orange or grapefruit juice … are encouraging and justify further research on larger numbers of subjects. This suggests that the flavonoids in purple grape juice and red wine may inhibit the initiation of atherosclerosis by one or more of the mechanisms described above. It will take years to fully characterize the potential benefits of daily consumption of red wine or purple grape juice …

Testing the effects of drying methods on willow flavonoids, tannins, and salicylates.

In this study, we compared the effects of several preservation methods on the secondary phenolics of the mature leaves of purple willow (Salix purpurea L., salicaceae) with results obtained with fresh leaf analyses. Conventional freeze-drying, in which the leaves were first frozen with liquid nitrogen and then placed in a freeze-dryer, produced substantial qualitative and quantitative changes in purple willow flavonoids and salicylates. Modified freeze-drying, in which leaves were put into a freeze-dryer without being prefrozen, gave concentrations that, for most secondary components, were com…

In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites.

The inhibitory effect of flavonoids and phenolic acids, which could be transformed from flavonoids by human intestinal microflora, on the growth of Helicobacter pylori (HP) was investigated. Ponciretin, hesperetin, naringenin and diosmetin were active against HP. Among them, ponciretin was the most potent and its MIC was 10-20 micrograms/ml. However, these active compounds against HP did nearly not inhibit the urease activity of HP.

Dose-Dependent Effects, Metabolic Paradoxes, and Nutritional Implications of Flavonoids and Cancer.

Flavonoids are widely consumed dietary polyphenols that have been extensively investigated for their antioxidant, anti-inflammatory, and anticancer properties. However, their role in oncology is more complex than is often assumed, as their biological effects may vary according to dose, bioavailability, metabolic transformation, tumour type, disease stage, and treatment context. This narrative review examines the dual and context-dependent nature of flavonoids in cancer biology, with emphasis on redox-dependent liabilities, genotoxicity, pharmacokinetic limitations, gut microbiota-mediated vari…

[Prenylated flavonoids from Sophorae Tonkinensis Radix et Rhizoma and their cytotoxic activities].

Comprehensive chromatographic separation methods were employed to isolate and purify the chemical constituents from the non-alkaloidal fraction of Sophorae Tonkinensis Radix et Rhizoma, and the structures of the compounds were identified with mass spectrometry(MS) and nuclear magnetic resonance(NMR) data. Fourteen prenylated flavonoids were isolated and identified, namely 5-isopentenylsophotonin Ⅰ(1),(2S)-6-isopentenyl-2'-hydroxyglabrol(2), sophoradin(3), sophoradochromene(4), 1-prenylpterocarpin(5), sophoranone(6), glabrol(7), 7,4'-dihydroxy-6,8-diprenyldihydroflavone(8), isobavachin(9), soph…

Prostate Cancer, JAK/STAT3 Dysregulation, and Flavonoids: Is There a Possible Link?

Worldwide, prostate cancer (PC) has a rising incidence and is the sixth leading cause of death globally, especially with increasing cases in … g JAK and STAT3 tested in vivo have shown potential to inhibit malignant cell growth. Additionally, flavonoids are bioactive plant compounds that are important in preventing inflammation, oxidative stress, and cancer. Research indicates that natural flavonoids can be developed into cancer-preventive and therapeutic agents. Experimental studies have demonstra …

Neuroprotective Role of Flavonoids: Implications for Natural Epilepsy Therapy-A Systematic Review.

INTRODUCTION: Epilepsy is a chronic neurological disorder characterised by recurrent, unprovoked seizures due to abnormal neuronal hyperexcitability and dysfunction. Despite the availability of several Antiepileptic Drugs (AEDs), approximately one-third of epilepsy patients are drugresistant and often experience adverse effects. This has led to the search for plant- derived bioactive compounds such as flavonoids, which have been reported to have widespread neuroprotective effects. This study aims to evaluate the neuroprotective role of flavonoids and their therapeutic implications in the manag…

Preparation, immunological and pharmacological effects of flavonoids in Scutellariae radix: a review.

In traditional Chinese medicine theory, Scutellaria baicalensis Georgi [Lamiaceae; Scutellariae radix] (SR) is bitter and cold in nature. It enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. It clears heat and dries dampness, purges fire and detoxifies, stops bleeding, and stabilizes pregnancy. It excels at clearing lung fire and upper-body heat. Flavonoids, the primary active compound of SR, undergo metabolism in vivo through Phase I and Phase II reactions as well as intestinal flora-mediated processes. Modern pharmacological research indicates that flavono…

Beyond Antibiotics: Traditional Chinese Medicine and Flavonoids in the Management of Endometritis.

Endometritis-inflammation of the endometrial lining-imposes a substantial reproductive and economic burden in both human gynecology and live … sm-based, host-directed alternatives. Here we synthesize the expanding evidence positioning dietary flavonoids and traditional Chinese medicine (TCM) formulations as such interventions. Across diverse compounds and preparations, anti-endometriotic activity converges on a tractable set of molecular nodes: TLR4/NF-κB signaling, the NLRP3 inflammasome-pyroptosi …

Regulatory effects of dandelion flavonoids in LPS-induced immune stress in broilers.

This study investigated the protective effect of dandelion flavonoids (DF) against lipopolysaccharide (LPS)-induced immune stress in broilers. A total of 400 healthy one-day-old Cobb 500 broilers with similar body weight were randomly assigned to five groups, with 8 replicates per group and 10 broilers per replicate. The treatments included CON, LPS, DF200, DF300 and DF400. The CON and LPS groups received a basic diet, while the DF200, DF300, and DF400 groups received 200, 300 and 400 mg/kg dietary DF, respectively. One bird per replicate was randomly selected. Broilers in the LPS and DF group…

Role of Flavonoids in Protecting Against Neurodegenerative Diseases-Possible Mechanisms of Action.

Neurodegenerative and mood disorders represent growing medical and social problems, many of which are produced by oxidative stress, neuroinflammation, disruption in the metabolism of various neurotransmitters, and some disturbances in lipid/carbohydrate homeostasis. Biologically active plant compounds, including flavonoids, have been shown to exert a positive impact on central nervous system function. This review assesses the studies of naturally occurring flavonoids belonging to various polyphenol subclasses and their mechanisms of neuroprotective action, especially against neurodegenerative …

Flavonoids and anthocyanins in seagrasses: implications for climate change adaptation and resilience.

Seagrasses are a paraphyletic group of marine angiosperms and retain certain adaptations from the ancestors of all embryophytes in the transition to terrestrial environments. Among these adaptations is the production of flavonoids, versatile phenylpropanoid secondary metabolites that participate in a variety of stress responses. Certain features, such as catalytic promiscuity and metabolon interactions, allow flavonoid metabolism to expand to produce novel compounds and respond to a variety of stimuli. As marine environments expose seagrasses to a unique set of stresses, these plants display i…

Metabolic regulation and oxidative stress attenuation in LPS-stimulated macrophages by flavonoids.

Periodontal disease, prevalent in 20% to 50% of the population, is a chronic multifactorial inflammation caused by a dysbiotic oral biofilm, with gingivitis and periodontitis being the most common forms. Flavonoids, such as myricetin and catechin, have antioxidant and anti-inflammatory potential, reducing nitric oxide (NO) and reactive oxygen species (ROS) in lipopolysaccharide (LPS)-stimulated macrophages. This study compared the effects of different flavonoids on viability and oxidative response of LPS-stimulated macrophages. RAW 264.7 macrophages were cultured at a density of 1-5 × 105 cell…

Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus.

Flavonoids in fruits, vegetables, and plant-based drinks have potential neuroprotective properties, with clinical research focusing on their role in reducing oxidative stress, controlling inflammation, and preventing apoptosis. Some flavonoids, such as quercetin, kaempferol, fisetin, apigenin, luteolin, chrysin, baicalein, catechin, epigallocatechin gallate, naringenin, naringin, hesperetin, genistein, rutin, silymarin, and daidzein, have been presented to help heal damage to the central nervous system by affecting key signaling pathways including PI3K/Akt and NF-κB. This review systematically…

Nrf2 Activation as a Therapeutic Target for Flavonoids in Aging-Related Osteoporosis.

Biological aging is a substantial change that leads to different diseases, including osteoporosis (OP), a condition involved in loss of bone … ardiovascular, and stroke. At the same time, multiple categories of natural products, in particular flavonoids, were proposed as safe alternatives with antioxidant activity and substantial anti-osteoporotic effects.

Bioactive flavonoids from Ohwia caudata stems influence small intestinal motility ex vivo.

This study reveals the therapeutic potential of Ohwia caudata in treating diarrhea-predominant irritable bowel syndrome (IBS-D), with a focus on its flavonoid constituents and their multimodal mechanisms. Forty flavonoids were identified, twelve of which are newly reported. Among these, twelve active compounds markedly suppressed intestinal contraction through distinct pathways: one (compound 21) acted as a calcium channel blocker, while others functioned via nitric oxide synthase activation (compounds 9, 10, and 23) or alternative mechanisms (compounds 25 and 29). Key structural determinants …

Фармакологическое разнообразие флавоноидов и их клинические перспективы применения в неврологических расстройствах.

Флавоноиды представляют собой разнообразную группу полифеноловых соединений, встречающихся в растительных продуктах питания и травах, для которых характерны различные формы гидроксилирования и гликозилирования. Их сложные молекулярные структуры обеспечивают широкий спектр фармакологической деятельности, включая эффект антиоксидантов путем улавливания реактивных видов кислорода (РОС) и активации Nrf2, антивоспалительные свойства с помощью ингибиции NF-IB, антиапоптотические эффекты и модуляция деятельности ионовых каналов. Эти механизмы делают флавоноидов перспективными кандидатами для терапевт

Совпадение в аннотации оригинала
Flavonoids are a diverse group of polyphenolic compounds found in plant-based foods and herbs, characterized by their varied hydroxylation and glycosylation patterns. Their complex molecular structures confer a wide range of pharmacological activities, including antioxidant effects through reactive oxygen species (ROS) scavenging and Nrf2 activation, anti-in…

Enzyme-Assisted Supercritical Fluid Extraction of Flavonoids from Apple Pomace (Malus×domestica).

Herein an enzyme-assisted supercritical fluid extraction (EA-SFE) was developed using the enzyme mix snailase to obtain flavonols and dihydrochalcones, subgroups of flavonoids, from globally abundant waste product apple pomace. Snailase, a commercially available mix of 20-30 enzymes, was successfully used to remove the sugar moieties from quercetin glycosides, kaempferol glycosides, phloridzin and 3-hydroxyphloridzin. The resulting flavonoid aglycones quercetin, kaempferol, phloretin and 3-hydroxyphloretin were extracted using supercritical carbon dioxide (scCO2) and minimum amounts of polar c…

Flavonoids modulate regenerative-related cellular events in LPS-challenged dental pulp cells.

OBJECTIVE: To investigate the effects of quercetin (QU), hesperetin (HT), and taxifolin (TX) on human dental pulp cells (hDPCs) chronically … ased, while ROS production and inflammatory response were significantly decreased. In addition, the flavonoids significantly stimulated cell migration, reduced NF-κB activation, and increased biomineralization by LPS-challenged hDPCs compared to cells exposed to LPS alone and without any other treatment. CONCLUSION: Flavonoids can modulate the metabolism of …