Результаты поиска

Diagnostic yield of bone marrow examination in HIV associated FUO in ART naïve patients.

A bone marrow (BM) aspiration and biopsy is often believed to be a much needed diagnostic procedure in the work up of patients with fever of unknown origin (FUO), especially in the setting of AIDS. Is it worthwhile to proceed with this invasive diagnostic method? The usefulness of a BM aspiration or biopsy to assist in the diagnosis of FUO or prolonged fever in AIDS patients has been reported previously to range from 4% to 40%. The purpose of this study was to assess the usefulness of a BM aspiration and biopsy in diagnosing the cause of FUO in patients with AIDS and to identify the utility of

Comparison of the BACTEC MYCO/F Lytic bottle to the isolator tube, BACTEC Plus Aerobic F/bottle, and BACTEC Anaerobic Lytic/10 bottle and comparison of the BACTEC Plus Aerobic F/bottle to the Isolator tube for recovery of bacteria, mycobacteria, and fungi from blood.

The BACTEC MYCO/F Lytic blood culture bottle (Becton Dickinson Diagnostic Instrument Systems, Sparks, Md.) is designed to optimize the recov … e on SDA, 30 days; and sediment from Isolator tube in a BACTEC 13A bottle, 42 days. Two isolates of Histoplasma capsulatum were recovered from the Isolator tube only. Three isolates of Mycobacterium tuberculosis complex were recovered: two isolates from the MYCO/F Lytic bottle only and one isolate from the Isolator tube (whose sediment was inoculated into the …

Infection related membranoproliferative glomerulonephritis secondary to anaplasmosis: A case report.

BACKGROUND: Anaplasmosis is a tick-borne disease with a range of clinical manifestations, from a flu-like illness with fever and myalgias to a severe systemic disease with multisystem organ failure. Although renal involvement is not a common presentation, there have been few cases reporting acute kidney injury from Anaplasmosis. CASE SUMMARY: We present a 55-year-old female with anaplasmosis who developed acute kidney injury due to membranoproliferative glomerulonephritis (MPGN). The patient originally presented with cough and shortness of breath. She was admitted to the hospital with a diagn

Совпадение в полном тексте источника
… Undetected Serum Anaplasma phagocytophilum antibody, IgG | < 1:64 titer | 1:512 Ehrlichia chaffeensis, PCR | Negative | Negative Ehrlichia chaffeensis (HME) antibody, IgG | < 1:64 | < 1:64 Bartonella antibody panel, IgG and IgM | Negative | Negative Serum Blastomyces antibody, EIA | Negative | Negative Histoplasma … A repeat workup with urine cultures, blood cultures, human immunodeficiency virus (HIV) testing, viral hepatitis panel, Histoplasma antibodies, Blastomyces antibodies, Bartonella antibodies, and PCR for Epstein–Barr virus (EBV), Cytomegalovirus (CMV), Anaplasma, Methicillin-resistant Staphylococcus aureus …

Global control of dimorphism and virulence in fungi.

Microbial pathogens that normally inhabit our environment can adapt to thrive inside mammalian hosts. There are six dimorphic fungi that cause disease worldwide, which switch from nonpathogenic molds in soil to pathogenic yeast after spores are inhaled and exposed to elevated temperature. Mechanisms that regulate this switch remain obscure. We show that a hybrid histidine kinase senses host signals and triggers the transition from mold to yeast. The kinase also regulates cell-wall integrity, sporulation, and expression of virulence genes in vivo. This global regulator shapes how dimorphic fung

Adverse human health effects associated with molds in the indoor environment.

Molds are common and important allergens. About 5% of individuals are predicted to have some allergic airway symptoms from molds over their … ic fungi for persons with nonimpaired immune function, Blastomyces, Coccidioides, Cryptococcus, and Histoplasma, may find their way indoors with outdoor air but normally do not grow or propagate indoors. Due to the ubiquity of fungi in the environment, it is not possible to prevent immunecompromised individuals from being exposed to molds and fungi outside th …

The Management of Hematopoietic Stem Cell Transplant in People with HIV.

Hematopoietic stem cell transplant (HSCT) is now recognized as a standard treatment option for people with HIV (PWH) who develop high-risk hematologic malignancies. However, the involved polypharmacy can lead to complications from drug interactions and toxicities, affecting the efficacy and safety of chemotherapy and antiretroviral therapy (ART). Managing these patients requires a personalized approach, including the careful selection of ART based on previous therapies and potential interactions, alongside risk assessment for infections. This discussion will address the history of HSCT in PWH

Совпадение в полном тексте источника
… Endemic Fungal Infections Endemic fungal infections such as Histoplasma capsulatum , Coccidioides immitis, and Taloromyces (Penicillium) marneffei are opportunistic in PWH. … Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis Case Rep. Hematol. 2020 2020 8124137 10.1155/2020/8124137 32099699 PMC7039042 122. Reynolds G. Hall V.G. Teh B.W. …

Critically Ill Immunosuppressed Host

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Some antigen or nucleic acid detection systems for blood or other body fluids can be useful for detecting cryptococcus, histoplasma, hepatitis B and C, HIV, mycobacteria, pneumococci, and Legionella . … The frequency of Cryptococcus, Histoplasma, Blastomyces, and Coccidioides organisms as causes of pneumonia depends on the geographic exposure of the patient. Among these mycoses, antigen detection techniques can be useful for finding Cryptococcus and Histoplasma organisms. …

Infectious Diseases

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… migrans), Treponema pallidum (chancre, secondary syphilis) rickettsial —Rocky Mountain spotted fever, ehrlichiosis, typhus viral exanthem —acute HIV, mononucleosis, rubella, measles, roseola, erythema infectiosum, chickenpox, shingles, coxsackie virus, echovirus fungal — Blastomyces , Coccidioides , Histoplasma … Endemic fungal infections include Blastomyces dermatitidis (southeastern states, Manitoba, and Ontario), Coccidioides immitis (southwestern states), and Histoplasma capsulatum (Mississippi, Ohio River valleys, and Quebec) HISTORY —pattern and duration of fever, associated symptoms (cough, dyspnea, …

Infectious Diseases

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… migrans), Treponema pallidum (chancre, secondary syphilis) rickettsial —Rocky Mountain spotted fever, ehrlichiosis, typhus viral exanthem —acute HIV, mononucleosis, rubella, measles, roseola, erythema infectiosum, chickenpox, shingles, coxsackie virus, echovirus fungal —Blastomyces, Coccidioides, Histoplasma … Endemic fungal infections include Blastomyces dermatitidis (southeastern states, Manitoba, and Ontario), Coccidioides immitis (southwestern states), and Histoplasma capsulatum (Mississippi, Ohio River valleys, and Quebec) HISTORY —pattern and duration of fever, associated symptoms (cough, dyspnea, chest …

Immune defects in 28-kDa proteasome activator gamma-deficient mice.

Protein complexes of the 28-kDa proteasome activator (PA28) family activate the proteasome and may alter proteasome cleavage specificity. Initial investigations have demonstrated a role for the IFN-gamma-inducible PA28alpha/beta complex in Ag processing. Although the noninducible and predominantly nuclear PA28gamma complex has been implicated in affecting proteasome-dependent signaling pathways, such as control of the mitotic cell cycle, there is no previous evidence demonstrating a role for this structure in Ag processing. We therefore generated PA28gamma-deficient mice and investigated their

Atypical Calcitriol-Mediated Hypercalcemia in Late Life: A Hypothesis-Generating Case.

Calcitriol-mediated hypercalcemia is most commonly associated with granulomatous disease or lymphoma and rarely occurs without an identifiable cause. We present the case of a 96-year-old woman who developed severe symptomatic hypercalcemia with elevated 1,25-dihydroxyvitamin D (calcitriol), low 25-hydroxyvitamin D (calcidiol), suppressed parathyroid hormone, and no evidence of malignancy, granulomatous disease, endocrine dysfunction, or vitamin D intoxication. She improved with intravenous fluids, calcitonin, and corticosteroids. We hypothesize that age-related impairment of the fibroblast gro

Совпадение в полном тексте источника
… Investigation | Result | Normal Range Endemic mycoses Histoplasma yeast | <1:8 | <1:8 Histoplasma mycelia | <1:8 | <1:8 Coccidioides antibody | <1:2 | <1:2 Tuberculosis Quantiferon NIL (IU/mL) | 0.315 | Not applicable Quantiferon mitogen-NIL (IU/mL) | >10.000 | Not applicable Quantiferon TB1 antigen-NIL …

Pneumonia in the Cancer Patient

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Dysfunction Nocardia asteroides complex Salmonella species Rhodococcus equi R. bronchialis Listeria monocytogenes Mycobacterium tuberculous Nontuberculous mycobacteria Aspergillus and non- Aspergillus filamentous molds Pneumocystis jiroveci (P. carini) Cryptococcus neoformans Endemic mycoses due to Histoplasma … Dysfunction | Nocardia asteroides complex Salmonella species Rhodococcus equi R. bronchialis Listeria monocytogenes Mycobacterium tuberculous Nontuberculous mycobacteria | Aspergillus and non- Aspergillus filamentous molds Pneumocystis jiroveci (P. carini) Cryptococcus neoformans Endemic mycoses due to Histoplasma …

Serious infections associated with anticytokine therapies in the rheumatic diseases.

The ability to target and neutralize macrophage-derived inflammatory cytokines, particularly tumor necrosis factor-alpha (TNF-alpha), has emerged in recent years as one of the most important advances in the treatment of rheumatoid arthritis, Crohn's disease, and several other systemic inflammatory diseases. In rheumatoid arthritis, for example, these biological agents rapidly reduce signs and symptoms of joint inflammation and profoundly slow the progression of joint damage. However, data that have emerged following Food and Drug Administration approval of these agents have alerted clinicians

Dengue-Related Hemophagocytic Lymphohistiocytosis in an Adult: A Case Report and Brief Update.

Dengue virus is an arbovirus transmitted through the bite of infected Aedes mosquitoes. Many unusual clinical features are being reported in dengue. Dengue complicated with hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal condition. Here, we report an 18-year-old otherwise healthy female with dengue fever complicated with HLH. The diagnosis was made by fulfilling the clinical and laboratory criteria of HLH. She was managed successfully with a methylprednisolone pulse regimen. Our case highlights the importance of early recognition of complications and prompt treatment f

Совпадение в полном тексте источника
… Staphylococcus aureus, Campylobacter spp., Fusobacterium spp., Mycoplasma spp., Chlamydia spp., Legionella spp., Salmonella typhi, Rickettsia spp., Brucella spp., Ehrlichia spp., Borrelia burgdorferi, Mycobacterium tuberculosis Fungal infections | Candida spp., Cryptococcus spp., Pneumocystis spp., Histoplasma …

Community-acquired pneumonia

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… influenzae , Moraxella catarrhalis , Legionella spp., enteric Gram-negatives Residence in nursing home | Strep. pneumoniae , Gram-negative bacilli, H. influenzae , Staphylococcus aureus , anaerobes, Chlamydophila pneumoniae ; consider Mycobacterium tuberculosis Poor dental hygiene | Anaerobes Bat exposure | Histoplasma … capsulatum Bird exposure | Chlamydia psittaci , Cryptococcus neoformans , Histoplasma capsulatum Rabbit exposure | Francisella tularensis Travel to south-west USA | Coccidioidomycosis, hantavirus in selected areas Exposure to farm animals or parturient cats | Coxiella burnetii (Q fever) Travel to South …

babesiosis при ультранизком паразите, представляющем в качестве вторичного гемофагоцитического лимфохистиоцитоза у пациента на клеточной терапии B.

Бэбэзия микроти, паразит, передающийся клещами иксодов, может вызывать инфекции, начиная от асимптоматических и заканчивая болезненными, угрожающими жизни болезнями. Ocrelizumab, anti-CD20 Б-лимфоциты моноклональные антитела, используемые для лечения множественных склерозов, повышают риск серьезных или повторных инфекций патогенами, передаваемыми тиками. В редких случаях младециоз может вызвать гемофагоцитический лимфохистицитоз (HLH). КАСЕ КРАТКОЕ ИЗЛОЖЕНИЕ: Мы сообщаем о случае, когда педициоз проявляется в субакуте с вторичным HLH. 51-year-old Женщина с клеточной терапией B. Она представила

Совпадение в полном тексте источника
… Notable negative infectious workup included Histoplasma and Blastomyces antigen and antibodies, Bartonella IgG/IgM and PCR, Coxiella PCR, Brucella antibodies, EBV DNA PCR, CMV PCR, adenovirus PCR in blood, and beta-D-glucan in blood. Additionally, all blood and urine cultures were without growth. …

Idiopathic CD4 lymphocytopenia: An uncommon but fatal cause of Pneumocystis pneumonia.

Pneumocystis pneumonia (PCP) is a fungal infection with primary occurrence in immunocompromised individuals by the etiologic agent Pneumocystis jirovecii. In those without previously identified risk factors, maintaining an index of suspicion for this diagnosis with search for underlying immunosuppressive cause is of utmost importance. Here, we present a case of fatal PCP in a patient without a known history of immunocompromise subsequently diagnosed with idiopathic CD4 lymphocytopenia (ICL) with an absolute CD4+ T-cell count of 7 cells/uL.

Совпадение в полном тексте источника
… Fungitell, QuantiFERON, Coccidioides, Histoplasma, and Blastomycosis were ordered and negative. An absolute CD4 + T-cell count was 7 cells/uL. Given his hypogammaglobulinemia and extremely low CD4 + T-cell count, one dose of intravenous immunoglobulin (IVIG) was administered. …

10th Trends in Medical Mycology Held on 8 to 11 October 2021, Aberdeen, Scotland, Organized by the European Confederation of Medical Mycology (ECMM).

Plenary Sessions: [...].

Совпадение в полном тексте источника
… S01.3 Histoplasmosis Alessandro Pasqualotto Histoplasma capsulatum is a major killer in AIDS patients. Histoplasmosis is endemic in the Americas, and in many countries the disease leads to more deaths in AIDS than tuberculosis. … This talk will review diagnostic strategies for histoplasmosis, with an emphasis on the detection of Histoplasma antigen in urine samples. …

Совместное обнаружение вируса кори и сезонного коронавируса у иммунокомпромиссированного пациента с пневмонией.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Рекомендована вакцинация от кори для лиц, получающих трансплантацию стволовых клеток (ГХЦТ) ≥24 месяцев после трансплантации в отсутствие трансплантации и иммунодепрессивной терапии. Управление живыми вакцинами во время иммунодепрессии может привести к иатрогенным повреждениям. РЕЗЮМЕ: Мы описываем 76-year-old пациент со сценой 3 Множественная миэлома, которая прошла аутологический HSCT и получила многотрадиционную терапию, включая химерик антигенный рецептор Т-клеток и недавнюю терапию даратумумаба. Примерно 1 Через месяц после прививки от кори, свинки и краснухи у неё

Совпадение в полном тексте источника
… Other BAL studies were negative, including bacterial, fungal, Nocardia , and AFB cultures; Legionella PCR; Coccidioides PCR; Histoplasma / Blastomyces PCR; Aspergillus PCR; Aspergillus galactomannan; and Pneumocystis jirovecii PCR. …