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Uncovering the hidden hunger in translational research for periconceptional folic acid awareness among health care providers.

BACKGROUND: Although healthcare providers (HCPs) know folic acid (FA), many are unaware of its various fetal-maternal-offspring beneficial effects. METHODS: A cross-sectional study (September 2024) was conducted among HCPs using a pretested interviewer-based questionnaire. The total knowledge score was 30. The awareness score was good, average, and low for total scores >20, 11-20, and ≤10, respectively. RESULTS: Out of 300 participants, 96 were excluded because of incomplete responses to the questions marked for outcome assessment. The participants were medical officers (42/206; 20.38%), nur

Primary Biliary Cholangitis: Medical and Specialty Pharmacy Management Update.

BACKGROUND: Chronic liver disease and cirrhosis are a leading cause of morbidity and mortality in the United States. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis and which has been designated an orphan condition, is a chronic autoimmune disease resulting in the destruction of the small bile ducts in the liver. Without effective treatment, disease progression frequently leads to liver failure and death. Until May 2016, the only FDA-approved treatment for PBC was ursodiol (UDCA), an oral hydrophilic bile acid, which can slow progression of liver damage due to

Changes in cancer diagnoses and stage distribution during the first year of the COVID-19 pandemic in the USA: a cross-sectional nationwide assessment.

BACKGROUND: The emergence of COVID-19 disrupted health care, with consequences for cancer diagnoses and outcomes, especially for early stage diagnoses, which generally have favourable prognoses. We aimed to examine nationwide changes in adult cancer diagnoses and stage distribution during the first year of the COVID-19 pandemic by cancer type and key sociodemographic factors in the USA. METHODS: In this cross-sectional study, adults (aged ≥18 years) newly diagnosed with a first primary malignant cancer between Jan 1, 2018, and Dec 31, 2020, were identified from the US National Cancer Database

Oral deucrictibant for on-demand treatment of hereditary angioedema attacks (RAPIDe-1): a randomised, double-blind, placebo-controlled, phase 2 trial.

BACKGROUND: Hereditary angioedema is a bradykinin-mediated disorder characterised by recurrent painful swelling attacks. Treatment relies on medications to prevent attacks and on-demand therapies for attack manifestations. Parenteral administration associated with most available on-demand therapies often leads to treatment being delayed or forgone. Deucrictibant is an orally bioavailable bradykinin B2 receptor antagonist under development for prophylaxis and on-demand treatment of hereditary angioedema attacks. We aimed to investigate the efficacy and safety of deucrictibant for the on-demand

Wildlife as Sentinels of Antimicrobial Resistance in Germany?

The presence of bacteria carrying antimicrobial resistance (AMR) genes in wildlife is an indicator that resistant bacteria of human or livestock origin are widespread in the environment. In addition, it could represent an additional challenge for human health, since wild animals could act as efficient AMR reservoirs and epidemiological links between human, livestock and natural environments. The aim of this study was to investigate the occurrence and the antibiotic resistance patterns of several bacterial species in certain wild animals in Germany, including wild boars (Sus scrofa), roe deer (

[Reassessment of practice of Chinese surgeons since introduction of the watch and wait strategy after neoadjuvant therapy for rectal cancer].

Objective: To investigate perspectives and changes in treatment selection by Chinese surgeons since introduction of the watch-and-wait approach after neoadjuvant therapy for rectal cancer. Methods: A cross-sectional survey was conducted using a questionnaire distributed through the "Wenjuanxing" online survey platform. The survey focused on the recognition and practices of Chinese surgeons regarding the strategy of watch-and-wait after neoadjuvant therapy for rectal cancer and was disseminated within the China Watch-and-Wait Database (CWWD) WeChat group. This group targets surgeons of deputy c

Redefining venereology practice in Tamil Nadu, South India - Nakshatra Health - A networking model.

BACKGROUND: Accessing care for sexual health has always been a challenge in our Indian context. The primary reason is a lack of awareness of modes of transmission of sexually transmitted diseases (STD), appropriate testing, and treatment options. The second is taboo associated with the morality of the individual. The third is the accessibility and availability of Quality STD care by allopathic specialists in comparison to the demand. This has paved way for lots of myths and misconceptions among the general public regarding STDs and HIV disease. Compounding it is the mushrooming of nonqualified

The current status of treatment-related severe hypoglycemia in Japanese patients with diabetes mellitus: A report from the committee on a survey of severe hypoglycemia in the Japan Diabetes Society.

Despite great strides in pharmacotherapy for diabetes, there is increasing concern over the risk of hypoglycemia in patients with diabetes receiving pharmacotherapy as they become increasingly older. This has prompted the Japan Diabetes Society (JDS) to initiate a survey on the current status of severe hypoglycemia in clinical settings. In July 2015, following approval from the JDS Scientific Survey/Research Ethics Committee, the JDS extended an invitation to executive educators, who represented a total of 631 healthcare facilities accredited by the JDS for diabetes education, to participate i

Optimal Pouch Training: Investigating Operative and Nonoperative Needs Study.

BACKGROUND: Ileal pouch anal anastomosis is an important part of colorectal surgery training. However, decreasing case numbers create fewer … rviews, surveys, and online consensus conference. PARTICIPANTS: Faculty who were at North American Accreditation Council for Graduate Medical Education colorectal residencies, and participants from each round were invited to subsequent rounds. MAIN OUTCOME MEASURES: Three rounds of surveys were used to select high-priority items for inclusion in the curriculu …

A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study.

CONTEXT: Recent changes in usage guidelines have created the potential for millions more Americans to be prescribed statin medications. Caution should be advised because the risk of adverse effects of statins may outweigh their benefits and preclude their preventive use for patients without confirmed cardiovascular disease (CVD) who present with elevated blood lipids. However, statins have shown some benefit in primary CVD prevention. Red yeast rice (RYR) is a dietary supplement that has been demonstrated to reduce low-density lipoprotein (LDL) cholesterol levels in blood and omega-3 polyunsat

Incidentally Detected Carcinoma Ex Pleomorphic Adenoma of Parotid Gland by F-18 FDG PET/CT.

Despite great strides in pharmacotherapy for diabetes, there is increasing concern over the risk of hypoglycemia in patients with diabetes receiving pharmacotherapy as they become increasingly older. This has prompted the Japan Diabetes Society (JDS) to initiate a survey on the current status of severe hypoglycemia in clinical settings. In July 2015, following approval from the JDS Scientific Survey/Research Ethics Committee, the JDS extended an invitation to executive educators, who represented a total of 631 health-care facilities accredited by the JDS for diabetes education, to participate

European Cancer Organisation Essential Requirements for Quality Cancer Care: Hematological malignancies.

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… Accreditation Accreditation is the means by which a center can demonstrate that it is performing to a required level of practice in accordance with agreed standards of excellence. Accreditation systems vary among institutions and between countries. … ESMO accredited designated centres. Accessed March 6, 2025. https://www.esmo.org/for-patients/esmo-designated-centres-of-integrated-oncology-palliative-care/esmo-accredited-designated-centres …

Small Centers with Big Ventures: Autologous Stem Cell Transplantation Survival Data

We present the first-ever autologous stem cell transplantation (ASCT) outcome data from a secondary-care healthcare facility. Albeit exact details of patient and disease characteristics and co-morbidity scores for all patients are not available, the engraftment and survival data is very similar to those published from large tertiary-care cancer centres, both regionally and internationally. Transplant Related Mortality (TRM) of 3.1% is within the expected range and includes a patient who died of acute drug reaction (ADR) during conditioning chemotherapy, prior to the ASCT. Furthermore, cyclopho

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… In addition, ASCT may yet rarely be performed at the secondary-level healthcare centres which may house facilities and manpower to perform ASCT and adhere to international standards [The Foundation for the Accreditation of Cellular Therapy (FACT) and the Joint Accreditation Committee – ISCT and EBMT … Great Western Hospital (GWH) in the southwest city of Swindon, England is one such secondary-level centre which is JACIE-accredited and perform ASCT regularly. …

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Chimeric Antigen Receptor-T Cell Therapy: Practical Considerations for Implementation in Europe.

Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies that involves ex vivo genetic modification of T cells to incorporate an engineered CAR. After infusion into the patient, the CAR-expressing T cells recognize specific tumor targets and induce an immune response against them. The technology utilized is fundamentally different from previously available cancer treatments. Currently, most CAR-T cell therapies use autologous T cells. Tisagenlecleucel (formerly CTL019) is an anti-CD19 CAR-T cell therapy that was recently approved in the United States for the tr

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… Foundation for the Accreditation of Cellular Therapy. Accreditation Process. Available at: http://factwebsite.org/Accreditation/ . Accessed September 26, 2017 . 71. … Joint Accreditation Committee–International Society for Cellular Therapy (ISCT) and European Society for Blood and Marrow Transplatation (EBMT; JACIE). Why accreditation? Available at: http://www.jacie.org/applicants/why . Accessed September 26, 2017 . 72. …

A roadmap for establishing institutional readiness for cellular therapies targeting solid tumours and autoimmune diseases.

Adoptive cellular therapies have revolutionised treatment of haematological malignancies and demonstrate potential in solid tumours and autoimmune disease. Real-world implementation remains limited by biological, logistical, and manufacturing barriers, restricting global uptake despite a rapidly expanding clinical trial portfolio. Effective implementation requires national and institutional readiness, multidisciplinary collaboration, scalable manufacturing, and robust infrastructure. Efforts should prioritise decentralised and "off the shelf" platforms, integrated referral networks, and AI-ass

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… These were subsequently incorporated into existing joint accreditation committee of international society for cellular therapy and European Group for blood and marrow transplantation (JACIE) -accredited SOPs through the haematology department, ensuring consistency, governance and sustainability of practice … Tier 3 centres serve as comprehensive hubs with advanced infrastructure, accreditation, and clinical trial capability, supporting innovation and regional networks. …

Eliminating REMS for CAR T-Cell Therapies: An Opportunity to Improve Access.

Autologous Chimeric antigen receptor (CAR) T-cell therapies have demonstrated substantial efficacy in patients with relapsed or refractory hematologic malignancies; however, their implementation has been constrained by regulatory barriers. Risk Evaluation and Mitigation Strategies (REMS), mandated by the U.S. Food and Drug Administration (FDA), were initially implemented to mitigate risks associated with cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and other treatment-related toxicities. On 27 June 2025, the FDA removed REMS requirements for

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… Accreditation Challenges However, many access barriers are structural. … Most community sites do not hold Foundation for Accreditation of Cellular Therapies (FACT) designation, which many payers have historically required despite a lack of evidence showing superior outcomes in FACT-accredited hospitals. …

First Clinical Nutrition Outpatient Consultation: A Review of Basic Principles in Nutritional Care of Adults with Hematologic Disease.

MethodsA bibliographic survey was carried out between 2020 and 2022 using two databases: PubMed/MEDLINE and Scientific Electronic Library Online (SciELO) and the information source Academic Google, irrespective of language or geography.ResultsIn the first nutrition consultation (FNC), there should be an investigative direction focused on nutritional interventions in the short, medium, and long term. The record in the patient's medical record is relevant for carrying out the consultation, according to the recommendations of the normative councils of medicine and nutrition. The main steps to be

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… In Brazil, the accreditation methodologies that most certify health services are those applied by the Joint Commission International (JCI) and the National Accreditation Organization (NAO), which adopted the JCI and Canadian Accreditation models to the Brazilian context [ 26 ]. … The patient's medical record, for example, is a fundamental document in quality control and hospital accreditation [ 27 , 28 ]. …

CAR-T cell therapy for multiple myeloma: a practical toolkit for treatment in Brazil.

IntroductionChimeric antigen receptor T (CAR-T) cell therapy is an emerging treatment option for relapsed/refractory multiple myeloma (RRMM) that is a multi-step process involving various stakeholders. Appropriate education on the practical logistics is therefore paramount to ensure treatment success.MethodsA group of key opinion leaders met to explore the key elements of setting up and running a CAR-T center in Brazil. For each step in the CAR-T cell therapy process, the experts agreed on basic requirements, gave their key recommendations from practical experience, and considered any remainin

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… and the Foundation for the Accreditation of Cellular Therapy-Joint Accreditation Committee, ISCT/EBMT (FACT-JACIE). 16 Standard operating procedures must be in place for every step of the CAR-T process, and continuous training provided to all relevant staff. … Best-practice recommendations While FACT-JACIE accreditation is no longer a requirement for CAR-T cell therapy, such accreditation will speed up the validation process carried out by the manufacturer, and help ensure the site maintains all required quality processes. …

Balancing Quality, Cost, and Access During Delivery of Newer Cellular and Immunotherapy Treatments.

Purpose of reviewThe chimeric antigen receptor (CAR) T-cell therapy is currently changing the landscape of hematologic malignancies with multiple FDA-approved cell therapy products in the USA. The current administration process of the CAR T-cell therapy is complicated, labor-intensive, and expensive.Recent findingsThe chimeric antigen receptor (CAR) T-cell therapy is currently changing the landscape of hematologic malignancies with multiple FDA-approved cell therapy products in the USA. The current administration process of the CAR T-cell therapy is complicated, labor-intensive, and expensive.

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… They look for objective metrics of quality and efficiency of care delivery, such as accreditation by FACT (Foundation for Accreditation for Cellular Therapy), center volume, survival rates, resources available to the center, and ability to deliver care for complex patients. … HSCT standards are updated and jointly published with the Joint Accreditation Committee ISCT-Europe and EBMT (JACIE). …