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Prebiotic and Synbiotic Treatment before Colorectal Surgery--Randomised Double Blind Trial.

The aim of our study was to demonstrate higher concentrations of lactic acid bacteria (LAB) on the colonic mucosa in operated colorectal cancer patients treated with oral intake of synbiotics or prebiotics preoperatively. We also tried to prove that the systemic inflammatory response after surgery is not so severe in patients who took synbiotics or prebiotics, furthermore these patients have less postoperative complications and a favorable postoperative course. 73 patients with preceding colorectal operations were recruited. They were randomized into three groups. One group received preoperati

Phase I trial of CJRB-101 plus pembrolizumab in patients with metastatic non-small cell lung cancer, head and neck squamous cell carcinoma and melanoma.

BACKGROUND: Dysbiosis of gut microbiome leads to resistance to immunotherapy in various advanced solid tumors. CJRB-101 is a live biotherapeutic product consisting of a novel strain belonging to the species Leuconostoc mesenteroides. To modulate the tumor microenvironment, CJRB-101 was combined with pembrolizumab. METHODS: Preclinical efficacy and mechanistic studies were performed using humanized non-small cell lung cancer (NSCLC) patient-derived xenograft (PDX) models. This is a multicenter, first-in-human, two-part, phase I, open-label study of CJRB-101 (1×1011 or 4×1011 colony forming uni…

A bacterial gene homologous to ABC transporters protect Oenococcus oeni from ethanol and other stress factors in wine.

The wine lactic acid bacteria Oenococcus oeni has to cope with harsh environmental conditions including an acidic pH, a high alcoholic content, non-optimal growth temperatures, and growth inhibitory compounds such as fatty acids, phenolic acids and tannins. We here describe characterisation and cloning of the O. oeni omrA gene encoding a protein belonging to the ATP-binding cassette superfamily of transporters. The OmrA protein displays the highest sequence similarity with the subfamily of ATP-dependent multidrug resistance (MDR) proteins, most notably the bacterial Lactococcus lactis LmrA hom

The ftsH gene of the wine bacterium Oenococcus oeni is involved in protection against environmental stress.

The wine bacterium Oenococcus oeni has to cope with harsh environmental conditions, including an acidic pH, a high alcoholic content, nonoptimal growth temperatures, and growth-inhibitory compounds such as fatty acids, phenolic acids, and tannins. We describe the characterization and cloning of the O. oeni ftsH gene, encoding a protease belonging to the ATP binding cassette protein superfamily. The O. oeni FtsH protein is closest in sequence similarity to the FtsH homologue of Lactococcus lactis. The O. oeni ftsH gene proved to be stress-responsive, since its expression increased at high tempe

Microbial communities and volatile profile of Queijo de Azeitão PDO cheese, a traditional Mediterranean thistle-curdled cheese from Portugal.

The production of ovine or caprine milk cheeses with thistle rennet is a common practice in the Mediterranean basin. The aim of the present … parently shared by the three producers, whose cheese manufactures were dominated by the presence of Leuconostoc mesenteroides (37% of the relative frequency in average), Lactococcus lactis (29%), Lacticaseibacillus zeae (4.7%), Lentilactobacillus kefiri (4.4%), Serratia spp. (3.5%), Lactiplantibacillus plantarum (2.7%), and Latilactobacillus sakei (2.5%). The …

Emerging Immunotherapy and Antibody-Derived Therapeutics for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Review.

Background: In the last decade, a surge of advancements in and approvals of immunotherapies has revolutionized the treatment of non-small-cell lung cancer (NSCLC). Even as an increasing number of immune checkpoint inhibitors and antibody-drug conjugates gained FDA approval for the remarkable response and durable remission they imparted to some patients, persistent challenges of primary and acquired resistance, imperfect predictive biomarkers, and toxicity remain. Methods: This review identifies and summarizes the most significant emerging clinical data being reported for immunotherapies in NSC

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… Leuconostoc mesenteroides Leuconostoc mesenteroides is a lactic acid bacterium primarily used in the fermentation of foods such as kimchi, sauerkraut, and dairy products [ 85 ]. … Exploring the Therapeutic Potential of Leuconostoc mesenteroides Lysates in Wound Healing and Immune Modulation on Keratinocyte Cells Arch. Dermatol. Res. 2024 316 548 10.1007/s00403-024-03324-2 39162738 88. Zununi Vahed S. Barzegari A. Rahbar Saadat Y. Goreyshi A. Omidi Y. …

Сосуществование Лактиплантацилла и Виккерхамомиц в верхнем слое сахарного тростника стимулирует потенциальное подавление патогенов и аэробную стабильность за счет увеличения производства лактической кислоты и уксусной кислоты.

Чтобы определить сосуществующие бактерии и дрожжи в верхнем слое сахарного тростника, которые определяют качество ферментации и повышают безопасность корма, мы манипулировали эпифитической микробиотой сверху сахарного тростника путем селективного подавления дрожжей (АФ) или бактерий с лактической кислотой (АБ) перед повторной цензурой, используя в качестве контроля неочищенные (КК) и стерилизованные стерилизованные силизы (НА). Результаты показывают, что высокоурожайное производство лактической кислоты и уксусной кислоты (p) < 0.05), лучшая аэробная стабильность и высокая плотность Лактипланта

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… Others, when certain yeasts (e.g., S accharomyces cerevisiae , Pichia anomala ) are co‑inoculated with LAB (e.g., Lactobacillus spp., Leuconostoc citreum ), these yeasts enhance LA and AA accumulation by promoting LAB growth through synergistic effects (e.g., supplying amino acids and vitamins) [ 13 … Pichia anomala enhances the growth and lactic acid production of Leuconostoc citreum : synergistic improvement for sweet sorghum silage quality. Bioresour Technol. 2026. 10.1016/j.biortech.2026.134128. 41638590 10.1016/j.biortech.2026.134128 17. …

Probiotics for the prevention of pediatric antibiotic-associated diarrhea.

BACKGROUND: Antibiotics are frequently prescribed in children. They alter the microbial balance within the gastrointestinal tract, commonly … er Bacillus spp., Bifidobacterium spp., Clostridium butyricum, Lactobacilli spp., Lactococcus spp., Leuconostoc cremoris, Saccharomyces spp., orStreptococcus spp., alone or in combination. Eleven studies used a single strain probiotic, four combined two probiotic strains, three combined three probiotic strains, one combined four probiotic strains, two combine …

Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea.

UNLABELLED: Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, Johnston BC. Probiotics for the prevention of pediatric antibiotic-asso … er Bacillus spp., Bifidobacterium spp., Clostridium butyricum, Lactobacilli spp., Lactococcus spp., Leuconostoc cremoris, Saccharomyces spp., or Streptococcus spp., alone or in combination. Eleven studies used a single-strain probiotic, four combined two probiotic strains, three combined three probiotic strains, one combined four probiotic strains, two combin …

Are patients with cancer with sepsis and bacteraemia at a higher risk of mortality? A retrospective chart review of patients presenting to a tertiary care centre in Lebanon.

ObjectiveMost sepsis studies have looked at the general population. The aim of this study is to report on the characteristics, treatment and hospital mortality of patients with cancer diagnosed with sepsis or septic shock.SettingA single-centre retrospective study at a tertiary care centre looking at patients with cancer who presented to our tertiary hospital with sepsis, septic shock or bacteraemia between 2010 and 2015.Participants176 patients with cancer were compared with 176 cancer-free controls.Primary and secondary outcomesThe primary outcome of this study was the in hospital mortality

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… †Others included: Bacteroides fragilis , Candida albicans , Citrobacter , Diphteroids spp., Enterobacter cloacae , Haemophilus influenzae (type B), Haemophilus parainfluenzae , Legionella pneumophila , Leuconostoc , Morganella morgani , Peptococcus spp., Providncia stuartii , Serratia marsescens , Stenotrophomonas …

Probiotics for the prevention of pediatric antibiotic-associated diarrhea.

BACKGROUND: Antibiotics alter the microbial balance within the gastrointestinal tract. Probiotics may prevent antibiotic-associated diarrhea … ded treatment with either Bacillus spp., Bifidobacterium spp., Lactobacilli spp., Lactococcus spp., Leuconostoc cremoris, Saccharomyces spp., or Streptococcus spp., alone or in combination. Nine studies used a single strain probiotic agent, four combined two probiotic strains, one combined three probiotic strains, one product included ten probiotic agents, an …

Probiotics for the prevention of pediatric antibiotic-associated diarrhea.

BACKGROUND: Antibiotics alter the microbial balance commonly resulting in antibiotic-associated diarrhea (AAD). Probiotics may prevent AAD v … ed Bacillus spp., Bifidobacterium spp., Clostridium butyricum, Lactobacilli spp., Lactococcus spp., Leuconostoc cremoris, Saccharomyces spp., orStreptococcus spp., alone or in combination. The risk of bias was determined to be high in 20 studies and low in 13 studies. Complete case (patients who did not complete the studies were not included in the analysis) …

A case of recto-sigmoid endometriosis mimicking carcinoma.

OBJECTIVE: To evaluate the technical success, safety and outcome of endovascular coiling procedure in intracranial aneurysms. METHODS: From April 2003 to April 2009, 43 patients (23 males and 20 females), age range 11 to 70 years, mean age 46.67 +/- 11.57 years were treated for intracranial aneurysms by detachable coil deployment at Radiology Department of Aga Khan University Hospital. Aneurysm rupture with subarachnoid haemorrhage was the cause of presentation in 39 patients while 4 patients were diagnosed with un-ruptured aneurysms. At time of presentation, grading of subarachnoid haemorrha

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… Microbial strains, inoculum preparation, and establishment of OD 600 –CFU calibration curves Yeast ( Kluyveromyces marxianus and Saccharomyces bayanus ), AAB ( Komagataeibacter xylinus and Gluconobacter oxydans ), and LAB ( Leuconostoc mesenteroides ) were used in this study. …

метрики соотношений на основе пропорциональности при подсчете данных о составе.

Составные данные включают векторы, описывающие составные части целого. Данные, полученные с помощью различных -омикических платформ, таких, как 16S и RNA, носят составный характер. В таких данных корреляции между характеристиками первичных счетов не имеют сколько-нибудь значимого толкования. Для решения этой проблемы были сформулированы критерии пропорциональности. Однако имманентная погрешность возникает тогда, когда эти метрики рассчитываются эмпирически на основе показателей, основанных на подсчете, из-за изменчивости глубин считываемого материала. Мы подсчитали погрешность, введенная путем

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… between MS ( ) and control samples ( ) Genus 1 | Genus 2 | | | Gallibacterium | Escherichia | 0.7002 | 0.3253 | 0.3749 Dialister | Phascolarctobacterium | 0.5322 | 0.1975 | 0.3347 Escherichia | Adlercreutzia | 0.5599 | 0.231 | 0.329 Serratia | Escherichia | 0.6953 | 0.3716 | 0.3237 Escherichia | Leuconostoc …

Late-occurring infections in a contemporary cohort of hematopoietic cell transplantation survivors.

BackgroundThere is a paucity of studies describing the incidence and risk factors for late-occurring (≥1 year) infectious complications in contemporary survivors of hematopoietic cell transplantation (HCT).MethodsThis was a retrospective cohort study of 641 1-year survivors of HCT, transplanted between 2010 and 2013 as adults, and in remission from their primary disease. Standardized definitions were used to characterize viral, fungal, and bacterial infections. Cumulative incidence of infections was calculated, with relapse/progression considered as a competing risk event. Fine-Gray subdistrib

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… .: Acinetobacter , Stenotrophomonas , Actinomyces , Alcaligenes , Xylosus , Bacillus , Clostridium , Corynebacterium , Gardnerella , Haemophilus influenzae , Hafnia alvei , Serratia , Leuconostoc mesenteroides , Lysinibacillus , Moraxella , Mycobacterium , Mycoplasma , Propionibacterium , Proteus , Rhizobium …

The Link Between the Gut Microbiome and Bone Metastasis.

The gut microbiome is essential for regulating host metabolism, defending against pathogens, and shaping the host's immune system. Mounting evidence highlights that disruption in gut microbial communities significantly impacts cancer development and treatment. Moreover, tumor-associated microbiota, along with its metabolites and toxins, may contribute to cancer progression by promoting epithelial-to-mesenchymal transition, angiogenesis, and metastatic spread to distant organs. Bones, in particular, are common sites for metastasis due to a rich supply of growth and neovascularization factors an

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… spine, integral and vertebral trabecular BMD, and biochemical marker of bone resorption/formation and analyze gut microbiome function | 220 participants | Subjects will be daily supplemented with SBD111 medical food (oligofructose, dried berry powder, Pseudomonas fluorescens , Lactobacillus brevis , Leuconostoc …

Abstracts cont.

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Chimeric antigen receptor T-cell therapies related to immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome: Diagnosis, high-risk factors, and management.

AbstractImmune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS) is a life-threatening complication of chimeric antigen receptor T cell (CAR-T) therapy. Despite its high mortality rate, IEC-HS remains underrecognized due to overlapping clinical and laboratory features with severe cytokine release syndrome (CRS), leading to delayed diagnosis and suboptimal management. This review systematically analyzes key strategies to distinguish IEC-HS from severe CRS in the literature. The analysis focuses on temporal patterns, such as the delayed onset of IEC-HS after CAR-

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… It has been observed that Bifidobacterium and Leuconostoc are enriched in patients with MM with high-grade CRS. [ 120 ] High-grade CRS, which is one of the high-risk factors, further mediates the development of IEC-HS. …

Pharmacomicrobiomics in precision cancer therapy: bench to bedside.

The burgeoning field of pharmacomicrobiomics offers promising insights into the intricate interplay between the microbiome and cancer, shaping responses to diverse treatment modalities. This review aims to analyze the molecular mechanisms underlying interactions between distinct microbiota types and cancer, as well as their influence on treatment outcomes. We explore how the microbiome impacts antitumor immunity, and response to chemotherapy, immunotherapy, and radiation therapy, unveiling its multifaceted roles in cancer progression and therapy resistance. Moreover, we discuss the challenges

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… Reduce the short-term infectious complications | ( 130 ) CRC | 150 | ST | Probiotics: Lactobacillus plantarum (CGMCC no.1258), Lactobacillus acidophilus -11 and Bifidobacterium longum -88 | Reduce the rate of postoperative septicemia | ( 131 ) CRC | 75 | ST | Synbiotics: Pediococcus pentosaceus 5-33:3, Leuconostoc …

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.

The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interac

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… For example, Thermicanus aegyptius, Anaerococcus nagyae, Leuconostoc garlicum, Neisseria bacilliformis, Corynebacterium vitaeruminis, L. mesenteroides, and Ethanoligenens harbinense were observed to only colonize the benign tissue whereas Mycoplasma vulturii, Phaeocystis antarctica, Spirosoma navajo, …