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Approaches to Managing Safety With Lenalidomide in Hematologic Malignancies.

Lenalidomide is an oral immunomodulatory agent approved in relapsed multiple myeloma with dexamethasone, for transfusion-dependent anemia in myelodysplastic syndrome associated with deletion 5q, and in relapsed/progressive mantle cell lymphoma following bortezomib. In recent clinical trials, lenalidomide has shown promising activity in hematologic malignancies, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). Starting doses and dosing schedules vary by malignancy, with lenalidomide started at a lower dose for CLL than for NHL or multiple myeloma. Certain adverse eve

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… Expert opinion on drug safety 2012 11 107 120 22066855 10.1517/14740338.2011.619975 31 Romaguera Jorge E Fayad Luis Rodriguez Maria A Broglio Kristine R Hagemeister Frederick B Pro Barbara McLaughlin Peter Younes Anas Samaniego Felipe Goy Andre Sarris Andreas H Dang Nam H Wang Michael Beasley Virginia …

ITF6475, a New Histone Deacetylase 6 Inhibitor, Prevents Painful Neuropathy Induced by Paclitaxel.

Chemotherapy-induced peripheral neuropathy remains a significant side effect of cancer treatment, often requiring dose reductions or even discontinuation of therapy. Paclitaxel (PTX), a widely used chemotherapeutic agent for solid tumors, is particularly neurotoxic, and no effective treatment exists for paclitaxel-induced peripheral neuropathy (PIPN). Histone deacetylases (HDACs) are enzymes that remove acetyl groups from histone and non-histone proteins, including transcription factors and cytoskeletal components. This study evaluates the HDAC6 inhibitor ITF6475 for its potential to prevent P

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… Acknowledgments The expert technical assistance of Elisa Ballarini, Mario Bossi, Paola Cordella, Virginia Rodriguez, and Chiara Zoia is gratefully acknowledged. …

Nursing care for chimeric antigen receptor T cell therapy survivors: A literature review.

Chimeric antigen receptor T cell (CAR-T) therapy is an immunotherapy that involves genetically modifying the patient's own T cells to express a chimeric antigen receptor, enabling them to recognize and destroy cancer cells. This treatment has revolutionized the prognosis and management of hematological malignancies, leading to a significant increase in long-term survivors. However, there is limited evidence regarding late sequelae and post-treatment care due to the recent emergence of this therapy. The rapid advancement of CAR-T therapies has created opportunities for advanced practice nurses

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… The most commonly used data collection structures are Marjory Gordon's functional health patterns or Virginia Henderson's basic needs, which often serve as a template for the initial exploratory phase of the interview. …

Follicular Lymphoma in Chile in the Adult Public Cancer Program: The Impact of Chemoimmunotherapy.

BACKGROUND: Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma (NHL) in the United States and Europe. However, data on FL from Latin America are scant. AIMS: This study aims at better understand the clinical features, treatment patterns and outcomes of patients with FL in Chile. Of special interest was to evaluate POD24 as an adverse marker. METHODS AND RESULTS: We collected retrospective data from 722 patients 15 years or older diagnosed with FL and treated in 17 cancer centers in Chile between 2000 and 2019. Time to first treatment (TTFT), progression-free survival (

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… Virginia Martinez, MD, Instituto de Anatomia Patologica, Santiago, who reviewed most of the pathologic samples. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1. …

Short Course of Antibiotic Therapy for Gram-Negative Bacilli Bacteremia in Patients with Cancer and Hematopoietic Stem Cell Transplantation: Less Is Possible.

Data about short courses of antibiotic therapy for Gram-negative bacilli (GNB) bacteremia in immunosuppressed patients are limited. This is a prospective observational study performed on adult patients with cancer and hematopoietic stem cell transplant (HSCT) who developed GNB bacteremia and received appropriate empirical antibiotic therapy (EAT), had a clinical response within 7 days and survived 48 h after the end of therapy. They received antibiotic therapy in the range of 7-15 days and were divided into short course, with a median of 7 days (SC), or long course, with a median of 14 days (L

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… Diff Quick Check Complete TECHLAB Inc, Blacksburg, Virginia, USA). …

IFN-β mediates the anti-osteoclastic effect of bisphosphonates and dexamethasone.

Zoledronic acid (Zol) is a potent bisphosphonate that inhibits the differentiation of monocytes into osteoclasts. It is often used in combination with dexamethasone (Dex), a glucocorticoid that promotes the resolution of inflammation, to treat malignant diseases, such as multiple myeloma. This treatment can result in bone pathologies, namely medication related osteonecrosis of the jaw, with a poor understanding of the molecular mechanism on monocyte differentiation. IFN-β is a pro-resolving cytokine well-known as an osteoclast differentiation inhibitor. Here, we explored whether Zol and/or Dex

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… Revealing the aforementioned molecular pathway may perpetuate the development of new biological treatments to inhibit osteoclastogenesis and prevent the worsening of osteolytic lesions following chemotherapy. 2 Methods 2.1 Cell culture RAW 264.7 macrophage cells (ATCC, TIB-71, Virginia) were cultured …

Clinical Posters From JADPRO Live 2023.

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… Workman, 1 MSN, APRN-Rx, AGCNS-BC, Valerie Ferguson, 4 MS, APRN-Rx, FNP-C, AOCNP ® , Virginia McMahon, 1 BA, Jeffrey Berenberg, 1 MD, MACP; 1 University of Hawaii Cancer Center, 2 National Cancer Institute, 3 Hawaii Cancer Care, 4 Hawaii Pacific Health - Kapiolani Women's Center Background: The Hawaii …

Invited Lectures : Overviews Purinergic signalling: past, present and future.

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… Activation of Adenosine A 2A Receptors on CD4 + T Cells Reduces Reperfusion Injury Joel Linden Department of Medicine, Cardiovascular Research Center, University of Virginia, Charlottesville, VA, 22908 USA Agonists of adenosine A 2A receptors (A 2A R) such as ATL146e can substantially reduce necrosis … Jamal Mustafa Department of Physiology & Pharmacology and Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University, Morgantown, West Virginia, 26505, USA E-mail address: smustafa@hsc.wvu.edu Adenosine, a purine nucleoside acts through its cell surface receptors (A …

2021 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Las Vegas, Nevada, 31 August–3 September 2021: Video Loops

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… V166 Robotic revision of ureteral stricture in a transplant kidney with Boari flap Daisuke Imai ; Yuzuru Sambommatsu; Aamir Khan; Seung Duk Lee; Amit Sharma; David Bruno; Vinay Kumaran; Adrian Cotterell; Marlon Levy; Chandra Bhati; Virginia Commonwealth University. …

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid

Increased Indoleamine 2, 3-Dioxygenase expression modulates Th1/Th17/Th22 and Treg pathway in humans with Helicobacter Pylori-Infected gastric mucosa.

Introduction and purposeIndoleamine 2, 3- dioxygenase (IDO) plays an importantrole in immunosuppressive pathway, as inhibits responsesof T cells and promotes immune tolerance. Host responsetoHelicobacter pylori (H. pylori) is involved in the infection persistenceand it is also associatedwith different clinical outcomes. The aim of this study was to investigate the role of IDO in H. pylori-infected patients with gastritis diseases and peptic ulcer diseases (PUD) through the assessment of the relationship among IDO protein expression and the numbers of T helper (Th)-1, Th17, Th22, and T regulato

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… Weiss, Nephrology and Renal Transplantation, Virginia Mason Medical Center, Seattle, Washington, UNITED STATES| Aim: A 64 year-old African American female with a CPRA of 26% was listed for kidney transplantation in 2018 due to hypertensive nephrosclerosis. …

34th Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2019): part 1 : National Harbor, MD, USA. 6-10 November 2019.

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Assisted reproductive technology surveillance--United States, 2011.

PROBLEM/CONDITION: Since the first U.S. infant conceived with Assisted Reproductive Technology (ART) was born in 1981, both the use of advan … , Hawaii, Illinois, Maryland, Massachusetts, New Hampshire, New Jersey, New York, Rhode Island, and Virginia), the District of Columbia, and New York City, this proxy measure was higher than the national rate, and of these, in three states (Massachusetts, New Jersey, and New York) and the District of Columbia, it exceeded twice the national rate. Nationall …

Global Budget Revenue Model and Care for Patients Receiving Chemotherapy.

ImportanceMaryland's Global Budget Revenue (GBR) model provided fixed global payments to hospitals, aiming to control revenue growth while improving care quality. The implications of GBR implementation in 2014 for cancer care have not been robustly evaluated.ObjectiveTo examine the association between GBR implementation and subsequent changes in episode-based Medicare payments, hospital utilization, and quality of care among Medicare beneficiaries undergoing systemic therapy for cancer.Design, setting, and participantsThis cohort study used a difference-in-differences approach to compare chang

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… We included Medicare beneficiaries in Maryland and 11 control states: Connecticut, Delaware, Illinois, Massachusetts, Michigan, New Jersey, New York, Ohio, Rhode Island, Vermont, and West Virginia. …

Qualitative Study of Breast Cancer and Lymphoma Patients Participating in a Physical Activity Intervention: The Case for Tailored Physical Activity.

BACKGROUND: Exercise mitigates chemotherapy-related cardiotoxicity, but implementing exercise interventions during chemotherapy treatment can be challenging. Understanding the patient perspective can help refine exercise programs and facilitate successful implementation of future interventions. PURPOSE: To utilize qualitative data to optimize adherence and retention for a future randomized clinical trial involving a tailored physical activity (PA) intervention among breast cancer and lymphoma patients receiving potentially cardiotoxic chemotherapy. METHODS: Eighteen breast cancer and lymphom

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… PALS was conducted at Atrium Health Wake Forest Baptist Medical Center (AHWFBMC) and Virginia Commonwealth University Masssey Comprehensive Cancer Center (VCUMCCC). …

Facing the COVID-19 pandemic: An Italian feasibility study of a mixed in-person/telerehabilitation intervention for cancer patients.

IntroductionThe COVID-19 pandemic impacted healthcare organizations, necessitating a rapid transition from in-person to virtual care. Our study explored the feasibility of a mixed in-person/telerehabilitation intervention for cancer patients and its effects on cancer-related fatigue (CRF), quality of life (QoL), physical function, patient satisfaction, and perceived usefulness.MethodsTRACE 2020 is an observational prospective study that enrolled adult cancer patients, between January 2021 and March 2023, who were eligible for a rehabilitation program to be provided also in telerehabilitation.

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… The authors are grateful to Virginia Dolcini and Vinci Sabrina Francesca for their administrative and technical support. Denti M, Pecorari A, Accogli MA, et al. Facing the COVID‐19 pandemic: An Italian feasibility study of a mixed in‐person/telerehabilitation intervention for cancer patients. …

A decision exercise to engage cancer patients and families in deliberation about Medicare coverage for advanced cancer care.

BackgroundConcerns about unsustainable costs in the US Medicare program loom as the number of retirees increase and experiences serious and costly illnesses like cancer. Engagement of stakeholders, particularly cancer patients and their families, in prioritizing insured services offers a valuable strategy for informing Medicare coverage policy. We designed and evaluated a decision exercise that allowed cancer patients and family members to choose Medicare benefits for advanced cancer patients.MethodsThe decision tool, Choosing Health plans All Together (CHAT) was modified to select services fo

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… Alexandria, Virginia: American Society of Clinical Oncologists; 2012. Reducing the cost of cancer care: How to bend the curve downward; pp. e46–e51. …

Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor.

No approved therapy exists for cancer-associated cachexia. The colon-26 mouse model of cancer cachexia mimics recent late-stage clinical failures of anabolic anti-cachexia therapy and was unresponsive to anabolic doses of diverse androgens, including the selective androgen receptor modulator (SARM) GTx-024. The histone deacetylase inhibitor (HDACi) AR-42 exhibited anti-cachectic activity in this model. We explored combined SARM/AR-42 therapy as an improved anti-cachectic treatment paradigm. A reduced dose of AR-42 provided limited anti-cachectic benefits, but, in combination with GTx-024, sign

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… Luteinizing hormone analyses Luteinizing hormone was measured in serum by a two‐site sandwich radioimmunoassay performed by the Ligand Assay and Analysis Core at the Center for Research in Reproduction, University of Virginia School of Medicine (Charlottesville, VA). … The luteinizing hormone assays were performed by the University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core, which is supported by the Eunice Kennedy Shriver NICHD/NIH (NCTRI) Grant P50‐HD28934. …

Clinical Posters From JADPRO Live 2022

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… Zitella, 6 MS, RN, ACNP-BC, AOCN, Wendy Vogel, 7 FNP AOCNP, Jessica Tamasi, 7 MS, Molly Coffey, 7 MS; 1 The University of Arizona Cancer Center, 2 Baptist Health Lexington, 3 Virginia Oncology Associates, 4 Georgia Cancer Specialists, 5 Moffitt Cancer Center, 6 University of California San Francisco, … Additionally, a career pathway program for nurses was introduced to the Inova Health System in Virginia and job turnover rates decreased from 8.9% to 5.2% and job satisfaction rates were improved by 21%. …

Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy.

T-cell-based immunotherapy, such as CAR-T cells and bispecific T-cell engagers (BiTEs), has shown promising clinical outcomes in many cancers; however, these therapies have significant limitations, such as poor pharmacokinetics and the ability to target only one antigen on the cancer cells. In multiclonal diseases, these therapies confer the development of antigen-less clones, causing tumor escape and relapse. In this study, we developed nanoparticle-based bispecific T-cell engagers (nanoBiTEs), which are liposomes decorated with anti-CD3 monoclonal antibodies (mAbs) targeting T cells, and mAb

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… Cells H929, MM.1S, and RPMI-8226 were purchased and authenticated by American Type Culture Collection (Manassas, Virginia). All cell lines were tested for mycoplasma contamination. BCWM.1 and MWCL.1 were a gift from Irene Ghobrial. …