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A scoping review of breakthrough cancer pain: Multidimensional patient needs and influencing factors.

ObjectivesBreakthrough cancer pain (BTcP), a common complication among cancer patients, has been confirmed to have extensive impacts on patients' lives. However, existing research remains fragmented, lacking a systematic theoretical framework to integrate these findings. This scoping review aimed to systematically examine the multidimensional needs and influencing factors of BTcP patients based on Kolcaba's Comfort Theory, construct a conceptual mapping of BTcP needs and influences, and explore the theoretical foundations and practical pathways of related interventions.MethodsUsing a scoping r

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… Table 1 Author Country Research Design Study Participants Research Location Research Objective Assessment Tools Outcome Indicators Research Results Homdee 2024 1 Thailand Cross-sectional Study 5 Advanced Cancer Patients Patient and Caregiver Homes in Central Virginia To explore the impact of environmental … Author | Country | Research Design | Study Participants | Research Location | Research Objective | Assessment Tools | Outcome Indicators | Research Results Homdee 2024 1 | Thailand | Cross-sectional Study | 5 Advanced Cancer Patients | Patient and Caregiver Homes in Central Virginia | To explore the …

Advances in Drug Delivery and Biomaterials: Facts and Vision.

Drug delivery and biomaterials are different fields of science but, at the same time, are tightly related and intertwined. The 2018 CRS Italy Chapter Annual Workshop aims to explore recent advances in design and development in these areas. Many colleagues from Europe participated to the Workshop, stimulating the discussion. To foster the discussion on recent research and networking opportunities, especially among younger attendees, all poster-presenting authors were asked to provide a short talk. The very friendly and stimulating atmosphere allowed the attendees to explore new frontiers and ta

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… Nanomedicine in Cancer: Toward Overcoming Chemoresistance Virginia Campani , Simona Giarra , Giuseppe De Rosa Cancer represents one of the diseases with a major impact on society across the world. …

Late Breaking Orals.

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ICIMH 2022 Abstracts

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… , United States 4 Georgetown University Medical Center/MedStar Washington Hospital Center, Washington, DC, Virginia, United States 5 Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States 6 Georgetown University Medical Center/MedStar Washington Hospital Center, Washington … , DC, Virginia, United States Contact: dnemati@iu.edu Abstract Background: Palliative care is a holistic medical approach to chronic illness management that helps patients achieve the best possible quality of life incorporating psychological and physical symptoms. …

Oral Presentations

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Инструменты скрининга для раннего выявления потребностей в паллиативном уходе у пациентов с повышенными хроническими условиями: обновленный систематический обзор.

Предыстория/задачи: Более раннее начало паллиативного ухода способствует улучшению клинических результатов, включая повышение эффективности мер по борьбе с симптомами, повышение качества жизни и сокращение использования ресурсов здравоохранения для лечения передовых заболеваний. Цель этого систематического обзора заключалась в выявлении и критической оценке существующих инструментов, разработанных как в обычном порядке, так и на основе искусственного интеллекта, предназначенных для выявления пациентов, имеющих право на раннее паллиативное лечение. Методы: Six Были изучены электронные базы данн

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… Palliative Care HUIL-Group: Soledad Acedo-Gutiérrez, Teresa Blanco-Moya, Natalia Pavón-Muñoz, Elena Díaz-Sánchez, Marina Chivato-Cabanal, Alicia Sánchez-Pizarro, David Escudero-Rodríguez, Beatriz Fernández-Rodríguez, Eva Moya-Mateo, Teresa Bellver-Álvarez, Marta Bustamante-Vega, Mercedes Duffort-Falcó, Virginia …

"What I wanted to do was build myself back up and prepare": qualitative findings from the PERCEPT trial of prehabilitation during autologous stem cell transplantation in myeloma.

BackgroundThe addition of qualitative methodology to randomised controlled trials evaluating complex interventions allows better understanding of contextualised factors and their potential influence on trial delivery and outcomes, as well as opportunities for feedback on trial participation to improve future trial protocols. This study explored the experiences of participation in cancer rehabilitation research during active cancer treatment. Participants were people living with haematological cancer myeloma, undergoing autologous stem cell transplantation (ASCT) recruited to the PERCEPT myelom

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… Successful qualitative research: a practical guide for beginners / Virginia Braun & Victoria Clarke. In: Clarke V, Clarke V, editors. Los Angeles. London: Los Angeles: SAGE; 2013. 23. Mukumbang FC. …

Trichloroethylene: An Invisible Cause of Parkinson's Disease?

The etiologies of Parkinson's disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common environmental contaminant little recognized for its likely role in PD: trichloroethylene (TCE). TCE is a simple, six-atom molecule that can decaffeinate coffee, degrease metal parts, and dry clean clothes. The colorless chemical was first linked to parkinsonism

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… Between active duty and the reserves, Captain Lindberg served for 26 years, before she and her husband retired in northern Virginia. …

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

The development of chemotherapy-induced painful peripheral neuropathy is a major dose-limiting side effect of many chemotherapeutics, including bortezomib, but the mechanisms remain poorly understood. We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P. Accordingly, genetic and pharmacological disruption of S1PR1 with multiple S1PR1 antagonists, including FTY720, blocked and reversed neuropathic pain. Mice with astrocyte-sp

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… Spiegel), and NIH-National Cancer Institute Cancer Center Support Grant P30 CA016059 (to the Virginia Commonwealth University Lipidomics Core). D. Salvemini and G.J. Bennett are founders of BioIntervene, Inc., which has licensed related intellectual property from Saint Louis University. …

The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods.

BACKGROUND: The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors. METHODS: The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardi

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… Sciences Centre) Prasad Devarajan, MD (Cincinnati Children's Hospital Medical Center) Zhu Wang, PhD (Yale University) Michael Zappitelli, MD, MSc (Montreal Children's Hospital) Elizabeth Dombrowski, MS, MBA (Yale University) Catherine Krawczeski, MD (Cincinnati Children's Hospital Medical Center) Virginia …

Proceedings of the International Cancer Imaging Society Meeting and 21st Annual Teaching Course : Boston, MA, USA. 12-14 September 2022

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… Winks Virginia Commonwealth University Health System, Richmond, VA, USA Correspondence: V. …

Oral Presentations

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Second-Class Care: How Immigration Law Transforms Clinical Practice in the Safety Net.

This article examines how U.S. immigration law extends into the health care safety net, enacting medical legal violence that diminishes noncitizens' health chances and transforms clinical practices. Drawing on interviews with health care workers in three U.S. states from 2015 to 2020, I ask how federal citizenship-based exclusions within an already stratified health care system shape the clinical trajectories of noncitizens in safety-net institutions. Focusing specifically on cancer care, I find that increasingly anti-immigrant federal policies often reshape clinical practices toward noncitize

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… Hallowell Benjamin D., Endeshaw Meheret, McKenna Matthew T., Senkomago Virginia, Razzaghi Hilda, Saraiya Mona. 2019. “Cancer Mortality Rates among U.S. and Foreign-Born Individuals: United States 2005–2014.” Preventive Medicine 126:105755. doi: 10.1016/j.ypmed.2019.105755. …

Intestinal Microbes and Hematological Malignancies.

Hematological malignancies are diverse, with high malignancy characteristics, poor prognoses, and high mortality rates. The development of hematological malignancies is driven by genetic factors, tumor microenvironment factors, or metabolic factors; however, even when considering all of these factors, one still cannot fully estimate the risk of hematological malignancies. Several recent studies have demonstrated an intimate connection between intestinal microbes and the progression of hematological malignancies, and gut microbes play a primary role in the initiation and progression of hematolo

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… The World Health Organization classification of hematological malignancies report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997. Mod. Pathol. 2000;13:193–207. doi: 10.1038/modpathol.3880035. 4. Sender R., Fuchs S., Milo R. Are We Really Vastly Outnumbered? …

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

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… Anderson Cancer Center | Phase 2 | NS | Hematopoietic, lymphoid cell, or solid malignant neoplasms | Duloxetine vs. neurofeedback training vs. their combination Study of nicotine for pain associated with chemotherapy-induced peripheral neuropathy | NCT04468230 | Virginia Commonwealth University | Phase …

Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment.

Primary gastric lymphoma (PGL) is the most common extranodal non-Hodgkin lymphoma and represents a wide spectrum of disease, ranging from indolent low-grade marginal zone lymphoma or mucosa-associated lymphoid tissue (MALT) lymphoma to aggressive diffuse large B-cell lymphoma. The PGL is a relatively rare cancer and easily misdiagnosed due to its unspecific symptoms of the digestive tract. The medical literature and ongoing clinical trials were reviewed on the clinical presentation, diagnosis, prognosis, prevention, and treatment of PGL. Primary gastric lymphoma is an event in the course of ca

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… [PMID: 8075046] . 8075046 10.1093/oxfordjournals.annonc.a058869 60 Harris NL Jaffe ES Diebold J The World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997 . …

Oral Presentations

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… and Spine Program, University of Toronto, Canada 11 Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases - Langone Medical Center, New York, United States 12 Department of Orthopaedic Surgery, Lenox Hill Hospital, New York, United States 13 Department of Neurosurgery, University of Virginia … following adult spine deformity surgery: results from the AO Spine survey of post-operative management of adult spine deformity patients So Kato 1 , Justin Smith 2 , Stephen Lewis 3 , Christopher Shaffrey 4 , Lawrence Lenke 5 , and AO Spine KF Deformity 6 1 The University of Tokyo, Japan 2 University of Virginia …

Четвертое Международное совещание ИСЕВ, ISEV2015.

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Exploring the Molecular Adaptations, Benefits, and Future Direction of Exercise Training: Updated Insights into Cardiovascular Health.

This review emphasizes the globally accepted physical activity guidelines and explores the various molecular adaptations that occur with continuous exercise. It is essential to highlight the critical roles of cardiorespiratory fitness, muscular strength, and muscle mass in reducing mortality and enhancing quality of life. It has been shown in various studies that there are certainly substantial reductions in cardiovascular and all-cause mortality among individuals with high cardiorespiratory fitness levels. Resistance training is also examined, which, likewise, reveals significant mortality be

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… University of Virginia School of Medicine Exercise Physiology Core Laboratory VO2 Max Testing. [(accessed on 5 April 2024)]. Available online: https://med.virginia.edu/exercise-physiology-core-laboratory/fitness-assessment-for-community-members/vo2-max-testing/ 20. Artero E.G., Lee D. …

The Insider: Impact of the Gut Microbiota on Cancer Immunity and Response to Therapies in Multiple Myeloma.

The human microbiota is a unique set of microorganisms colonizing the human body and evolving within it from the very beginning. Acting as an insider, the microbiota provides nutrients, and mutualistically interacts with the host's immune system, thus contributing to the generation of barriers against pathogens. While a strong link has been documented between intestinal dysbiosis (i.e., disruption to the microbiota homeostasis) and diseases, the mechanisms by which commensal bacteria impact a wide spectrum of mucosal and extramucosal human disorders have only partially been deciphered. This is

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… Single group assignment, open label trial of prebiotics and HSCT | Primary: frequency of participants ingesting the required diet; secondary: incidence and severity of acute GVHD and acute GI GVHD, C. difficile infection, patient weight and days to neutrophil engraftment | – | Recruiting (University of Virginia …