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Когнитивно стимулирующая деятельность в области множественного склероза: качественное технико-экономическое обоснование.

ВВЕДЕНИЕ: Некоторые люди с множественным склерозом (pwMS) имеют высокий когнитивный запас (CR), что потенциально смягчает когнитивный спад. Когнитивно стимулирующая деятельность (СПД) способствует ОК, что предполагает, что меры, связанные с СВГ, могут повысить когнитивную функцию в НР. ЦЕЛИ/AIMS: Оценка целесообразности принятия мер, направленных на расширение участия в ККА (например, чтение, письменность, изучение языка). МЕТОДЫ: Участники были опрошены после 12-недельного вмешательства в произвольное контролируемое испытание. Участники отбирались на основе заранее определенных критериев для

Совпадение в аннотации оригинала
INTRODUCTION: Some people with multiple sclerosis (pwMS) exhibit high cognitive reserve (CR), potentially mitigating cognitive decline. Cognitively stimulating activities (CSAs) contribute to CR, suggesting that interventions entailing CSAs may enhance cognitive function in MS. OBJECTIVES/AIMS: To evaluate the feasibility of an intervention designed to incr…

Количественная оценка резерва движения в множестве склероза с помощью дневных квантовой активности.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Обычные клинические оценки по множественным склерозам (МС), таким, как расширенная шкала взносов для инвалидов (EDSS), часто не учитывают тонкие функциональные изменения. Хотя акселерометрия является объективным показателем реальной моторной активности, большинство ежедневных сводок концентрируются на средних значениях, игнорируя как пиковые характеристики, так и их изменчивость в течение дня. Эта дневная максимальная изменчивость показателей может отражать способность человека поддерживать высокую активность, несмотря на усталость, явление, которое мы называем наблюдаем

Совпадение в аннотации оригинала
BACKGROUND: Conventional clinical assessments in multiple sclerosis (MS), such as the Expanded Disability Status Scale (EDSS), often miss subtle functional changes. While accelerometry provides an objective measure of real-world motor activity, most daily summaries focus on average values, neglecting both peak performance and its variability throughout the d…

Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome.

IMPORTANCE: Understanding the risk factors for symptom development will allow clinicians to stratify people with radiologically isolated syndrome (pwRIS) more effectively and tailor their management strategies accordingly. OBJECTIVE: To identify prognostic factors at radiologically isolated syndrome (RIS) diagnosis associated with the development of multiple sclerosis (MS) symptoms. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was performed in samples collected between July 2004 and September 2022 and included 33 MS centers. All pwRIS who meet the 2017 McDonald criteria for dissemina…

Characterization of cortico-meningeal translocator protein expression in multiple sclerosis.

Compartmentalized meningeal inflammation is thought to represent one of the key players in the pathogenesis of cortical demyelination in multiple sclerosis. PET targeting the 18 kDa mitochondrial translocator protein (TSPO) is a molecular-specific approach to quantifying immune cell-mediated density in the cortico-meningeal tissue compartment in vivo. This study aimed to characterize cortical and meningeal TSPO expression in a heterogeneous cohort of multiple sclerosis cases using in vivo simultaneous MR-PET with 11C-PBR28, a second-generation TSPO radioligand, and ex vivo immunohistochemistry…

Vitamin D receptor gene polymorphism in Egyptian multiple sclerosis patients.

One of the most common neurological illnesses in the world is multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS). MS has both a genetic and an environmental origin. In terms of environmental factors, vitamin D deficiency is one of the most important risk factors and closely connected with gene polymorphisms involved in vitamin D metabolism, transport, or activity. Since vitamin D activity requires a receptor-mediated response, any changes to the vitamin D receptor (VDR) may have an effect on the pathophysiology of the disease. In this study,…

Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis.

The development of disease-modifying therapies (DMTs) for neurological disorders is an important goal in modern neurology, and the associated challenges are similar in many chronic neurological conditions. Major advances have been made in the multiple sclerosis (MS) field, with a range of DMTs being approved for relapsing MS and the introduction of the first DMTs for progressive MS. By contrast, people with Parkinson disease (PD) still lack such treatment options, relying instead on decades-old therapeutic approaches that provide only symptomatic relief. To address this unmet need, an in-perso…

Thromboembolic Event in Isolated Non-compaction Cardiomyopathy With Multiple Sclerosis.

Non-compaction cardiomyopathy (NCCM) is a complex, exceedingly rare form of cardiomyopathy. Transient ischemic attack/stroke in NCCM may be cardioembolic or atherosclerotic in origin. While the connection between NCCM and neuromuscular conditions has been documented before, its association with neurological conditions, such as multiple sclerosis has not been established. Here, we present a case of a 45-year-old female with multiple sclerosis (MS) who presented in the context of a transient ischemic attack (TIA) and was found to have non-compaction cardiomyopathy complicated by thromboembolism.…

SUNCT syndrome secondary to multiple sclerosis: Not only trigeminal neuralgia.

BACKGROUND: Facial pain in multiple sclerosis is often due to trigeminal neuralgia but atypical pictures can be observed. CASE PRESENTATION: A man with primary progressive multiple sclerosis developed severe unilateral facial pain in the right orbital region. Spontaneous and triggered attacks were associated with ipsilateral conjunctival injection and lacrimation. A diagnosis of short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing was made, and symptoms significantly improved with lamotrigine. CONCLUSION: Pain is poorly investigated in multiple scler…

Bruton tyrosine kinase inhibitors in multiple sclerosis: evidence and expectations.

PURPOSE OF REVIEW: Despite availability of high-efficacy therapies for multiple sclerosis (MS), many patients experience significant disability worsening due to limited effects of currently available drugs on central nervous system (CNS)-compartmentalized inflammation. Bruton tyrosine kinase (BTK) is an intracellular signaling molecule involved in regulation of maturation, survival, migration, and activation of B cells and microglia, which are central players in the immunopathogenesis of progressive MS. Therefore, CNS-penetrant BTK inhibitors may better prevent disease progression by targeting…

Plasma proteomic profiles of UK Biobank participants with multiple sclerosis.

ObjectiveWe aimed to describe plasma protein biomarkers of multiple sclerosis risk and to explore protein biomarkers of disease severity using radiological outcome measures.MethodsMultiple sclerosis cases and controls were identified in UK Biobank, a longitudinal cohort study of ~500,000 British adults. Plasma proteins were assayed in ~50,000 UK Biobank participants using the Olink proximity extension assay. We performed case-control association testing to examine the association between 2911 proteins and multiple sclerosis, using linear models adjusted for confounding covariates. Associations…

BCG vaccination and multiple sclerosis risk: A Norwegian cohort study.

IntroductionBacillus Calmette-Guérin (BCG) vaccination induces long-lasting effects on the adaptive and innate immune systems and prevents development of experimental autoimmune encephalomyelitis and possibly also inflammatory disease activity in multiple sclerosis (MS).ObjectiveThe objective is to examine if BCG given in early adulthood decreases MS risk.MethodsFrom 791,369 (52% females) Norwegians participating in a national tuberculosis screening program from 1963 to 1975, we collected information on BCG vaccination and tuberculosis disease status. Later, MS disease was ascertained through …

Усовершенствованные методы МРТ: диагностика и последующая деятельность в связи с множественным склерозом

Снимки мозга и спинного мозга играют ключевую роль в оказании помощи врачам в диагностике и мониторинге множественных склерозов. Тем не менее значение магнитного резонансного изображения в MS выходит за рамки его клинической полезности. Усовершенствованные методы визуализации способствовали обнаружению в vivo различных компонентов MS патогенеза, и в последние годы для оценки реакции пациентов с повторной эмиссией MS на имеющиеся методы лечения использовались биомаркеры MRI. Аналогичным образом, показатели МРТ, характеризующие нейродегенерацию, демонстрируют потенциал в качестве первичных и вто

Совпадение в аннотации оригинала
Brain and spinal cord imaging plays a pivotal role in aiding clinicians with the diagnosis and monitoring of multiple sclerosis. Nevertheless, the significance of magnetic resonance imaging in MS extends beyond its clinical utility. Advanced imaging modalities have facilitated the in vivo detection of various components of MS pathogenesis, and, in recent yea…

Impact of Continuous Ofatumumab Exposure During Pregnancy in Multiple Sclerosis.

OBJECTIVES: Anti-CD20 therapies are highly effective treatment options for patients with multiple sclerosis (MS), an inflammatory disorder of the CNS commonly affecting women of childbearing age. Anti-CD20 therapies are however unlicensed for use in pregnancy. Belonging to the IgG1 family, anti-CD20 monoclonal antibodies are likely to cross the placenta, especially after the 20th week of gestation. Our objective was to analyze the impact of ofatumumab (OFA), a subcutaneous anti-CD20 monoclonal antibody, during pregnancy. METHODS: We present the case of a woman with MS who accidentally adminis…

Obsessive-compulsive symptoms and brain lesions compatible with multiple sclerosis.

Autoimmune-mediated obsessive-compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction. Neopterin wa…

Multiple sclerosis: Pregnancy, fertility, and assisted reproductive technology-a review.

BACKGROUND: Pregnancy is not discouraged in multiple sclerosis (MS) patients. However, MS patients tend to delay motherhood since they must wait for a low clinical and radiological activity before considering pregnancy, which impacts their fertility and their need for assisted reproductive technology (ART). This review aimed to cover, from a multidisciplinary perspective, the most critical aspects revolving around pregnancy in MS patients. METHODS: A group of seven experts (four neurologists and three gynaecologists) met for three discussion sessions to review current knowledge on ART in pati…

Exploring Spinal Cord Changes in Multiple Sclerosis Patients Using MRI.

Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS). The diagnosis of MS is based on clinical signs and symptoms as well as findings in magnetic resonance imaging (MRI) sequences by demonstrating the spatial and temporal dispersion of white matter lesions, which are thought to be typical of MS in distribution, shape, extent, and signal abnormalities. Spinal cord MRI can identify asymptomatic lesions and rule out malignancies or spinal stenosis in patients for whom brain imaging is not helpful in making an MS diagnosis. This study examines the MRI feature…

Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis.

BACKGROUND AND OBJECTIVES: The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS). METHODS: Antibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared wit

Пироптоз - формирующаяся связь между микробиотой Гут и множественным склерозом.

В настоящем обзоре разъясняется ключевая роль пироптоза, вызванного микробиотой кишечника, в развитии множественного склероза (МС), при этом подчеркивается его значение в рамках оси кишечника. Наш всеобъемлющий анализ последней литературы показывает, как дисбиоз в кишечной микробиоте пациентов MS, характеризуемый сокращением микробного разнообразия и сдвигами в бактериальных популяциях, оказывает глубокое воздействие на иммунное регулирование и целостность центральной нервной системы (СНК). Пиропотоз, предохраняющая форма запрограммированной клеточной смерти, значительно усугубляет НР, содейст

Совпадение в аннотации оригинала
This review elucidates the pivotal role of pyroptosis, triggered by gut microbiota, in the development of multiple sclerosis (MS), emphasizing its significance within the gut-brain axis. Our comprehensive analysis of recent literature reveals how dysbiosis in the gut microbiota of MS patients-characterized by reduced microbial diversity and shifts in bacteri…

Astrocytes Undergo Metabolic Reprogramming in the Multiple Sclerosis Animal Model.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that presents a largely unknown etiopathology. The presence of reactive astrocytes in MS lesions has been described for a long time; however, the role that these cells play in the pathophysiology of MS is still not fully understood. Recently, we used an MS animal model to perform high-throughput sequencing of astrocytes' transcriptome during disease progression. Our data show that astrocytes isolated from the cerebellum (a brain region typically affected in MS) showed a strong alteration in the genes that e…

Migraine in multiple sclerosis patients: potential links and treatment approach.

INTRODUCTION: Migraine has been reported to be twice as prevalent in patients with multiple sclerosis (MS) compared to the non-MS population. However, prospective, controlled studies that could lead to robust conclusions are still lacking. AREAS COVERED: Treatment of migraine in patients with MS can be challenging. Comorbidities need to be assessed and managed early, and preventive treatment should be initiated when indicated. Caution is warranted regarding the selection of the preventive medication since certain agents can magnify MS symptoms and particularly cognitive symptoms. This paper a…