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Investigating socioecological obesogenic factors in children with Autism Spectrum Disorder.

Obesity-related information in children with Autism Spectrum Disorder (ASD) is limited, and research findings are contradictory. Thus, this study aimed to use a nationwide non-clinical sample to examine the association of sociological factors with overweight status in children with ASD and reveal the degree of differences in the risk factors for overweight in children with and without ASD. The data for this cross-sectional study, based on the modified ecological system theory model, were obtained from the 2019 National Survey of Children's Health. The weighted logistic regressions were perform

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… Factors related to family health and activities contributing to children's obesity included parents' health, drinking, drug use status, stress coping ability, family meals, and food security. … Food security was measured on a four-point Likert scale as the child's household's ability to afford food for the past 12 months (1 = always get enough nutritious food to 4 = often not enough). Three childhood obesity-related community- and school-activity variables were investigated. …

Using Genomic Data in Personalized Oncology Medicine: An Exploratory Expert-Elicitation Study with Narrative Regulatory Mapping of Regulations, Implementations, and Challenges in Saudi Arabia.

BACKGROUND/OBJECTIVES: Personalized medicine represents a transformative approach to healthcare in Saudi Arabia. However, a significant research gap exists regarding the specific regulatory, implementation, and practical challenges of integrating genomic data into personalized oncology care in the Saudi context. We aimed to conduct an exploratory assessment of the current regulatory landscape, practices, and challenges related to genomic data use in personalized oncology in Saudi Arabia and to identify regulatory and practical gaps, propose actionable solutions, and outline future directions f

Accelerating novel therapies for sickle cell disease with RWE: ASH RC Data Hub as a strategically coordinated registry network.

AbstractReal-world evidence (RWE) has been used to improve quality of care, accelerate innovation, and evaluate emerging therapies for drugs, devices, and biologics. The Coordinated Registry Network (CRN), aggregating and linking highly curated patient data, has emerged as a model for RWE generation that has guided the development of the American Society of Hematology Research Collaborative (ASH RC) Data Hub. With the aim of bolstering research, enhancing clinical care, and expediting evidence generation using RWE, the ASH RC and the Innovative Genomics Institute launched a joint initiative, "

Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.

Marine macroalgae, microalgae, and associated microorganisms are increasingly recognised as valuable sources of bioactive compounds with applications across biotechnology and health. The environmental and ecological conditions they inhabit shape their metabolite diversity, leading to the production of high-value compounds such as sulphated polysaccharides, lipids, pigments, phenolics, and peptides. These compounds exhibit conserved biological activities that underpin potent antioxidant, anti-inflammatory, cytotoxic, and pro-regenerative effects with strong potential for translation. Although e

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… Nutraceuticals and Food Security Beyond their role as sources of diverse bioactive metabolites, macroalgae and microalgae are increasingly recognised as valuable nutraceutical ingredients and functional food resources with relevance to chronic disease prevention, dietary quality, and food security [ … Microalgae are also highly relevant to food security, particularly at the systems level. …

A review of big data and medical research.

Universally, the volume of data has increased, with the collection rate doubling every 40 months, since the 1980s. "Big data" is a term that was introduced in the 1990s to include data sets too large to be used with common software. Medicine is a major field predicted to increase the use of big data in 2025. Big data in medicine may be used by commercial, academic, government, and public sectors. It includes biologic, biometric, and electronic health data. Examples of biologic data include biobanks; biometric data may have individual wellness data from devices; electronic health data include t

Последствия применения обеспеченных предписаний для амбулаторного использования прегабалина во Франции: региональная оценка во Французском Нувеле-Аквитане.

AIM: Французские власти разрешили использовать в мае безопасные рецепты на догабалин. 2021. Цель этого исследования заключалась в оценке воздействия этой меры на использование и неправильное использование догабалинов в Нувеле-Акитане, юго-западном французском регионе, расположенном вокруг six million Жители. МЕТОДЫ: Это исследование было проведено на основе региональных баз данных французской системы медицинского страхования " Нувел-Аквитейн " . В нее входят все лица, которые получают по крайней мере one Возмещение расходов на догабалин между 24 Май 2020 и 24 Май 2022. Мы проанализир

Establishing a Cardiac Implantable Electronic Device Lead Extraction Program in a Resource-Limited Setting.

BackgroundThe rising number of cardiac implantable electronic device (CIED) implantations in Asia is expected to increase CIED-related infections and lead malfunctions. Establishing a lead extraction program is therefore essential. We describe the set-up and early implementation of the University of the Philippines-Philippine General Hospital (UP-PGH) Lead Extraction Program.MethodsData on preoperative, intraoperative, and postoperative management were collected, along with details on resources, personnel, and workflows. A descriptive analysis was performed.ResultsThe UP-PGH Lead Extraction Pr

Public health and international drug policy.

UNLABELLED: In September 2015, the member states of the United Nations endorsed sustainable development goals (SDG) for 2030 that aspire to human rights-centered approaches to ensuring the health and well-being of all people. The SDGs embody both the UN Charter values of rights and justice for all and the responsibility of states to rely on the best scientific evidence as they seek to better humankind. In April 2016, these same states will consider control of illicit drugs, an area of social policy that has been fraught with controversy, seen as inconsistent with human rights norms, and for wh

Viewing the US presidential electoral map through the lens of public health.

Health, disease, and mortality vary greatly at the county level, and there are strong geographical trends of disease in the United States. Healthcare is and has been a top priority for voters in the U.S., and an important political issue. Consequently, it is important to determine what relationship voting patterns have with health, disease, and mortality, as doing so may help guide appropriate policy. We performed a comprehensive analysis of the relationship between voting patterns and over 150 different public health and wellbeing variables at the county level, comparing all states, including

The value of survival gains from therapeutic innovations for US patients with relapsed/refractory multiple myeloma.

AIMS: This study quantifies the value of survival gains attributable to novel treatments approved since 2003 for United States (US) patients with relapsed/refractory multiple myeloma (RRMM). METHODS: We estimated the increase in survival attributable to lenalidomide and bortezomib for multiple myeloma (MM) patients in the 1983-2013 Surveillance, Epidemiology, and End Results (SEER) registry. To estimate the survival benefit of treatments approved since 2015 (carfilzomib, elotuzomab, daratumumab, used in combination with lenalidomide and dexamethasone) we used clinical trial data to calibrate

Инвалидность и связанные со здоровьем качество жизни при множественном склерозе: перспективы 10-year Веб-исследование основанной на народонаселении модели реальной жизни в Нидерландах.

ЦЕЛЬ: Оценить на уровне населения долгосрочные изменения в показателях инвалидности и качества жизни, связанного со здоровьем (HRQOL), у лиц с множественным склерозом (PwMS) в Нидерландах. ПАТИЕНТЫ И МЕТОДЫ: перспективное исследование на базе Интернета в реальных группах населения на основе самопрокатов; 6- месячные оценки на основе Профильа воздействия склероза (MSIP) и Множественного склероза Life-54 (В тыс.MSQoL-54) вопросники; анализ общих линейных смешанных моделей (GLMM); предопределенные якорные точки 5, 8 и 10 :: последующие годы. РЕЗУЛЬТАТЫ: Общенациональные 391 (начало лечения)2011-2

Изменчивость генотипов кассавы (Manihot Escelenta [Cranz]) для состава питания в юго-западной Эфиопии.

В ходе исследования было использовано в общей сложности 100 Генотипы кассавы, полученные из МИТА, Нигерия (биофортифицированные генотипы), и собранные на месте земли Эфиопии, сохранены в Центре сельскохозяйственных исследований Джиммы. Таким образом, понимание изменчивости состава рациона питания может служить ориентиром для будущего генетического совершенствования и поддерживать развитие питательных разновидностей маниоки. Цель этого исследования заключалась в оценке изменчивости генотипов кассавы на основе их анализа состава питательных веществ. Анализ различий (АНОВА) выявил весьма значител

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… It ensures food security for millions of people, mainly in developing countries of Sub-Saharan countries 2 . It is a great source of starch for human food and animal feed and provides high nutritional values to the urban and rural population 3 – 5 . … It is extensively produced in SSA ensuring food security for the low-income community, and hence considered “poor people crop” and also called “dangerous crop” due to the low quality and quantity of protein and the presence of cyanogenic glycoside 7 , 8 . …

Ca2+ involvement in the action potential generation of myenteric neurones in the rat oesophagus.

OBJECTIVE: Arterial aneurysms are life-threatening but usually asymptomatic before requiring hospitalization. Oculomics of retinal vascular features (RVFs) extracted from retinal fundus images can reflect systemic vascular properties and therefore were hypothesized to provide valuable information on detecting the risk of aneurysms. By integrating oculomics with genomics, this study aimed to (i) identify predictive RVFs as imaging biomarkers for aneurysms and (ii) evaluate the value of these RVFs in supporting early detection of aneurysms in the context of predictive, preventive and personalize

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… A Review of the 2011 Sphere indicators for wash, food security and nutrition, and health action. PLoS Currents. 2018;10:ecurrents.dis.40805a591152be1c1431b5dab43e516d. 10.1371/currents.dis.40805a591152be1c1431b5dab43e516d. 26. Blanchet K, Ramesh A, Frison S, Warren E, Hossain M, Smith J, et al. …

Средиземноморская диета и достаточность питательных микроэлементов в связи с риском повторного возникновения множественных склерозов: тематическое исследование.

Множественный склероз (MS) является хроническим аутоиммунным и нейродегенеративным заболеванием, под влиянием экологических факторов, включая рацион питания. Средиземное питание (MeDi), богатое антивоспалительными и антиокислительными соединениями, а также адекватность питательных микроэлементов могут снизить риск и прогрессировать в плане НР. АИМ: Цель настоящего исследования заключается в изучении связей между Средиземноморским диетическим счётом (MDS), средним коэффициентом достаточности (MAR) и риском, связанным с НР, в рамках контроля за конкретными случаями. МЕТОДЫ: Это тематическое иссл

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… Project I , “Data4Diets: Building Blocks for Diet‐Related Food Security Analysis,” USAID Advancing Nutrition, 2018. 16. …

Patient Perspectives on Palliative Care Outreach to Adults Living With Homelessness.

ImportancePeople experiencing homelessness face higher rates of early mortality, multimorbidity, and unmet needs at the end of life, but despite these risks, they often encounter systemic barriers to accessing palliative care. Outreach-based models have emerged to address this gap, yet little is known about how these models are perceived by those receiving care.ObjectiveTo evaluate a palliative care outreach intervention, the Palliative Education and Care for the Homeless (PEACH) program, from the perspective of patients living with homelessness and life-limiting illness.Design, setting, and p

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… Food security | 10 | [The PEACH doctor], she was the one coming there, sending food—how do you call it? The chocolate stuff. … Four subthemes emerged: financial support, housing, food security, and connecting with loved ones. PEACH addressed financial challenges by helping participants access disability benefits, medication coverage, and providing essential items. …

The burden of illness in patients with paroxysmal nocturnal hemoglobinuria receiving treatment with the C5-inhibitors eculizumab or ravulizumab: results from a US patient survey.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare and life-threatening disease with symptoms of hemolysis and thrombosis. Current therapies for this complement-mediated disease rely predominantly on inhibition of the C5 complement protein. However, data on treatment responses and quality of life in C5-inhibitor (C5i)-treated PNH patients are scarce. The objective of this study was to determine C5i treatment effects on clinical parameters, PNH symptoms, quality of life, and resource use for PNH patients. This cross-sectional study surveyed 122 individuals in the USA receiving treatment for PN

Pharmacovigilance in Cell and Gene Therapy: Evolving Challenges in Risk Management and Long-Term Follow-Up.

Cell and gene therapies, including CAR T-cells, CRISPR-based genome editing, and next-generation viral and non-viral delivery platforms, are transforming treatment paradigms across cancer, rare genetic disorders, immune dysregulation, and neurodegenerative disease. These therapies offer curative potential but also present safety challenges owing to prolonged biological activity, systemic immune engagement, and lasting genomic alterations. This review examines the range of related toxicities, including immune complications, genotoxicity, and organ-specific effects, with attention to atypical pr

Социальные детерминанты здоровья, качества ухода за больными и результаты лечения неврологических расстройств: систематический обзор.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Социальные детерминанты здоровья (SDOH) оказывают значительное влияние на оказание медицинской помощи и ее результаты, однако их конкретное воздействие на качество неврологической медицинской помощи по-прежнему недостаточно синтезировано. ЦЕЛЬ: Цель этого систематического обзора заключалась в обобщении данных о связях между СДОГ и качеством медицинского обслуживания и результатах лечения пациентов в связи с серьезными неврологическими расстройствами. МЕТОДЫ: ПОСЛЕ ПРИСМА 2020 Руководящие принципы, мы систематически искали Пуббмеда, Интернет науки и Эмбазу для исследовани

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… security (7.7%), and language/immigration status (10.8%). … Employment loss or reduction due to disability generated cascading financial consequences affecting housing stability and food security. …

Emergency Care

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Разграничение Genotype X Environment Cooperation for Green Yeeld в Весне Барли в условиях необработанной и фунгицидной среды.

Барли (Hordeul vulgare L.) — четвёртый по величине урожай зерновых культур, выращиваемый на основе производства и возделывания. Биотические стрессы, особенно грибковые заболевания в ячменях, являются разрушительными и сопряжены с высокой вероятностью абсолютной потери урожайности. Для удовлетворения растущего спроса на ячмень решающее значение имеет выявление более высоких и стабильных генотипов. Вместе с тем выявление и рекомендация генотипов высшего сорта сопряжены с трудностями из-за взаимосвязи между генотипом и окружающей средой. Таким образом, настоящее исследование было направлено на оц

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… Assuring food security through the evaluation, identification and development of high-yield varieties is one of the core objectives of the plant breeding program. Grain yield is a complex quantitative trait influenced by genetic and environmental factors [ 6 , 7 ]. … Exploring the impacts of climate change and mitigation policies on UK feed barley supply and implications for national and transnational food security SN Appl. Sci. 2020 2 1 20 10.1007/s42452-020-2444-6 6. Tamm Y. Jansone I. Zute S. Jakobsone I. …