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Human-Centered Design of a Multistakeholder Reporting Dashboard for Disseminating HIV Implementation Research in the Ending the HIV Epidemic Initiative: Development and Formative Evaluation Study.

BACKGROUND: Interactive dashboards have expanded public access to HIV surveillance and programmatic data, but existing tools do not synthesize implementation research evidence into formats accessible to the diverse stakeholders who could use it. Designing such tools requires deliberate alignment with users' needs, language, and decision-making contexts. OBJECTIVE: We describe the human-centered design (HCD) process used to develop and conduct a formative evaluation of the Ending the HIV Epidemic (EHE) Implementation Science (IS) Reporting Dashboard, a public-facing tool intended to synthesize

How knowledge translation interventions involving health policy decision makers are evaluated: a scoping review protocol.

BACKGROUND: Knowledge translation (KT) interventions support the use of research evidence in health policymaking but vary substantially in form, complexity and evaluation. There is no comprehensive synthesis of how KT interventions involving health policy decision makers are evaluated across intervention types and policy contexts. OBJECTIVES: This scoping review aims to map and describe how KT interventions involving health policy decision makers are evaluated. It will identify evaluation approaches, designs and methods; describe theories, frameworks, programme logics and rationales informing

CELEBRATING 30 YEARS OF COCHRANE ORAL HEALTH: A LEGACY OF EVIDENCE AND IMPACT.

In 2024, Cochrane Oral Health (COH) celebrated its 30th anniversary, marking 3 decades of advancing global oral health through rigorous evid … thodological standards and promoting transparency through protocol publication and freely available plain language summaries. Our reviews are widely cited in international guidelines and policy documents, with notable contributions to evidence synthesis and knowledge translation in the areas of fluoride interventions, antimicrobial use, oral cancer management, and infecti …

Registered report: The effectiveness of a Bhagavad Gita intervention to reduce psychological distress in homeless people-A randomised controlled trial.

INTRODUCTION: The coronavirus disease pandemic has worsened psychological distress in people experiencing homelessness (PEH). This study eva … licly available upon publication. Efforts will be made to communicate results through infographics, plain language summaries, and tailored strategies, including community meetings and digital platforms, to engage and empower PEH in decision-making. TRIAL REGISTRATION: The trial has been registered with the Clinical Trials Registry of India (registration number: CTRI/2022 …

Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experience: the SPIN-CLEAR Trials.

BACKGROUND: Research results are often not communicated to study participants or others with relevant lived experience. Effective communication of research results would help study participants understand their contribution to research and could improve trust in research and likelihood of research participation. Few randomized controlled trials (RCTs), however, have compared the effectiveness of research communication tools, and it is not known which tools work best for different people. We will conduct the Scleroderma Patient-centered Intervention Network-Communicating Latest Evidence and Res

Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC Score: A Systematic Review and Meta-Analysis.

OBJECTIVE: We sought to summarize accuracy of physical examination, imaging, and Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score in diagnosis of necrotizing soft tissue infection (NSTI) in adults with a soft tissue infection clinically concerning for NSTI. SUMMARY OF BACKGROUND DATA: NSTI is a life-threatening diagnosis. Delay to diagnosis and surgical management is associated with increased mortality. METHODS: We searched 6 databases from inception through November 2017. We included English-language studies reporting diagnostic accuracy of testing or LRINEC Score. Outcome

Left-sided epileptiform activity influences language lateralization in right mesial temporal sclerosis.

OBJECTIVE: To investigate the association between left epileptiform activity and language laterality indices (LI) in patients with right mesial temporal sclerosis (MTS). METHODS: Twenty-two patients with right MTS and 22 healthy subjects underwent fMRI scanning while performing a language task. LI was calculated in multiple regions of interest (ROI). Data on the presence of left epileptiform abnormalities were obtained during prolonged video-EEG monitoring. RESULTS: After correction for multiple comparisons, LI was reduced in the middle temporal gyrus in the left interictal epileptiform disc

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

Совпадение в аннотации оригинала
INTRODUCTION: Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is co … vergence and compare recommendations answering the same guideline question. Lastly, we will develop plain language summaries of trustworthy recommendations and decision aids to support patient-physician decision making, and translate the platform to French, Spanish, and Mandarin. Finally, a mobilization phase in which, with our interest holders, we will co-create strategi …

Strategies for Implementing Research in Practice and Policy in CKD: A Workshop Report.

BACKGROUND: Routine implementation of chronic kidney disease research into practice and policy is delayed, fragmented and inconsistent. This workshop aimed to identify strategies to strengthen the implementation of research findings into practice and policy from the perspectives of patients, their caregivers and health professionals. METHODS: A workshop was conducted with patients (n=18), caregivers (n=9) and health professionals (n=102) from Australia and New Zealand. Thirteen simultaneous breakout groups of 6-10 participants were held online and in-person to discuss strategies for implement

DIAMONDS-a diabetes self-management intervention for people with severe mental illness: protocol for an individually randomised controlled multicentre trial.

INTRODUCTION: Type 2 diabetes mellitus (T2DM) is two to three times more common in people with severe mental illness (SMI) than in the gener … s will be published in peer-reviewed, academic and professional journals. We will also be producing plain language summaries, infographics and audio summaries on the website, as well as attending conferences and dissemination events. A summary of the results will be distributed to all participants and other relevant stakeholders, and we will use social media channels, web …

Safety of Maternal Immunization Against Pertussis: A Systematic Review.

The WHO recommends vaccination of all children against pertussis. However, newborn infants remain vulnerable to infection. Pertussis vaccination during pregnancy has been introduced in several countries to protect newborns via transplacental transfer of maternal pertussis antibodies to the infant. We reviewed the impact of maternal pertussis vaccination on the health of pregnant women, the developing fetus, and health of the newborn. We searched PubMed/MEDLINE, EMBASE, Scopus (Elsevier), Cochrane Database of Systematic Reviews, ProQuest, and Science Direct to identify studies that assessed the

Assessing Physical Activity and Sleep in Axial Spondyloarthritis: Measuring the Gap.

Patients with axial spondyloarthritis (axSpA) frequently report pain, stiffness, fatigue, and sleep problems, which may lead to impaired physical activity. The majority of reported-on measures evaluating physical activity and sleep disturbance in axSpA are self-reported questionnaires, which can be impacted by patient recall (reporting bias). One objective measure, polysomnography, has been employed to evaluate sleep in patients with axSpA; however, it is an intrusive measure and cannot be used over the long term. More convenient objective measures are therefore needed to allow for the long-te

GATAD2B-related developmental and epileptic encephalopathy (DEE): Extending the epilepsy phenotype and a literature appraisal.

Heterozygous pathogenic variants in GATAD2B gene have been related to the GATAD2B-associated neurodevelopmental disorders (GAND) characterized by neurodevelopmental delay with predominant language impairment, infantile hypotonia, macrocephaly, ophthalmological abnormalities, and dysmorphic facial features with nonspecific findings on brain magnetic resonance imaging (MRI). Occasionally, affected individuals exhibit drug responsive epilepsy, psychiatric disorders, and other extra-neurological comorbidities. We report a patient carrying a de novo heterozygous missense variant in GATAD2B gene. Sh

Insulin Therapy in Adults with Type 1 Diabetes Mellitus: a Narrative Review.

Here, we review insulin management options and strategies in nonpregnant adult patients with type 1 diabetes mellitus (T1DM). Most patients with T1DM should follow a regimen of multiple daily injections of basal/bolus insulin, but those not meeting individual glycemic targets or those with frequent or severe hypoglycemia or pronounced dawn phenomenon should consider continuous subcutaneous insulin infusion. The latter treatment modality could also be an alternative based on patient preferences and availability of reimbursement. Continuous glucose monitoring may improve glycemic control irrespe

Lateralization of memory function in temporal lobe epilepsy using scene memory fMRI.

Functional magnetic resonance imaging (fMRI) offers an alternative to the traditional Wada test for presurgical language and memory lateralization that carries almost no risk. However, fMRI lateralization of episodic memory remains challenging because the hippocampus, which is fundamental to episodic memory, is smaller, more prone to susceptibility artifact, and harder to functionally modulate than language regions. We previously showed that a complex scene memory task can lateralize memory function in the mesial temporal lobe. Using data acquired from N = 45 patients with temporal lobe epilep

A microsurgical approach to implant mechanical rescue.

The purpose of this paper is to describe and illustrate the value of using a microsurgical approach when resolving an implant mechanical rescue case (internally retained implant component fragments). Four cases involving screw retrieval issues are reviewed to demonstrate how microscopic visualization clarifies a diagnostic algorithm to determine correct treatment protocols. Microscopic visualization then continues to contribute an extreme advantage for guidance and predictability during treatment. When accompanied with appropriate tooling choices, the combination offers improved consistency an

Evaluation of online cancer information for Aboriginal and Torres Strait Islander peoples: a systematic environmental scan.

BACKGROUND: Aboriginal and Torres Strait Islander peoples experience greater cancer incidence rates, unmet information needs, and poorer cancer outcomes compared to the general Australian population. This environmental scan evaluated cancer websites for Aboriginal and Torres Strait Islander peoples in Australia. METHODS: An environmental scan using 8 Google searches was conducted in July 2025 to identify cancer-related websites targeted toward Aboriginal and Torres Strait Islander peoples in Australia. Patient-facing resources were assessed for readability, understandability, and actionabilit

A rare partnership: patient community and industry collaboration to shape the impact of real-world evidence on the rare disease ecosystem.

People with rare lysosomal storage diseases face challenges in their care that arise from disease complexity and heterogeneity, compounded b … iatives including patient representation at Rare Disease Registries advisory boards; development of plain language summaries of registry publications to increase availability of real-world evidence to patient communities; and implementation of digital innovations such as electronic patient-reported outcomes, and patient-facing registry reports and electronic consent (in d …

Addressing the need for patient-friendly medical communications: adaptation of the 2019 recommendations for the management of MPS VI and MPS IVA.

BACKGROUND: Patients are the most important stakeholders in the care of any disease and have an educational need to learn about their condit … atients and their caregivers can find the technical content challenging. Hence, we aimed to develop plain language summaries (PLS) of the MPS VI and MPS IVA guidelines with patients as the primary audience. RESULTS: A review of the guidelines by an expert team identified six domains of information relevant to patients: The multidisciplinary team, regular tests and check- …

Nurture Early for Optimal Nutrition (NEON) participatory learning and action women's groups to improve infant feeding and practices in South Asian infants: pilot randomised trial study protocol.

INTRODUCTION: Feeding practices developed in early life can impact a child's nutrition, growth, dental health, cognitive development and lif … ted at scientific conferences/workshops with commissioners, partners and participating communities. Plain language summaries will be disseminated through community groups, websites and social media. TRIAL REGISTRATION NUMBER: IRAS-ID-296259 (ISRCTN10234623).