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Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment.

Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from bone tissues and can be classified into primary and secondary types. Due to the specificity of the bone microenvironment, the results of traditional means of treating bone tumors are often unsatisfactory, so there is an urgent need to develop new treatments for malignant bone tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis and treatment. Nanoparticles (NPs) have gained significant attention due to their versatility, making them highly suitable for applica

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… Qiao et al. [ 229 ] developed a pH-responsive bone-targeting drug delivery system using lead-bismuth-loaded upconversion NPs PUCZP (Fig. 10 A and D). This system enabled the combination treatment of zoledronic acid and osthole, reducing tumorigenesis and osteoclastogenesis. … Fig. 10 A pH-responsive bone-targeting drug delivery system using lead-bismuth-loaded upconversion NPs. A ) Schematic illustration of the synthesis of theranostic bone-targeting Gd(III)-doped upconversion NPs PUCZP. B ) FTIR spectra of UCMS (black line) and UCZP (red line). …

Evolving role of biomaterials in diagnostic and therapeutic radiation oncology.

Radiation therapy to treat cancer has evolved significantly since the discovery of x-rays. Yet, radiation therapy still has room for improvement in reducing side effects and improving control of cancer. Safer and more effective delivery of radiation has led us to novel techniques and use of biomaterials. Biomaterials in combination with radiation and chemotherapy have started to appear in pre-clinical explorations and clinical applications, with many more on the horizon. Biomaterials have revolutionized the field of diagnostic imaging, and now are being cultivated into the field of theranostic

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… Metallic nanoparticles containing high-Z elements (e.g. gadolinium, bismuth, and gold) also have been proven to augment the efficacy of radiotherapy due to their interactions with low-energy photons, and are used as positive contrast agents in MRI and radiosensitizers as mentioned earlier [ 83 ]. …

UEG Week 2017 Oral Presentations

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Monoclonal antibodies in the treatment of multiple myeloma: current status and future perspectives.

The treatment landscape for patients with multiple myeloma (MM) is constantly evolving. Over the past decade, the introduction of novel agents such as proteasome inhibitors and immunomodulatory drugs has led to notable changes in therapeutic strategy, and improvements in survival, yet MM remains incurable in the vast majority of cases. More recently, a targeted approach to MM treatment has emerged, using monoclonal antibodies (mAbs) to target antigens expressed on the surface of MM cells. MAbs tested to date kill MM cells via the host's immune system and/or by promoting apoptosis, and appear t

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… Comparative analysis of multiple myeloma treatment by CD138 antigen targeting with bismuth-213 and Melphalan chemotherapy . Nucl Med Biol 2014 ; 41 : e30 –e35. 24759272 10.1016/j.nucmedbio.2014.02.008 Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H et al. …

The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation.

Heat-shock protein 70 (HSP70) and nanotechnology have emerged as promising avenues in glioblastoma multiforme (GBM) therapy, addressing the critical challenges posed by its aggressive nature and therapeutic resistance. HSP70's dual role in cellular stress response and tumour survival emphasises its potential as both a biomarker and therapeutic target. This review explores the innovative integration of HSP70 with nanotechnology, emphasising advancements in imaging, drug delivery and combination therapies. Nanoparticles, including SPIONs, liposomes, gold nanoparticles and metal-organic framework

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… in breast cancer treatment | HSP70 overexpression enhance the therapeutic effect by promoting cell survival, immune response modulation, and cellular stress adaptation, contributing to the efficacy of the treatment in breast cancer | [ 121 ] Nanorods | Bi 2 S 3 –Au nanorods | All types of cancer | Bismuth …

Glucagon-like Peptide-1 Receptor Agonists: Exciting Avenues Beyond Weight Loss.

The last two decades have proffered many remarkable choices in managing type 1 and type 2 diabetes mellitus. Leading the list are glucagon-like peptide-1 receptor agonists (GLP1RAs), the first of which, exenatide, was approved by the FDA in 2005. Two other major classes of drugs have also entered the market: dipeptidyl peptidase-4 (DPP-4) inhibitors, commonly known as gliptins and approved in 2006, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, with the first approval occurring in 2013. These drugs have revolutionized the treatment of diabetes. Additionally, on the horizon, the once-w

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… Meurot C., Jacques C., Martin C., Sudre L., Breton J., Rattenbach R., Bismuth K., Berenbaum F. Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity? J. Orthop. Transl. 2022;32:121–129. doi: 10.1016/j.jot.2022.02.001. 117. Rowlands J., Heng J., Newsholme P., Carlessi R. …

Oral complications and management strategies for patients undergoing cancer therapy.

With cancer survival rate climbing up over the past three decades, quality of life for cancer patients has become an issue of major concern. Oral health plays an important part in one's overall quality of life. However, oral health status can be severely hampered by side effects of cancer therapies including surgery, chemotherapy, radiotherapy, and hematopoietic stem cell transplantation. Moreover, prevention and treatment of these complications are often overlooked in clinical practice. The present paper aims at drawing health care professionals' attention to oral complications associated wit

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… One strategy on pain relief pertains to the use of an oral solution mixture known as “Magic Mouthwash;” it is composed of diphenhydramine, viscous lidocaine, bismuth, subsalicylate, and corticosteroids [ 116 ]. …

Неделя ГЭЭ 2018 Презентации на плакате

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From Innate Immunity to Cancer Therapy: Antimicrobial Peptides as Emerging Anticancer Agents.

The potential for the use of antimicrobial peptides (AMPs) as anticancer agents has garnered much interest because of their selective cytotoxicity to tumor cells and ability to evade multidrug resistance mechanisms. AMPs are shorter cationic amphiphilic molecules, part of our innate immune system, with direct membrane-disruptive activity and immunomodulatory effects. Anticancer peptides (ACPs) can be derived from natural biophysical sources or synthetically engineered, taking advantage of the unique biophysical properties of cancer cell membranes to exert their anti-tumor activities rapidly an

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… A Review on the Biodistribution, Pharmacokinetics and Toxicity of Bismuth-Based Nanomaterials. Int. J. Nanomed. 2020;15:7079–7096. doi: 10.2147/IJN.S250001. 104. Kim J., Narayana A., Patel S., Sahay G. …

Selinexor in acute myeloid leukemia: therapeutic applications and current challenges.

This article aims to review the current application status and research advancements of selinexor in the treatment of acute myeloid leukemia (AML). Selinexor, as the first oral selective inhibitor of nuclear export protein Exportin-1 (XPO1), inhibits the abnormal nuclear export of tumor suppressor proteins by blocking XPO1, thereby restoring their activity and exerting antitumor effects. Clinical studies have shown that selinexor monotherapy or combination therapy has demonstrated good anti-leukemia effects in AML, especially in patients with relapsed/refractory AML. In addition, the combinati

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… Neutropenia | 14% | 13% | Granulocyte Colony-Stimulating Factor (G-CSF): Filgrastim or Pegfilgrastim Gastrointestinal | Nausea | 53% | — | 5-HT3 antagonists, Neurokinin 1 receptor antagonists, Benzodiazepines, and Cannabinoid receptor antagonists, etc Vomiting | 38% | 5% Diarrhea | 39% | 3% | Loperamide and Bismuth …

Navigating Stomatologic Complications Secondary to Antineoplastic Agents-A Comprehensive Review.

This review systematically examines the oral complications associated with conventional and novel anti-cancer therapies. It highlights that while molecularly targeted agents including monoclonal antibodies targeting the vascular endothelial growth factor and its receptor, the epidermal growth factor receptor, tyrosine kinase inhibitors, and immune checkpoint inhibitors tend to exhibit a lower overall toxicity profile compared to traditional cytotoxic chemotherapeutics, they are nonetheless linked to significant oral adverse events. These complications encompass inflammatory mucosal reactions k

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… Additionally, a mouthwash formulation—comprising diphenhydramine, viscous lidocaine, bismuth subsalicylate, and corticosteroids is useful for symptomatic management [ 106 ]. Recent research has identified several interventions with proven efficacy in preventing and treating OM. …

Radiotheranostics - Precision Medicine in Nuclear Medicine and Molecular Imaging.

'See what you treat and treat what you see, at a molecular level', could be the motto of theranostics. The concept implies diagnosis (imaging) and treatment of cells (usually cancer) using the same molecule, thus guaranteeing a targeted cytotoxic approach of the imaged tumor cells while sparing healthy tissues. As the brilliant late Sam Gambhir would say, the imaging agent acts like a 'molecular spy' and reveals where the tumoral cells are located and the extent of disease burden (diagnosis). For treatment, the same 'molecular spy' docks to the same tumor cells, this time delivering cytotoxic

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… A first in human study showed promising results with liver targeted treatment with intraarterial application of Bismuth-213 ( 213 Bi)-DOTATOC 60 . …

Компьютерный подход к разработке лекарственных средств для множественного склероза с помощью модели QSPR, теории химических графиков и анализа решений по нескольким критериям.

Множественный склероз (MS) — сложное аутоиммунное заболевание центральной нервной системы с неизвестной этиологией. Несмотря на то, что медикаментозная терапия может замедлить прогресс, существует необходимость в более эффективном лечении. Модель количественного соотношения структуры и активности (QSAR) с использованием топографических индексов, полученных на основе теории химических графиков, является многообещающим подходом к рациональному проектированию новых лекарств для MS. Используя подход линейной регрессии, мы создаём модели количественного соотношения структуры и производительности (Q

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… Useful irregularity indices in QSPR Study for Bismuth Tri-iodide. J Chem. 16. Randić M Comparative regression analysis. Regressions based on a single descriptor Croat Chem Acta 1993 66 2 289 312 Randić M. Comparative regression analysis. Regressions based on a single descriptor. …

Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment-The Current State of Knowledge.

Hyperthermia (HT) is an anti-cancer therapy commonly used with radio and chemotherapies based on applying heat (39-45 °C) to inhibit tumor growth. However, controlling heat towards tumors and not normal tissues is challenging. Therefore, nanoparticles (NPs) are used in HT to apply heat only to tumor tissues to induce DNA damage and the expression of heat shock proteins, which eventually result in apoptosis. The aim of this review article is to summarize recent advancements in HT with the use of magnetic NPs to locally increase temperature and promote cell death. In addition, the recent develop

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… Abbreviations: nanoparticles (NPs), tungsten disulfide quantum dots (WS 2 NPs), bismuth selenide nanoparticles (Bi 2 Se 3 -NPs), cupric oxide nanoparticles (CuO-NPs), molybdenum disulfide nanoparticles (MoS 2 -NPs), polyethylene glycol (PEG), poly (caprolactone) (PCL), poly(lactic-co-glycolic acid) ( …

CAR-T-Cell Therapy in Multiple Myeloma: B-Cell Maturation Antigen (BCMA) and Beyond.

Significant progress has been achieved in the realm of therapeutic interventions for multiple myeloma (MM), leading to transformative shifts in its clinical management. While conventional modalities such as surgery, radiotherapy, and chemotherapy have improved the clinical outcomes, the overarching challenge of effecting a comprehensive cure for patients afflicted with relapsed and refractory MM (RRMM) endures. Notably, adoptive cellular therapy, especially chimeric antigen receptor T-cell (CAR-T) therapy, has exhibited efficacy in patients with refractory or resistant B-cell malignancies and

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… Comparative Analysis of Multiple Myeloma Treatment by CD138 Antigen Targeting with Bismuth-213 and Melphalan Chemotherapy Nucl. Med. Biol. 2014 41 e30 e35 10.1016/j.nucmedbio.2014.02.008 24759272 79. …

Tumor microenvironment signaling and therapeutics in cancer progression.

Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. Stromal cells can adopt new phenotypes to promote tumor cell invasion. A deep understanding of the signaling pathways involved in cell-to-cell and cell-to-ECM interactions is needed to design effective intervention strategies that might interrupt these interactions. In this review, we describe the tumor microenvironment (TME) components and associated therapeutics. We discuss t

Monoclonal Antibodies Against Myeloid Leukemia Cells: Current Knowledge and Future Directions.

Monoclonal antibodies targeting specific cell surface antigens have emerged as a promising therapeutic approach for acute myeloid leukemia (AML), thus widening the treatment landscape of this heinous disease. These antibodies have been designed to selectively target and eliminate leukemic cells while limiting damage to the normal hematopoietic counterpart. Among the potential targets on AML cells, CD33, CD123, and CD47 have shown the major potential in preclinical and clinical trials. Additionally, conjugation of monoclonal antibodies with cytotoxic agents has further enhanced their therapeuti

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… Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia. Clin. Cancer Res. 2010;16:5303–5311. doi: 10.1158/1078-0432.CCR-10-0382. 146. …

UEG Week 2015 Poster Presentations

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Neurotransmitters in cancer: how receptor signaling and posttranslational modifications modulate tumor progression and offer new therapeutic targets.

Recent studies highlight the multifaceted roles of neurotransmitters in tumor immunomodulation, offering novel avenues for increasing therapeutic efficacy. These signaling molecules are classified into cholinergic agents, monoamines, amino acids, and peptides and regulate tumorigenesis, metastasis, and immune evasion via autocrine/paracrine pathways and receptor-mediated interactions. Notably, neurotransmitters influence tumor cell proliferation, apoptosis, and immune cell activity by modulating intracellular signaling cascades through posttranslational modifications (serotonylation and dopami

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… Daher C, Vimeux L, Stoeva R, Peranzoni E, Bismuth G, Wieduwild E, Lucas B, Donnadieu E, Bercovici N, Trautmann A, Feuillet V. Blockade of beta-adrenergic receptors improves CD8 + T cell. Priming and cancer vaccine efficacy. Cancer Immunol Res. 2019;7:1849–63. 53. …

Совокупное и интерактивное воздействие тяжелых металлов на нейродегенеративные заболевания: сравнительный обзор болезни Альцгеймера, Паркинсона, амиотропического бокового склероза и множественного склероза.

Тяжелые металлы и металллоиды являются стойкими загрязнителями окружающей среды, которые накапливаются в центральной нервной системе и взаимодействуют с местными основными металлами, однако в большинстве нейротоксических исследований металлы по-прежнему рассматриваются как независимые агенты, а не как смешанные смеси. В настоящем обзоре систематически сопоставляются данные о совокупном и интерактивном воздействии смесей тяжелых металлов на четыре основных нейродегенеративных заболевания: болезнь Альцгеймера (AD), болезнь Паркинсона (PD), амиотропический боковой склероз (ALS) и множественный ск

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… deoxyguanosine 6-OHDA | 6-Hydroxidopamine Aβ | Amyloid-beta AD | Alzheimer’s Disease Ag | Silver Al | Aluminum ALS | Amyotrophic Lateral Sclerosis AMSTAR | Assessing the Methodological Quality of Systematic Reviews APP | Amyloid Precursor Protein As | Arsenic Au | Gold Ba | Barium BBB | Blood–Brain Barrier Bi | Bismuth …