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Skin manifestations associated with systemic diseases - Part I.

The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, skin as an organ, goes beyond its protective and barrier functions, as it provides clues for the identification of some systemic diseases. The dermatologist then raises diagnostic hypotheses for conditions related to all systems and refers them to the appropriate specialty. With easy access to examination by trained eyes and biopsies, the skin can present specific or non specific alterations on histopathology. In the first case this combination establishes

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… It may be related to infections (hepatitis B, hepatitis C, M. tuberculosis , HIV, HTLV, parvovirus B19, cytomegalovirus; and in children: streptococcosis), inflammatory diseases, rheumatoid arthritis, and drugs (penicillin, minocycline). …

The Production Processes and Biological Effects of Intravenous Immunoglobulin.

Immunoglobulin is a highly diverse autologous molecule able to influence immunity in different physiological and diseased situations. Its effect may be visible both in terms of development and function of B and T lymphocytes. Polyclonal immunoglobulin may be used as therapy in many diseases in different circumstances such as primary and secondary hypogammaglobulinemia, recurrent infections, polyneuropathies, cancer, after allogeneic transplantation in the presence of infections and/or GVHD. However, recent studies have broadened the possible uses of polyclonal immunoglobulin showing that it ca

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… Neutralizing antibodies against e.g., HAV, Polio-1 and Parvovirus B19 contribute significantly to the virus safety of IVIg preparations. Such antibodies are present in plasma pools and are concentrated during purification of IVIg [ 53 ]. 3. …

Recent advances in oncolytic virotherapy: insights from clinical trials and combination treatment strategies.

Background and aimOncolytic virotherapy is a novel therapeutic paradigm in oncology that uses viruses to selectively replicate within cancer cells, causing targeted tumor cell destruction with minimal toxicity to healthy tissues. With the rapid growth of oncolytic virotherapy and the accumulation of clinical studies on this subject, the present review aims to provide a comprehensive evaluation of current achievements in cancer treatments involving oncolytic viruses (OVs).Main textNumerous clinical trials have been conducted to assess the therapeutic efficacy and safety of OVs across a variety

Advanced Diagnostic Techniques

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… Neuroendocrine marker OCT3/4 Dog C-10 Santa Cruz Mast cell tumor Germ cell and mast cell tumors p63 Dog 4A4 Santa Cruz Skin, mammary gland Myoepithelium, basal cells Papilloma virus Dog B0580 Dako Infected tissue Infection Parathyroid hormone Dog only M7070 Dako Parathyroid Normal and neoplastic parathyroid Parvovirus … Cruz | Mast cell tumor | Germ cell and mast cell tumors p63 | Dog | 4A4 | Santa Cruz | Skin, mammary gland | Myoepithelium, basal cells Papilloma virus | Dog | B0580 | Dako | Infected tissue | Infection Parathyroid hormone | Dog only | M7070 | Dako | Parathyroid | Normal and neoplastic parathyroid Parvovirus …

2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis B Virus Infections.

Hepatitis B virus (HBV) infections affect approximately 296 million people around the world, and the prevalence of any past or present HBV infection during the years 2015-2018 was as high as 4.3%. Acute HBV infection often presents with nonspecific symptoms and is usually self-limited, but 5% of patients can have persistent infections leading to chronic HBV infection and the risk of turning into chronic HBV infection is significantly higher in babies with vertical transmission (95%). Patients with chronic HBV infection are usually asymptomatic, but 15 to 40% of chronic HBV carriers develop cir

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… Some viral infections, including human herpesvirus, HIV, parvovirus B19, and HBV, can activate autoreactive T cells and cause virus-induced tissue injury [ 112 ]. Rheumatic complaints may be the first symptoms in patients with clinically silent HBV infection. …

Emerging Therapies for Hepatocellular Carcinoma (HCC).

Hepatocellular carcinoma (HCC) arises from hepatocytes and accounts for 90% of primary liver cancer. According to Global Cancer Incidence, Mortality and Prevalence (GLOBOCAN) 2020, globally HCC is the sixth most common cancer and the third most common cause of cancer-related deaths. Reasons for HCC prognosis remaining dismal are that HCC is asymptomatic in its early stages, leading to late diagnosis, and it is markedly resistant to conventional chemo- and radiotherapy. Liver transplantation is the treatment of choice in early stages, while surgical resection, radiofrequency ablation (RFA) and

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… A study was performed with LPX encoding the large non-structural protein 1 (NS1) of rat parvovirus (H-1PV) which induced multimodal cell death only in transformed cells. LPX-NS1 induced cell death in multiple HCC cell lines and inhibited the growth of Hep3B xenografts [ 41 ]. …

Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer.

BackgroundThe overwhelming majority of dose-escalation clinical trials use methods that seek a maximum tolerable dose, including rule-based methods like the 3+3, and model-based methods like CRM and EWOC. These methods assume that the incidences of efficacy and toxicity always increase as dose is increased. This assumption is widely accepted with cytotoxic therapies. In recent decades, however, the search for novel cancer treatments has broadened, increasingly focusing on inhibitors and antibodies. The rationale that higher doses are always associated with superior efficacy is less clear for t

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… Phase i/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of parvovirus h-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol. BMC Cancer. 2012; 12(1). 10.1186/1471-2407-12-99. 68. …

Influenza-Associated Cardiac Manifestations: A Systematic Review of Case Reports and Case Series.

Background: Influenza is primarily a respiratory illness, but it is increasingly linked to acute cardiovascular complications, including myocarditis and sudden cardiac death. Evidence on influenza-associated cardiac involvement remains fragmented and largely derived from case-based reports. Methods: This systematic review followed PRISMA guidelines and was registered with PROSPERO (CRD420251249130). PubMed, Web of Science, and Google Scholar were searched for eligible studies. Case reports and case series were included to characterize rare, severe, or atypical cardiac manifestations that are n

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… Coinfection of parvovirus B19 with influenza A/H1N1 causes fulminant myocarditis and pneumonia. An autopsy case report. Pathogens. 2021;10:958. doi: 10.3390/pathogens10080958. 34. Marchetti L., Gandolfo C., Maglioni E., Contorni M., Arena F., Cusi M.G. …

IgG replacement in multiple myeloma.

T cell engagers (TCE) such as chimeric antigen receptor (CAR) T cell therapy and bispecific antibodies (BiAbs) for the treatment of multiple myeloma (MM) have significantly improved clinical outcomes, but have also raised awareness for ensuing post-treatment secondary immunodeficiency and hypogammaglobulinemia (HG). As patients with MM live longer, recurrent infections become a significant component of therapy-associated morbidity and mortality. Treatment of HG with immunoglobulin G replacement therapy (IgG-RT) has been a mainstay of the primary immunodeficiency (PI) world, and extrapolation t

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… The role of IgG-RT in preventing viral infections is less clear, although may have evidence in the treatment of CMV pneumonitis, rotaviral enterocolitis, enteroviral meningoencephalitis, RSV, and chronic parvovirus B19 [ 39 ]. …

A review of feline infectious peritonitis virus infection.

Feline infectious peritonitis (FIP) is an infectious disease characterized by non-specific laboratory changes and clinical signs. Clinical symptoms include anorexia, jaundice, fever, and weight loss. Moreover, some lesions are found in the digestive and respiratory systems. FIP, whose virulence varies, cannot be distinguished using several diagnostic methods. Moreover, feline coronaviruses (FCoVs) can be classified into two serotypes based on differences in their amino acid sequences, spike (S) protein sequences, and antibody (Ab) neutralization. There are two pathotypes, namely those caused b

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… Parvovirus infection in a Eurasian lynx (Lynx lynx) and in a European wildcat (Felis silvestris silvestris) J. Comp. Pathol. 2009;140(2–3):203–207. doi: 10.1016/j.jcpa.2008.11.003. 73. Tang Y.W, Procop G.W, Persing D.H. Molecular diagnostics of infectious diseases. Clin. …

Cell-based immunotherapy of glioblastoma multiforme.

Glioblastoma multiforme (GBM) is the most aggressive and lethal primary glial brain tumor. It has an unfavorable prognosis and relatively ineffective treatment protocols, with the median survival of patients being ~15 months. Tumor resistance to treatment is associated with its cancer stem cells (CSCs). At present, there is no medication or technologies that have the ability to completely eradicate CSCs, and immunotherapy (IT) is only able to prolong the patient's life. The present review aimed to investigate systemic solutions for issues associated with immunosuppression, such as ineffective

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… Alternative methods include the delivery of specific antigens to CSCs, using adenoviruses, lentiviruses, parvovirus and recombinant polioviruses DNX-2401 and PVS-RIPO ( 93 – 95 ). However, the relative treatment success associated with these methods remains low. …

Efficacy of oncolytic virus in the treatment of intermediate-to-advanced solid tumors: a systematic review and meta-analysis.

This meta-analysis assessed oncolytic virus therapy's efficacy for intermediate-to-advanced solid tumors. We systematically searched PubMed, Cochrane Library, and Embase databases until March 6, 2025. Our review included 87 studies, involving 5,385 individuals, encompassing 75 clinical trials and 12 retrospective studies. Patient response rates were as follows: complete response (CR) 11%, partial response (PR) 18%, stable disease (SD) 32%, and progressive disease (PD) 32%. The overall response rate (ORR) was 29%, and the durable response rate (DRR) was 39%. Comparing oncolytic virus therapy to

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… Phase 2 trial of oncolytic H-1 parvovirus therapy shows safety and signs of immune system activation in patients with metastatic pancreatic ductal adenocarcinoma. Clin Cancer Res 27:5546–5556. doi: 10.1158/1078-0432.CCR-21-1020 43. …

Hypoxia within the glioblastoma tumor microenvironment: a master saboteur of novel treatments.

Glioblastoma (GBM) tumors are the most aggressive primary brain tumors in adults that, despite maximum treatment, carry a dismal prognosis. GBM tumors exhibit tissue hypoxia, which promotes tumor aggressiveness and maintenance of glioma stem cells and creates an overall immunosuppressive landscape. This article reviews how hypoxic conditions overlap with inflammatory responses, favoring the proliferation of immunosuppressive cells and inhibiting cytotoxic T cell development. Immunotherapies, including vaccines, immune checkpoint inhibitors, and CAR-T cell therapy, represent promising avenues f

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… OVs utilizing modified herpes simplex virus, adenovirus, measles virus, parvovirus, reovirus, and poliovirus, amongst others, are being studied in clinical trials against GBM worldwide ( 93 ). …

Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

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… Further determination of the prevalence of Parvovirus B19 IgG antibodies and thyroid antibodies among T1DM pediatric patients revealed that there was significant association between them with a p < 0.0491. … Keywords : Parvovirus B19 antibody, thyroid autoantibodies, celiac autoantibodies, T1DM Disclosures : All authors indicated they had no financial relationships to disclose. …

Viral warfare: unleashing engineered oncolytic viruses to outsmart cancer's defenses.

Oncolytic virotherapy (OVT) has emerged as a promising and innovative cancer treatment strategy that harnesses engineered viruses to selectively infect, replicate within, and destroys malignant cells while sparing healthy tissues. Beyond direct oncolysis, oncolytic viruses (OVs) exploit tumor-specific metabolic, antiviral, and immunological vulnerabilities to reshape the tumor microenvironment (TME) and initiate systemic antitumor immunity. Despite promising results from preclinical and clinical studies, several barriers, including inefficient intratumoral virus delivery, immune clearance, and

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… Notable exceptions include reovirus (a double-stranded RNA virus) and parvovirus (a single-stranded DNA virus). …

Помимо генов: 3D-архитектура Эпизвита и Орион с помощью платформы "Орион" открывает общую биологию по всему ME/CFS, длинный COVID, ПТСР, ревматоидный артрит и множественный склероз.

КОЛИЧЕСТВО: Myalgic ensphalomyelit/хронический синдром усталости (ME/CFS), длинный COVID (LC19), посттравматическое стрессовое расстройство (PTSD), ревматоидный артрит (RA) и множественный склероз (MS) являются клинически отличными расстройствами, характеризующимися значительным совпадением симптомов, включая стойкую усталость, когнитивное расстройство, автономную дисфункцию и регулирование иммунной дисфункции. Хотя эти условия различаются в плане диагностики и клинического представления, их основополагающие биологические механизмы по-прежнему плохо понимаются и могут включать совпадающие пути

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… Rasa-Dzelzkaleja et al. [ 17 ] reported persistent HHV-6 A/B, HHV-7, and parvovirus B19 infection/co-infection in ME/CFS, with active infection associated with increased levels of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-12. …

Cancer vaccines: an update on recent achievements and prospects for cancer therapy.

Decades of basic and translational research have led to a momentum shift in dissecting the relationship between immune cells and cancer. This culminated in the emergence of breakthrough immunotherapies that paved the way for oncologists to manage certain hard-to-treat cancers. The application of high-throughput techniques of genomics, transcriptomics, and proteomics was conclusive in making and expediting the manufacturing process of cancer vaccines. Using the latest research technologies has also enabled scientists to interpret complex and multiomics data of the tumour mutanome, thus identify

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… AAVs are nonenveloped viruses of the parvovirus family. Their genome consists of single-stranded DNA (ssDNA) that is 4.7 kb in length and flanked on both ends by inverted terminal repeats (ITRs). The genome of AAVs consists of two coding regions for replication (Rep) and encapsidation (Cap). …

Application of Next Generation Sequencing in Laboratory Medicine.

The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation, has facilitated its wide clinical application in precision medicine. This review describes current sequencing technologies, including short- and long-read sequencing technologies, and highlights the clinical application of NGS in inherited diseases, oncology, and infectious diseases. We review NGS approaches and clinical diagnosis for constitutional disorders; summarize the application of U.S. Food and Drug Administr

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… The perils of pathogen discovery: origin of a novel parvovirus-like hybrid genome traced to nucleic acid extraction spin columns. J Virol. 2013;87:11966–77. doi: 10.1128/JVI.02323-13. 186. de Goffau MC, Lager S, Salter SJ, Wagner J, Kronbichler A, Charnock-Jones DS, et al. …

Ход работы сессии 25th Европейский конгресс педиатрической ремуматологии (ПСР) 2018) Лиссабон, Португалия. 5-8 сентябрь 2018

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