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Antidepressant Drug Sertraline against Human Cancer Cells.

The use of FDA-approved drugs for new indications represents a faster and more economical way to find novel therapeutic agents for cancer therapy, compared to the development of new drugs. Repurposing drugs is advantageous in a pharmacological context since these drugs already have extensive data related to their pharmacokinetics, facilitating their approval process for different diseases. Several studies have reported the promising anticancer effects of sertraline, both alone and combined, in different types of cancer cell lines. Here, we performed a literature review on the anticancer potent

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… A Model for Tumor Suppression Using H-1 Parvovirus Proc. Natl. Acad. Sci. USA 1993 90 8702 8706 10.1073/pnas.90.18.8702 8378352 PMC47426 37. Tuynder M. Fiucci G. Prieur S. Lespagnol A. Géant A. Beaucourt S. Duflaut D. Besse S. Susini L. Cavarelli J. …

Recent Advances of Acute Kidney Injury in Hematopoietic Cell Transplantation.

Acute kidney injury (AKI) is a common complication of allogeneic hematopoietic cell transplantation (allo-HCT) and is associated with non-relapse mortality (NRM) and quality of life (QOL). Multiple factors may contribute to AKI during allo-HCT and are often present at the same time making it difficult to determine the cause of AKI in each patient. Nephrotoxic drugs, infections, thrombotic microangiopathy (TMA), and sinusoidal obstruction syndrome (SOS) are well described causes of AKI during allo-HCT. Acute graft-versus-host disease (aGVHD) is a major complication of allo-HCT that mainly targe

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… TBI, high-dose BU, CNIs, aGVHD Grade II-IV, infections (BK virus, cytomegalovirus, parvovirus B19, aspergillus species, adenovirus), peripheral blood stem cell transplantation, and use of unrelated donors are all risk factors for TA-TMA ( 62 ). …

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome.

The recent outbreak of Covid19 has required urgent treatments for numerous patients. No suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of WHO therapies of choice, that are two antivirals developed for other pathologies, is controversial. Therefore, alternative approaches are required. Intravenous (IV) Vitamin C (Vit-C) has emerged as one of the other alternatives for this purpose. Here we review the effects of IV Vit-C on the immune system response, the antiviral properties of IV Vit-C, and finally the antioxidant properties of IV Vit-C to specificall

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… Persistent parvovirus B19 viremia with chronic arthralgia treated with ascorbic acid: a case report. J. Med. Case Rep. 2015;9:1. doi: 10.1186/1752-1947-9-1. 102. Moens B., Decanine D., Menezes S.M. …

Immunization Strategies in Pediatric Patients Receiving Hematopoietic Cell Transplantation (HCT) and Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: Challenges and Insights from a Narrative Review.

BackgroundHematopoietic cell transplantation (HCT) and chimeric antigen receptor T-cell (CAR-T) therapy have markedly improved survival in pediatric patients with hematological malignancies. However, these treatments cause profound immunosuppression, leading to significant susceptibility to vaccine-preventable diseases (VPDs), including invasive pneumococcal disease and measles. Timely and tailored immunization strategies are crucial to mitigate infectious risks in this vulnerable population.MethodsWe conducted a narrative review of the English-language literature from 2000 to 2024, including

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… Frequently detected viral pathogens include respiratory viruses, cytomegalovirus (CMV), Epstein–Barr virus (EBV), and parvovirus B19. …

CAR T-Cell Terrapy Opveiled: Навигация за пределы ССЗ и ИКАНС для решения проблем, связанных с отсроченными последствиями, и оптимизации стратегий управления.

Цимерическая антигенная рецепторная (КАР) T-клетологическая терапия положила начало эпохе преобразований в регулировании рецидивов/отсутствий гематологической гематологии. Кульминацией интенсивных испытаний второго этапа, направленных на борьбу с повторной/охотничьей лимфомой, включая различные подтипы, такие, как диффузная большая лимфома B-клеток, фолликулярная лимфома и лимфома мантичной клетки, а также многочисленные миелома и острая лимфоболическая лейкемия B-клеток, стало одобрение различных продуктов CAR-T-клеток для этих конкретных указаний Администрацией по вопросам продовольствия и н

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… At the Day 30 mark, a bone marrow biopsy (BMB) was obtained to rule out infectious causes of bone marrow failure and tested for adenovirus, parvovirus, human herpesvirus 6 (HHV-6), Epstein-Barr virus, CMV, disseminated tuberculosis, and histoplasma. …

Ferret coronavirus-associated diseases.

A novel coronavirus of ferrets was first described in 1993. This coronavirus caused an enteric disease called epizootic catarrhal enteritis (ECE). Recently, a ferret systemic coronavirus (FRSCV)-associated disease was discovered. This new systemic disease resembles the dry form of feline infectious peritonitis (FIP) and has been reported in the United States and Europe. This article addresses the clinical signs, pathology, pathogenesis, diagnosis, treatment, and prevention of this ferret FIP-like disease.

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… Differential diagnoses for hypergammaglobulinemia in domestic ferrets include Aleutian disease, lymphoma/lymphosarcoma, multiple myeloma, chronic infection ( Helicobacter ), or chronic inflammation from inflammatory bowel disease. 7 , 14 , 16 , 18 Counterimmunoelectrophoresis testing for anti-Aleutian disease parvovirus …

Hematology and Immune-Related Disorders

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Primary IgA nephropathy: current challenges and future prospects.

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, exhibiting a variable clinical and pathological course and significantly contributing to the global burden of chronic kidney disease and end-stage renal disease. Current standards of care focus on optimization of antihypertensive and antiproteinuric therapies (typically renin- angiotensin system blockade) to reduce disease progression. Much recent attention has focused on whether additional immunosuppression confers better outcomes than supportive management alone, and indeed, several trials have demonstrat

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… IgA reacting with pathogens, including Haemophilus parainfluenzae , parvovirus, cytomegalovirus, Epstein–Barr virus, and Helicobacter pylori has been detected in both serum and glomerular samples from patients with IgAN. …

Oncogenes: The Passport for Viral Oncolysis Through PKR Inhibition.

The transforming properties of oncogenes are derived from gain-of-function mutations, shifting cell signaling from highly regulated homeostatic to an uncontrolled oncogenic state, with the contribution of the inactivating mutations in tumor suppressor genes P53 and RB, leading to tumor resistance to conventional and target-directed therapy. On the other hand, this scenario fulfills two requirements for oncolytic virus infection in tumor cells: inactivation of tumor suppressors and presence of oncoproteins, also the requirements to engage malignancy. Several of these oncogenes have a negative i

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… In parvovirus-mediated oncolysis, VP (viral capsid) proteins phosphorylation by the Raf-1 kinase at Ser-2, -6, and -10 on the VP2 N-terminal domain is essential for the nuclear translocation and capsid formation of MVM assembly intermediates. 59 MEK/ERK MEK is a key regulatory kinase activated by RAF …

Potential Approaches Versus Approved or Developing Chronic Myeloid Leukemia Therapy.

Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of patients with chronic myeloid leukemia (CML). However, continued use of these inhibitors has contributed to the increase in clinical resistance and the persistence of resistant leukemic stem cells (LSCs). So, there is an urgent need to introduce additional targeted and selective therapies to eradicate quiescent LSCs, and to avoid the relapse and disease progression. Here, we focused on emerging BCR-ABL targeted and non-BCR-ABL targeted drugs employed in clinical trials and on alternative CML treatments, including antioxidan

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… In detail, the most exploited oncolytic viruses in virotherapy are: adenovirus, herpesvirus, herpes simplex (HSV), measles virus, parvovirus and reovirus ( 110 – 113 ). … Oncolytic Parvoviruses: From Basic Virology to Clinical Applications. Virol J (2015) 12:6. doi: 10.1186/s12985-014-0223-y 114. Shen Y, Nemunaitis J. Herpes Simplex Virus 1 (HSV-1) for Cancer Treatment. Cancer Gene Ther (2006) 13:975–92. doi: 10.1038/sj.cgt.7700946 115. …

Role of Proteasomes in Inflammation.

The ubiquitin-proteasome system (UPS) is involved in multiple cellular functions including the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen processing, cell cycle proliferation and signaling. In humans, proteasome loss-of-function mutations result in autoinflammation dominated by a prominent type I interferon (IFN) gene signature. These genomic alterations typically cause the development of proteasome-associated autoinflammatory syndromes (PRAAS) by impairing proteasome activity and perturbing protein homeostasis. However, an abnormal increased proteasomal

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… Genetic mutations resulting in USP18 loss-of-function of present with a pseudo-TORCH (toxoplasmosis, other [syphilis, varicella, mumps, parvovirus and HIV], rubella, cytomegalovirus, and herpes simplex) fetopathy due to the unmitigated IFN-induced inflammation [ 106 ]. …

Oncologic Emergencies: Immune-Based Cancer Therapies and Complications.

Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from chemotherapy and radiation. This review evaluates immune-based therapies and their complications for emergency clinicians. Therapy complications include immune-related adverse events (irAE), cytokine release syndrome (CRS), autoimmune toxicity, and chimeric antigen receptor (CAR) T-cell-related encephalopathy syndrome (CRES). Immune-related adverse

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… Aplastic anemia presents with findings of anemia, thrombocytopenia, and lymphopenia/neutropenia. 2 , 3 , 97 – 101 Evaluation for viral diseases such as CMV, Epstein-Barr virus, HIV, and parvovirus is recommended, along with B12/folate levels and bone marrow aspiration during admission. …

Р

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… These function as recognition sites for cleavage by restriction endonuclease enzymes or secondary structures as the folding of RNA molecules or the hairpin structures found at the termini of the single-stranded DNA genomes of parvoviruses. … panleukopenia [ pan″loo-ko-pe′ne- ] 1. abnormal depression in numbers of white blood cells. 2. the name of a disease caused by feline parvovirus; see feline panleukopenia. feline p. virus feline parvovirus; the etiologic agent of feline panleukopenia. p. …

SOGC Guideline Retirement Notice No. 2.

These documents have been archived because they contain outdated information. They should not be consulted for clinical use, but for histori … (2002) 62-67] Breast Cancer, Pregnancy, and Breastfeeding [J Obstet Gynaecol Can 24 (2002) 164-171] Parvovirus B19 Infection in Pregnancy [J Obstet Gynaecol Can 24 (2002) 727-734] Diversity [J Obstet Gynaecol Can 25 (2003) 1042] Conflict of Interest [J Obstet Gynaecol Can 25 (2003) 1044] Canadian Contraception Consensus [J Obstet Gynaecol Can 26 (2004) 347-3 …

Magnetic Resonance Imaging in 50 Captive Non-domestic Felids - Technique and Imaging Diagnoses.

Magnetic resonance imaging (MRI) is the recognized gold standard for diagnostic imaging of the central nervous system in human and veterinary patients. Information on the use of this modality and possible imaging abnormalities in captive non-domestic felids is currently limited to individual case reports or small case series. This retrospective study provides information on technique and imaging findings in a cohort of cases undergoing MRI at an academic Veterinary Medical Center. The University of Tennessee College of Veterinary Medicine MRI database was searched for non-domestic felids under

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… Leukoencephalomyelopathy of unknown cause has also been reported in domestic cats, with vitamin A and B12 deficiency, feline parvovirus, feline leukemia virus, toxic and metabolic causes considered as possible etiologies ( 46 ). Diffuse brain atrophy was the main finding in two geriatric cats. …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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… It has been associated with reactivation or acute exacerbation of viral hepatitis (both hepatitis B virus [HBV] and C virus [HCV]) and, more rarely, with disseminated parvovirus infections, enteroviral meningitis, progressive multifocal leukoencephalopathy, babesiosis, and pneumocystosis. 41 Bacterial … Both adenoviruses and parvovirus B19 have been reported as rare causes of severe gastrointestinal disease in cancer patients. Finally, the reactivation of hepatotropic viruses (HBV and HCV) represents an important problem in areas of high endemicity. …

IgA Vasculitis (Henoch-Schönlein Purpura): An Update on Treatment.

Objective: IgA vasculitis (IgAV), previously named as Henoch-Schönlein purpura, is the most frequent systemic vasculitis in children. In adults, IgAV is less common although it is associated with more severe disease. In fact, the frequency of glomerulonephritis (referred to as IgAV nephritis) in adults is higher than in children and tends to present more severely, with around 10-30% of those affected eventually progressing to end-stage renal disease. In this review, we describe the pathophysiology, main clinical features, diagnosis of the disease, and latest clinical data regarding IgAV therap

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… Mucosal infections often precede IgAV onset, and several pathogens have been implicated in triggering the disease, such as viruses (Hepatitis B or parvovirus) or bacteria, among which Streptococcus, Staphylococcus or Helicobacter pylori stand out [ 20 ]. …

Kidney Disease and Hematopoietic Stem Cell Transplantation.

Hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for patients with hematologic malignancies and certain solid tumors and nonmalignant hematologic conditions. Both AKI and CKD occur commonly after HSCT and are associated with significant morbidity and mortality. AKI and CKD in this setting may result from direct effects of the transplant or be caused by pretransplant bone marrow conditioning regimens and/or nephrotoxic agents administered in the post-transplant period. In this article, we review the epidemiology, risk factors, etiologies, pathophysiology, diagnos

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… **Systemic, BK virus, CMV, parvovirus B19, adenovirus. …

Epidemiology, Clinical Data, and Management of Aseptic Abscess Syndrome: Review of Published Cases Outside France.

Aseptic abscess syndrome is a clinical entity that is being increasingly documented. Unfortunately, apart from the French registry, there are no other studies presenting collective data. In this review, we sought to analyze clinical and laboratory data from case reports published from the rest of the world. A total of 107 articles were found through our literature search in PubMed, Scopus, and Google, which contained 108 patients who met our eligibility criteria, including pediatric cases. The mean age at diagnosis was 39.1 years, and 54.6% of the patients were female. Cases were found affecti

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… A Case of Sweet Syndrome with Spleen and Lymph Node Involvement Preceded by Parvovirus B19 infection, and a Review of the Literature on Extracutaneous Sweet Syndrome. Am. J. Dermatopathol. 2010;32:621–627. doi: 10.1097/DAD.0b013e3181ce5933. 30. …

Гут Микробиом и мальгический энцефаломилит/хронический синдром утомления (ME/CFS): Понимание механизмов борьбы с заболеваниями.

Myalgic Encephalomyelitis/Chronic Fatige (ME/CFS) — клиническая болезнь, характерная особенность которой заключается в постэкспертальной болезни (PEM). Она может влиять на многие органы и системы, что приводит к серьезному ухудшению качества жизни пациентов. Несмотря на многочисленные постинфекционные, иммунологические, неврологические, метаболические и эндокринные изменения, не существует ни окончательного диагностического маркера, ни утвержденного лечения. Этиология и патофизиология по-прежнему не до конца понимаются; однако появляющиеся данные свидетельствуют о том, что кишечная микробиомия

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… These include Epstein–Barr Virus, Ross River virus, human herpesvirus-6, human cytomegalovirus, parvovirus B19, human retroviruses, and enteroviruses [ 12 ]. The recent pandemic of COVID-19 infection has renewed interest in post-viral syndromes and their link to ME/CFS. …