Результаты поиска

Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes.

Improved understanding as to the biology of multiple myeloma (MM) and the bone marrow microenvironment has led to the development of new drugs to treat MM. This explosion of new and highly effective drugs has led to dramatic advances in the management of MM and underscores the need for supportive care. Impressive and deep response rates to chemotherapy, monoclonal antibodies, and small molecule drugs provide hope of a cure or prolonged remission for the majority of individuals. For most patients, long-term, continuous therapy is often required to suppress the malignant plasma cell clone, thus

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… Tariman J, Love G, McCullagh E, Sandifer S, IMF Nurse Leadership Board Peripheral neuropathy associated with novel therapies in patients with multiple myeloma: consensus statement of the IMF nurse leadership board. Clin J Oncol Nurs. 2008;12:29–35. doi: 10.1188/08.CJON.S1.29-35. 108. …

Navigating isolation- barriers and multidimensional support needs in symptom self-management for HSCT patients within laminar airflow rooms: a descriptive qualitative study.

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a crucial therapy for hematological malignancies and other conditions. However, the intensive therapy and required isolation place significant physical and psychological burdens on patients. Although effective symptom self-management during isolation is pivotal, the current efforts are often challenged, leading to distress and feelings of loss of control. Nevertheless, research specifically addressing the self-management needs and barriers faced by patients with HSCT confined to laminar airflow rooms is limited. This study aimed to

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… Through visits, emotional encouragement, and social support from loved ones, patients gain psychological comfort and strength, particularly when experiencing physical discomfort and fatigue. …

Mcl-1 downregulation enhances BCG treatment efficacy in bladder cancer by promoting macrophage polarization.

BackgroundBacillus Calmette-Guérin (BCG) is the primary method of postoperative perfusion treatment for bladder cancer. The myeloid cell leukemia gene-1 (Mcl-1) is closely associated with the development of malignant tumors. Previous research by our group has demonstrated that downregulating Mcl-1 using shRNA can enhance the efficacy of BCG treatment in bladder cancer. This study aims to investigate the impact of Mcl-1 downregulation in combination with BCG treatment on bladder cancer, macrophage polarization, and the underlying mechanism of action, with the goal of reducing recurrence and met

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… Love MI, Huber W, Anders S. Moderated estimation of Fold change and dispersion for rna-seq data with deseq2. Genome Biol. 2014;15(12):550. 20. Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, et al. Clusterprofiler 4.0: a universal enrichment tool for interpreting omics data. …

Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review.

PurposePhytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These metabolites, such as flavonoids, terpenoids, and alkaloids, possess significant anticancer potential but are often limited by poor solubility and low absorption. This review aims to investigate how phytosome encapsulation improves the pharmacokinetic profiles and anticancer effectiveness of these bioactive compounds.Patients and methodsThis comprehensive review is based on a

Проблемы, трудности и запоздалый диагноз множественной миеломы.

Фон: Множественная миелома (ММ) представляет собой разнородную плазменную порчу клеток с неконкретными симптомами и разнородностью болезней на клиническом и биологическом уровнях. Этот неконкретный набор симптомов, включая боль в костях, анемию, почечную недостаточность, гиперкальцемию и нейропатию, может ввести в заблуждение диагноз как хронические или доброкачественные заболевания, что приводит к задержкам в диагностике. Своевременное выявление имеет важнейшее значение для предотвращения повреждения органов и снижения заболеваемости. Методы: В настоящем обзоре мы представляем обзор последней

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… Rögnvaldsson S., Love T.J., Thorsteinsdottir S., Reed E.R., Óskarsson J.Þ., Pétursdóttir Í., Sigurðardóttir G.Á., Viðarsson B., Önundarson P.T., Agnarsson B.A., et al. …

Азиатские культурные ценности и поиск помощи: перекрестное исследование на тему навязчивого сексуального поведения.

Сексуальность является сложной конструкцией, на которую влияют различные социальные и культурные факторы, и хотя сексуальное поведение, как правило, считается адаптивным к физическому и психическому благополучию, оно может стать неконтролируемым и вредным, что ведет к навязчивому сексуальному поведению (CSB). Ограниченные исследования были посвящены изучению вопроса о том, как азиатские культурные ценности могут способствовать психологическим последствиям деятельности ЦСБ и влиять на отношение к поиску профессиональной психологической помощи. В этом исследовании рассматриваются взаимосвязи меж

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… Specifically, sexual acts are often viewed as a marital obligation or a means to ensure physical harmony before marriage, rarely as a legitimate expression of love or pleasure. …

Учет интересов общин при финансировании научных исследований: создание Национального общества по многоразовому склерозу при Научно-исследовательском комитете МЗ.

Учет мнений общин в научных исследованиях имеет важное значение для обеспечения того, чтобы результаты исследований отражали то, что имеет значение для этого сообщества. Вместе с тем процесс, в рамках которого отдельные лица из общин включаются в решения о финансировании научных субсидий, является различным и зачастую состоит только из представителя пациента в составе группы по обзору или консультативного совета, в состав которого в основном входят научные эксперты в этой области. Все более активно обсуждается вопрос о том, как найти правильный баланс в плане учета и уважения технического опыт

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… to once annually Competencies desired for members of the Community Review of MS Research Committee Table 2 Questions used during recruitment conversation with Nominees Discussion guiding questions Please share with us a high-level overview of your experience with MS, starting with how you (or your loved …

Promoting patient-centered care in CAR-T therapy for hematologic malignancy: a qualitative meta-synthesis.

BackgroundCAR-T therapy has emerged as a potentially effective treatment for individuals diagnosed with hematologic malignancies. Understanding patients' unique experiences with this therapeutic approach is essential. This knowledge will enable the development of tailored nursing interventions that align with the increasing importance of patient-centered care.ObjectiveTo examine and synthesize qualitative data on patients and their family caregivers' experiences during the treatment journey.DesignWe conducted a systematic review and qualitative meta-synthesis. Eligible studies contained adult

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… . …. feeling isolated or confined and being away from family [ 19 ] (Patient) Not being present with loved ones (especially children or pets) [ 13 ] (Patient) Theme 2 Patients emphasized that concerns regarding treatment efficacy and adverse reactions intensified treatment-related distress. (20/238, …

Клемастин фумарат ускоряет аккумуляцию инвалидности в прогрессивном множественном склерозе, усиливая пироптоз.

Множественный склероз (MS) — иммунопосредованное демиелинизирующее заболевание центральной нервной системы (CNS). Клемастин фумарат, внезапный антигистамин и мускариновый блокатор рецепторов, обладает ремиелионирующим потенциалом в MS. Климастичная рука была добавлена в текущее клиническое испытание платформы TRAP-MS ( " TRP-MS " )NCT03109288) для выявления сигнатуры ремиелинирования цереброспиновой жидкости (CSF) и для сбора данных о безопасности клемастина у пациентов независимо от рецидива (PIRA). Клемастинская рука была остановлена в соответствии с определенными протоколом критер

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… Patro R. , Duggal G. , Love M.I. , Irizarry R.A. , and Kingsford C. ( 2017 ). Salmon provides fast and bias-aware quantification of transcript expression . Nat Methods 14 , 417 – 419 . 10.1038/nmeth.4197 . 28263959 PMC5600148 55. Galaxy C. ( 2022 ). …

A Rapid Systematic Review on the Experiences of Cancer Survivors Residing in Rural Areas during the COVID-19 Pandemic.

The COVID-19 pandemic has caused considerable disruption to cancer care and may have exacerbated existing challenges already faced by cancer survivors from rural areas. This has created a need for a rapid evidence synthesis to inform the development of tailored interventions that address the specific needs of rural cancer survivors who continue to be affected by the pandemic. The review was conducted following guidance from the Cochrane Rapid Review Methods Group. Database searches were performed via the EBSCOHost interface (includes MEDLINE, CINAHL, PsycINFO) on 25 May 2022 and supplemented w

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… Love B. Lustberg M. Smith K.C. Tevaarwerk A. Yu X. Addressing the needs of cancer survivors during the COVID-19 pandemic J. Cancer Surviv. 2020 14 601 606 10.1007/s11764-020-00884-w 32335850 PMC7183255 10. Moss J.L. Pinto C.N. Mama S.K. Rincon M. Kent E.E. Yu M. Cronin K.A. …

HBV Reactivation During the Treatment of Non-Hodgkin Lymphoma and Management Strategies.

Hepatitis B virus reactivation (HBV-R), which can lead to HBV-related morbidity and mortality, is a common and well-known complication that occurs during the treatment of non-Hodgkin lymphoma (NHL) patients with current or past exposure to HBV infection. HBV-R is thought to be closely associated with chemotherapeutic or immunosuppressive therapies. However, immunosuppressive agents such as anti-CD20 antibodies (e.g., rituximab and ofatumumab), glucocorticoids, and hematopoietic stem cell transplantation (HSCT) administered to NHL patients during treatment can cause deep immunodepression and pl

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… Smalls DJ, Kiger RE, Norris LB, Bennett CL, Love BL. Hepatitis B Virus Reactivation: Risk Factors and Current Management Strategies. Pharmacotherapy (2019) 39(12):1190–203. 10.1002/phar.2340 45. Ziogas DC, Kostantinou F, Cholongitas E, Anastasopoulou A, Diamantopoulos P, Haanen J, et al. …

Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective.

BACKGROUND: Specialist palliative care team (SPCT) involvement has been shown to improve symptom control and end-of-life care for patients with cancer, but little is known as to how these have been impacted by the COVID-19 pandemic. Here, we report SPCT involvement during the first wave of the pandemic and compare outcomes for patients with cancer who received and did not receive SPCT input from multiple European cancer centres. METHODS: From the OnCovid repository (N = 1318), we analysed cancer patients aged ⩾18 diagnosed with COVID-19 between 26 February and 22 June 2020 who had complete sp

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… has been shown to be prevalent amongst hospitalised patients due to isolation from families and fear of deterioration. 28 It is important also to be cognisant that a paramount component of the ethos of SPCTs is to provide psychological support not only to the patient but also to their families and loved …

Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches.

In the last few years, substantial progress has been made in the treatment of ovarian cancer, with increased knowledge about the biology of the disease. Ovarian cancer is a neoplasm strongly linked to defects in DNA repair mechanisms, where deficiency in the homologous recombination (HR) system results in a better response of ovarian cancers to therapy, whether platinum-based chemotherapy, anthracyclines, or poly (ADP-ribose) polymerase (PARP) inhibitors. More recently, it has been demonstrated that different ovarian cancer histotypes may have different immunogenicity. Interestingly, defects i

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… Love P. Richard S.D. Esquivel J. Bowne W.B. Intraperitoneal immunotherapy: Historical perspectives and modern therapy Cancer Gene Ther. 2016 23 373 381 10.1038/cgt.2016.49 27834358 101. Katz S.C. Point G.R. Cunetta M. Thorn M. Guha P. Espat N.J. Boutros C. Hanna N. Junghans R.P. …

Oncogenes: The Passport for Viral Oncolysis Through PKR Inhibition.

The transforming properties of oncogenes are derived from gain-of-function mutations, shifting cell signaling from highly regulated homeostatic to an uncontrolled oncogenic state, with the contribution of the inactivating mutations in tumor suppressor genes P53 and RB, leading to tumor resistance to conventional and target-directed therapy. On the other hand, this scenario fulfills two requirements for oncolytic virus infection in tumor cells: inactivation of tumor suppressors and presence of oncoproteins, also the requirements to engage malignancy. Several of these oncogenes have a negative i

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… with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy Oncotarget 2015 6 6 4467 4481 25714011 10.18632/oncotarget.2901 PMC4414204 23 Moore AE Viruses with oncolytic properties and their adaptation to tumors Ann N Y Acad Sci 1952 54 945 952 12976996 10.1111/j.1749-6632.1952.tb39969.x 24 Love …

Expert Perspective: Hematologic Malignancies and Vasculitis.

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… It is essential to determine and discuss prognosis of each diagnosis with patients and their loved ones to help them make decisions that impact both clinical outcome and quality of life. …

Using Dose-Escalation and -Expansion Cohort Study as Pivotal Trial for Targeted Anticancer Drug Approval.

Early-phase clinical trials (EPCTs) have been increasingly adopted as the pivotal trial to support US Food and Drug Administration (FDA) approval of novel anticancer drugs. Among EPCT designs, dose-escalation and -expansion cohort (DEEC) substantially reduces the time and resources that are required in the traditional three-phase paradigm. DEEC facilitates expedited approvals of investigational drugs, particularly those targeting novel mechanisms, helping to address the pressing needs of patients with cancer. From 2012 to 2023, DEECs provided pivotal trial evidence that supported the FDA appro

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… Love SB, Brown S, Weir CJ, et al. : Embracing model-based designs for dose-finding trials. Br J Cancer 117:332-339, 2017 34. Ananthakrishnan R, Lin R, He C, et al. : An overview of the BOIN design and its current extensions for novel early-phase oncology trials. …

Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer.

Novel strategies are needed to combat multidrug resistance in pancreatic ductal adenocarcinoma (PDAC). We applied genomic approaches to understand mechanisms of resistance in order to better inform treatment and precision medicine. Altered function of chromatin remodeling complexes contribute to chemoresistance. Our study generates and analyzes genomic and biochemical data from PDAC cells overexpressing HDAC1, a histone deacetylase involved in several chromatin remodeling complexes. We characterized the impact of overexpression on drug response, gene expression, HDAC1 binding, and chromatin st

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… Love MI Huber W Anders S Moderated estimation of Fold change and dispersion for RNA-seq data with DESeq2 Genome Biol 2014 15 550 10.1186/s13059-014-0550-8 25516281 PMC4302049 47. …

Effectiveness of routine provision of feedback from patient-reported outcome measurements for cancer care improvement: a systematic review and meta-analysis.

BackgroundResearch shows that feeding back patient-reported outcome information to clinicians and/or patients could be associated with improved care processes and patient outcomes. Quantitative syntheses of intervention effects on oncology patient outcomes are lacking.ObjectiveTo determine the effects of patient-reported outcome measure (PROM) feedback intervention on oncology patient outcomes.Data sourcesWe identified relevant studies from 116 references included in our previous Cochrane review assessing the intervention for the general population. In May 2022, we conducted a systematic searc

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… Lavallee DC, Chenok KE, Love RM, et al. Incorporating patient-reported outcomes into health care to engage patients and enhance care. Health Aff. 2016;35:575–582. doi: 10.1377/hlthaff.2015.1362. 15. Velikova G, Booth L, Smith AB, et al. …

The beginning of a new therapeutic era in acute myeloid leukemia.

In the field of AML, the early 2000s were shaped by the advent of novel molecular biology technologies including high-throughput sequencing that improved prognostic classification, response evaluation through the quantification of minimal residual disease, and the launch of research on targeted therapies. Our knowledge of leukemogenesis, AML genetic diversity, gene-gene interactions, clonal evolution, and treatment response assessment has also greatly improved. New classifications based on chromosomal abnormalities and gene mutations are now integrated on a routine basis. These considerable ef

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… Crossnohere NL, Richardson DR, Reinhart C, O'donoghue B, Love SM, Smith BD, et al. Side effects from acute myeloid leukemia treatment: results from a national survey. Curr Med Res Opin. 2019;35:1965–70. 106. Rashidi A, Walter RB, Tallman MS, Appelbaum FR, Dipersio JF. …

Treatment of Patients with Monoclonal Gammopathy of Clinical Significance.

Monoclonal gammopathy of undetermined significance (MGUS) is defined as the presence of a monoclonal protein (M-protein) produced by a small amount of plasma cells. The majority of patients remain asymptomatic; however, a fraction of them develop clinical manifestations related to the monoclonal gammopathy despite not fulfilling criteria of multiple myeloma or other lymphoproliferative disorder. These patients constitute an emerging clinical issue coined as monoclonal gammopathy of clinical significance (MGCS). The mechanisms involved are poorly understood, and literature is scarce regarding m

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… Rögnvaldsson S., Love T.J., Thorsteinsdottir S., Reed E.R., Óskarsson J.Þ., Pétursdóttir Í., Sigurðardóttir G.Á., Viðarsson B., Önundarson P.T., Agnarsson B.A., et al. …