Результаты поиска

Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study.

BACKGROUND AND OBJECTIVES: Cladribine tablets (CladT) represent an effective immune reconstitution therapy, administered in short treatment courses over two consecutive years. To better understand the amplitude of immune changes, we performed a comprehensive analysis during the 2-year study period for the entire MAGNIFY-MS population (N=270). In addition to lymphocyte kinetics, we studied intracellular cytokines serum proteins, and their associations with clinical outcomes. To put these changes into perspective, we analyzed transcriptional changes in T and B cells and associated biological pat

Совпадение в полном тексте источника
… Canada: Western University Health Sciences Research Ethics Board, London, ON (Project ID: 111575); University of Alberta Health Research Ethics Board, Edmonton, AB (Study ID: Pro00081437); The University of British Columbia Office of Research Ethics, Vancouver, BC (ID: H1801523); McGill University Health …

Economic evaluation: immunoglobulin vs prophylactic antibiotics in hypogammaglobulinemia and hematological malignancies.

AbstractPatients with hematological malignancies are at high risk of developing hypogammaglobulinemia (HGG) and infections. Immunoglobulin (Ig) is one recommended option to prevent these infections, but it is expensive, and its cost-effectiveness compared with other prevention strategies remains unknown. We conducted a trial-based economic evaluation from the Australian health care system perspective to estimate the 12-month cost-effectiveness of prophylactic Ig vs prophylactic antibiotics in 63 adults with HGG and hematological malignancies participating in the RATIONAL feasibility trial. Two

Совпадение в полном тексте источника
… secondary immunodeficiencies in Canada Allergy Asthma Clin Immunol 10 1 2014 23 24872821 10.1186/1710-1492-10-23 PMC4036390 42 Ritchie B Martins KJB Tran DT Blain H Richer L Klarenbach SW Economic impact of self-administered subcutaneous versus clinic-administered intravenous immunoglobulin G therapy in Alberta …

Cardiovascular Symptom Tracking Among Patients With Cancer in Cardio-Oncology Care: Qualitative Study Using the Capability, Opportunity, Motivation-Behavior (COM-B) Framework.

BACKGROUND: Cardiovascular disease is a leading noncancer cause of morbidity and mortality among individuals diagnosed with cancer. Although modern cancer therapies have improved survival, many are associated with cardiotoxic effects that increase the risk of cardiovascular complications. Early identification of cardiovascular symptoms and signs may support timely clinical management. However, tracking cardiovascular health during cancer care can be complex for both patients and medical team participants, and important indicators, such as blood pressure changes, heart rate variability, fluid r

Совпадение в полном тексте источника
… In a population-based cohort study conducted in Alberta, Canada, more than 4.5 million adults were followed for a median of 11.8 (IQR 6.4-11.8) years [ 5 ]. …

Completeness Evaluation of Adult-Population-Based Cancer Registries: A Systematic Review.

Population-based cancer registries are crucial for tracking cancer trends, supporting research, guiding policy decisions, and ensuring efficient healthcare resource allocation. However, their effectiveness relies heavily on data quality, specifically the completeness of the cancer registration process.Background/objectivesThis systematic review aims to identify the methods used by adult population-based cancer registries worldwide to assess the completeness of their data. It also considered the significant role of high-quality data in method selection and the significant challenges of data han

Совпадение в полном тексте источника
… The Impact of Hospital Discharge Linkage on Case Ascertainment of Brain Tumors in the Alberta Cancer Registry, 2010–2015 J. Regist. Manag. 2018 45 109 116 31017880 75. Plouvier S.D. Bernillon P. Ligier K. Theis D. Miquel P.-H. Pasquier D. Rivest L.-P. …

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

Совпадение в полном тексте источника
… , Evidence, and Impact, McMaster University, Hamilton, ON, Canada), Fei Yutong (GRADE center, Beijing University of Chinese Medicine, China), Gabriel Rada (Epistemonikos Foundation, Santiago, Chile), Glen Hazlewood (Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta …

Genetic Syndromes, Maternal Diseases and Antenatal Factors Associated with Autism Spectrum Disorders (ASD).

Autism spectrum disorder (ASD) affecting about 1% of all children is associated, in addition to complex genetic factors, with a variety of prenatal, perinatal, and postnatal etiologies. In addition, ASD is often an important clinical presentation of some well-known genetic syndromes in human. We discuss these syndromes as well as the role of the more important prenatal factors affecting the fetus throughout pregnancy which may also be associated with ASD. Among the genetic disorders we find Fragile X, Rett syndrome, tuberous sclerosis, Timothy syndrome, Phelan-McDermid syndrome, Hamartoma tumo

Совпадение в полном тексте источника
… Analysis of 218,890 singleton live births in Alberta, Canada, between 1998 and 2004 also found greater odds of ASD (OR = 1.49; Burstyn et al., 2010 ). … Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada. Chronic Dis. Can. 30, 125–134. Carvill S., Marston G. (2002). People with intellectual disability, sensory impairments and behaviour disorder: a case series. J. Intellect. …

Lifestyle Factors in Cancer Survivorship: Where We Are and Where We Are Headed.

Advances in early detection and curative therapies have led to an increased number of cancer survivors over the last twenty years. With this population comes the need to evaluate the late and long term effects of cancer treatment and develop recommendations about how to optimally care for these survivors. Lifestyle factors (diet, body weight, physical activity, and smoking) have been linked to a higher risk of many medical comorbidities (cardiovascular, metabolic, etc.). There is increasing evidence linking these factors to the risk of developing cancer and likely cancer-related outcomes. This

Совпадение в полном тексте источника
… The Alberta moving beyond breast cancer (amber) cohort study: A prospective study of physical activity and health-related fitness in breast cancer survivors BMC Cancer 2012 12 e525 10.1186/1471-2407-12-525 23153358 PMC3534483 104. Yothers G. Land S.R. Ganz P.A. Fehrenbacher L. Giguere J.K. …

Exercise Interventions to Address Sarcopenia in People with Multiple Myeloma: A Scoping Review.

Background: The clinical characteristics of sarcopenia, including low muscular strength, are commonly seen among people with multiple myeloma. A scoping review was conducted to explore the role of exercise as a potential countermeasure for sarcopenia in this population. Our objectives were to (1) describe the design and findings of the studies and (2) identify the outcomes used in exercise-related studies to characterize sarcopenia. Methods: A systematic search (to March 2025) was conducted for published studies involving exercise or physical activity for individuals with multiple myeloma usin

Совпадение в полном тексте источника
… Acknowledgments Thanks to Liz Dennett, from the Geoffrey and Robyn Sperber Health Sciences Library at the University of Alberta, for her assistance with the scoping review search strategy. …

Cost-effectiveness and public health impact of recombinant zoster vaccine versus no herpes zoster vaccination in selected populations of immunocompromised adults in Canada.

BACKGROUND: The risk of herpes zoster (HZ) increases with age and in immunocompromised (IC) patients. Recombinant zoster vaccine (RZV) is currently recommended in Canada for people aged ≥ 50 years. The objectives of the current study were to evaluate the cost-effectiveness and public health impact of RZV versus no HZ vaccination in select Canadian IC adult populations. METHODS: The ZOster ecoNomic Analysis ImmunoCompromised (ZONA IC) model followed a base-case cohort of 1600 patients with hematopoietic stem-cell transplant (HSCT) from a starting age of 55 years, who maintained IC status for 5

Совпадение в полном тексте источника
… Shingles in Alberta: Before and after publicly funded varicella vaccination. Vaccine. 2014;32(47):6319–24. 67. Tanuseputro P, Zagorski B, Chan KJ, Kwong JC. Population-based incidence of herpes zoster after introduction of a publicly funded varicella vaccination program. …

Trazodone in the Management of Major Depression Among Elderly Patients with Dementia: A Narrative Review and Clinical Insights.

ObjectiveMajor depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses, such as dementia.ResultsBecause of its mechanism of action, trazodone can treat several depression symptoms often seen in people with dementia, including insomnia, agitation, anxiety, cognitive impair

Совпадение в полном тексте источника
… Comparative risk of harm associated with zopiclone or trazodone use in nursing home residents: a retrospective cohort study in Alberta, Canada. Can Geriatr J . 2023;26(1):9–22. doi: 10.5770/cgj.26.622 78. Assimon MM, Flythe JE. …

Examining anxiety and depression in haematology cancer patients in ongoing treatment and under watchful waiting: A systematic review and meta-analysis.

IntroductionThe present review aimed to establish prevalence rates of anxiety and depression in adults with haematology cancer, with a focus on the differences between patients under treatment and patients under watchful waiting.MethodFive databases (Scopus, Medline, PsycINFO, EThOS, CINAHL) were searched throughout June 2021. Key search terms included haematology cancer, anxiety, depression, in treatment and watchful waiting. Study and sample characteristics, prevalence rates and mean self-reported scores of anxiety and depression data were extracted.ResultsA total of 18 eligible papers were

Совпадение в полном тексте источника
… Alberta Heritage Foundation for Medical Research (AHFMR). Koizumi, K. , Tayama, J. , Ishioka, T. , Nakamura‐Thoma, H. , Suzuki, M. , Hara, M. , & Hamaguchi, T. (2018). Anxiety, fatigue, and attentional bias toward threat in patients with hematopoietic tumors. …

Показатели качества консенсуса для мониторинга множественного склероза.

Множественный склероз (МС) как хроническое, дегенеративное аутоиммунное заболевание центральной нервной системы имеет продольный и разнородный курс с увеличением вариантов лечения и профилей рисков, требующих постоянного мониторинга растущего числа параметров. Несмотря на руководящие принципы лечения, отсутствуют стратегические и индивидуализированные пути мониторинга, включая соответствующие показатели качества (КИ). Для решения этой проблемы мы систематически разрабатывали транспарентные, отслеживаемые и измеримые КИ для мониторинга НР. С помощью обзора литературы, дискуссий экспертов и форм

Совпадение в полном тексте источника
… Co-designing person-centred quality indicator implementation for primary care in Alberta: a consensus study Res Involv Engagem 8 2022 59 10.1186/s40900-022-00397-z 36348406 PMC9641306 69 Ziemann S. Coburn M. Rossaint R. …

Clinical practice guidelines and consensus statements in oncology--an assessment of their methodological quality.

BackgroundConsensus statements and clinical practice guidelines are widely available for enhancing the care of cancer patients. Despite subtle differences in their definition and purpose, these terms are often used interchangeably. We systematically assessed the methodological quality of consensus statements and clinical practice guidelines published in three commonly read, geographically diverse, cancer-specific journals. Methods Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal o

Совпадение в полном тексте источника
… Vickers MM, Pasieka J, Dixon E, McEwan S, McKay A, et al. (2012) Report from the 13th annual Western canadian gastrointestinal cancer consensus conference; calgary, alberta; september 8–10, 2011. Curr Oncol 19: e468–477. 23. …

The functional imperative in high-grade glioma.

Precision oncology has emerged as a promising strategy for treating high-grade gliomas, yet its clinical impact has been disappointing, with over 300 clinical trials on targeted therapies failing to yield substantial improvements in patient outcomes. Current approaches primarily focus on static, marker-driven tumor features, which capture only a small portion of the complex biology that governs therapeutic responses. Functional precision oncology (FPO) offers a complementary approach, enhancing treatment selection in a personalized manner by dynamically testing patient-derived tumor cells agai

Совпадение в полном тексте источника
… Treatment Strategy on Recurrent HGGs | Recurrent HGGs | Adults | 30 | NCT05473923 | Beijing, China | Interventional | Active, not recruiting | 12 August 2022 | 30 June 2025 | Nil Pilot trial for treatment of recurrent glioblastoma | Recurrent IDH wild-type glioblastoma | Adults | 10 | NCT05432518 | Alberta …

45th International Symposium on Intensive Care & Emergency Medicine.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… J Chin Med Assoc 2016;79:678–682 P011 Preventing aspiration events in hospital using prophylactic antiemetics: a systematic review and meta-analysis K.B Tworek 1 , M Giovannoni 1 , J Kung 2 , V Lau 3 1 University of Alberta, Department of Medicine, Edmonton, Canada, 2 University of Alberta, Geoffrey … Robyn Sperber Health Sciences Library, Edmonton, Canada, 3 University of Alberta, Department of Critical Care Medicine, Edmonton, Canada Critical Care 2026, 30 (Suppl 1): P011 Introduction: Aspiration events in hospitalized adults are common and linked to substantial morbidity and mortality. …

Diagnosis, treatment, and follow-up of patients with hypophosphatasia.

INTRODUCTION: Hypophosphatasia is a rare inherited systemic metabolic disorder, with an estimated prevalence in the severe forms of the disease of 1/100.000-1/300.000, that affects the typical architecture of bone, leading to defective mineralization during growth and remodeling. It is characterized by loss-of-function variants in the ALPL gene, resulting in low activity of tissue-nonspecific alkaline phosphatase. In severe cases, it can be fatal. OBJECTIVE: To generate recommendations on the diagnosis, treatment, and follow-up of patients with hypophosphatasia based on available evidence. M

Совпадение в полном тексте источника
… For pediatric patients under five years old, motor evaluation using the Gross Motor Function Measurement (GMFM), or the Alberta Infant Motor Scale (AIMS) is suggested. For patients over five years old, the 6-minute walk test (6MWT) is recommended [ 19 , 58 ]. …

Role of Fibroblast Growth Factors Receptors (FGFRs) in Brain Tumors, Focus on Astrocytoma and Glioblastoma.

Despite pharmacological treatments and surgical practice options, the mortality rate of astrocytomas and glioblastomas remains high, thus representing a medical emergency for which it is necessary to find new therapeutic strategies. Fibroblast growth factors (FGFs) act through their associated receptors (FGFRs), a family of tyrosine kinase receptors consisting of four members (FGFR1-4), regulators of tissue development and repair. In particular, FGFRs play an important role in cell proliferation, survival, and migration, as well as angiogenesis, thus their gene alteration is certainly related

Совпадение в полном тексте источника
… Alberta J.A. Bachoo R.M. Kane M. Louis D.N. Depinho R.A. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma Neuron 2007 53 503 517 10.1016/j.neuron.2007.01.009 17296553 PMC1810344 76. Bribian A. Barallobre M.J. …

Application of wearables for remote monitoring of oncology patients: A scoping review.

ObjectiveThis review aims to systematically map and categorize the current state of wearable applications among oncology patients and to identify determinants impeding clinical implementation.MethodsA Medline, Embase and clinicaltrials.gov search identified journal articles, conference abstracts, letters, reports, dissertations and registered studies on the use of wearables in patients with malignancies published up to 10 November 2021.ResultsOf 2509 records identified, 112 met the eligibility criteria. Of these, 9.8% (11/112) were RCTs and 47.3% (53/112) of publications were observational. We

Совпадение в полном тексте источника
… The Alberta moving beyond breast cancer (AMBER) cohort study: recruitment, baseline assessment, and description of the first 500 participants. BMC Cancer 2016; 16: 481. 10.1186/s12885-016-2534-4. 86. Dadhania S, Pakzad-Shahabi L, Mistry S, et al. …

Frailty in Aging and the Search for the Optimal Biomarker: A Review.

In the context of accelerated aging of the population worldwide, frailty has emerged as one of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome is defined as a reduced state of physiological reserve and functional capacity. The main diagnostic tools for frailty are based on scales that show deficits compared to their clinical application, such as the Fried frailty phenotype, among others. In this context, it is important to have one or more biomarkers with clinical applicability that can objectively and precisely determine the degree or risk of fra

Совпадение в полном тексте источника
… On the other hand, there is also the Edmonton Frail Scale (EFS), which was developed at the University of Alberta in the Canadian city of Edmonton by Rolfson and collaborators [ 20 ]. …

42nd International Symposium on Intensive Care & Emergency Medicine

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.