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Bacterial probiotic modulation of dendritic cells.

Intestinal dendritic cells are continually exposed to ingested microorganisms and high concentrations of endogenous bacterial flora. These cells can be activated by infectious agents and other stimuli to induce T-cell responses and to produce chemokines which recruit other cells to the local environment. Bacterial probiotics are of increasing use against intestinal disorders such as inflammatory bowel disease. They act as nonpathogenic stimuli within the gut to regain immunologic quiescence. This study was designed to determine the ability of a bacterial probiotic cocktail VSL#3 to alter cell …

Glucosamine-Producing Engineered Probiotics Enhance the Immune Function of Microglia.

Dysregulated microglial activation underlies both neuroinflammation and neurodegenerative pathology. GlcN has well-documented anti-inflammatory activity across multiple cell types, yet whether it acts on microglia in any meaningful way has not been directly tested. Here we show that GlcN shifts microglia toward an M2 anti-inflammatory state by altering their metabolic program, an effect accompanied by a clear improvement in immune function. A practical barrier complicates direct translation of this finding, oral GlcN is rapidly cleared and reaches target tissues at concentrations too low to be

ROS-triggerable dual nanocoated probiotics for inflammatory bowel disease treatment.

Inflammatory bowel disease (IBD), an immune-mediated chronic gastrointestinal disease, is difficult to treat because its specific pathogenic mechanisms are currently unclear, and its recurrence rate is high. Probiotic therapies have been used to treat IBD; however, challenges, including poor digestive stability and unstable treatment effects, remain. Catechins are natural flavonoids with anti-inflammatory and anti-oxidant properties. In this study, we link catechins to the amino side chain of ethylene glycol chitosan through phenylboronic acid as a nano coating for probiotics, and enhance thei…

Emulsion Gel for Intestine-Specific Enzyme-Triggered Release of Probiotics.

Probiotics are crucial for building a healthy microbiota in the intestine. However, most probiotics could not survive when exposed to the acidic stomach condition after oral administration, imposing a significant barrier to their broad applications. Here, a water-in-oil jammed Pickering emulsion gel (JPEG) is prepared to encapsulate probiotics, which effectively protects probiotics from the harsh acidic condition and specifically releases them in the intestine. Probiotics-loaded JPEG (PL-JPEG) demonstrates good stability against centrifugation forces, pH changes, temperature changes, and over …

Probiotics for ulcerative colitis: mechanisms, therapeutic advances, and emerging strategies.

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease with a rising global incidence. Existing therapies are often limited by suboptimal efficacy and frequent relapse. Gut microbiota dysbiosis is central to UC pathogenesis, providing a rationale for probiotic-based, microbiota-targeted interventions. This review synthesizes evidence that probiotics mitigate UC through multiple synergistic mechanisms: competitive exclusion to rebalance the microbiota, upregulation of tight junction proteins to restore the intestinal barrier, and bidirectional immunomodulation to restrain ex…

Glucose-responsive probiotics for glycaemic modulation in mice and monkeys.

Sustained and controlled delivery of glucose-lowering agents using engineered designer cells is recognized as an effective strategy for diab … ional regulator HexR, coupled with a synthetic promoter. Upon oral administration of the engineered probiotics carrying the sensor, the cells reside temporarily in the intestine and regulate the expression of therapeutic transgenes in response to glucose levels that exceed the normal threshold. We show efficacy from the engineered probiotics for glycaemic co …

Prebiotics, Probiotics, and Postbiotics for Acne Vulgaris: A Systematic Review.

INTRODUCTION: Microbiome-modulating therapies including prebiotics, probiotics, and postbiotics have been increasingly investigated as adjuncts or alternatives for managing acne vulgaris through effects on the gut-skin axis, inflammation, and barrier function. The objective of this systematic review is to characterize the safety and efficacy of oral and topical prebiotics, probiotics, and postbiotics in managing acne vulgaris. METHODS: We conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic review of randomized controlled trials, cohort stu…

Evaluation of dietary Bacillus-based commercial probiotics in broiler chickens.

Commercial Bacillus-based probiotics are widely used in poultry production, but their biological mechanisms of action in broiler chickens are still not fully understood. This study evaluated the effects of dietary supplementation with Bacillus-based commercial probiotics on the performance, meat and tibia traits, gut health (ileal morphology and cecal volatile fatty acids), antioxidant status, nutrient digestibility, and intestinal gene expression in broiler chickens. Day-old Ross 308 broiler chicks (288 in total) were randomly assigned to one of four dietary treatments, with six replicate pen…

Lactose intolerance and probiotics: from pathophysiological mechanisms to clinical applications.

Lactose is a disaccharide found in dairy products, which provide energy and essential nutrients. Digestion of lactose relies on the intestin … der to improve tolerance to lactose. This review aims to explore the evidence supporting the use of probiotics as a potential treatment strategy to alleviate the symptoms of lactose intolerance by modulating colonic metabolism and enhancing lactose digestion.

Probiotics combat sarcopenia by restoring gut integrity in Alzheimer's disease.

BACKGROUND AND AIMS: Patients with Alzheimer's disease (AD) exhibit muscle decline and physical compromise. Probiotic supplements may mitigate muscle decline and physical impairment; however, empirical investigations remain limited. We hypothesized that probiotics improve muscle strength and physical performance by repairing intestinal leak in AD patients. METHODS: We conducted a randomized, double-blind, monocenter trial of AD patients receiving either a placebo (n = 54, 68-84 years old) or a probiotic (Vivomixx 112 billion*, one capsule daily, n = 51, 72-84 years old) for four months. We me…

Гут Микробиота и аутоиммунные заболевания: терапевтический потенциал пробиотики.

В последние годы все большее внимание уделяется роли кишечного микробиота в патогенезе аутоиммунных заболеваний, таких, как тип 1 диабет (T1D), ревматоидный артрит (RA) и множественный склероз (MS). Многочисленные исследования показали, что кишечный дисбиоз-несбалансированность кишечного микробного сообщества может повлиять на иммунную реакцию хост-компании путем модуляции подстрекательских путей, целостности кишечного барьера и функции иммунных клеток. Пациенты с T1D, RA и MS часто имеют меньшее количество противовоспалительных бактерий (например, Feecalibacterium prausnitzii) и слишком много

Совпадение в аннотации оригинала
In recent years, increasing attention has been directed toward the role of gut microbiota in the pathogenesis of autoimmune diseases such as … bacterium prausnitzii) and an overrepresentation of pro-inflammatory taxa (e.g., Prevotella copri). Probiotics and fecal microbiota transplantation have shown therapeutic potential by restoring microbial balance, enhancing short-chain fatty acid production, supporting regulatory T cell function, and suppressing pro-inflammatory Th1 and Th17 responses. Despit …

Probiotics: a promising future in the treatment of ulcerative colitis?

Ulcerative colitis is an idiopathic and chronic inflammatory bowel disease, characterized by inflammation of the mucosa of the colon and rec … t can prolong remission and reduce symptom burden is important. Experimental evidence suggests that probiotics may extend remission duration in ulcerative colitis. Moreover, probiotics exhibit efficacy in amelioration clinical symptoms by reducing inflammation markers, preserving, and restoring intestinal epithelial. This review explores the advantages of th …

Subphenotypes of Long COVID and the clinical applications of probiotics.

As the number of infections and deaths attributable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to r … otentially attributable to immune system dysfunction. A promising solution lies in the potential of probiotics to mitigate Long COVID symptoms by restoring gut microbiota balance and modulating the immune response. By evaluating the current clinical development landscape of the use of probiotics to treat Long COVID symptoms, this paper provides recommendatio …

Probiotics for pediatric diarrhea and constipation: an umbrella meta-analysis.

BACKGROUND: The current evidence regarding the impact of probiotics on diarrhea and constipation outcomes in children is inconclusive. This umbrella review of systematic reviews and meta-analyses aims to deliver a comprehensive and conclusive summary of the effectiveness of probiotics in managing these conditions in pediatric populations. METHODS: Meta-analyses were collected from Scopus, PubMed, Embase, and the Web of Science until May 2025. The overall effect size was calculated using a random effect model. RESULTS: This umbrella study comprises a systematic review of 35 studies. Our findi…

Gut allies against metabolic disorders: the therapeutic promise of probiotics.

Metabolic disorders, including obesity, type 2 diabetes mellitus, dyslipidemia, and non-alcoholic fatty liver disease, represent a growing global health challenge driven by lifestyle, genetic, and environmental factors. Emerging evidence highlights the critical role of gut microbiota in metabolic regulation, with dysbiosis contributing to systemic inflammation, insulin resistance, and altered lipid metabolism. Probiotics have shown promise in modulating gut microbiota composition and function. Through mechanisms such as enhancing gut barrier integrity, producing beneficial metabolites (e.g., S…

Can probiotics be protective and growth-promoting to coffee plants?

Probiotics show well-documented benefits to animal and human health and are safe for organisms and the environment. This study explored the potential of five commercial probiotics - Colostrum® BS Liquid, Colostrum® BS Powder, Colostrum® BIO 21 Liquid, and Colostrum® BIO 21 MIX Powder (widely used in poultry production), and Enterogermina® (used for humans) in managing coffee leaf rust (CLR), brown eye spot (BES), bacterial leaf blight (BHB) and dieback, as well as their effect on coffee seedlings growth. In vitro experiments revealed that only Colostrum® BIO 21 Liquid completely inhibited ured…

Modulation of the Human Microbiome: Probiotics, Prebiotics, and Microbial Transplants.

The balance between health and disease is intrinsically linked to the interactions between microbial communities and the host. This complex … ntimicrobial resistance, novel approaches to reduce the burden of disease are essential. The use of probiotics and prebiotics is one such strategy. Probiotics introduce non-pathogenic bacteria into the environment to compete with pathogens for nutrients and attachment sites, or to produce metabolites that counteract disease aetiologies. Prebiotic compounds e …

Probiotics ameliorates hypothalamic amenorrhea in a rat model of PCOS.

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrinometabolic disorder affecting women of reproductive age, characterized by hormonal imbalances, irregular menstrual cycles, and often, infertility. Hypothalamic amenorrhea, a condition marked by the cessation of menstruation due to disruptions in the hypothalamic-pituitary-gonadal axis, is a frequent manifestation in PCOS. Probiotics, beneficial microorganisms known for improving metabolic health, have shown promise in restoring hormonal balance and enhancing fertility. In this study, we hypothesize that probiotics would ameliorat…

Gut Microbiota Modulation in Osteoporosis: Probiotics, Prebiotics, and Natural Compounds.

Osteoporosis is a multifactorial bone metabolic disorder characterized by the deterioration of bone mass and microarchitecture, leading to i … nisms remain poorly understood. This review examines the latest findings on the role of prebiotics, probiotics, and natural bioactive substances in modulating the gut microbiota to improve bone health. We discuss how these interventions may restore microbial balance, enhance gut barrier function, and reduce systemic inflammation, thereby influencing bone met …

Efficacy of probiotics in dermatitis herpetiformis management: an umbrella review.

BACKGROUND: The available evidence on probiotics in Dermatitis Herpetiformis (DH) remains severely limited. Given the shared pathophysiology of DH and Coeliac disease (CD), we aimed to provide the hypothesis to synthesize the narrative reviews carried out so far on the use of probiotics in the treatment of DH, its impact on gut microbiota dysbiosis, and the gut-skin axis. METHODS: Relevant narrative reviews were searched for in electronic databases such as PubMed, Scopus, Cochrane Library, Embase, and Google Scholar. RESULTS: All 7 included reviews commented on gut microbiota dysbiosis as a …