Результаты поиска

Correlation between IGFBP7 and inflammatory cytokines in patients with multiple sclerosis.

BACKGROUND: Inflammatory cytokines contribute to neuroinflammation in multiple sclerosis (MS), yet their diagnostic value in serum and cerebrospinal fluid (CSF) remains inconsistent. Insulin-like growth factor binding protein 7 (IGFBP7) has been implicated in inflammatory and repair-related pathways, but its clinical relevance and relationship with cytokine activity in MS are not well defined. OBJECTIVE: This study aimed to evaluate the diagnostic and clinical relevance of serum and CSF inflammatory cytokines and IGFBP7 in MS, and to determine whether combining IGFBP7 with key cytokines impro…

Real-world effectiveness, safety and immunogenicity of ocrelizumab in turkish multiple sclerosis patients: a single-center experience for 4-year follow-up.

OBJECTIVE: The aim of this study was to evaluate postmarketing ocrelizumab safety and effectiveness in a real-world population with multiple sclerosis (MS) and matching these parameters among MS disease types. METHODS: This was a retrospective, single-center study with MS patients treated with ocrelizumab. Demographic, clinical characteristics and immunological data were analyzed, including annualized relapse rate (ARR), relapse-free rate, Expanded Disability Status Scale (EDSS), complete blood count parameters, immunoglobulin (Ig) levels, liver function tests (LFT), hepatitis markers and adv…

[HTLV-I retrovirus in Chile: study on 140 neurological patients].

We screened 140 patients with different neurological diseases for the presence of anti HTLV-1 virus antibodies. ELISA test confirmed with Western Blot analysis was performed in CSF and blood. Positive findings were obtained in 23 out of 52 patients with progressive spastic paraparesis (44%). All patients with multiple sclerosis, polymyositis, amyotrophic lateral sclerosis or chronic polyneuropathy were negative. Patients with progressive spastic paraparesis and positive HTLV-1 antibodies were most commonly women (78%) and middle aged (mean 46 years old), with a history of surgical intervention…

Serum sTREM2 Levels and Disability Progression in Patients With Primary Progressive Multiple Sclerosis.

BACKGROUND: Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia surface receptor that aids in tissue repair and debris c … at baseline using a single-molecule array assay in a multicenter cohort of 137 primary progressive multiple sclerosis (PPMS) patients. Univariable and multivariable linear models evaluated the association between sTREM2 levels and EDSS change at 2 years, 6 years, and last follow-up. RESULTS: While an association was observed at 2 years only in non-inflammatory PPM …

Увязка патогенеза с падением риска при множественном склерозе.

Множественный склероз — это хроническое неврологическое расстройство, характеризующееся постепенной инвалидностью, при этом падение является значительным следствием его физических и когнитивных расстройств. В настоящем обзоре рассматриваются основные вкладчики, с тем чтобы снизить риск для лиц с множественным склерозом, и анализируются более широкие последствия этих факторов, такие, как боязнь падения. К основным факторам, связанным с падением риска, относятся аномалии, когнитивная дисфункция и усталость. Эти факторы часто взаимодействуют друг с другом, что приводит к ограничению мобильности и

Совпадение в аннотации оригинала
Multiple Sclerosis is a chronic neurological disorder characterized by progressive disability, with falls being a significant consequence of its physical and cognitive impairments. This review explores the major contributors to fall risk in individuals with multiple sclerosis and explores the broader implications of these factors, such as the fear of falling…

Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis.

The involvement of proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and lymphotoxin (LT) in multiple sclerosis is suggested by the parallel occurrence of these proinflammatory cytokines in acute and chronic active multiple sclerosis brain lesions. We describe the use of in situ hybridization with radiolabelled cDNA oligonucleotide probes to detect and enumerate TNF-alpha and LT mRNA expressing mononuclear cells without culture, and after culture in the presence of myelin basic protein (MBP), control antigens or without antigen. Compared with patients with aseptic meningo-ence…

Clinical course of critical demyelinating lesion-associated progressive multiple sclerosis.

BACKGROUND: Progressive multiple sclerosis (MS) is usually associated with progressive asymmetrical motor impairment. A single critical demyelinating lesion anatomically associated with motor impairment was seen in > 20% of patients with progressive MS. The assessment of critical lesion-associated progressive MS requires understanding their clinical course, how prior inflammatory relapse location and their first MRI appearance relates to progressive motor impairment. OBJECTIVES: To determine: (1) clinical course and prior relapse location and (2) interval between first MRI critical lesion evi…

A systematic review and meta-analysis of real-world data predictors for conversion to progressive multiple sclerosis.

BACKGROUND: Available fluid biomarkers, neuroimaging techniques, and clinical assessments may enhance prediction of conversion to secondary progressive multiple sclerosis (SPMS). OBJECTIVES: To identify robust real-world predictors of MS progression in the literature. METHODS: A systematic review was conducted in EMBASE. A total of 20,338 MS patients from 64 eligible studies were included. A p-value meta-analysis and a tipping point analysis were performed to assess associations with MS progression and EDSS. RESULTS: Among CSF biomarkers, GFAP (p = 6.2 × 10⁻¹⁰) and CHI3L1 (p = 1.7 × 10⁻¹¹) …

Нейрофильтрационная тяжелая цепочка в вторичном прогрессивном множественном склерозе.

Для отслеживания прогресса в испытаниях MS необходимы биомаркеры. Нейрофильтрационная тяжелая цепочка (NfH) используется недостаточно из-за ограничений на анализ. ЦЕЛЬ: Изучение дополнительной ценности церебрально-пинальной жидкости (CSF) NfH в вторичном прогрессивном множественном склерозе (SPMS) с использованием современных иммуномасс. Это исследовательское исследование было частью судебного процесса по делу MS-SMART. Клинические оценки (включая расширенную шкалу показателей инвалидности, функцию верхней и нижней частей конечностей, визуальную акумуляцию и проверку параметров символических з

Совпадение в аннотации оригинала
BACKGROUND: Biomarkers are needed to track progression in MS trials. Neurofilament heavy chain (NfH) has been underutilized due to assay limitations. OBJECTIVE: To investigate the added value of cerebrospinal fluid (CSF) NfH in secondary progressive multiple sclerosis (SPMS) using contemporary immunoassays. METHODS: This exploratory study was part of the M…

Spinal cord size as promising biomarker of disability outcomes after hematopoietic stem cell transplantation in multiple sclerosis.

BACKGROUND: Biomarkers predictive of disability outcomes in individual multiple sclerosis (MS) patients undergoing autologous haematopoietic stem cell transplantation (AHSCT) are currently lacking. As correlations between spinal cord atrophy and clinical disability in MS were previously described, in this study spinal cord size was investigated in MS patients treated with AHSCT, exploring whether baseline spinal cord volume may predict disability progression after AHSCT. METHODS: relapsing-remitting (RR-) and secondary-progressive (SP-) MS patients treated with AHSCT (BEAM/ATG regimen) at a s…

Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis.

Retinal optical coherence tomography has been identified as biomarker for disease progression in relapsing-remitting multiple sclerosis (RRMS), while the dynamics of retinal atrophy in progressive MS are less clear. We investigated retinal layer thickness changes in RRMS, primary and secondary progressive MS (PPMS, SPMS), and their prognostic value for disease activity. Here, we analyzed 2651 OCT measurements of 195 RRMS, 87 SPMS, 125 PPMS patients, and 98 controls from five German MS centers after quality control. Peripapillary and macular retinal nerve fiber layer (pRNFL, mRNFL) thickness pr…

Role of Demographic and Clinical Factors in Cognitive Functioning of Persons with Relapsing-Remitting and Progressive Multiple Sclerosis.

BACKGROUND: Age and time post-diagnosis can significantly impact cognitive and motor functions in multiple sclerosis (MS); however, studies often fail to account for these factors when assessing differences between disease courses. OBJECTIVES: Examine differences between relapsing-remitting and progressive MS in cognition, motor function, and everyday activities, controlling for age, education, and time post-diagnosis. METHODS: Twenty-one persons with relapsing-remitting MS (RRMS group), 21 with progressive MS (PMS group), and 21 healthy participants (HCs), matched on age, education, and tim…

Correlating multiple MRI parameters with clinical features: an attempt to define a new strategy in multiple sclerosis.

MRI is the most powerful imaging technique in managing patients with suspected or confirmed multiple sclerosis (MS). However, conventional MRI variables show nonspecific abnormalities weakly correlated with clinical progression of the disease. New techniques, now routinely available, offer better characterisation of the pathophysiology. We combined conventional MRI, including lesion load, contrast enhancement and "black holes" with magnetisation transfer and diffusion-weighted imaging and localised proton MR spectroscopy (MRS) to study their relationship with disability, course and duration of…

Diagnostic overshadowing in primary progressive multiple sclerosis with coexisting tethered cord syndrome and long-standing urological dysfunction: a case report and literature review.

BACKGROUND: Primary progressive multiple sclerosis (PPMS) may be diagnostically challenging when coexisting structural spinal abnormalities produce overlapping neurological and urinary manifestations. Tethered cord syndrome (TCS) and PPMS can both present with progressive myelopathy and lower urinary tract symptoms, increasing the risk of diagnostic overshadowing. CASE PRESENTATION: A 42-year-old woman with a history of sacrococcygeal meningocele and prior surgical resection presented with a 20-year history of urinary dysfunction and a 2-year history of progressive ascending sensory symptoms …

Efficacy and safety of mesenchymal stem cell transplantation for progressive multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials with clinical implications for patient stratification and treatment optimization.

BACKGROUND: Progressive multiple sclerosis (PMS) is a disabling demyelinating disease characterized by irreversible neurodegeneration. Unlike relapsing-remitting MS, for which many disease-modifying therapies exist, treatment options for PMS are extremely limited. Only two agents (ocrelizumab and siponimod) have modest efficacy, and no effective therapies exist for non-active disease. Mesenchymal stem cell (MSC) transplantation has emerged as a promising strategy due to its immunomodulatory and neurotrophic properties. However, clinical trials have yielded inconsistent results, and prior meta-…

Angiogenesis and Hypoxia Biomarkers Are Dysregulated in Progressive Multiple Sclerosis.

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative CNS disorder characterized by a state of "virtual hypoxia." Angiogenesis, one of the main homeostatic responses to hypoxia, has been implicated in the pathophysiology of MS. The study objective was to determine whether angiogenic and hypoxia-related molecules are dysregulated in the serum and CNS of patients with progressive multiple sclerosis (PMS). METHODS: Baseline serum samples were obtained from a phase II trial of Ibudilast in PMS (n = 203 analyzed) and matched to healthy controls (n = 53). P…

What Is the Evidence on Immunomodulators and Immunosuppressants for Progressive Multiple Sclerosis? - A Cochrane Review Summary with Commentary.

BackgroundMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system and is a major cause of disability in adults, particularly in those affected by progressive MS. A variety of drugs with different effects, some carrying significant risks, are currently available, making evidence-based approach essential for clinicians treating MS patients.ObjectiveTo compare the efficacy and safety of immunomodulators and immunosuppressants for progressive multiple sclerosis (PMS).MethodsA systematic search was performed in CENTRAL, MEDLINE, Embase, and trial…

Lower cortical gamma-aminobutyric acid level contributes to increased connectivity in sensory-motor regions in progressive MS.

BACKGROUND: Large-scale functional abnormalities and decreased synchronization between functionally connected regions within brain networks were reported in progressive multiple sclerosis (P-MS) patients. Low concentration of gamma-aminobutyric acid (GABA) was observed in the sensorimotor cortex (SMC) of these patients and was associated with reduced motor functions of limbs. Yet, the role of GABA in modulating functional connectivity (FC) has not been investigated in MS patients. OBJECTIVES: To determine the relationship between GABA concentration in the SMC and short-term FC changes within …

The Prevalence and Impact of Urinary Incontinence on Multiple Sclerosis Patients in Taif City, Saudi Arabia.

Introduction Multiple sclerosis (MS) is a chronic inflammatory disease that results in demyelination and progressive loss of nerve cells within the central nervous system. Multiple sclerosis, as well as other neurological diseases that impact brain structures and spinal pathways involved in sphincter control, may cause lower urinary tract symptoms (LUTS) Our aims are to determine the prevalence, severity, and impact on the quality of life of urinary incontinence among MS patients in Taif, Saudi Arabia, as well as its potential association with demographics and clinical features. Method A cross…

Proteomics Reveals Age as Major Modifier of Inflammatory CSF Signatures in Multiple Sclerosis.

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) can start as relapsing or progressive. While their clinical features and treatment responses are distinct, it has remained uncertain whether their pathomechanisms differ. A notable age-related effect on MS phenotype and response to immunotherapies is well acknowledged, but the underlying pathophysiologic reasons are yet to be fully elucidated. We aimed to identify disease-specific and age-related proteomic signatures using a comprehensive targeted proteomic analysis. METHODS: In our retrospective cohort study, we analyzed the CSF and serum pr…