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ICIMH 2022 Abstracts

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Искусственный интеллект в педиатрической нейрорадиологии: текущий ландшафт, проблемы и будущие направления.

В настоящем обзоре содержится информация о нынешнем ландшафте искусственного интеллекта (АИ) в области педиатрической и эмбриональной нейрорадиологии, критическая оценка текущей практики, барьеров на пути к клиническому усыновлению и будущего потенциала. Мы искали рецензированные исследования за последнее десятилетие, сфокусировавшись на сегментации изображений, обнаружении повреждений, классификации, прогнозировании и поддержке клинического решения при педиатрической съемке мозга. Особое внимание было уделено уникальным педиатрическим факторам, таким, как развитие мозга и нехватка данных. Мет

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… suggestion VUNO Med-DeepBrain‚ VUNO MR Atrophy, Dementia Brain parcellation, Atrophy quantification During: perception aid (prompting all abnormalities/results/heatmaps), interactive decision support (shows abnormalities/results only on demand), report suggestion AI Artificial intelligence, ASPECTS Alberta … Reproduced from Kelly et al 2025 [ 43 ] AI Artificial intelligence, ASPECTS Alberta Stroke Program Early CT Score, CSS central spinal stenosis, CT computed tomography, HDVS hyperdense vessel sign, ICA internal carotid artery, ICH intracranial haemorrhage, M1 first segment of the middle cerebral artery …

A national portfolio of bone oncology trials-The Canadian experience in 2012.

BackgroundThe impact of both cancer and its treatment on bone is an essential component of oncological practice. Bone oncology not only affects patients with both early stage and metastatic disease but also covers the entire spectrum of tumour types. We therefore decided to review and summarise bone oncology-related trials that are currently being conducted in Canada.MethodWe assessed ongoing and recently completed trials in Canada. We used available North American and Canadian cancer trial websites and also contacted known investigators in this field for their input.ResultsTwenty seven clinic

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… The, “Breast cancer to bone (B2B)” metastases research program is a large multidisciplinary population study funded by the Alberta Cancer Foundation. …

Распространение, коморбиды и связанные с болезнями осложнения ревматоидного артрита в Колумбии: национальное межсекторальное исследование на основе данных об административных претензиях.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: До настоящего времени в Колумбии проводились ограниченные исследования, особенно в национальном масштабе, по вопросу о распространенности коморбидов и осложнений, связанных с ревматоидным артритом (RA). Мы поставили перед собой цель проанализировать характер распространенности коморбидов и связанных с болезнями осложнений у пациентов из числа РА, охваченных колумбийским режимом медицинского обслуживания. МЕТОДЫ: Мы провели общенациональное описательное исследование наблюдений с использованием данных об административных претензиях. Мы использовали набор чувствительных и к

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… Based on the 2015–2016 Alberta Health Care Insurance Plan, RA crude prevalence was 1.08% (95% CI 1.07-1.09) [ 25 ]. …

Cancer Patients' Experiences with Telehealth before and during the COVID-19 Pandemic in British Columbia.

BackgroundPatients have had their cancer care either postponed or changed to telehealth visits to reduce exposure to COVID-19. However, it is unclear how these changes may have affected their experiences. We aim to identify patient characteristics that affect telehealth experiences and evaluate their preferences for using telehealth in the future.MethodsPatients who completed the Outpatient Cancer Care (OCC) Patient Experience Survey were invited to participate. They comepleted the modified OCC Survey, which focused on telehealth during the pandemic. Linear and logistic regression analyses wer

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… Virtual cancer care during the COVID-19 pandemic in Alberta: Evidence from a mixed methods evaluation and key learnings JCO Oncol. Pract. 2021 17 e1354 e1361 10.1200/OP.21.00144 34351822 PMC8457798 11. …

Effects of an Electronic Patient Reported Outcome Measures (e-PROMs) Program on Symptom Reporting, Use of Healthcare, and Overall Survival in Patients With Lymphoma: A Multicenter Prospective Study.

BackgroundHealthcare is shifting from a disease-centered to patient-centered approach, and aspects of health such as quality of life (QoL) are becoming increasingly relevant. "E-Res Salud" for hematological malignancies is a value-based healthcare program aiming to improve patient experience and outcomes. The program collects e-PROMs via automatically deployed, validated questionnaires over a mobile application.MethodsA multicenter prospective observational cohort study including 243 patients with Hodgkin and non-Hodgkin lymphoma receiving outpatient intravenous immunochemotherapy at four teac

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… Qi , et al., “ Utilizing Patient Reported Outcome Measures (PROMs) in Ambulatory Oncology in Alberta: Digital Reporting at the Micro, Meso and Macro Level ,” Journal of Patient‐Reported Outcomes 5 , no. S2 ( 2021 ): 97 , 10.1186/S41687-021-00373-3 . 34637003 PMC8511222 …

Digital Health Portals for Individuals Living With or Beyond Cancer: Patient-Driven Scoping Review.

BackgroundDigital health portals are online platforms allowing individuals to access their personal information and communicate with health care providers. While digital health portals have been associated with improved health outcomes and more streamlined health care processes, their impact on individuals living with or beyond cancer remains underexplored.ObjectiveThis scoping review aimed to (1) identify the portal functionalities reported in studies involving individuals living with or beyond cancer, as well as the outcomes assessed, and (2) explore the diversity of participant characterist

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… study objective | Not mentioned or unrelated to the study objective | Differences in EHR access attitudes and experiences between patients with cancer and those with other conditions Santos et al [ 69 ], 2021; Canada | “MyAHS Connect” (formerly “MyChart”) was piloted in select clinics before joining Alberta … Informatics J 2020 12 11 26 4 2915 29 10.1177/1460458220944727 32914701 32914701 69 Santos AD Caine V Robson PJ Watson L Easaw JC Petrovskaya O Oncology patients' experiences with novel electronic patient portals to support care and treatment: qualitative study with early users and nonusers of portals in Alberta …

Screening mammography for women aged 40 to 49 years at average risk for breast cancer: an evidence-based analysis.

OBJECTIVE: The aim of this review was to determine the effectiveness of screening mammography in women aged 40 to 49 years at average risk f … mination. In addition to this, 2 separate reviews, one conducted in Quebec in 2005 and the other in Alberta in 2000, each concluded that there is an absence of convincing evidence on the effectiveness of screening mammography for women in this age group who are at average risk for breast cancer. In the United States, there is disagreement among organizati …

Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation.

A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical target for treating chronic inflammatory conditions, mitigating fibrosis progression, and improving the efficacy of existing cancer chemotherapies and radiotherapy. Nearly half of the literature on this axis has been published during the last five years. In cancer biology, LPA signaling is increasingly being recognized as a central mediator of the progression of chronic inflammation in the establishment of a tumor microenvironmen

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… Acknowledgments The work was supported by the Canadian Cancer Society Research Institute, the Canadian Breast Cancer Foundation, the Women and Children’s Health Institute of the University of Alberta (WCHRI) and the Cancer Research Institute of Northern Alberta (CRINA). …

Analysis of reasons and risk factors for non-completion of radiotherapy courses in patients with tumors.

PurposeNon-completion of radiotherapy courses (NCRC) may happen in patients undergoing intensity-modulated radiotherapy (IMRT). Analyzing the reasons and risk factors for NCRC can lead to possible targeted measures to reduce the incidence rate. This six-year retrospective study will present a cohort analysis of NCRC from a single center.MethodsData from patients treated with IMRT between January 2018 and December 2023 were collected for analysis. The collected characteristics included age, gender, residential area, body mass index (BMI), tumor clinical stage, tumor type, tumor location, therap

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… An analysis of clinical and systemic factors associated with palliative radiotherapy delivery and completion at the end of life in Alberta, Canada . Curr Oncol . ( 2023 ) 30 : 10043–56 . doi: 10.3390/curroncol30120730 , PMID: 38132364 PMC10742975 …

A qualitative study of cancer survivors' exercise behaviour 4 months after a telerehabilitation program.

PURPOSE: Although telerehabilitation can improve access to exercise programs for cancer survivors, it is not known if these programs lead to ongoing change in exercise habits. This study explored participant experiences of exercise 4 months after finishing specialized cancer exercise-based telerehabilitation. METHOD: A qualitative study embedded in a randomized controlled trial evaluated exercise-based cancer telerehabilitation delivered in groups. Data were collected via semistructured interviews that were audio-recorded and transcribed verbatim. Seventeen adult cancer survivors (age 21 to 8

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… clinical settings is usually short term, it is important to be able to identify those with low levels of exercise experience and provide extra support to them in the community whether it be in-person or via telehealth such as through cancer-specific trainer-led programs such as LiveStrong [ 39 ] or the Alberta …

Attrition Rates in Multiple Myeloma Treatment under Real World Conditions-An Analysis from the Austrian Myeloma Registry (AMR).

Multiple myeloma (MM) is characterized by serial relapses, necessitating the application of sequential lines of therapy (LoT). Reports on attrition rates (ARs) vary widely. The present study analysed ARs from the Austrian Myeloma Registry. Attrition was defined as being either deceased, progressive without having received another LoT, or lack of follow-up for ≥5 years. A total of 571 patients diagnosed between January 2009 and August 2021 were included (median age: 72 years; median follow-up: 50.8 months). Some 507 patients received at least one LoT. Of the total, 43.6% underwent autologous st

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… Real-world treatment patterns for patients with newly diagnosed multiple myeloma in Alberta, Canada. Leuk. Lymphoma. 2022;63:2557–2564. doi: 10.1080/10428194.2022.2092852. 14. Raab M.S., Cavo M., Delforge M., Driessen C., Fink L., Flinois A., Gonzalez-McQuire S., Safaei R., Karlin L., Mateos M. …

The work of managing multiple myeloma and its implications for treatment-related decision making: a qualitative study of patient and caregiver experiences.

BackgroundThe evolving nature of multiple myeloma (MM) therapies, including the introduction of novel oral agents, has produced a shift in the delivery of care from hospital to home. Within this context, patients and their caregivers are becoming increasingly engaged in the work of illness management, however the exact nature of this work as well as the ways in which this work informs treatment preferences and decisions within this population has not been explored. This qualitative study sought to develop an in-depth understanding of patient and caregiver experiences with different MM treatmen

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… children: | 2 | 1 Education High school | 6 | – College | 1 | 4 Undergraduate degree | 7 | 3 Graduate degree(s) | 2 | 1 Employment status Employed full time | 2 | 4 Part time | 1 | – Retired | 10 | 3 Sick leave | 3 | 1 Private health Insurance Yes | 13 | 5 No | 3 | 3 Province British Columbia (BC) | 9 | 2 Alberta …

Построение олигодендроцитов, подобных прекурсорам, из эмбриональных фибробатластов мыши с использованием miR-7a Имитация.

ЦЕЛИ: Разработка эффективных стратегий повышения эффективности мер по ликвидации последствий по-прежнему является одной из основных терапевтических проблем в связи с такими демиелинизирующими расстройствами, как множественный склероз (МС). МикроРНК (миРНК) стали мощным регулятором клеточной судьбы. Было показано, что miR-7a , в значительной степени выражается в олигодендроцитных клетках-прекурсорах (ОПК). Цель этого исследования заключалась в изучении вопроса о том, является ли завышенное выражение мнений miR-7a :: может перепрограммировать эмбриональные фибробатласты мыши (МЭФ) в похожие на O

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… Simonetta Sipione’s lab (Department of Pharmacology, University of Alberta, Edmonton, Canada). Culture flasks (25 cm²) were pre-coated with 0.1% gelatin before seeding. …

What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Liposomes are considered one of the most successful drug delivery systems (DDS) given their established utility and success in the clinic. In the past 40⁻50 years, Canadian scientists have made ground-breaking discoveries, many of which were successfully translated to the clinic, leading to the formation of biotech companies, the creation of research tools, such as the Lipex Extruder and the NanoAssemblr™, as well as contributing significantly to the development of pharmaceutical products, such as Abelcet®, MyoCet®, Marqibo®, Vyxeos®, and Onpattro™, which are making positive impacts on patient

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… In Canada, some of the early studies investigating the use of antibody-mediated targeting of liposomes to treat cancer were conducted by Theresa (Terry) Allen’s group at the University of Alberta [ 121 ]. … delivery/polymer/lipid technology based companies in operation are significant and these include the BC–based companies, Evonik, Precision Nanosystems, iCo Therapeutics, Acuitus, Sitka Biopharma, Cuprous Pharmaceuticals, Integrated Nanotherapeutics, Genevant Sciences, as well as Nanostics Precison Health (Alberta …

Antibody and aptamer-based therapies for osteoarthritis: Application of antibodies and promise of aptamers.

Osteoarthritis (OA) is a common degenerative inflammatory joint disease with progressive loss of articular cartilage that undermines patients' quality of life. There are no regulatory-approved, disease-modifying OA medications, despite a great deal of studies done to elucidate OA pathogenesis. Until now, OA pharmacological treatment focused mainly on generalized inhibition of inflammation and pain. Currently, monoclonal antibodies and nucleic-acid aptamers emerge as targeted therapies offering potential alternatives by addressing the complex challenges posed by OA, such as specifically reducin

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… relief in individuals with hand OA who were not responding to analgesics and NSAIDs. patients received two subcutaneous injections of 40 mg adalimumab at intervals of 15 days, or a placebo, at random, and were followed for six months with hand OA 07-2012 Chevalier et al. 71 NCT00686439 (University of Alberta … in individuals with hand OA who were not responding to analgesics and NSAIDs. | patients received two subcutaneous injections of 40 mg adalimumab at intervals of 15 days, or a placebo, at random, and were followed for six months with hand OA | 07-2012 | Chevalier et al. 71 NCT00686439 (University of Alberta …

Optical coherence tomography for age-related macular degeneration and diabetic macular edema: an evidence-based analysis.

OBJECTIVE: The purpose of this evidence-based review was to examine the effectiveness and cost-effectiveness of spectral-domain (SD) optical … hed between January 2006 to February 2009; however, two technology assessments were found, one from Alberta and the other from Germany, both of which contain evidence for TD OCT. Although these HTAs included eight studies each, only one study from each report was specific to this review. Additionally, one systematic review was identified for OCT and DME. …

Анализ иммунологической памяти Джона Каннингема о мексиканском населении пациентов с множественным склерозом под лечением.

Фон/цели: Множественный склероз (MS) - это болезнь, характеризующаяся демиелинацией и аксонным повреждением центральной нервной системы. Несмотря на наблюдаемые преимущества, высокоэффективная терапия на основе ВИЧ-инфекции имеет негативные последствия, включая повышенный риск развития прогрессивной многофукальной лейкоэнцефалопатии (ПМП). Кроме того, риск возрастает, если пациент имеет антитела для вируса Джона Каннингема (JCV). Появляется ПМЛ редко, и в Мексике имеется лишь один доклад. Цель этого исследования состояла в том, чтобы определить и проанализировать иммунологическую память ОЖЦ у

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… Bhan et al. [ 39 ] recruited 4198 MS patients from Quebec, Ontario, the Atlantic provinces (Nova Scotia, New Brunswick, and Newfoundland), the western provinces (Manitoba, Saskatchewan, Alberta, and British Columbia), and the rest of Canada. Seropositivity was determined by ELISA (two steps). …

Вакцинация в множественных миеломах: проблемы и стратегии.

Множественная миелома (ММ) — гематологическая халатность, характеризующаяся глубоким иммунодепрессией, вызванной как механизмами, связанными с заболеваниями, так и иммунной дисфункцией, вызванной лечением. Это скомпрометировало иммунный статус, что значительно повышает подверженность инфекциям, что является одной из основных причин заболеваемости и смертности у пациентов с ОМ. Хотя вакцинация является краеугольным камнем профилактики инфекции, стандартные стратегии иммунизации часто дают неоптимальную реакцию для этой группы населения. ЦЕЛИ: В настоящем обзоре обобщены имеющиеся данные об имму

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… One retrospective study from Alberta, Canada, reported an annual incidence of 673.9 IPD cases per 100 000 individuals with MM, compared to 11.0 per 100 000 in the general adult population—an odds ratio of 62.8 (95% CI: 39.6–99.8; p < 0.001) [ 26 ]. …

Antimicrobial Stewardship Program for Patients in the Hematological Department Receiving Carbapenem Therapy: A Single-Center and Interrupted Time Series Analysis.

As antibiotic resistance has become a global problem, the intervention of an antimicrobial stewardship team (AST) is warranted. In hematological disorders, infectious complications are crucial owing to abnormal neutrophil function and decreased cell-mediated immunity. Despite the widespread implementation of AST intervention, the effectiveness of stewardship practices for immunocompromised patients remains uncertain. We determined the effect of AST interventions on carbapenem therapy in the department of hematology. Patients admitted to the department and undergoing carbapenem therapy were enr

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… Alberta Provincial Tumour Teams Management of febrile neutropenia in adult cancer patients. Albertha. Health Serv. 2014;3:2–19. 29. Sethi S., Murphy T.F. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N. Engl. J. …