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Устные доклады

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Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer.

Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic

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… Hershey Medical Center Icosapent Ethyl | - | Liver Metastasis | 3/R | NCT03428477 | Mark A Hull, PhD FRCP DHA | - | Breast Cancer | 2/R | NCT03831178 | AHS Cancer Control Alberta EPA | NSCLC | NR | NCT04175769 | AHS Cancer Control Alberta EPA | Lung Cancer | 2/3/U | NCT01048970 | National Institute of …

The Role of Injectables in the Treatment and Prevention of Cancer-Associated Thrombosis.

Cancer-associated thrombosis (CAT) is a leading cause of death among patients with cancer. CAT can manifest itself as venous thromboembolism (VTE), in the form of deep vein thrombosis or pulmonary embolism, or arterial thromboembolism. The pathophysiology of CAT is complex and depends on cancer-, patient-, treatment- and biomarkers-related factors. Treatment of VTE in patients with cancer is complex and includes three major classes of anticoagulant agents: heparin and its derivatives, e.g., low molecular weight heparins, direct oral anticoagulants (DOACs), and vitamin K inhibitors. Given the t

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… Retrospective Review of Prescribing Patterns in Cancer-Associated Thrombosis: A Single Center Experience in Edmonton, Alberta, Canada. Clin. Appl. Thromb. Hemost. 2021;27:1076029620975489. doi: 10.1177/1076029620975489. 87. Crowther M.A., Berry L.R., Monagle P.T., Chan A.K. …

Clinical development of gene therapy: results and lessons from recent successes.

Therapeutic gene transfer holds the promise of providing lasting therapies and even cures for diseases that were previously untreatable or for which only temporary or suboptimal treatments were available. For some time, clinical gene therapy was characterized by some impressive but rare examples of successes and also several setbacks. However, effective and long-lasting treatments are now being reported from gene therapy trials at an increasing pace. Positive outcomes have been documented for a wide range of genetic diseases (including hematological, immunological, ocular, and neurodegenerativ

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… Importantly, their Alberta Infant Motor Scale, Peabody Developmental Motor Scale, and Comprehensive Developmental Inventory for Infants and Toddlers scores were better after 15 to 24 months of gene therapy, indicating improvement in their motor and cognitive functions. …

Strategies to Improve Sensitivity to Radiotherapy in Pediatric Solid Tumors.

The primary goal in the treatment of pediatric malignancies is to maintain effective cancer control while minimizing toxicities and late effects. Radiotherapy is a component of standard therapy against many pediatric cancers, but tumor cell DNA damage repair mechanisms and the hypoxic tumor microenvironment may limit the effectiveness of this modality. Additionally, irradiated cancer cells often acquire resistance to radiotherapy that permits cancer cell survival or stimulates tumor regrowth after treatment, further limiting the efficacy of radiotherapy. Various preclinical studies have invest

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… Pal S., Kozono D., Yang X., Fendler W., Fitts W., Ni J., Alberta J.A., Zhao J., Liu K.X., Bian J., et al. Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. …

Autoimmune Neuromuscular Disorders at a Molecular Crossroad: Linking Pathogenesis to Targeted Immunotherapy.

Myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, and idiopathic inflammatory myopathies are among the most widely recognized autoimmune neuromuscular disorders. Although they differ in clinical presentation, shared immunopathogenic mechanisms place them at a molecular crossroads. Evidence of overlapping pathways has led to the development of targeted strategies including complement inhibition, FcRn antagonism, B-cell depletion, and the CAR-T cell approach. In this review, we analyze current knowledge regarding pathogenic mechanisms and their link to immunotherapy, extensiv

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… Incidence and prevalence, and medication use among adults living with dermatomyositis: An Alberta, Canada population-based cohort study Sci. Rep. 2023 13 16444 10.1038/s41598-023-43880-7 37777591 PMC10542346 4. Broers M.C. De Wilde M. Lingsma H.F. Van Der Lei J. Verhamme K.M.C. Jacobs B.C. …

Malignant mesothelioma tumours: molecular pathogenesis, diagnosis, and therapies accompanying clinical studies.

The pathetic malignant mesothelioma (MM) is a extremely uncommon and confrontational tumor that evolves in the mesothelium layer of the pleural cavities (inner lining- visceral pleura and outer lining- parietal pleura), peritoneum, pericardium, and tunica vaginalis and is highly resistant to standard treatments. In mesothelioma, the predominant pattern of lesions is a loss of genes that limit tumour growth. Despite the worldwide ban on the manufacture and supply of asbestos, the prevalence of mesothelioma continues to increase. Mesothelioma presents and behaves in a variety of ways, making dia

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… Columbia University Medical Center New York | Alopecia, thrombocytopenia, leukopenia, peripheral neuropathy, and dyspnea Mesothelioma Treatment Using Tomotherapy | Phase 2 | Completed | NCT00469196 | Tomotherapy | October 2006; n= 18 | Results not mentioned | Cross Cancer Institute Edmonton, Alberta, …

СРП 2013

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Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 1.

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… Rheumatology, Department of Paediatrics, Immunology and Institute of Medical Science, The Hospital for Sick Children, University of Toronto, Toronto, Ontaria; 4 Department of Community Health Services, McCaig Institute for Bone an Joint Health, O’Brien Institute for Public Health, University of Calgary; 5 Alberta … Children’s Hospital Research Institute, University of Calgary; 6 Division of Rheumatolgoy, Department of Pediatrics, Alberta Children’s Hospital, Cumming School of Medicine, University of Calgary, Calgary, Canada Correspondence: Jelleke B. …

The Role of Irisin and Physical Activity in Breast Cancer.

BACKGROUND/AIM: Irisin, a myokine released during physical activity, has been proposed as a mediator of exercise's protective effects against breast cancer (BC). This review underscores the critical role of irisin in mediating the anticancer effects of exercise and its potential application in BC prevention and prognosis. MATERIALS AND METHODS: Studies published up to 2025 were identified in PubMed, Scopus, and Web of Science databases. Data from experimental models, clinical trials, and observational studies were analyzed with emphasis on exercise-induced irisin secretion and its effects on

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… Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol. 2010;28(9):1458–1466. doi: 10.1200/JCO.2009.24.9557. 113. Słojewska K. The effect of physical activity on sex hormone levels in women. …

Chemoprevention in Skin Cancer: What Advice?

The incidence of melanoma and non-melanoma skin cancers (NMSCs) is increasing worldwide. While NMSCs are more common, melanoma remains the most challenging because of its higher aggressiveness. Although the use of sunscreens is key in high-risk populations, it provides limited protection, which highlights the need for alternative solutions. In this review, we discuss current evidence on chemopreventive therapies, as well as their efficacy and adverse events, including immunocompetent and immunosuppressed patients. Acitretin, nicotinamide, 5-fluorouracil, and photodynamic therapy have shown ove

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… Alberta D.S. Trial of retinol and isotretinoin in skin cancer prevention: A randomized, double-blind, controlled trial Cancer Epidemiol. Biomark. Prev. 1997 6 957 961 9367070 20. Tangrea J.A. Edwards B.K. Taylor P.R. Hartman A.M. Peck G.L. Salasche S.J. Menon P.A. Benson P.M. Mellette J.R. …

Drug Repurposing at the Interface of Melanoma Immunotherapy and Autoimmune Disease.

Cancer cells have a remarkable ability to evade recognition and destruction by the immune system. At the same time, cancer has been associated with chronic inflammation, while certain autoimmune diseases predispose to the development of neoplasia. Although cancer immunotherapy has revolutionized antitumor treatment, immune-related toxicities and adverse events detract from the clinical utility of even the most advanced drugs, especially in patients with both, metastatic cancer and pre-existing autoimmune diseases. Here, the combination of multi-omics, data-driven computational approaches with

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… Created and maintained by the University of Alberta and The Metabolomics Innovation Centre. | http://www.drugbank.ca/ Chemspider | Chemical structures are included in databases, giving users quick text and structure search access to more than 100 million structures from countless data sources. | http …

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases.

The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects that include certain types of cancers and strokes, hence the ongoing quest for the discovery of alternatives with little or no side effects. Natural products (NPs), mainly of plant origin, have shown compelling promise in the treatments of BDs, with little or no side effects. However, the paucity in knowledge of the mechanisms behind their activities on bone remodeling has remained a hindrance to NPs' adoption. This review discusses the pathological development of some BDs, the NP-targeted components, an

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… Pea Protein Derived Bioactive Peptides Stimulate Bone Health Promoting Effects Master’s Thesis University of Alberta Edomton, AB, Canada 2020 179. Bayle M. Neasta J. Dall’Asta M. Gautheron G. Virsolvy A. Quignard J.-F. Youl E. Magous R. Guichou J.-F. Crozier A. …

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies.

JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the myriad of cellular processes initiated by various types of ligands such as growth factors, hormones, and cytokines. The physiological processes regulated by JAK/STAT signaling are immune regulation, cell proliferation, cell survival, apoptosis and hematopoiesis of myeloid and non-myeloid cells. Dysregulation of JAK/STAT signaling is reported in various immunological disorders, hematological and other solid malignancies through various oncogenic activation mutations in receptors, downstream mediators, and a

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… Canada : University of Alberta . Thesis . He K. Wu L. Ding Q. Haider F. Yu H. Wang H. ( 2019 ). Apatinib Promotes Apoptosis of Pancreatic Cancer Cells through Downregulation of Hypoxia-Inducible Factor-1α and Increased Levels of Reactive Oxygen Species . Oxidative Med. …

Е-постеры.

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ISEV2018 абстрактная книга

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… Laurent 2 ; Wei Yang 1 ; Andries Zijlstra 6 ; Dolores Di Vizio 7 1 Cedars Sinai Medical Center, Los Angeles, USA; 2 University of California, San Diego, San Diego, USA; 3 University of Alberta, Edmonton, Canada; 4 Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, USA; 5 Cedars-Sinai Medical …

2023 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Montréal, Canada, 19 March–April 1 2023: Posters

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Optimal Treatment of Retinal Vein Occlusion: An Updated Canadian Review and Recommendations.

Retinal vein occlusion (RVO) represents a heterogeneous group of disorders that remains the second most common retinal vascular disease and can be associated with vision loss. RVO confers a substantial burden of illness that affects patients, caregivers, medical systems, and physicians. Complications of RVO - including cystoid macular edema, macular ischemia, and neovascularization sequelae - may result in severe visual morbidity and blindness. Canadian expert consensus recommendations on the optimal treatment of patients with RVO were published in 2015. Since that time, advances in diagnosis

Oral Communication abstracts

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Ход работы сессии 29th Европейский конгресс педиатрии.

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