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Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave dreams study (brain venous drainage exploited against multiple sclerosis): study protocol for a randomized controlled trial.

BackgroundMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with a disabling progressive course. Chronic cerebrospinal venous insufficiency (CCSVI) has recently been described as a vascular condition characterized by restricted venous outflow from the brain, mainly due to blockages of the internal jugular and azygos veins. Despite a wide variability among studies, it has been found to be associated with MS. Data from a few small case series suggest possible improvement of the clinical course and quality of life by performing percutaneous ball

Effectiveness of a culturally adapted psychoeducational intervention for family caregivers of children with hematologic malignancy: a randomized controlled trial.

ObjectiveThis study aimed to develop and evaluate a culturally adapted psychoeducational intervention to address the severe psychological distress and caregiving burden commonly experienced by caregivers of newly diagnosed pediatric hematologic malignancy patients during the early stages of illness.MethodsAmong 116 randomized caregivers, 90 completed all three assessments and were included in the complete-case analysis. The intervention group received a 4-week psychoeducation program delivered by medical social workers, whereas the control group received routine care. Outcomes were assessed at

Translation and validation of the Dutch Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0) to evaluate health-related quality of life in patients with symptomatic spinal metastases.

BackgroundThe primary goal of palliative treatment of spinal metastases is to maintain or improve health-related quality of life (HRQOL). We translated and validated a Dutch version of The Spine Oncology Study Group Outcome Questionnaire (SOSGOQ2.0), a valid and reliable 20-item questionnaire to evaluate HRQOL in patients with spinal metastases.MethodsAfter cross-cultural translation and adaptation, the questionnaire was pre-tested in fifteen patients referred for spine surgery and/or radiotherapy. This resulted in a final questionnaire that was sent to patients for assessment of internal cons

Mental Health Assessment of Cancer Patients: Prevalence and Predictive Factors of Depression and Anxiety.

BackgroundPatients with oncological diseases often have mental disorders in the form of comorbidity. The aim of this study was to research the association of cancer with the presence of symptoms of depression and anxiety in primary health care patients.MethodsThis prospective observational study done in 2020 included adult users of health care at the Health Center Trstenik, Central Serbia, aged 19 and over, both sexes, with a diagnosis of oncological disease. A research instrument to assess depressive symptoms is used PHQ-9 (The Patient Health Questionnaire) questionnaire, derived from PRIME M

A prospective observational study to assess clinical decision-making, prognosis, quality of life and satisfaction with care in patients with relapsed/refractory multiple myeloma: the CLARITY study protocol.

BACKGROUND: Treatment decision-making in patients with relapsed/refractory multiple myeloma (RRMM) is challenging for a number of reasons including, the heterogeneity of disease at relapse and the number of possible therapeutic approaches. This study broadly aims to generate new evidence-based data to facilitate clinical decision-making in RRMM patients. The primary objective is to investigate the prognostic value of patient self-reported fatigue severity for overall survival. METHODS: This multicenter prospective observational study will consecutively enroll 312 patients with multiple myelom

Изучение связей физических, умственных и эмоциональных симптомов и сыворотки биомаркеров ангиогенеза в множестве склерозов.

Множественный склероз (MS) связан с симптомами, которые могут быть затронуты ангиогенезом. В ранних периодах MS повышается коэффициент экспозелевого роста (VEGF) - мощная проангиогенная молекула, но его активность в более поздних болезнях недооценивается. [Met5]-enkephalin (ENK) имеет антиангиогенную активность и снижается у людей с MS (PwMS). ЦЕЛИ: Определение основных симптомов MS и оценка взаимосвязей между общими симптомами MS и биомаркерами, связанными с ангиогенезом. МЕТОДЫ: В рамках этого межсекторального исследования были определены участники ПwMS и не связанные с СУ контрольные органы

Harmonising Hope: Impact of Music Therapy on Cancer Pain and Palliative Care.

ObjectivesMusic therapy can be a harmonising hope for cancer patients under palliative care to overcome fear, anxiety, anger, depression, pain and the range of emotional responses. Music therapists contribute to a comprehensive approach to providing holistic, patient-centred care to mainstream medical treatment. Hence, the study aims to understand the clinical impact of music therapy in cancer pain and palliative care.Materials and methodsAfter approval from the Institutional Review Committee and getting informed consent, a total of 102 individual music therapy sessions were conducted for 43 p

Действенность и безопасность цифрового таперинга для пациентов, которым предписывается опиоид после хирургической операции: протокол для перспективного исследования кохарта.

Предыстория 300 million Каждый год во всем мире проводятся хирургические операции, и опиоиды по-прежнему являются одним из основных методов борьбы с острой послеоперационной болью. Исследования показали, что значительное число пациентов не прекращают опиоидное лечение и продолжают использовать опиоиды в течение месяцев или даже лет после операции. Известная практика применения опиоидов рецептурного отпуска и управления ими является частью нынешних клинических руководящих принципов безопасного прописывания. Каждый пациент должен получать тщательный контроль, образование и план скрининга, когда

Prospective Study of Multiparametric Renal MRI for CKD Progression (AFiRM).

IntroductionChronic kidney disease (CKD) has major population health implications, but current imaging approaches provide limited pathophysiological insights. We designed a study to evaluate renal multiparametric magnetic resonance imaging (MRI; mpMRI) as a tool to improve diagnosis, risk stratification, disease monitoring, and therapeutic decision-making in CKD.MethodsThe application of functional renal MRI to improve assessment of CKD (AFiRM study; NCT04238299) is a multicenter, prospective, observational cohort study in people with CKD. Participants underwent renal mpMRI using the harmonize

A pilot study of improved psychological distress with art therapy in patients with cancer undergoing chemotherapy.

BACKGROUND: Art therapy may improve the physical, mental, and emotional wellbeing of individuals for a variety of purposes. It remains understudied and underutilized in cancer care. We sought to determine the ability of a pilot art therapy program to improve the physical, mental, and emotional well-being of cancer patients. METHODS: Chemotherapy-recipients, age 18 years and older, diagnosed with any type or stage of cancer, were considered eligible to participate in this single arm, pilot study, using four visual analog scales (VAS) with visually-similar, 0-10 scale (10 being worst) thermomet

Japanese POEMS syndrome with Thalidomide (J-POST) Trial: study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial.

IntroductionPolyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a fatal systemic disorder associated with plasma cell dyscrasia and the overproduction of the vascular endothelial growth factor (VEGF). Recently, the prognosis of POEMS was substantially improved by introduction of therapeutic intervention for myeloma. However, no randomised clinical trial has been performed because of the rarity and severity of the disease.Methods and analysisThe Japanese POEMS syndrome with Thalidomide (J-POST) Trial is a phase II/III multicentre, double-blinded, randomi

Dengue-Related Hemophagocytic Lymphohistiocytosis in an Adult: A Case Report and Brief Update.

Dengue virus is an arbovirus transmitted through the bite of infected Aedes mosquitoes. Many unusual clinical features are being reported in dengue. Dengue complicated with hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal condition. Here, we report an 18-year-old otherwise healthy female with dengue fever complicated with HLH. The diagnosis was made by fulfilling the clinical and laboratory criteria of HLH. She was managed successfully with a methylprednisolone pulse regimen. Our case highlights the importance of early recognition of complications and prompt treatment f

Adaptation of the PERCEPT myeloma prehabilitation trial to virtual delivery: changes in response to the COVID-19 pandemic.

Introduction and objectiveResearch activity was impacted by the novel COVID-19 pandemic, the PERCEPT myeloma trial was no exception. This pilot randomised trial delivered a face-to-face exercise intervention prior to and during autologous stem cell transplantation (ASCT) in myeloma patients, as a consequence of COVID-19 it required significant adaptions to continue. This brief communication describes how the previously published study protocol was adapted for virtual delivery. In addition, we highlight the challenge of continuing the study which was embedded within a clinical pathway also impa

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… Participants were sent trial consent forms, self-complete questionnaire measures and a pre-programmed ActivPAL accelerometer by post and a Zoom video call appointment was arranged for approximately 3 days later. … Completion of consent forms, baseline questionnaires and fitting of accelerometer discussed and conducted virtually over Zoom appointment. …

В центре внимания пользователей находятся проектирование и формальная оценка приборной панели для многомерной оценки ходьбы при множественном склерозе.

Цифровой анализ походов с использованием изношенных датчиков и приборов все чаще проводится в рамках обычного ухода за людьми с множественным склерозом. Однако многоаспектные оценки ходьбы приводят к получению продольных и разнородных результатов, которые часто представляются в разрозненных, трудно интерпретируемых докладах, ограничивая их полезность для клинической коммуникации и совместного принятия решений. Цель этого исследования заключалась в разработке ориентированной на пациента приборной панели, которая включает многоплановые данные о походах в последовательный и интуитивный обзор, в п

Романтические отношения, сексуальность и близость между молодыми людьми и подростками с тяжелыми психическими заболеваниями: обзор литературы.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Лица с тяжелыми психическими заболеваниями (СМИ), включая шизофрение и психотические расстройства, часто сталкиваются с серьезными проблемами в развитии и поддержании романтических и интимных отношений. Несмотря на сильное стремление к общению и сексуальному выражению, эти люди часто сталкиваются с такими препятствиями, как общественное осуждение, когнитивные проблемы и психические симптомы, влияющие на социальное функционирование. В рамках существующих исследований основное внимание уделяется прежде всего общей социальной вовлеченности, а не специфическим сложностям ром

Physical Performance, Sarcopenia and Malnutrition-Basic Test Set for Everyday Use in Cancer Therapy.

PURPOSE: Testing physical performance, malnutrition, and sarcopenia is recommended in numerous guidelines for hematological-oncological patients. However, due to economic conditions and the large number of test options, these tests have not made it into clinical routine. The aim of this study is to propose a practical compromise that could allow routine testing under the current conditions. METHODS: We conducted a prospective, monocentric, small-scale cohort study. In our interdisciplinary tumor outpatient clinic, we investigated time required for malnutrition screening (PG-SGA long form), ma

The Immuno-oncology-Induced Cytokine Release Syndrome Patient Diary: A Content-Valid, Patient-Reported Outcome Measure.

INTRODUCTION: Cytokine release syndrome (CRS) occurs when the immune system reacts excessively to infections or certain immunotherapies, leading to a systemic inflammatory response. The clinical presentation of CRS is highly variable, ranging from mild symptoms, such as fever and fatigue, to severe, life-threatening conditions. Currently, there is no standardized method for collecting patient-reported data on CRS experiences. This study aims to develop a novel patient-reported outcome measure (PROM) to capture patients' experience with CRS. METHODS: A comprehensive, multistep evidence-generat

Healthcare professionals' perspectives of the management of people with palliative care needs in the emergency department of a UK hospital.

BackgroundThe Emergency Department (ED) is not always the optimal place for people with palliative care needs but is the most common route for treatment when urgent care is sought. The aim of this study,''REasons for PalLIative Care Admissions (REPLICA)' was to explore the perspectives of ED healthcare professionals of hospital admission or discharge via ED for palliative care patients.MethodsThis is a sequential mixed methods study comprising (i) quantitative descriptive analysis of Hospital Episode Statistics (HES) of palliative care patients (code Z51.5) who were admitted through ED in a We

Качественное сопоставление восприятия врачами усталости как симптома в неврологических условиях: наблюдения из центра третичной медицинской помощи в Саудовской Аравии.

ВВЕДЕНИЕ: Усталость как симптом серьезно сказывается на людях с неврологическими заболеваниями, однако ее понимание и управление остаются ограниченными, особенно в уникальном контексте здравоохранения Саудовской Аравии. Несмотря на то, что он широко изучался в инсульте, его проявления в неврологических условиях и представления медицинских работников не были тщательно изучены в этой конкретной обстановке. Учитывая глубокое воздействие усталости на результаты лечения пациентов, понимание отношения медицинских работников имеет решающее значение для определения адресных мер и существенного улучшен

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… An informed consent form was given to the potential participants. Prior to the start of the interview, participants were asked to read the information sheet and sign the informed consent form. … Physical documents, including consent forms, were secured in a secure cabinet, and data were safely kept in encrypted files that were only accessible by the research team. …

Amyloidosis due to TTR mutations in Mexico with 4 distincts genotypes in the index cases.

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