Результаты поиска

TAR DNA-binding protein 43 pathology in a case clinically diagnosed with facial-onset sensory and motor neuronopathy syndrome: an autopsied case report and a review of the literature.

We report an autopsy case of a 48-year-old female clinically diagnosed with facial-onset sensory and motor neuronopathy (FOSMN) syndrome wit … the anterior corticospinal tracts at the cervical cord level. Additionally there was severe myelin pallor in the right spinal trigeminal tract and right fasciculus cuneatus of the cervical cord. The right spinal root ganglion showed numerous Nageotte's nodules and focal lymphocytic infiltration. The present case manifested FOSMN syndrome clinically, whi …

Re-irradiation using interstitial brachytherapy increases vaginal mucosal reaction compared to initial brachytherapy in patients with gynecological cancer.

AIM: To examine the vaginal mucosal reaction in gynecological cancer patients after re-irradiation using interstitial brachytherapy (re-ISBT … s no difference between re-ISBT and fresh brachytherapy with regard to telangiectasia, stenosis and pallor reactions. Increased cumulative (previous plus present treatment) equivalent dose in a 2-Gy fraction was correlated to a higher grade of erythema and ulceration. CONCLUSION: Re-ISBT increased the vaginal mucosal reaction, as shown by increased eryt …

Retinal function and structure in the hypotransferrinemic mouse.

PURPOSE: The iron carrier transferrin is expressed at remarkably high levels in normal retinas and is upregulated during retinal degeneratio … otentials were significantly suppressed in HPX mice, and ophthalmoscopy demonstrated marked retinal pallor. Quantitative immunostaining revealed a 39% reduction of transferrin content in HPX⁻/⁻ compared with WT retinas (P = 0.01). mRNA levels of Tf, Tf receptor, and ceruloplasmin were decreased, whereas mRNA for antioxidant genes were elevated in HPX⁻/⁻ …

Visual function alterations in orbital tumors and factors predicting visual outcome after surgery.

PURPOSE: To study the effect of orbital tumors on visual functions and highlight the factors predictive of visual outcome after surgery. ME … tively. Keratometry showed higher astigmatism in the involved eye (P=0.004). The fundus showed disc pallor, edema, and/or choroidal folds, of which disc edema resolved in all cases after surgery. In all, 40% of the affected eyes had a deficient color vision and this partially improved postoperatively (P=0.25). GVF had abnormalities in 10 cases, half of w …

Hepatitis G virus associated aplastic anemia: a recent case from Pakistan.

BACKGROUND: Aplastic anemia (AA) is a serious and rare disorder characterized by a hypocellular bone marrow. Hepatitis associated aplastic a … s and poor oral intake for last few days is reported here. The physical examination presents fever, pallor whereas bleeding, hepatomegaly, Splenomegaly and bruising were absent, abdominal ultrasonography confirmed the absence of hepatomegaly, Splenomegaly and lymphodenopathy. The laboratory investigation parameters were: haemoglobin 6.2 g/L, total leucoc …

Вскрытие болезни V180I Creutzfeldt-Jakob, вызванной патологией панэнцефалопатического типа и характерным белком приона.

73-летняя японская женщина демонстрировала медленно прогрессирующую афазию, апраксию и слабоумие. У неё не было семейной истории приионной болезни или слабоумия. Год спустя она продемонстрировала паркинсонизм, а кортикобасальная дегенерация первоначально подозревалась. На МРТ левая временная неокортекс, казалось, распухла на изображениях, взвешенных по Т2, на начальной стадии, и позднее в церебральной коре была замечена область высокой интенсивности сигнала. Пациент развивал миоклонус и акинетический мутизм, соответственно, через 15 и 22 месяца после начала. Последовательная электроэнцефалогра

Совпадение в аннотации оригинала
A 73-year-old Japanese woman showed slowly progressive aphasia, apraxia and dementia. She had no family history of prion disease or dementia … nerally moderate for such long-term disease, but cerebral white matter showed diffuse severe myelin pallor with tissue rarefaction suggestive of panencephalopatic-type pathology. The cerebellar cortex was relatively well preserved with observation of mild spongiform change in the molecular layer, moderate neuron loss in the Purkinje neuron layer, and sca …

[The relationship between hypothyroidism and rhinitis].

OBJECTIVES: This study proposed relationship between rhinitis and hypothyroidism and the possibility of whether hypothyroid patients with sy … ints resolved significantly (p=0.005). The difference between the turbinate hypertrophy and mucosal pallor before and after treatment was significant (p=0.005). The clearance time difference before and after treatment was highly significant (p=0.001). The nasal peak flow meter results after treatment were also significantly improved (p=0.001). CONCLUSIO …

Identification of two novel OPA1 mutations in Chinese families with autosomal dominant optic atrophy.

PURPOSE: To report the clinical features and identification of two novel mutations in two Chinese pedigrees with autosomal dominant optic at … RESULTS: The affected individuals all presented with bilateral visual failure and temporal or total pallor of the optic discs. Genotyping of family F1 revealed the linkage to the OPA1 gene on 3q28-29. After sequencing of OPA1 gene, a novel heterozygous splicing site mutation c.985 -2A>G in intron 9 was found in family F1. RT-PCR result showed the skippin …

Kidney failure in the elderly due to hypothyroidism: a case report.

CONTEXT: Hypothyroidism is more prevalent in the elderly and its symptoms can be confused with other changes due to aging. Doctors caring fo … ctable to treatment with diuretics. Physical examination revealed bradycardia (heart rate: 52 bpm), pallor, dry and infiltrated skin, macroglossia, edema in the lower limbs and a palpable thyroid with hard consistency. Laboratory tests showed: creatinine 3.9 mg/dl; urea 95 mg/dl; potassium 6.0 mEq/l; thyroid-stimulating hormone > 100 mUI/ml; triiodothyro …

Aquatic Francisella-like bacterium associated with mortality of intensively cultured hybrid striped bass Morone chrysops x M. saxatilis.

The present study identifies an emerging disease associated with an aquatic Francisella-like bacterium that can cause mortality in hybrid striped bass Morone chrysops x M. saxatilis reared intensively in freshwater. Clinically affected fish were lethargic, had scattered haemorrhagic cutaneous lesions and diffuse gill pallor. The head kidney and spleen were markedly swollen and contained numerous interstitial granulomas; histological examination revealed small, pleomorphic Gram-negative coccobacilli within vacuolated cells. The bacterium could not be cultured from head kidney homogenates either…

Catecholamine-secreting metastatic carcinoid as differential diagnosis in pheochromocytoma: clinical, laboratory, and imaging clues in the search for the lurking neuroendocrine tumor (NET).

Catecholamine-secreting metastatic carcinoid should be considered in differential diagnosis of malignant pheochromocytoma. Paroxysmal functi … resis; diarrhea; abdominal pain; unexplained pancreatitis; joint pain; and paroxysmal flushing with pallor. GI studies (including endoscopic ultrasound) and multiple imaging modalities (including 2D CT, MRI with gadolinium, [18]FDG PET/CT, [123I]MIBG, and SRS [111In]Octreotide [OctreoScan]) were not diagnostic. 24-h BP, Holter and 30-day cardiac event mo …

Lymphomatosis cerebri as a cause of white matter dementia.

Primary central nervous system lymphoma most often presents as a solitary, isolated lesion in immunocompetent patients. Rarely, the disease … lky periventricular disease at autopsy. Microglial and astrocytic reactions, but only subtle myelin pallor, were evident as individual tumor cells permeated the entire brain and spinal cord, albeit with considerable variation in cell density. Individual tumor cells could be identified from the optic nerve to spinal cord, documenting the "whole-brain" nat …

Pregnancy associated aplastic anemia--a series of 10 cases with review of literature.

INTRODUCTION: Pregnancy induced aplastic anemia is a rare entity and the association is not well explained. There are approximately 80 cases in the literature and we are presenting the largest series, so far, of 10 cases. RESULTS: Total of 10 cases had 11 pregnancies. Mean age at presentation was 25.45 years and mean gestation when symptoms first developed was 17.09 weeks. Pallor and bleeding manifestations were the most common presenting complaints. Mean Hb, TLC, ANC and platelets were 4.97 g/dl, 2.74 x 10(9)/l, 1.11 x 10(9)/l and 41 x 10(9)/l, respectively. Bone biopsy cellularity ranged fr…

High-dose methylprednisolone therapy in pure red cell aplasia.

OBJECTIVE: To report our experience using high-dose methylprednisolone (HDMP) treatment in a patient with primary acquired pure red cell aplasia (PRCA) who failed to respond to conventional prednisone therapy. CASE SUMMARY: A 29-year-old woman reported weakness, was easily fatigued, and had developed palpitations. On physical examination, pallor and splenomegaly were detected. On blood smear, mild macrocytic anemia was seen. Bone marrow aspiration and biopsy revealed normocellularity, erythroid hypoplasia (E/M: 1/10), reduction in erythroid precursors, and normal megakaryocytes and myeloid se…

Cyclic vomiting syndrome: evolution in our understanding of a brain-gut disorder.

Cyclic vomiting syndrome (CVS) remains a mysterious disorder despite our increasing knowledge since its classic description by Gee in 1882. … ing as many as 1.9% of school-aged children. Besides the relentless vomiting, the child usually has pallor (87%), lethargy (91%), anorexia (74%), nausea (72%), and abdominal pain (80%). There is evidence of clinical and physiologic overlap among CVS, abdominal migraine, and migraine headaches. We propose revised criteria for abdominal migraine that inclu …

Compartment syndrome following intravenous regional anesthesia.

PURPOSE: To present two cases of upper extremity compartment syndrome following intravenous regional anesthesia. CLINICAL FEATURES: Case 1: A 57-yr-old man presented for surgical release of a left-hand Dupuytren's contracture. The procedure was performed under iv regional anesthesia with 360 mg lidocaine and sedation with 150 microg fentanyl and 1.5 mg midazolam. Tourniquet time was 107 min at a pressure of 260 mmHg using three different tourniquet sites. Within minutes of tourniquet release, increased forearm muscle tension, hand anesthesia, pallor, and limited motor function developed. Seru…

[Hemolytic uremic syndrome in children of Mendoza, Argentina: association with Shiga toxin-producing Escherichia coli infection].

Shiga toxin-producing Escherichia coli (STEC) has been associated with pathogenesis of hemolytic uremic syndrome (HUS) worldwide. The aim of … ng summer and the beginning of autumn. The acute stage of the disease occurred with presentation of pallor (100%), edema (25%), anuria (38.9%), oliguria (41.7%), hemolytic anemia (97.2%), thrombocytopenia (86.1%) and neurological involvement (41.7%). Twenty-five of them presented the full clinical syndrome. Peritoneal dialysis were performed in 50% and p …

Profile of central nervous system pathology in patients with AIDS: an autopsy study from India.

OBJECTIVE: To study the spectrum of neuropathological brain lesions in HIV/AIDS cases. DESIGN: Retrospective autopsy study between 1988 and … myelin loss was observed in 18 cases (21%), microglial nodules in 15 cases (18%), and angiocentric pallor in five cases (6%). Infarcts/haemorrhages were present in 13 cases (15%), choroid plexitis in 21 cases (25%), lymphocytic meningitis without opportunistic infection in 21 cases (25%), and calcification in four cases (5%). A dual infectious pathology …

Multiple system atrophy: a review of 203 pathologically proven cases.

We report the clinicopathological features of 203 cases of pathologically proven multiple system atrophy (MSA) from 108 publications up to F … th the degree of olivopontocerebellar atrophy. Pyramidal signs were associated with pyramidal tract pallor. Our analysis also confirmed an association of postural hypotension with intermediolateral cell column degeneration.

Terbutaline nebulization and epinephrine injection in treating acute asthmatic children.

Ninety children with acute asthma, equally divided into two study groups, were studied to compare the efficacy and safety of nebulized terbu … of adverse effects occurred in patients given epinephrine (47% vs 11%, p = 0.0002); these included pallor, tremor, dizziness, headache, palpitation, soreness of legs, numbness of extremities, cold sweating, general weakness and nausea. Considering the general trend to noninvasive therapy in children and the more frequent adverse effects after epinephrin …