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Pneumonia in Transplant Recipients: A Comprehensive Review of Diagnosis and Management.

Transplant recipients have an increased risk of complications, including graft dysfunction and infections, which can be life-threatening if not recognized early. Pneumonia ranks as one of the most frequent complications in both solid organ and hematopoietic stem cell transplants. Clinical symptoms manifest late during infections in immunocompromised patients. An aggressive approach centered on early confirmatory diagnosis and a low threshold for empiric therapy is often the most effective strategy. The isolation of a pathogen in an upper airway sample does not necessarily mean the same organis

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… Geographic exposure can increase susceptibility to endemic fungal infections of Histoplasma (Ohio and Mississippi River valleys), Coccidioides (Southwest US), Paracoccidioides (Central and South America), Cryptococcus , and Blastomyces (Mid West, South-central, and Southeastern United States). …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

Manifestations of systemic disease in the retina and fundus of cats and dogs.

The fundus is unique in that it is the only part of the body that allows for a noninvasive and uninterrupted view of vasculature and nervous tissue. Utilization of this can be a powerful tool in uncovering salient incidental findings which point to underlying systemic diseases, and for monitoring response to therapy. Retinal venules and arterioles allow the clinician to assess changes in vascular color, diameter, outline, and tortuosity. The retina and optic nerve may exhibit changes associated with increased or decreased thickness, inflammatory infiltrates, hemorrhages, and detachments. While

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… Systemic mycoses occur more frequently in dogs than in cats, with Cryptococcus neoformans and Histoplasma capsulatum being the commonest in cats. …

Oral and Maxillo-Facial Manifestations of Systemic Diseases: An Overview.

Many systemic (infective, genetic, autoimmune, neoplastic) diseases may involve the oral cavity and, more generally, the soft and hard tissues of the head and neck as primary or secondary localization. Primary onset in the oral cavity of both pediatric and adult diseases usually represents a true challenge for clinicians; their precocious detection is often difficult and requires a wide knowledge but surely results in the early diagnosis and therapy onset with an overall better prognosis and clinical outcomes. In the current paper, as for the topic of the current Special Issue, the authors pre

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… Also, oro-maxillo-facial signs may include manifestations of bacterial, viral and fungal infections (mostly sustained by Mycobacterium, HPV, HSVs, CMV, Cryotococcus, Histoplasma, Aspergillus, Mucoraceae, etc.), ( Figure 2 a–d) pseudo-tumoral lesions (necrotizing gingivitis or periodontitis, uni/bilateral …

Acute Pneumonia

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… Measles virus Coronavirus (SARS, MERS-CoV) | Coxsackievirus Echovirus Coronavirus (SARS, MERS-CoV) Hantavirus Epstein-Barr virus Cytomegalovirus Parainfluenza virus Herpes simplex virus Human herpesvirus 6 Varicella-zoster virus TABLE 69-1C Causative Agents of Acute Pneumonia: Fungi COMMON | UNCOMMON Histoplasma … , a component of the cell wall of fungi except for Cryptococcus spp. and Zygomycetes, have high specificity for invasive fungal infections and can be used for detection of invasive pulmonary aspergillosis in immunocompromised hosts, as well as for the detection of pneumonia due to the endemic fungi Histoplasma …

Acute and Chronic Respiratory Failure in Cancer Patients

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… On the other hand, patients with T-cell defects are subject to infections with Cryptococcus, PJP, and endemic mycosis such as Coccidioides immitis, Blastomyces dermatitidis, and Histoplasma capsulatum . …

POSTER PRESENTATIONS

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Pulmonary and Hepatic Complications of Hematopoietic Cell Transplantation

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… Fungi are historically classified as either yeasts ( Candida , Trichosporon , Cryptococcus ) or molds, with molds subdivided by septate hyphae ( Aspergillus , Scedosporium , Fusarium , Histoplasma , Penicillium ) or aseptate hyphae ( Mucor , Rhizopus ). …

Haematological Diseases in the Tropics

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Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL).

A multitude of new agents for the treatment of hematologic malignancies has been introduced over the past decade. Hematologists, infectious disease specialists, stem cell transplant experts, pulmonologists and radiologists have met within the framework of the European Conference on Infections in Leukemia (ECIL) to provide a critical state-of-the-art on infectious complications associated with immunotherapeutic and molecular targeted agents used in clinical routine. For brentuximab vedotin, blinatumomab, CTLA4- and PD-1/PD-L1-inhibitors as well as for ibrutinib, idelalisib, HDAC inhibitors, mTO

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… The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proceedings of the National Academy of Sciences. 2008;105(7):2658–2663. doi: 10.1073/pnas.0711918105. 69. …

Hematology

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… leukemia), leukemia (CLL, CML), myeloproliferative disorders (PRV, CML, ET, MF), splenic tumor, metastasis amyloidosis sarcoidosis congenital storage diseases —Gaucher, Niemann-Pick disease REACTIVE infections — bacterial (endocarditis, sepsis, TB, MAC), viral (mononucleosis, hepatitis), fungal ( Histoplasma …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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… Finally, infections or reactivations of dimorphic fungi, such as Histoplasma or Coccidioides, are possible in patients who live or used to live in endemic areas. …

Epidemiology of infections in cancer patients.

Although major advances in the care of cancer patients over the past several decades have resulted in improved survival, infectious complications remain a significant cause of morbidity and mortality. To successfully identify, treat, and prevent infections, a comprehensive understanding of risk factors that predispose to infection and of commonly encountered pathogens is necessary. In addition, clinicians must keep abreast of the changing epidemiology of infections in this population. As therapeutic modalities continue to evolve, as established pathogens become increasingly drug resistant, and

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… These include the bacteria Listeria monocytogenes, Salmonella spp., Nocardia asteroides, and Legionella; mycobacteria including both Mycobacterium tuberculosis and the non-tuberculous mycobacteria; fungi such as Cryptococcus neoformans, Histoplasma capsulatum, Coccidioides immitis, and Pneumocystis jiroveci …

Hematology

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… malignancy —lymphoma (Hodgkin’s, non-Hodgkin’s, hairy cell leukemia), leukemia (CLL, CML), myeloproliferative disorders (PRV, CML, ET, MF), splenic tumor, metastasis amyloidosis sarcoidosis Reactive infections — bacterial (endocarditis, sepsis, TB, MAC), viral (mononucleosis, hepatitis), fungal ( Histoplasma …

Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

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2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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… Repeated evaluations for HIV, syphilis, Histoplasma, CMV, HHV6, HHV8, Bartonella, Coxciella, Brucella, HTLV, toxoplasma were negative. HTLV1 and 2 antibodies had been negative prior to transplantation. …

Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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Biology and Diseases of Dogs

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Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.

Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellular equilibrium, cellular zinc has been increasingly spotlighted in the context of disease development. Extensive research suggests zinc's involvement in promoting malignancy and invasion in cancer cells, despite its low tissue concentration. This has led to a growing body of literature investigating zinc's cellular metabolism, particularly the functions of

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… activation of pro-inflammatory cytokines like IL-6, IL-12, and TNF-α. 288 Studies have demonstrated that bacterial endotoxin LPS acutely induces MT1 expression in various organs, such as liver, heart, kidney, and brain tissues involved in systemic response. 289 – 291 In the cellular environment of Histoplasma …

Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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